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1. 发明申请

US20120022347A1 USING MUSCLE TENSION SENSING TO LOCATE AN ANALYTE MEASUREMENT SITE ON THE SKIN 审中-公开
标题翻译：使用肌肉张力感测来定位皮肤上的分析测量站点
公开(公告)号：US20120022347A1
公开(公告)日：2012-01-26
申请号：US13262785
申请日：2010-04-07
申请人： Yan Liu , Bastiaan Wilhelmus Maria Moeskops , Golo Von Basum , Alberto Bonomi
发明人： Yan Liu , Bastiaan Wilhelmus Maria Moeskops , Golo Von Basum , Alberto Bonomi
IPC分类号： A61B5/1455 , A61B5/103 , A61B5/0488
CPC分类号： A61B5/0488 , A61B5/0059 , A61B5/061 , A61B5/14532 , A61B2562/046
摘要： Apparatus for determining where to locate a measuring device (3) on skin, the apparatus having a muscle tension sensing device (1) arranged to sense muscle tension at different locations on the skin, and a processor (2) for determining and outputting an indication of where to locate the measuring device on the muscle, based on the sensed muscle tensions. This can help make the skin measurements such as non invasive glucose measurements more consistent, and more accurate.
摘要翻译：用于确定在皮肤上定位测量装置（3）的位置的装置，所述装置具有布置成感测皮肤上不同位置处的肌肉张力的肌肉张力感测装置（1），以及用于确定和输出指示基于感测到的肌肉紧张度，将测量装置定位在肌肉上的位置。这可以帮助皮肤测量如非侵入性葡萄糖测量更一致，更准确。

2. 发明申请

US20110125004A1 Analysis by photo acoustic displacement and interferometryl 审中-公开
标题翻译：通过光声位移和干涉仪分析
公开(公告)号：US20110125004A1
公开(公告)日：2011-05-26
申请号：US13055531
申请日：2009-07-24
申请人： Kiran Kumar Thumma , Bastiaan Wilhelmus Maria Moeskops , Golo Von Basum , Yan Liu
发明人： Kiran Kumar Thumma , Bastiaan Wilhelmus Maria Moeskops , Golo Von Basum , Yan Liu
IPC分类号： A61B5/05
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/0064 , A61B5/0095 , A61B5/14532
摘要： A device for analyzing a material, the device having a photo acoustic generator (40) for generating pressure waves in the material by pulsed illumination by a light source, and a sensor (20, 30, 50) for producing a signal using self mixing interferometry, the signal representing displacements of the material due to the pressure waves, and a signal processor (60) for processing the signal to analyze the material. This combination of photo acoustic stimulation and self mixing interferometry sensing helps reduce or avoid errors or distortions caused by sensor contact on the material, and can provide a better ratio of sensitivity for a given degree of compactness of the device.
摘要翻译：一种用于分析材料的装置，所述装置具有用于通过光源的脉冲照明在材料中产生压力波的光声发生器（40），以及用于使用自混合干涉测量法产生信号的传感器（20,30,50）表示由压力波引起的材料的位移的信号，以及用于处理信号以分析材料的信号处理器（60）。光声刺激和自混合干涉测量传感的这种组合有助于减少或避免由材料上的传感器接触引起的误差或失真，并且可以为设备的给定程度的紧凑性提供更好的灵敏度比。

3. 发明申请

US20110071419A1 LOCATION INDICATING DEVICE 审中-公开
标题翻译：位置指示装置
公开(公告)号：US20110071419A1
公开(公告)日：2011-03-24
申请号：US12992635
申请日：2009-05-20
申请人： Yan Liu , Bastiaan Wilhelmus Maria Moeskops , Alexander Franciscus Kolen , Femke Wagemakers , Golo Von Basum
发明人： Yan Liu , Bastiaan Wilhelmus Maria Moeskops , Alexander Franciscus Kolen , Femke Wagemakers , Golo Von Basum
IPC分类号： A61B5/053
CPC分类号： A61B5/0531 , A61B5/0053 , A61B5/150022 , A61B5/150106 , A61B5/150748 , A61B5/150824 , A61B5/151 , A61B5/4824 , A61B5/4827 , A61B5/489 , A61B5/6842 , A61B2562/046
摘要： The present invention provides a location indicating device (10) for determining on skin of a human or animal body a location for performing measurement of a physiological parameter in and/or treatment of the human or animal body. The location indicating device (10) comprises a matrix (7) of electrodes for determining skin resistance at different locations on skin of a human or animal body and a calculating unit (8) for calculating a location with highest skin resistance. The location indicating device (10) furthermore comprises visualisation means (9) for indicating the location of highest skin resistance to a user. The present invention also provides a method for making such a location indicating device (10) and a method for determining on skin of a human or animal body a location for performing measurement of a physiological parameter in and/or treatment of the human or animal body by using such a location indicating device (10).
摘要翻译：本发明提供一种位置指示装置（10），用于在人体或动物体的皮肤上确定用于在人体或动物体内进行和/或治疗的生理参数的测量的位置。位置指示装置（10）包括用于确定人体或动物体皮肤上不同位置处的皮肤电阻的电极矩阵（7）和用于计算具有最高皮肤电阻的位置的计算单元（8）。位置指示装置（10）还包括用于指示对使用者的最高皮肤电阻位置的可视化装置（9）。本发明还提供了一种用于制造这样的位置指示装置（10）的方法和用于在人或动物身体的皮肤上确定用于在人或动物体内进行和/或治疗的生理参数的测量的位置的方法通过使用这样的位置指示装置（10）。

4. 发明申请

US20110066092A1 PERFUSION REGULATION DEVICE 审中-公开
标题翻译：灌注调节装置
公开(公告)号：US20110066092A1
公开(公告)日：2011-03-17
申请号：US12992605
申请日：2009-05-12
申请人： Bastiaan Wilhelmus Maria Moeskops , Yan Liu , Kiran Kumar Thumma , Golo Von Basum
发明人： Bastiaan Wilhelmus Maria Moeskops , Yan Liu , Kiran Kumar Thumma , Golo Von Basum
IPC分类号： A61H9/00 , B23P17/04
CPC分类号： A61B5/0261 , A61B5/0053 , A61B5/14532 , A61B5/14546 , A61B5/6843 , Y10T29/49826
摘要： A perfusion, regulation device (10) for regulating tissue perfusion at a target site (2) on a human or animal body. The perfusion regulation device (10) comprises a pressure regulator (4) for determining and regulating pressure exerted by the perfusion regulation device (10) on the target site (2) and a perfusion monitor (5) for measuring tissue perfusion at the target site (2). The perfusion regulation device (10) furthermore comprises a control system (6) for driving the pressure regulator (4) so as to regulate pressure exerted by the perfusion regulation device (10) to the target site (2) thereby using feedback from the perfusion monitor (5). There is also a method for making such a perfusion regulation device (10) and a method for regulating tissue perfusion at a target site (2) on a human or animal body using such a perfusion regulation device (10).
摘要翻译：一种用于调节人体或动物体上目标部位（2）的组织灌注的灌注调节装置（10）。灌注调节装置（10）包括用于确定和调节由灌注调节装置（10）施加在目标部位（2）上的压力的压力调节器（4）和用于测量目标部位组织灌注的灌注监测器（5）（2）。灌注调节装置（10）还包括用于驱动压力调节器（4）的控制系统（6），以便调节由灌注调节装置（10）施加到目标部位（2）的压力，由此使用来自灌注的反馈监视器（5）。还有一种使用这种灌注调节装置（10）制造这种灌注调节装置（10）的方法和用于调节人体或动物体上目标部位（2）的组织灌注的方法。

5. 发明授权

US09060322B2 Method and system for preventing loops in mesh networks 有权
标题翻译：用于防止网状网络环路的方法和系统
公开(公告)号：US09060322B2
公开(公告)日：2015-06-16
申请号：US13281072
申请日：2011-10-25
申请人： Xu Zou , Kangchang Huang , Yan Liu
发明人： Xu Zou , Kangchang Huang , Yan Liu
IPC分类号： H04L12/28 , H04W4/00 , H04W40/02 , H04L12/705 , H04L12/715 , H04L12/707
CPC分类号： H04W40/02 , H04L45/04 , H04L45/18 , H04L45/24
摘要： The present disclosure discloses a network device and/or method for preventing loops in routing paths of network frames in a wireless digital network. The disclosed network device at a network node receives a frame from a wired network. The frame includes a site identifier uniquely corresponding to the wired network, a source physical address, and a destination physical address. If the network node is selected as a representative portal node, the network device forwards the frame. Otherwise, if another network node is selected as the representative portal node, the network device drops the received frame to prevent forming a loop in a routing path corresponding to the frame. If not other network is selected as the representative portal node, the network device floods the frame to other network nodes in the wireless network.
摘要翻译：本公开公开了一种用于防止无线数字网络中的网络帧的路由路径中的环路的网络设备和/或方法。在网络节点处公开的网络设备从有线网络接收帧。帧包括与有线网络唯一对应的站点标识符，源物理地址和目的地物理地址。如果选择网络节点作为代表性门户节点，则网络设备转发该帧。否则，如果选择另一网络节点作为代表门户节点，则网络设备丢弃所接收的帧，以防止在对应于该帧的路由路径中形成环路。如果不选择其他网络作为代表门户网站节点，则网络设备会将该帧洪泛到无线网络中的其他网络节点。

6. 发明申请

US20150150843A1 CARDIOPROTECTIVE COMPOUNDS, THEIR USE WITH CHEMOTHERAPY, AND METHODS FOR IDENTIFYING THEM 审中-公开
标题翻译：保护性化合物，其与化疗有关的使用方法及其鉴定方法
公开(公告)号：US20150150843A1
公开(公告)日：2015-06-04
申请号：US14402512
申请日：2013-05-16
申请人： Randall T. Peterson , Yan Liu
发明人： Randall T. Peterson , Yan Liu
IPC分类号： A61K31/352 , A61K49/00
CPC分类号： A61K31/352 , A61K31/17 , A61K31/37 , A61K31/496 , A61K31/704 , A61K49/0008 , A61K2300/00
摘要： The invention provides a method of reducing anthracycline-induced cardiotoxicity by administering a toxicity-reducing compound, such as a compound of Formulas (I), (II) or (III) or a combination thereof, and/or diphenyl urea (DPU), dexrazoxane (DEX), to a patient receiving an anthracycline. The invention also provides a method of identifying toxicity-reducing compounds.
摘要翻译：本发明提供了通过施用毒性降低化合物，例如式（I），（II）或（III）的化合物或其组合和/或二苯基脲（DPU），降低蒽环类诱导的心脏毒性的方法，右美沙芬（DEX）给予接受蒽环类抗生素的患者。本发明还提供鉴定毒性降低化合物的方法。

7. 发明授权

US08895302B2 Directed differentiation of primate pluripotent stem cells into functional basal forebrain cholinergic neurons (BFCNs) and medium spiny gabaergic projection neurons 有权
标题翻译：灵长类多能干细胞定向分化为功能性基底前脑胆碱能神经元（BFCNs）和中度多刺的神经元投射神经元
公开(公告)号：US08895302B2
公开(公告)日：2014-11-25
申请号：US13207202
申请日：2011-08-10
申请人： Su-Chun Zhang , Yan Liu , Lixiang Ma
发明人： Su-Chun Zhang , Yan Liu , Lixiang Ma
IPC分类号： C12N5/02 , C12N5/0793 , G01N33/50
CPC分类号： C12N5/0619 , C12N2501/01 , C12N2501/105 , C12N2501/115 , C12N2501/13 , C12N2501/15 , C12N2501/155 , C12N2501/392 , C12N2501/41 , C12N2502/086 , C12N2506/02 , C12N2506/45 , C12N2533/52 , G01N33/5058 , G01N2500/10
摘要： Methods of efficiently converting primate pluripotent stem cells to GABA neurons or cholinergic neurons, as well as applications thereof, are disclosed.
摘要翻译：公开了将灵长类多能干细胞有效转化为GABA神经元或胆碱能神经元的方法及其应用。

8. 发明授权

US08879233B2 Electrostatic chuck with polymer protrusions 有权
标题翻译：具有聚合物突起的静电卡盘
公开(公告)号：US08879233B2
公开(公告)日：2014-11-04
申请号：US13266657
申请日：2010-05-13
申请人： Richard A. Cooke , Nate Richard , Steven Donnell , Mark Vose , Yan Liu
发明人： Richard A. Cooke , Nate Richard , Steven Donnell , Mark Vose , Yan Liu
IPC分类号： H01T23/00 , H01L21/683 , H01L21/687
CPC分类号： H01L21/6831 , H01L21/6875
摘要： In accordance with an embodiment of the invention, there is provided an electrostatic chuck. The electrostatic chuck comprises a surface layer activated by a voltage in an electrode to form an electric charge to electrostatically clamp a substrate to the electrostatic chuck. The surface layer includes a plurality of polymer protrusions and a charge control layer to which the plurality of polymer protrusions adhere, the plurality of polymer protrusions extending to a height above portions of the charge control layer surrounding the plurality of polymer protrusions to support the substrate upon the plurality of polymer protrusions during electrostatic clamping of the substrate.
摘要翻译：根据本发明的实施例，提供了一种静电卡盘。静电卡盘包括由电极中的电压激活的表面层，以形成电荷以将基板静电夹持到静电卡盘。表面层包括多个聚合物突起和电荷控制层，多个聚合物突起粘附在该电荷控制层上，多个聚合物突起延伸到围绕多个聚合物突起的电荷控制层的部分上方的高度，以将基底支撑在在基板的静电夹持期间的多个聚合物突起。

9. 发明申请

US20140252316A1 QUANTUM DOTS, RODS, WIRES, SHEETS, AND RIBBONS, AND USES THEREOF 有权
标题翻译：量子，线，线，片和RIBBONS及其用途
公开(公告)号：US20140252316A1
公开(公告)日：2014-09-11
申请号：US14238775
申请日：2012-10-03
申请人： Hao Yan , Zhengtao Deng , Yan Liu
发明人： Hao Yan , Zhengtao Deng , Yan Liu
IPC分类号： H01L29/06 , H01L29/775 , H01L29/66
CPC分类号： C09K11/883 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B19/002 , C01B19/007 , C01G9/08 , C01G19/00 , C01P2002/72 , C01P2002/84 , C01P2002/85 , C01P2004/04 , C01P2004/16 , C01P2004/17 , C01P2004/64 , C01P2004/86 , C01P2004/88 , C09K11/02 , C09K11/08 , C09K11/0811 , C09K11/54 , C09K11/565 , C09K11/574 , C09K11/661 , G01N33/588 , H01B1/02 , H01L29/0669 , H01L29/122 , H01L29/127 , H01L29/22 , H01L29/66977 , H01L29/775 , Y10T428/12431 , Y10T428/294
摘要： Described are ZnxCd1-xSySe1-y/ZnSzSe1-z core/shell nanocrystals, CdTe/CdS/ZnS core/shell/shell nanocrystals, optionally ally doped Zn(S,Se,Te) nano- and quantum wires, and SnS quantum sheets or ribbons, methods for making the same, and their use in biomedical and photonic applications, such as sensors for analytes in cells and preparation of field effect transistors.
摘要翻译：描述了ZnxCd1-xSySe1-y / ZnSzSe1-z核/壳纳米晶体，CdTe / CdS / ZnS核/壳/壳纳米晶体，任选地掺杂Zn（S，Se，Te）纳米和量子线，以及SnS量子片或丝带，制造方法，以及它们在生物医学和光子应用中的应用，如细胞中分析物的传感器和场效应晶体管的制备。

10. 发明授权

US08738361B2 Systems and methods for extracting patterns from graph and unstructered data 有权
标题翻译：从图形和非结构化数据中提取模式的系统和方法
公开(公告)号：US08738361B2
公开(公告)日：2014-05-27
申请号：US12496252
申请日：2009-07-01
申请人： Wojciech Gryc , Richard Lawrence , Yan Liu
发明人： Wojciech Gryc , Richard Lawrence , Yan Liu
IPC分类号： G06F17/27
CPC分类号： G06F17/27 , G06F17/2745
摘要： A computing system receives input data having both graph and unstructured data and computes a current log likelihood of the input data. The computing system compares the current log likelihood with a previous log likelihood of the input data. If the current log likelihood is larger than the previous log likelihood, the computing system update topic modeling parameters, community modeling parameters, and the link generation parameter until the computing system obtains a maximal value of the log likelihood of the input data. Then, the computing system creates a graph indicating topic similarity between the input data based on the topic modeling parameters, creates another graph indicating community similarity between entities associated with the input data based on the community modeling parameters, and predicts a link existence between input data or entities based on the link generation parameter, the topic modeling parameter and the community modeling parameter.
摘要翻译：计算系统接收具有图形和非结构化数据的输入数据，并计算输入数据的当前对数似然性。计算系统将当前对数似然率与输入数据的先前对数似然比较。如果当前对数似然度大于先前的对数似然度，则计算系统更新主题建模参数，社区建模参数和链路生成参数，直到计算系统获得输入数据的对数似然性的最大值。然后，计算系统基于主题建模参数创建指示输入数据之间的主题相似性的图形，基于社区建模参数创建指示与输入数据相关联的实体之间的社区相似性的另一图形，并且预测输入数据之间的链接存在或基于链接生成参数，主题建模参数和社区建模参数的实体。

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