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1. 发明申请

US20120073001A1 METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS 审中-公开
标题翻译：用于治疗或预防PRURITIS的方法和组合物
公开(公告)号：US20120073001A1
公开(公告)日：2012-03-22
申请号：US13132268
申请日：2009-11-30
申请人： Xinzhong Dong , Qin Liu , David J. Anderson
发明人： Xinzhong Dong , Qin Liu , David J. Anderson
IPC分类号： A61K49/00 , A61K31/439 , C07D453/02 , C07H21/00 , C07H21/02 , C12N15/113 , C12N15/63 , C12N15/85 , C12N5/10 , A61K31/56 , C12Q1/68 , G01N33/566 , C12Q1/02 , A61P17/04 , A61K31/7088
CPC分类号： C12N15/1138 , A61K31/439 , A61K31/46 , A61K31/56 , A61K31/7088 , A61K31/713 , A61K45/06 , C07K14/705 , G01N33/5023 , G01N33/5041 , A61K2300/00
摘要： The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
摘要翻译：本发明的特征在于包含可用于治疗或预防瘙痒症的药剂的治疗组合物，以及用于鉴定这些药物的方法。

2. 发明申请

US20110150769A1 IDENTIFICATION AND USE OF COMPOUNDS FOR TREATING PERSISTENT PAIN 审中-公开
标题翻译：化合物用于治疗疼痛的鉴别和使用
公开(公告)号：US20110150769A1
公开(公告)日：2011-06-23
申请号：US12851436
申请日：2010-08-05
申请人： David J. Anderson , Xinzhong Dong , Qin Liu , Yun Guan
发明人： David J. Anderson , Xinzhong Dong , Qin Liu , Yun Guan
IPC分类号： A61K49/00 , A61K31/7088 , A61K38/02 , A61K31/501 , A61K31/5517 , A61P25/04 , A61P29/00
摘要： The present application provides methods and compositions that can be used to treat persistent pain and to identify compounds that can be used for treating persistent pain. More specifically, agonists of members of the Mrgpr receptor family, particularly agonists of MrgprX1, can identified and screened for use in treating persistent pain, such as pain caused by inflammation or nerve injury.
摘要翻译：本申请提供了可用于治疗持续性疼痛并鉴定可用于治疗持续性疼痛的化合物的方法和组合物。更具体地，Mrgpr受体家族的成员的激动剂，特别是MrgprX1的激动剂，可以鉴定和筛选用于治疗持续性疼痛，例如由炎症或神经损伤引起的疼痛。

3. 发明授权

US07691604B1 MRG polypeptides and nucleic acids encoding the same 有权
标题翻译： MRG多肽和编码其的核酸
公开(公告)号：US07691604B1
公开(公告)日：2010-04-06
申请号：US09704707
申请日：2000-11-03
申请人： Xinzhong Dong , David J. Anderson
发明人： Xinzhong Dong , David J. Anderson
IPC分类号： C12N15/12 , C07K14/705
CPC分类号： C07K14/70571
摘要： The invention relates generally to novel genes expressed in normal but not neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
摘要翻译：本发明一般涉及在正常但不是神经元素-1缺乏的动物中表达的新基因。本发明具体涉及G蛋白偶联受体的新家族和在背根神经节中表达的双跨膜区段蛋白质的新家族，以及筛选在伤害性感觉神经元中特异性表达的基因的方法。

4. 发明授权

US08916355B2 Pain signaling molecules 有权
标题翻译：疼痛信号分子
公开(公告)号：US08916355B2
公开(公告)日：2014-12-23
申请号：US11703062
申请日：2007-02-05
申请人： David J. Anderson , Xinzhong Dong , Mark Zylka , Sang-kyou Han , Melvin I. Simon
发明人： David J. Anderson , Xinzhong Dong , Mark Zylka , Sang-kyou Han , Melvin I. Simon
IPC分类号： G01N33/567 , G01N33/50 , G01N33/543 , C07K14/705 , A61K38/00
CPC分类号： C07K14/70571 , A61K38/00 , C07K14/705 , G01N33/5041 , G01N33/5058 , G01N33/5082 , G01N33/54366 , G01N2333/726 , G01N2500/02
摘要： The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
摘要翻译：本发明一般涉及在正常但不是神经元素-1缺陷的动物中表达的新基因。本发明具体涉及G蛋白偶联受体的新家族和在背根神经节中表达的双跨膜区段蛋白质的新家族，以及筛选在伤害性感觉神经元中特异性表达的基因的方法。

5. 发明授权

US07510845B2 Assay employing G protein-coupled receptor expressed in dorsal root ganglia 有权
标题翻译：使用在背根神经节中表达的G蛋白偶联受体的测定
公开(公告)号：US07510845B2
公开(公告)日：2009-03-31
申请号：US11083611
申请日：2005-03-17
申请人： David J. Anderson , Xinzhong Dong , Mark J. Zylka , Sang-Kyou Han , Melvin I. Simon
发明人： David J. Anderson , Xinzhong Dong , Mark J. Zylka , Sang-Kyou Han , Melvin I. Simon
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： C07K14/70571 , A61K38/00
摘要： The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
摘要翻译：本发明一般涉及在正常但不是神经元素-1缺陷的动物中表达的新基因。本发明具体涉及G蛋白偶联受体的新家族和在背根神经节中表达的双跨膜区段蛋白质的新家族，以及筛选在伤害性感觉神经元中特异性表达的基因的方法。

6. 发明授权

US10071310B2 Methods and systems for establishing games with automation using verbal communication 有权
公开(公告)号：US10071310B2
公开(公告)日：2018-09-11
申请号：US14805552
申请日：2015-07-22
申请人： David J. Anderson , Senis Busayapongchai
发明人： David J. Anderson , Senis Busayapongchai
IPC分类号： G10L17/00 , G10L15/00 , H04L29/06 , A63F13/424 , A63F13/215 , A63F13/79 , A63F13/54
CPC分类号： A63F13/424 , A63F13/12 , A63F13/215 , A63F13/54 , A63F13/79 , A63F2300/1081 , A63F2300/50 , A63F2300/6072 , A63F2300/6081 , G10L15/00 , G10L17/00 , H04L65/00
摘要： A thick-game client device includes all of the game data processing on-board while a thin-game client device includes only a small portion of game data processing such as to render visual displays while the majority of the game data processing is network based. A thick-voice client devices includes all of the voice processing on-board while a thin-voice client device includes only a small portion of the voice processing such as to generate acoustic parameter data discussed below while the remainder of the voice processing occurs at a voice services node. It will be appreciated that a client device may be thick with respect to both game processing and voice processing, may be thick with respect to one type of processing and thin with respect to the other, or may be thin with respect to both types of processing.

7. 发明申请

US20130091591A1 ARTERY- AND VEIN-SPECIFIC PROTEINS AND USES THEREFOR 审中-公开
标题翻译：特异性和特异性蛋白质及其用途
公开(公告)号：US20130091591A1
公开(公告)日：2013-04-11
申请号：US13597626
申请日：2012-08-29
申请人： Hai U. Wang , Zhoufeng Chen , David J. Anderson
发明人： Hai U. Wang , Zhoufeng Chen , David J. Anderson
IPC分类号： A61K49/00 , A61K39/395 , A61K47/48 , A01K67/027
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0375 , A61K39/3955 , A61K49/00 , A61K49/0002 , A61K49/0008 , C07K14/705 , C07K16/2866 , C07K16/30 , C07K2317/76 , C12N5/0691 , C12N2503/02 , G01N33/573 , G01N33/6863 , G01N2333/52
摘要： Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells and vein cells, for example.
摘要翻译：动脉和静脉内皮细胞与血管生成的最早阶段分子不同。通过在受体EphB4在静脉细胞上表达的称为EphrinB2的跨膜配体的动脉细胞上的表达来揭示这种区别。 EphrinB2基因的靶向破坏阻止了从毛细血管丛将静脉重构成适当的分支结构。此外，它还破坏动脉重塑，这表明预先规定的动脉和静脉内皮细胞之间的相互作用对于血管发生是必需的。这种区别可用于改变血管生成的方法，评估药物对动脉细胞和静脉细胞的作用的方法，以及鉴定和分离动脉细胞和静脉细胞的方法。

8. 发明授权

US08332046B2 Neural interface system 有权
标题翻译：神经界面系统
公开(公告)号：US08332046B2
公开(公告)日：2012-12-11
申请号：US12848828
申请日：2010-08-02
申请人： David J. Anderson , Rio J. Vetter , Jamille F. Hetke , Daryl R. Kipke
发明人： David J. Anderson , Rio J. Vetter , Jamille F. Hetke , Daryl R. Kipke
IPC分类号： A61N1/05
CPC分类号： A61B5/04001 , A61N1/0534 , A61N1/0539 , Y10T29/49204
摘要： A neural interface system including an electrode array and a carrier that supports the electrode array, in which the electrode array includes a substrate rolled into a three-dimensional shape, a plurality of conductive traces patterned on the substrate and adapted to transmit electrical signals, and a plurality of elliptically shaped, externally facing electrode sites coupled to the plurality of conductive traces that electrically communicate with their surroundings. The plurality of electrodes are arranged in a triangular lattice circumferentially around and axially along the carrier, and the substrate includes an edge that extends axially along the carrier and is constrained between a first axial row portion of the plurality of electrode sites and a second axial row portion of the plurality of electrode sites adjacent to the first axial row portion.
摘要翻译：一种神经接口系统，包括支撑电极阵列的电极阵列和载体，其中电极阵列包括滚动成三维形状的基底，在基底上图案化并适于透射电信号的多个导电迹线，以及耦合到与其周围环境电连通的多个导电迹线的多个椭圆形的外部对置的电极位置。所述多个电极沿着所述载体围绕并且轴向地布置成三角形晶格，并且所述基板包括沿着所述载体轴向延伸并且被约束在所述多个电极位置的第一轴向行部分和第二轴向行多个电极位置的与第一轴向行部分相邻的部分。

9. 发明授权

US08229085B2 Automatic message management utilizing speech analytics 有权
标题翻译：使用语音分析的自动消息管理
公开(公告)号：US08229085B2
公开(公告)日：2012-07-24
申请号：US11888074
申请日：2007-07-31
申请人： David J. Anderson
发明人： David J. Anderson
IPC分类号： H04M1/64
CPC分类号： H04M3/5307 , G06F17/279 , H04M1/64 , H04M3/53333
摘要： Embodiments are provided for utilizing speech analytics for automatically managing messages in a communications network. A message from a calling party to an unavailable called party is recorded in a messaging management module. The messaging management module automatically identifies a category for assigning to the content of the message based on information associated with the unavailable called party or a calling party and associates a language model with the message content based on the category. An analysis module utilizes the language model to identify grammar making up the message content. The messaging management module automatically performs a messaging management function on the message content based on a set of rules. The messaging management function may include automatically determining a priority for the message (enabling the message to be retrieved out of order) or automatically triggering an action in response to the message which is directed to the unavailable called party.
摘要翻译：提供实施例以利用语音分析来自动管理通信网络中的消息。从呼叫方到不可用呼叫方的消息被记录在消息收发管理模块中。消息管理模块基于与不可用的被叫方或主叫方相关联的信息，自动识别用于分配消息的内容的类别，并且基于该类别将语言模型与消息内容相关联。分析模块利用语言模型来识别构成消息内容的语法。消息管理模块基于一组规则自动对消息内容执行消息管理功能。消息收发管理功能可以包括自动确定消息的优先级（使得消息无法被检索出来）或响应于针对不可用被叫方的消息来自动触发动作。

10. 发明申请

US20110287480A1 NEUROGENIN 有权
标题翻译：神经母细胞瘤
公开(公告)号：US20110287480A1
公开(公告)日：2011-11-24
申请号：US12941936
申请日：2010-11-08
申请人： David J. Anderson , Qiufa Ma , Lukas Sommer
发明人： David J. Anderson , Qiufa Ma , Lukas Sommer
IPC分类号： C12P21/00 , C12N1/21 , C12N1/00 , C12N1/15 , C07K16/18 , C12N5/10 , G01N33/566 , C07H21/00 , C07K14/00 , C12N15/63 , C12N1/19
CPC分类号： C07K14/475
摘要： The invention relates to novel neurogenin proteins, nucleic acids and antibodies.
摘要翻译：本发明涉及新型神经元蛋白，核酸和抗体。

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