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1. 发明申请

US20050042272A1 Vesiles derived from t cells, production and uses 审中-公开
标题翻译： Vesiles衍生自t细胞，生产和使用
公开(公告)号：US20050042272A1
公开(公告)日：2005-02-24
申请号：US10502333
申请日：2003-03-13
申请人： Yafei Hou , Du-Hwei Hsu , Anita Mehta-Damani , Henry Lamparski , Redro Paz , Jean-Bernard Le Pecq
发明人： Yafei Hou , Du-Hwei Hsu , Anita Mehta-Damani , Henry Lamparski , Redro Paz , Jean-Bernard Le Pecq
IPC分类号： C12N5/02 , A61K35/26 , A61K39/00 , A61K39/29 , A61K39/39 , A61K45/00 , C07K14/18 , C12N5/0783 , C12N5/0784 , C12N5/10 , A61K9/127 , C12P7/64 , A61K38/20
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/5154 , A61K2039/5158 , A61K2039/55555 , C12N5/0636 , C12N5/0639 , C12N2500/14 , C12N2501/20 , C12N2501/515 , C12N2510/00 , C12N2510/02 , C12N2770/24222 , C12N2770/24234
摘要： The present invention relates to compositions comprising vesicles released from activated T lymphocytes, as well as to methods for their production and uses. Said vesicles contain a set of bioactive molecules which confer remarkable properties, such as antigen recognition, antigen presentation and other regulatory and effector functions. This invention also relates to methods for transferring or delivering antigenic molecules (e.g., peptides, peptide/MHC complexes, TCR or subunit thereof, etc.) to antigen presenting cells (APCs) using said vesicles, to induce specific immune responses, particularly specific CTL responses. The invention further relates to methods of delivering molecules selectively or specifically to target cells using said vesicles.
摘要翻译：本发明涉及包含从活化的T淋巴细胞释放的囊泡的组合物，以及其生产和用途的方法。所述囊泡含有一组生物活性分子，其具有显着的性质，例如抗原识别，抗原呈递和其它调节和效应子功能。本发明还涉及使用所述囊泡将抗原分子（例如肽，肽/ MHC复合物，TCR或其亚基等）转移或递送至抗原呈递细胞（APC）以诱导特异性免疫应答，特别是特异性CTL 回应。本发明还涉及使用所述囊泡选择性地或特异性地递送靶向细胞的方法。

2. 发明授权

US06812023B1 Methods of producing membrane vesicles 有权
标题翻译：膜囊泡的制备方法
公开(公告)号：US06812023B1
公开(公告)日：2004-11-02
申请号：US09561205
申请日：2000-04-27
申请人： Henry Lamparski , Curtis Ruegg , Jean-Bernard Le Pecq , Di-Hewi Hsu , Jenq Yuan Yao
发明人： Henry Lamparski , Curtis Ruegg , Jean-Bernard Le Pecq , Di-Hewi Hsu , Jenq Yuan Yao
IPC分类号： C12N506
CPC分类号： H01J37/32431 , A61K2039/55555 , C12N5/0639 , C12N2500/90 , C12N2501/22 , C12N2501/23 , C12N2501/24 , C23C16/4401 , C23C16/509 , G01N33/5432 , Y10S435/82
摘要： The present invention relates to methods of preparing biological material, for use in various experimental, diagnostic or therapeutic uses, including immunotherapy treatment or prophylaxy of tumors. More particularly, the present invention relates to methods of preparing membrane vesicles (in particular exosomes) released by various types of mammalian cells, comprising diafiltration and/or density cushion centrifugation. The invention also provides novel methods for characterizing and analyzing exosome preparations, which can be used in quality control assay for the purpose of pharmaceutical product production. The invention is suitable to produce pharmaceutical grade preparations of such membrane vesicles and to fully characterize said preparations, for use in human beings.
摘要翻译：本发明涉及制备生物材料的方法，用于各种实验，诊断或治疗用途，包括免疫治疗或预防肿瘤。更具体地说，本发明涉及制备由各种哺乳动物细胞释放的膜泡囊（特别是外来体）的方法，包括渗滤和/或密度缓冲离心。本发明还提供用于表征和分析外来体制剂的新方法，其可用于药物产品生产目的的质量控制测定。本发明适用于生产这种膜泡囊的药物级制剂，并且完全表征所述制剂用于人类。

3. 发明申请

US20090148460A1 EXOSOME LIGANDS, THEIR PREPARATION AND USES 审中-公开
标题翻译：异常配偶，他们的准备和使用
公开(公告)号：US20090148460A1
公开(公告)日：2009-06-11
申请号：US11988440
申请日：2006-07-07
申请人： Alain Delcayre , Jean-Bernard Le Pecq
发明人： Alain Delcayre , Jean-Bernard Le Pecq
IPC分类号： A61K39/395 , A61K38/17 , A61K39/00 , C07K16/18 , C40B30/04 , A61P35/00 , A61P31/18 , A61P31/14 , A61P31/04 , A61P37/06
CPC分类号： A61K39/0012 , C07K16/18 , C07K2317/56
摘要： The present invention relates to exosome-specific ligands and compositions comprising the same. The invention also relates to methods of generating said ligands and compositions, to methods of using said ligands or compositions, e.g., to block the exosome pathway or to detect and/or characterize exosomes in a sample or subject, as well as to the antigens contacted by said ligands or compositions. The application can be used in experimental, research, therapeutic, prophylactic or diagnostic areas.
摘要翻译：本发明涉及外来体特异性配体和包含其的组合物。本发明还涉及产生所述配体和组合物的方法，使用所述配体或组合物的方法，例如阻断外来体途径或检测和/或表征样品或受试者中的外来体以及所接触的抗原通过所述配体或组合物。该应用可用于实验，研究，治疗，预防或诊断领域。

4. 发明授权

US07914792B2 Methods and compounds for raising antibodies and for screening antibody repertoires 有权
标题翻译：用于产生抗体和筛选抗体库的方法和化合物
公开(公告)号：US07914792B2
公开(公告)日：2011-03-29
申请号：US10545557
申请日：2004-02-13
申请人： Alain Delcayre , Jean-Bernard Le Pecq
发明人： Alain Delcayre , Jean-Bernard Le Pecq
IPC分类号： A61K39/00 , C12P21/04
CPC分类号： C07K16/18 , C07K16/00
摘要： The present invention relates to compositions and methods for raising antibodies generally comprising 1) providing highly immunogenic vesicles bearing at least one target antigen and 2) immunizing animals with the said antigen-bearing vesicles to induce antigen-specific antibody responses. The invention also relates to methods of screening antibody repertoires comprising 1) providing vesicles bearing at least one target antigen and one marker and 2) isolating antibody-producing cells or particles with defined antigen specificity using the said antigen- and marker-bearing vesicles. Antibodies with defined antigen specificity can then be prepared from isolated antibody-producing cells using known methods of the art. This invention can be used in experimental, research, therapeutic, prophylactic or diagnostic areas.
摘要翻译：本发明涉及用于产生抗体的组合物和方法，通常包括：1）提供具有至少一种靶抗原的高度免疫原性的囊泡，和2）用所述含有抗原的囊泡免疫动物以诱导抗原特异性抗体应答。本发明还涉及筛选抗体库的方法，其包括：1）提供具有至少一种靶抗原和1个标记的囊泡; 2）使用所述含抗原和标记的囊泡分离具有确定的抗原特异性的抗体产生细胞或颗粒。然后可以使用本领域已知的方法从分离的产生抗体的细胞制备具有确定的抗原特异性的抗体。本发明可用于实验，研究，治疗，预防或诊断领域。

5. 发明授权

US07704964B2 Methods and compounds for the targeting of protein to exosomes 有权
标题翻译：用于将蛋白质靶向外来体的方法和化合物
公开(公告)号：US07704964B2
公开(公告)日：2010-04-27
申请号：US10485360
申请日：2002-08-14
申请人： Alain Delcayre , Jean-Bernard Le Pecq
发明人： Alain Delcayre , Jean-Bernard Le Pecq
IPC分类号： A61K31/70 , C12N15/74 , C12N15/09 , A61N63/00
CPC分类号： C12N15/62 , A61K47/64 , A61K47/6901 , C07K14/47 , C07K14/55 , C07K2319/00 , C07K2319/01 , C07K2319/41 , C07K2319/75
摘要： The present invention relates to compositions and methods for selectively expressing a polypeptide in a membrane vesicle. The invention also relates to genetic constructs and recombinant cells suitable to produce such membrane vesicles. This invention also relates to such functionalized membrane vesicles as well as to methods of making antibodies, methods of producing or regulating an immune response as well as to methods of screening or identifying binding partners using the same. The invention more particularly uses lactadherin or portions thereof to selectively express polypeptides in membrane vesicles, of natural or synthetic origin. This invention can be used in experimental, research, therapeutic, prophylactic or diagnostic areas.
摘要翻译：本发明涉及用于在膜囊泡中选择性表达多肽的组合物和方法。本发明还涉及适于产生这种膜囊泡的遗传构建体和重组细胞。本发明还涉及这种功能化膜囊泡以及制备抗体的方法，产生或调节免疫应答的方法以及筛选或鉴定使用其的结合配偶体的方法。本发明更特别地使用乳胶素或其部分选择性地表达天然或合成来源的膜囊泡中的多肽。本发明可用于实验，研究，治疗，预防或诊断领域。

6. 发明申请

US20060222654A1 Methods and compounds for raising antibodies and for screening antibody repertoires 有权
标题翻译：用于产生抗体和筛选抗体库的方法和化合物
公开(公告)号：US20060222654A1
公开(公告)日：2006-10-05
申请号：US10545557
申请日：2004-02-13
申请人： Alain Delcayre , Angeles Estelles , Jeffrey Sperinde , Thibaut Roulon , Jean-Bernard Le Pecq
发明人： Alain Delcayre , Angeles Estelles , Jeffrey Sperinde , Thibaut Roulon , Jean-Bernard Le Pecq
IPC分类号： A61K39/00 , C12P21/04
CPC分类号： C07K16/18 , C07K16/00
摘要： The present invention relates to compositions and methods for raising antibodies generally comprising 1) providing highly immunogenic vesicles bearing at least one target antigen and 2) immunizing animals with the said antigen-bearing vesicles to induce antigen-specific antibody responses. The invention also relates to methods of screening antibody repertoires comprising 1) providing vesicles bearing at least one target antigen and one marker and 2) isolating antibody-producing cells or particles with defined antigen specificity using the said antigen- and marker-bearing vesicles. Antibodies with defined antigen specificity can then be prepared from isolated antibody-producing cells using known methods of the art. This invention can be used in experimental, research, therapeutic, prophylactic or diagnostic areas.
摘要翻译：本发明涉及用于产生抗体的组合物和方法，通常包括：1）提供具有至少一种靶抗原的高免疫原性囊泡，和2）用所述抗原携带囊泡免疫动物以诱导抗原特异性抗体应答。本发明还涉及筛选抗体库的方法，其包括：1）提供具有至少一种靶抗原和1个标记的囊泡; 2）使用所述含抗原和标记的囊泡分离具有确定的抗原特异性的抗体产生细胞或颗粒。然后可以使用本领域已知的方法从分离的产生抗体的细胞制备具有确定的抗原特异性的抗体。本发明可用于实验，研究，治疗，预防或诊断领域。

7. 发明授权

US4483989A Synthesis of pyrido[4,3-b]carbazole derivatives 失效
标题翻译：吡啶并[4,3-b]咔唑衍生物的合成
公开(公告)号：US4483989A
公开(公告)日：1984-11-20
申请号：US307296
申请日：1981-09-30
申请人： Jean-Bernard Le Pecq , Claude Paoletti , Nguyen Dat-Xuong
发明人： Jean-Bernard Le Pecq , Claude Paoletti , Nguyen Dat-Xuong
IPC分类号： A61K31/435 , A61P9/04 , A61P35/00 , A61P35/02 , C07D471/04 , C07D471/02
CPC分类号： C07D471/04
摘要： Derivatives of 9-hydroxy ellipticine, preparation thereof, and use thereof for the treatment of leukemias and solid tumors.
摘要翻译： 9-羟基玫瑰树碱的衍生物，其制备及其用于治疗白血病和实体瘤的用途。

8. 发明授权

US4310667A 2-N Quaternary ammonium salt derivatives of 9-hydroxy ellipticine 失效
标题翻译： 9-羟基玫瑰树碱的2-N季铵盐衍生物
公开(公告)号：US4310667A
公开(公告)日：1982-01-12
申请号：US942793
申请日：1978-09-15
申请人： Jean-Bernard Le Pecq , Claude Paoletti
发明人： Jean-Bernard Le Pecq , Claude Paoletti
IPC分类号： A61K31/435 , A61K31/403 , A61K31/439 , A61P35/00 , C07D209/88 , C07D453/06 , C07D471/00 , C07D471/04 , C07D471/02 , A61K31/475
CPC分类号： C07D471/04 , C07D209/88 , Y02P20/55 , Y10S514/908
摘要： Derivatives of 9-hydroxy ellipticine, preparation thereof, and use thereof for the treatment of leukemias and solid tumors.
摘要翻译： 9-羟基玫瑰树碱的衍生物，其制备及其用于治疗白血病和实体瘤的用途。

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