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1. 发明申请

US20150011508A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS 审中-公开
标题翻译：化合物和组合物作为C-KIT激酶抑制剂
公开(公告)号：US20150011508A1
公开(公告)日：2015-01-08
申请号：US14241883
申请日：2012-08-28
申请人： Xiaodong Liu , Xiaolin Li , Jon Loren , Valentina Molteni , Juliet Nabakka , Bao Nguyen , Hank Michael James Petrassi , Vince Yeh
发明人： Xiaodong Liu , Xiaolin Li , Jon Loren , Valentina Molteni , Juliet Nabakka , Bao Nguyen , Hank Michael James Petrassi , Vince Yeh
IPC分类号： C07D471/04 , C07F9/6561
CPC分类号： C07D471/04 , A61K31/4245 , C07F9/6561
摘要： The invention provides compounds of formulae (I) and (II) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的式（I）和（II）化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα，PDGFR＆bgr））激酶的异常活化的疾病或病症的方法。

2. 发明授权

US09199981B2 Compounds and compositions as C-kit kinase inhibitors 有权
标题翻译：化合物和组合物作为C-kit激酶抑制剂
公开(公告)号：US09199981B2
公开(公告)日：2015-12-01
申请号：US13595575
申请日：2012-08-27
申请人： Vince Yeh , Xiaolin Li , Xiaodong Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Bao Nguyen , Hank Michael James Petrassi
发明人： Vince Yeh , Xiaolin Li , Xiaodong Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Bao Nguyen , Hank Michael James Petrassi
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα，PDGFR＆bgr））激酶的异常活化的疾病或病症的方法。

3. 发明授权

US09023839B2 Compounds and compositions as c-kit kinase inhibitors 有权
标题翻译：化合物和组合物作为c-kit激酶抑制剂
公开(公告)号：US09023839B2
公开(公告)日：2015-05-05
申请号：US14258963
申请日：2014-04-22
申请人： Valentina Molteni , Hank Michael James Petrassi , Xiaolin Li , Xiaodong Liu , Jon Loren , Juliet Nabakka , Bao Nguyen , Vince Yeh
发明人： Valentina Molteni , Hank Michael James Petrassi , Xiaolin Li , Xiaodong Liu , Jon Loren , Juliet Nabakka , Bao Nguyen , Vince Yeh
IPC分类号： C07D498/04 , C07D471/04 , C07D491/044 , C07D491/107 , C07D491/048
CPC分类号： C07D491/107 , C07D471/04 , C07D491/044 , C07D491/048 , C07D498/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα，PDGFR＆bgr））激酶的异常活化的疾病或病症的方法。

4. 发明授权

US08569283B2 Compounds and compositions as c-Kit kinase inhibitors 有权
标题翻译：化合物和组合物作为c-Kit激酶抑制剂
公开(公告)号：US08569283B2
公开(公告)日：2013-10-29
申请号：US13598213
申请日：2012-08-29
申请人： Valentina Molteni , Hank Michael James Petrassi , Xiaolin Li , Xiaodong Liu , Jon Loren , Juliet Nabakka , Bao Nguyen , Vince Yeh
发明人： Valentina Molteni , Hank Michael James Petrassi , Xiaolin Li , Xiaodong Liu , Jon Loren , Juliet Nabakka , Bao Nguyen , Vince Yeh
IPC分类号： A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61P1/00 , A61P1/16 , A61P3/00 , A61P3/10 , A61P7/00 , A61P9/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P29/00 , A61P37/00 , A61P37/08 , C07D471/04 , C07D491/048 , C07D491/107
CPC分类号： C07D491/107 , C07D471/04 , C07D491/044 , C07D491/048 , C07D498/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα，PDGFRβ）激酶异常活化的疾病或病症的方法。

5. 发明申请

US20150051206A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS 审中-公开
标题翻译：化合物和组合物作为C-KIT激酶抑制剂
公开(公告)号：US20150051206A1
公开(公告)日：2015-02-19
申请号：US14241884
申请日：2012-08-29
申请人： Jon Loren , Xiaolin Li , Xiaodong Liu , Valentina Molteni , Juliet Nabakka , Bao Nguyen , Hank Michael James Petrassi , Vince Yeh , Paul Vincent Rucker
发明人： Jon Loren , Xiaolin Li , Xiaodong Liu , Valentina Molteni , Juliet Nabakka , Bao Nguyen , Hank Michael James Petrassi , Vince Yeh , Paul Vincent Rucker
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα，PDGFR＆bgr））激酶的异常活化的疾病或病症的方法。

6. 发明申请

US20140031333A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS 有权
标题翻译：化合物和组合物作为C-KIT激酶抑制剂
公开(公告)号：US20140031333A1
公开(公告)日：2014-01-30
申请号：US14031792
申请日：2013-09-19
申请人： Valentina MOLENTI , Hank Michael James Petrassi , Xiaolin Li , Xiaodong Liu , Jon Loren , Juliet Nabakka , Bao Nguyen , Vince Yeh
发明人： Valentina MOLENTI , Hank Michael James Petrassi , Xiaolin Li , Xiaodong Liu , Jon Loren , Juliet Nabakka , Bao Nguyen , Vince Yeh
IPC分类号： C07D471/04 , C07D498/04 , C07D491/048
CPC分类号： C07D491/107 , C07D471/04 , C07D491/044 , C07D491/048 , C07D498/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα，PDGFRβ）激酶异常活化的疾病或病症的方法。

7. 发明授权

US08754071B2 Compounds and compositions as c-kit kinase inhibitors 有权
标题翻译：化合物和组合物作为c-kit激酶抑制剂
公开(公告)号：US08754071B2
公开(公告)日：2014-06-17
申请号：US14031792
申请日：2013-09-19
申请人： Valentina Molenti , Hank Michael James Petrassi , Xiaolin Li , Xiaodong Liu , Jon Loren , Juliet Nabakka , Bao Nguyen , Vince Yeh
发明人： Valentina Molenti , Hank Michael James Petrassi , Xiaolin Li , Xiaodong Liu , Jon Loren , Juliet Nabakka , Bao Nguyen , Vince Yeh
IPC分类号： A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61P1/00 , A61P1/16 , A61P3/00 , A61P3/10 , A61P7/00 , A61P9/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P29/00 , A61P37/00 , A61P37/08
CPC分类号： C07D491/107 , C07D471/04 , C07D491/044 , C07D491/048 , C07D498/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα，PDGFR＆bgr））激酶的异常活化的疾病或病症的方法。

8. 发明申请

US20120077854A1 COMPOSITIONS AND METHODS FOR MODULATING RETINOL BINDING TO RETINOL BINDING PROTEIN 4 (RBP4) 审中-公开
标题翻译：用于调节RETINOL结合蛋白质结合蛋白4（RBP4）的组合物和方法
公开(公告)号：US20120077854A1
公开(公告)日：2012-03-29
申请号：US13258341
申请日：2010-04-13
申请人： Hank Michael James Petrassi , David C. Tully , Brian T. Masick , Bao Nguyen
发明人： Hank Michael James Petrassi , David C. Tully , Brian T. Masick , Bao Nguyen
IPC分类号： A61K31/426 , C07D271/06 , C07D263/32 , A61P27/02 , C12N5/071 , A61K31/4245 , A61K31/421 , A61K31/427 , C07D277/593 , C07D417/06
CPC分类号： C07D277/30 , C07D261/08 , C07D263/32 , C07D271/06 , C07D417/06
摘要： The present invention relates to compositions and methods for modulating retinol binding to retinol binding protein 4 (RBP4). In particular, the present invention provides compounds having Formula (1) or (2) (Formulae (1), (2)); wherein R1, R2, R3, R4, R5, R6, Y1, Y2, Y3, Y4 and m are as defined above.
摘要翻译：本发明涉及调节视黄醇与视黄醇结合蛋白4（RBP4）结合的组合物和方法。特别地，本发明提供具有式（1）或（2）（式（1），（2））的化合物; 其中R1，R2，R3，R4，R5，R6，Y1，Y2，Y3，Y4和m如上所定义。

9. 发明授权

US09688689B2 Compounds and compositions for inducing chondrogenesis 有权
公开(公告)号：US09688689B2
公开(公告)日：2017-06-27
申请号：US14709852
申请日：2015-05-12
申请人： Ha-Soon Choi , James Paul Lajiness , Srinivasa Reddy Natala , Bao Nguyen , Hank Michael James Petrassi , Zhicheng Wang
发明人： Ha-Soon Choi , James Paul Lajiness , Srinivasa Reddy Natala , Bao Nguyen , Hank Michael James Petrassi , Zhicheng Wang
IPC分类号： C07D493/08 , A61K31/443 , A61K31/4245 , A61K31/4155 , A61K31/506 , A61K31/34 , A61K31/4439 , A61K31/5377 , A61K31/351 , A61K31/4545 , A61K31/4525 , A61K31/497 , A61K31/444 , A61K45/06 , C07D491/18
CPC分类号： A61K31/443 , A61K31/34 , A61K31/351 , A61K31/4155 , A61K31/416 , A61K31/4245 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06 , A61L27/54 , A61L2300/412 , A61L2430/06 , C07D491/18 , C07D493/08 , C12N5/0655 , C12N2501/999 , C12N2506/1346
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

10. 发明申请

US20070153730A1 Method and apparatus to perform persistence tests in a network 有权
标题翻译：在网络中执行持久性测试的方法和装置
公开(公告)号：US20070153730A1
公开(公告)日：2007-07-05
申请号：US11327242
申请日：2006-01-05
申请人： Tom Chin , Bao Nguyen
发明人： Tom Chin , Bao Nguyen
IPC分类号： H04Q7/00
CPC分类号： H04W74/0816 , H04W52/0261 , H04W74/0866 , Y02D70/142 , Y02D70/146
摘要： A method and apparatus to perform persistence tests for a mobile station in a network are described. The apparatus includes a random number generator, a timer module, and a processor coupled to the random number generator and the timer module. A counter for the random number generator configured to count access slots is initialized. One or more random numbers are successively generated, until a value of a generated random number is lower than a first predetermined value. At the same time, the counter is successively incremented based on the number of generated random numbers. When the counter value is higher than or equal to a second predetermined value of successive iterations, or, in the alternative, when the value of the generated random number is lower than the first predetermined value, the mobile station is deactivated for a predetermined number of access slots equal to the counter value. A timer interrupt further runs subsequent to the expiration of the predetermined number of access slots. Finally, if an access probe needs to be transmitted to the network, the timer interrupt is disabled and a random access number is generated in preparation for transmission of the access probe to enable access to the network.
摘要翻译：描述了对网络中的移动台执行持久性测试的方法和装置。该装置包括随机数发生器，定时器模块和耦合到随机数发生器和定时器模块的处理器。被配置为对接入时隙进行计数的随机数发生器的计数器被初始化。连续产生一个或多个随机数，直到生成的随机数的值低于第一预定值。同时，计数器依据生成的随机数的顺序依次递增。当计数器值高于或等于连续迭代的第二预定值时，或者替代地，当生成的随机数的值低于第一预定值时，移动站停用预定数量的访问时隙等于计数器值。在预定数量的接入时隙到期之后，定时器中断进一步运行。最后，如果接入探测器需要发送到网络，则定时器中断被禁用，随机接入号码被准备用于传输接入探测器以便能够访问网络。

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