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1. 发明申请

US20080050393A1 Novel nucleic acids and polypeptides 审中-公开
标题翻译：新型核酸和多肽
公开(公告)号：US20080050393A1
公开(公告)日：2008-02-28
申请号：US10302689
申请日：2002-11-22
申请人： Y. Tom Tang , Vinod Asundi , Dennis Ballinger , Ivan Labat , Dena Leshkowitz , Jin Liu , Deborah Loeb , Julia R. Montgomery , Ann M. Pace , James P. Sheridan , Radoje T. Drmanac
发明人： Y. Tom Tang , Vinod Asundi , Dennis Ballinger , Ivan Labat , Dena Leshkowitz , Jin Liu , Deborah Loeb , Julia R. Montgomery , Ann M. Pace , James P. Sheridan , Radoje T. Drmanac
IPC分类号： A61K39/00 , A61K38/00 , C07H21/04 , C07K14/00 , C12N15/00 , C12P21/00 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译：本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。

2. 发明授权

US07109030B2 Methods of therapy and diagnosis using insulin-like growth factor binding protein-like polypeptides and polynucleotides 失效
标题翻译：使用胰岛素样生长因子结合蛋白样多肽和多核苷酸的治疗和诊断方法
公开(公告)号：US07109030B2
公开(公告)日：2006-09-19
申请号：US10218325
申请日：2002-08-12
申请人： Douglas A. Dedera , Victoria Yamazaki , Vinod Asundi , Chenghua Liu , Y. Tom Tang , Radoje T. Drmanac
发明人： Douglas A. Dedera , Victoria Yamazaki , Vinod Asundi , Chenghua Liu , Y. Tom Tang , Radoje T. Drmanac
IPC分类号： C12N15/00 , G01N33/53 , A61K38/00 , C07K14/435
CPC分类号： G01N33/57488 , A61K38/00 , C07K14/71 , G01N2333/65
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted IGFBP-like polypeptides, compositions, and methods of use for such polypeptides including in cancer.
摘要翻译：本发明提供由这样的多核苷酸编码的新型多核苷酸和多肽，其对应于新型人分泌的IGFBP样多肽的突变体或其变体。本发明的其它方面包括含有生产新型人分泌IGFBP样多肽的方法的载体，组合物，以及包括癌症在内的多肽的使用方法。

3. 发明授权

US06783969B1 Cathepsin V-like polypeptides 失效
标题翻译：组织蛋白酶V样多肽
公开(公告)号：US06783969B1
公开(公告)日：2004-08-31
申请号：US09799451
申请日：2001-03-05
申请人： Y. Tom Tang , Ryle W. Goodrich , Vinod Asundi , Radoje T. Drmanac
发明人： Y. Tom Tang , Ryle W. Goodrich , Vinod Asundi , Radoje T. Drmanac
IPC分类号： C12N950
CPC分类号： C07K14/475 , C07K14/47
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译：本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。

4. 发明授权

US06743619B1 Nucleic acids and polypeptides 失效
标题翻译：核酸和多肽
公开(公告)号：US06743619B1
公开(公告)日：2004-06-01
申请号：US09774528
申请日：2001-01-30
申请人： Y. Tom Tang , Ping Zhou , Ryle Goodrich , Chenghua Liu , Vinod Asundi , Feiyan Ren , Jie Zhang , Qing A. Zhao , Yonghong Yang , Aidong J. Xue , Tom Wehrman , Jian-Rui Wang , Dunrui Wang , Radoje T. Drmanac
发明人： Y. Tom Tang , Ping Zhou , Ryle Goodrich , Chenghua Liu , Vinod Asundi , Feiyan Ren , Jie Zhang , Qing A. Zhao , Yonghong Yang , Aidong J. Xue , Tom Wehrman , Jian-Rui Wang , Dunrui Wang , Radoje T. Drmanac
IPC分类号： C12N990
CPC分类号： C07K14/47 , G01N2500/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译：本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。

5. 发明授权

US06610536B2 Nucleic acids and polypeptides 失效
公开(公告)号：US06610536B2
公开(公告)日：2003-08-26
申请号：US09808701
申请日：2001-03-14
申请人： Y. Tom Tang , Ryle Goodrich , Vinod Asundi , Radoje T. Drmanac
发明人： Y. Tom Tang , Ryle Goodrich , Vinod Asundi , Radoje T. Drmanac
IPC分类号： C12N502
CPC分类号： C07K14/47 , A61K38/00 , C07K14/8107
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

6. 发明授权

US06436703B1 Nucleic acids and polypeptides 失效
标题翻译：核酸和多肽
公开(公告)号：US06436703B1
公开(公告)日：2002-08-20
申请号：US09668680
申请日：2000-09-22
申请人： Y. Tom Tang , Chenghua Liu , Ping Zhou , Vinod Asundi , Jie Zhang , Jian-Rui Wang , Aidong J. Xue , Chongjun Xu , Radoje T. Drmanac
发明人： Y. Tom Tang , Chenghua Liu , Ping Zhou , Vinod Asundi , Jie Zhang , Jian-Rui Wang , Aidong J. Xue , Chongjun Xu , Radoje T. Drmanac
IPC分类号： C12N1512
CPC分类号： C07K14/47 , A61K38/00 , C07K14/8107
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译：本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。

7. 发明申请

US20080227200A1 Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and DNA coding for the same 审中-公开
标题翻译：具有支持造血干细胞和造血祖细胞的增殖或存活的活性的多肽和编码其的DNA
公开(公告)号：US20080227200A1
公开(公告)日：2008-09-18
申请号：US11986709
申请日：2007-11-26
申请人： Radoje T. Drmanac , Ivan Labat , Y. Tom Tang , Juhi Lee , Birgit Stache-Crain , Mitsuo Nishikawa
发明人： Radoje T. Drmanac , Ivan Labat , Y. Tom Tang , Juhi Lee , Birgit Stache-Crain , Mitsuo Nishikawa
IPC分类号： C12N5/06 , C12N15/11 , C07K14/00 , C07K16/18 , C12N15/00
CPC分类号： C12N5/0647 , A61K38/00 , C07K14/475
摘要： A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.
摘要翻译：通过比较支持造血干细胞或造血祖细胞的增殖或存活的细胞之间的表达基因和不支持增殖的细胞，分离编码具有支持造血干细胞或造血祖细胞增殖或存活的活性的多肽的基因或生存。通过使用分离的基因表达的基质细胞或分离的基因的基因产物来支持造血干细胞或造血祖细胞的增殖或存活。

8. 发明授权

US07319141B2 Stem cell growth factor-like polypeptides 失效
标题翻译：干细胞生长因子样多肽
公开(公告)号：US07319141B2
公开(公告)日：2008-01-15
申请号：US10968674
申请日：2004-10-19
申请人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy K. Mize , Mitsuo Nishikawa , Cheng-Chi Chao
发明人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy K. Mize , Mitsuo Nishikawa , Cheng-Chi Chao
IPC分类号： C07K14/475 , C07H21/04
CPC分类号： C07K14/475 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K16/00 , C07K2319/00 , C12N9/16 , C12N9/6432 , C12Y304/21006 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。这些多核苷酸包含从人胎儿皮肤（Hyseq克隆鉴定号15375176），成年脾（Hyseq克隆鉴定号14856094）和人内皮细胞的人睾丸细胞（Hyseq克隆鉴定号2880984和2881695）的cDNA文库中分离的核酸序列（Hyseq克隆鉴定号13804756,13687487,13804756）。本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

9. 发明授权

US06824973B2 Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell factor-like polypeptide 失效
标题翻译：通过使细胞与干细胞因子样多肽接触来促进干细胞增殖或存活的方法
公开(公告)号：US06824973B2
公开(公告)日：2004-11-30
申请号：US09894912
申请日：2001-06-28
申请人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
发明人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
IPC分类号： C12Q100
CPC分类号： C07K14/475 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K16/00 , C07K2319/00 , C12N9/16 , C12N9/6432 , C12Y304/21006 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。这些多核苷酸包含从人胎儿皮肤（Hyseq克隆鉴定号15375176），成年脾（Hyseq克隆鉴定号14856094）和人内皮细胞的人睾丸细胞（Hyseq克隆鉴定号2880984和2881695）的cDNA文库中分离的核酸序列（Hyseq克隆鉴定号13804756,13687487,13804756）。本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

10. 发明授权

US06667391B1 Stem cell growth factor-like polypeptide 失效
标题翻译：干细胞生长因子样多肽
公开(公告)号：US06667391B1
公开(公告)日：2003-12-23
申请号：US09764325
申请日：2001-01-16
申请人： Radoje T. Drmanac , Ivan Labat , Y. Tom Tang , Cheng-Chi Chao , Nancy K. Mize , John Childs
发明人： Radoje T. Drmanac , Ivan Labat , Y. Tom Tang , Cheng-Chi Chao , Nancy K. Mize , John Childs
IPC分类号： C07K200
CPC分类号： C07K14/475 , A61K38/00 , A61K2039/505 , C07K14/47 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human fetal liver spleen (Hyseq clone identification number 6118092), ovary (Hyseq clone identification number 8375786), adult brain (Hyseq clone identification numbers 701734, 15327638, 15741682, 15954941, 15955015), lung tumor (Hyseq clone identification number 11047146 and 10280328), spinal cord (Hyseq clone identification number 10102150), cervix (Hyseq clone identification numbers 10022437 and 14029194), ovary (Hyseq clone identification number 8319153), endothelial cells (Hyseq clone identification number 13815744), umbilical cord (Hyseq clone identification number 18568149), lymphocyte (Hyseq clone identification number 10257378), lung fibroblast (Hyseq clone identification number 17116257), fetal brain (Hyseq clone identification number 15266959), and testis. Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。这些多核苷酸包含从人胎儿肝脏脾脏（Hyseq克隆鉴定号6118092），卵巢（Hyseq克隆鉴定号8375786），成年脑（Hyseq克隆鉴定号701734,15327638,15741682,15954941,15955015）分离的核酸序列，肺癌（Hyseq克隆鉴定号11047146和10280328），脊髓（Hyseq克隆鉴定号10102150），宫颈（Hyseq克隆鉴定号10022437和14029194），卵巢（Hyseq克隆鉴定号8319153），内皮细胞（Hyseq克隆鉴定号13815744 ），脐带（Hyseq克隆鉴定号18568149），淋巴细胞（Hyseq克隆鉴定号10257378），肺成纤维细胞（Hyseq克隆鉴定号17116257），胎儿脑（Hyseq克隆鉴定号码15266959）和睾丸。本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

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