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    • 1. 发明授权
    • Methods and apparatus for automated base-calling on multiple DNA strands
    • 在多个DNA链上进行自动基本呼叫的方法和装置
    • US08126235B2
    • 2012-02-28
    • US12418933
    • 2009-04-06
    • Xiaomeng ShiMuriel MedardRalf KoetterNuala Ann Koetter, legal representativeDesmond S. Lun
    • Xiaomeng ShiMuriel MedardRalf KoetterDesmond S. Lun
    • G06K9/00
    • G06K9/0053G01N27/44717G01N30/8682G01N30/8696
    • In some aspects, a method of automated base-calling using at least one image obtained from a chemical sequencing process performed simultaneously on a plurality of DNA strands, the at least one image including intensity information corresponding to locations of at least one base in the plurality of DNA strands is provided. The method comprises processing the at least image to obtain a function corresponding to the intensity information in the at least one image for the at least one base, the function incorporating intensity information corresponding to each of the plurality of DNA strands, identifying a plurality of peaks in the function, the plurality of peaks indicating possible locations for the at least one base in the plurality of DNA strands, assigning membership to each of the plurality of peaks by determining whether each of the plurality of peaks is believed to have resulted from none, one or multiple of the plurality of DNA strands, and computing a sequence for the at least one base for each of the plurality of DNA strands based, at least in part, on the membership assignment.
    • 在一些方面,一种使用从多个DNA链同时执行的化学测序过程获得的至少一个图像进行自动基本呼叫的方法,所述至少一个图像包括对应于多个基因中至少一个基因位置的强度信息 的DNA链。 所述方法包括处理所述至少一个图像以获得对应于所述至少一个基底的所述至少一个图像中的强度信息的函数,所述功能包括对应于所述多个DNA链中的每一个的强度信息,识别多个峰 在所述功能中,所述多个峰指示所述多个DNA链中所述至少一个碱基的可能位置,通过确定所述多个峰中的每一个是否被认为是由所述多个峰中的每一个赋予的, 至少部分地基于成员分配来计算多个DNA链中的一个或多个,以及针对所述多个DNA链中的每一个为所述至少一个碱基计算序列。
    • 2. 发明申请
    • METHODS AND APPARATUS FOR AUTOMATED BASE-CALLING ON MULTIPLE DNA STRANDS
    • 用于自动基因多态DNA检测的方法和装置
    • US20100074492A1
    • 2010-03-25
    • US12418933
    • 2009-04-06
    • Xiaomeng ShiMuriel MedardRalf KoetterNuala Ann KoetterDesmond S. Lun
    • Xiaomeng ShiMuriel MedardRalf KoetterNuala Ann KoetterDesmond S. Lun
    • G06K9/00
    • G06K9/0053G01N27/44717G01N30/8682G01N30/8696
    • In some aspects, a method of automated base-calling using at least one image obtained from a chemical sequencing process performed simultaneously on a plurality of DNA strands, the at least one image including intensity information corresponding to locations of at least one base in the plurality of DNA strands is provided. The method comprises processing the at least image to obtain a function corresponding to the intensity information in the at least one image for the at least one base, the function incorporating intensity information corresponding to each of the plurality of DNA strands, identifying a plurality of peaks in the function, the plurality of peaks indicating possible locations for the at least one base in the plurality of DNA strands, assigning membership to each of the plurality of peaks by determining whether each of the plurality of peaks is believed to have resulted from none, one or multiple of the plurality of DNA strands, and computing a sequence for the at least one base for each of the plurality of DNA strands based, at least in part, on the membership assignment.
    • 在一些方面,一种使用从多个DNA链同时执行的化学测序过程获得的至少一个图像进行自动基本呼叫的方法,所述至少一个图像包括对应于多个基因中至少一个基因位置的强度信息 的DNA链。 所述方法包括处理所述至少一个图像以获得对应于所述至少一个基底的所述至少一个图像中的强度信息的函数,所述功能包括对应于所述多个DNA链中的每一个的强度信息,识别多个峰 在所述功能中,所述多个峰指示所述多个DNA链中所述至少一个碱基的可能位置,通过确定所述多个峰中的每一个是否被认为是由所述多个峰中的每一个赋予的, 至少部分地基于成员分配来计算多个DNA链中的一个或多个,以及针对所述多个DNA链中的每一个为所述至少一个碱基计算序列。
    • 5. 发明申请
    • RANDOM LINEAR CODING APPROACH TO DISTRIBUTED DATA STORAGE
    • 分布式数据存储的随机线性编码方法
    • US20120096124A1
    • 2012-04-19
    • US13267764
    • 2011-10-06
    • Muriel MedardSupratim DebRalf Koetter
    • Muriel MedardSupratim DebRalf Koetter
    • G06F15/16
    • H04L67/1095G06F17/30209H04L67/104
    • A method and computer program product for providing a random linear coding approach to distributed data storage is presented. A file is broken into a plurality of pieces. For every peer (peer means storage-location with limited storage space), the number of coded-pieces the peer can store is determined. Each of the coded-piece is determined by taking random linear combination of all the pieces of the entire file. The associate code-vector is stored for every coded-piece. The file is retrieved by collecting code-vectors and the coded-pieces from the peers and viewing the collected code-vectors as a matrix. When a dimension of the matrix is equal to the number of pieces of the file, the file is recovered using the collection of code vectors in the matrix.
    • 提出了一种用于向分布式数据存储提供随机线性编码方法的方法和计算机程序产品。 文件被分成多个部分。 对于每个对等体(对等体意味着具有有限存储空间的存储位置),确定对等体可以存储的编码的数量。 每个编码片段通过采用整个文件的所有片段的随机线性组合来确定。 为每个编码块存储关联码矢量。 通过收集来自对等体的代码矢量和编码块并以收集的码矢量作为矩阵来检索文件。 当矩阵的维数等于文件的数量时,使用矩阵中的代码向量的集合来恢复文件。
    • 6. 发明授权
    • Random linear coding approach to distributed data storage
    • 随机线性编码方法分布式数据存储
    • US08046426B2
    • 2011-10-25
    • US11026550
    • 2004-12-30
    • Muriel MedardSupratim DebRalf Koetter
    • Muriel MedardSupratim DebRalf Koetter
    • G06F15/16
    • H04L67/1095G06F17/30209H04L67/104
    • A method and computer program product for providing a random linear coding approach to distributed data storage is presented. A file is broken into a plurality of pieces. For every peer (peer means storage-location with limited storage space), the number of coded-pieces the peer can store is determined. Each of the coded-piece is determined by taking random linear combination of all the pieces of the entire file. The associate code-vector is stored for every coded-piece. The file is retrieved by collecting code-vectors and the coded-pieces from the peers and viewing the collected code-vectors as a matrix. When a dimension of the matrix is equal to the number of pieces of the file, the file is recovered using the collection of code vectors in the matrix.
    • 提出了一种用于向分布式数据存储提供随机线性编码方法的方法和计算机程序产品。 文件被分成多个部分。 对于每个对等体(对等体意味着具有有限存储空间的存储位置),确定对等体可以存储的编码的数量。 每个编码片段通过采用整个文件的所有片段的随机线性组合来确定。 为每个编码块存储关联码矢量。 通过收集来自对等体的代码矢量和编码块并以收集的码矢量作为矩阵来检索文件。 当矩阵的维数等于文件的数量时,使用矩阵中的代码向量的集合来恢复文件。