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1. 发明申请

US20130183252A1 COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND METHODS OF MAKING SAME 审中-公开
标题翻译：化合物组合物中的抑制（块状）双酚A的化合物及其制备方法
公开(公告)号：US20130183252A1
公开(公告)日：2013-07-18
申请号：US13370832
申请日：2012-02-10
申请人： Xiaodong LI , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
发明人： Xiaodong LI , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
IPC分类号： C07C311/17 , C07D223/18 , A61K8/46 , A61Q11/00 , C07D213/71 , C07D333/34 , C07D317/58 , A61K8/49 , C07C311/16 , C07C311/19 , C07C311/46 , C07C311/18 , C07C233/73 , C07D333/20 , C07D213/42 , C07D217/08 , A23L1/22 , C07D307/52
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人类味觉受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

2. 发明申请

US20110207937A1 Compounds that inhibit (block) bitter taste in composition and methods of making same 有权
标题翻译：在组合物中抑制（阻断）苦味的化合物及其制备方法
公开(公告)号：US20110207937A1
公开(公告)日：2011-08-25
申请号：US13051052
申请日：2011-03-18
申请人： Xiaodong LI , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
发明人： Xiaodong LI , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
IPC分类号： C07D413/14 , C07D413/06
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

3. 发明申请

US20090274632A1 Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in composition and use thereof 有权
标题翻译：识别在组合物中引起苦味的苦味化合物作用的人类T2R受体的鉴定及其在测定中用于鉴定组合物中抑制（阻断）苦味的化合物及其用途的用途
公开(公告)号：US20090274632A1
公开(公告)日：2009-11-05
申请号：US12222918
申请日：2008-08-19
申请人： Xiaodong Li , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
发明人： Xiaodong Li , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
IPC分类号： A61K9/68 , G01N33/68 , C12Q1/02 , G01N33/53 , C07D261/06 , C07C65/00 , C07D307/02 , C07D413/02 , A61K31/192 , A61K31/7034 , A61K31/4439 , A61K31/55 , C07K14/435 , C07D241/36 , C07D263/54 , C07D213/62 , C07D223/18 , C07D239/72 , C07D487/02 , C07D413/14 , C07D403/14 , C07D233/00 , C07D249/12 , C07D251/02 , A61K31/4164 , A61K31/4196 , A61K31/53 , A61K31/42 , A61K8/49 , A61P27/00 , A61Q11/00
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

4. 发明授权

US08148544B2 Compounds that inhibit (block) bitter taste in composition and methods of making same 有权
标题翻译：在组合物中抑制（阻断）苦味的化合物及其制备方法
公开(公告)号：US08148544B2
公开(公告)日：2012-04-03
申请号：US13051052
申请日：2011-03-18
申请人： Xiaodong Li , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
发明人： Xiaodong Li , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
IPC分类号： C07D261/06
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

5. 发明授权

US07939671B2 Compounds that inhibit (block) bitter taste in composition and use thereof 有权
标题翻译：在组合物中抑制（阻断）苦味的化合物及其用途
公开(公告)号：US07939671B2
公开(公告)日：2011-05-10
申请号：US12222918
申请日：2008-08-19
申请人： Xiaodong Li , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
发明人： Xiaodong Li , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
IPC分类号： C07D261/08 , C07D413/14 , A61K31/44 , A61K31/42
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

6. 发明申请

US20050065118A1 Organosulfur inhibitors of tyrosine phosphatases 审中-公开
标题翻译：酪氨酸磷酸酶的有机硫抑制剂
公开(公告)号：US20050065118A1
公开(公告)日：2005-03-24
申请号：US10493113
申请日：2002-10-16
申请人： Jing Wang , Darryl Rideout , Kalyanaraman Ramnarayan , Chung-Ying Tsai , Venkatachalapathi Yalamoori , Feiyue Wu , Colin Loweth , Hassan ElAbdellaoui , Leah Fung , Thomas Brady
发明人： Jing Wang , Darryl Rideout , Kalyanaraman Ramnarayan , Chung-Ying Tsai , Venkatachalapathi Yalamoori , Feiyue Wu , Colin Loweth , Hassan ElAbdellaoui , Leah Fung , Thomas Brady
IPC分类号： C07D277/20 , A61K31/155 , A61K31/325 , A61K31/41 , A61K31/426 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/454 , A61K31/542 , A61K31/5513 , A61K31/66 , A61K31/675 , A61P1/14 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/28 , A61P27/02 , A61P35/00 , A61P43/00 , C07D277/42 , C07D285/12 , C07D285/135 , C07D417/04 , C07D417/12 , C07D513/04
CPC分类号： A61K31/325 , A61K31/41 , A61K31/426 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/542 , A61K31/66
摘要： Organosulfur modulators of tyrosine phosphatases and their use in the treatment of disease are disclosed.
摘要翻译：公开了酪氨酸磷酸酶的有机硫调节剂及其在治疗疾病中的用途。

7. 发明申请

US20070197577A1 Inhibitors of anthrax lethal factor 审中-公开
标题翻译：炭疽致死因子抑制剂
公开(公告)号：US20070197577A1
公开(公告)日：2007-08-23
申请号：US10550372
申请日：2004-03-17
申请人： Darryl Rideout , Tseitin Vladimir , Mark Shenderovich , Edward Semple , Ruth Nutt , Yalamoori Venkatachalapathl , Tsai Chung-Ying , Michelle De Luna , Thomas Brady , Feiyue Wu
发明人： Darryl Rideout , Tseitin Vladimir , Mark Shenderovich , Edward Semple , Ruth Nutt , Yalamoori Venkatachalapathl , Tsai Chung-Ying , Michelle De Luna , Thomas Brady , Feiyue Wu
IPC分类号： A61K31/4745 , A61K31/4436 , A61K31/403 , A61K31/405 , A61K31/40 , A61K31/445 , A61K31/19 , A61K31/277
CPC分类号： A61K31/675 , A61K31/19 , A61K31/277 , A61K31/40 , A61K31/403 , A61K31/405 , A61K31/4436 , A61K31/445 , A61K31/4745 , C07D209/14 , C07D209/44 , C07D209/88 , C07D213/40 , C07D285/06 , C07D285/12 , C07D285/135 , C07D295/13 , C07D333/20 , C07D333/36 , C07D333/58 , C07D333/66 , C07D409/04 , C07D409/12 , C07D471/04
摘要： Methods, compounds and compositions for preventing and treating anthrax infections by inhibiting Anthrax Lethal Factor (LF) activity.
摘要翻译：通过抑制炭疽致死因子（LF）活性来预防和治疗炭疽感染的方法，化合物和组合物。

8. 发明授权

US4610090A Measuring instrument 失效
标题翻译：测量仪器
公开(公告)号：US4610090A
公开(公告)日：1986-09-09
申请号：US656649
申请日：1984-10-01
申请人： Thomas Brady
发明人： Thomas Brady
IPC分类号： G01B3/46 , G01B5/02
CPC分类号： G01B5/02 , G01B3/46
摘要： A precision caliper gage to measure an internal or external dimension of a body. The caliper gage provides for quick and easy attachment of measuring components and for automatic interplanar alignment of measuring components as they are attached to the gage. A mainframe has a portion parallel to a longitudinal plane and is adapted for attachment of a pivot member in alignment with the longitudinal plane. A first measuring arm is mountable on the pivot also in alignment with the longitudinal plane. A second measuring arm is mountable on the mainframe in alignment with the longitudinal plane and cooperates with the first arm to measure a dimension. A measurement indicator is mountable on the mainframe with a measurement-responsive indicator stem in alignment with the longitudinal plane and responsive to measuring movement of the first measuring arm. The measurement indicator is positioned in a manner that the linear distance along a base line from a vertical line through a measuring point on the first measuring arm to a vertical reference line through the pivot member is proportional to the linear distance along the base line from the vertical reference line through the pivot member to a vertical line through a measurement-responsive point on the indicator stem.
摘要翻译：精密卡尺测量身体的内部或外部尺寸。测量元件可以快速方便地附接测量元件，并可以在测量元件附着在量具上时进行自动平面对准。主机具有平行于纵向平面的部分，并且适于将枢转构件与纵向平面对齐。第一测量臂也安装在枢轴上，也与纵向平面对准。第二测量臂可安装在主机上，与纵向平面对准，并与第一臂配合以测量尺寸。测量指示器可安装在主机上，其具有与纵向平面对准的测量响应指示杆，并响应于测量第一测量臂的运动。测量指示器的定位方式是沿着基线从第一测量臂上的测量点到穿过枢转构件的垂直参考线的基线的直线距离与沿着基线的直线距离成比例垂直参考线通过枢转构件通过指示杆上的测量响应点到垂直线。

9. 发明申请

US20070147672A1 Medical image processing 有权
标题翻译：医学图像处理
公开(公告)号：US20070147672A1
公开(公告)日：2007-06-28
申请号：US11320153
申请日：2005-12-28
申请人： William Karl , Zhuangli Liang , Homer Pien , Thomas Brady
发明人： William Karl , Zhuangli Liang , Homer Pien , Thomas Brady
IPC分类号： G06K9/00
CPC分类号： G06T11/008
摘要： In one aspect, the invention is a method of medical image processing. The method includes receiving data representing a medical image. The method also includes generating the medical image based on a model. The model characterizes the medical image as a composition of at least two components having processing constraints.
摘要翻译：一方面，本发明是医疗图像处理方法。该方法包括接收表示医学图像的数据。该方法还包括基于模型生成医学图像。该模型将医学图像表征为具有处理限制的至少两个组件的组合。

10. 发明授权

US07170641B2 Method of generating medium resolution proofs from high resolution image data 失效
标题翻译：从高分辨率图像数据生成介质分辨率证明的方法
公开(公告)号：US07170641B2
公开(公告)日：2007-01-30
申请号：US10082284
申请日：2002-02-26
申请人： Thomas Brady
发明人： Thomas Brady
IPC分类号： H04N1/405 , G06K15/00
CPC分类号： H04N1/40075 , G06K15/02 , G06K15/025
摘要： A method provides for determining an optimal sample dimension when descreening high-resolution image data so that a lower resolution image color proof may be created without suffering the problems typical of over sampling image data. The method allows to generate a single set of image data to create on-the-fly either a medium resolution color proof or a high resolution printed image without having to RIP the data twice, once for the proof, and once for the printed image.
摘要翻译：一种方法提供了当对高分辨率图像数据进行分屏时确定最佳样本维数，使得可以创建较低分辨率图像色彩校正，而不会遇到过采样图像数据的典型问题。该方法允许生成单组图像数据，以便即时创建中等分辨率色彩校正或高分辨率打印图像，而无需RIP数据两次，一次用于证明，一次用于打印图像。

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