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1. 发明申请

US20070168001A1 Remotely RF powered conformable thermal applicators 有权
标题翻译：远程射频功率一致的热敷设器
公开(公告)号：US20070168001A1
公开(公告)日：2007-07-19
申请号：US11601083
申请日：2006-11-16
申请人： Xiao-Dong Xiang , Gang Wang , Haitao Yang , Jonathan Melman , Gerald Dionne
发明人： Xiao-Dong Xiang , Gang Wang , Haitao Yang , Jonathan Melman , Gerald Dionne
IPC分类号： A61F2/00
CPC分类号： A61N1/406 , A61K41/0052 , A61K49/1818
摘要： Embodiments of the present invention are generally related to apparatus and methodology of thermal applicators in cancer therapy. In particular, the present embodiments are directed to a technique called “nanoparticle ferromagnetic resonance heating,” where ferromagnetic resonance heating in addition to an RF hyperthermia treatment is used to cause cell apoptosis and necrosis. An apparatus for carrying out a ferromagnetic resonance heating treatment of a tumor, comprises a volume concentration of super paramagnetic particles contained within the interior of the tumor, the concentration ranging from about 0.1 to about 1 percent; a magnetic field source configured to deliver a gradient DC magnetic field to the region of the tumor; and an energy source configured to deliver to the tumor an RF field at a frequency ranging from about 100 to 200 MHz. The apparatus of claim 1, wherein the super paramagnetic particles are selected from the group consisting of maghemite (γ-Fe2O3) based compounds, and yttrium iron garnet (Y3Fe5O12) based compounds.
摘要翻译：本发明的实施例通常涉及癌症治疗中的热敷装置的装置和方法。特别地，本实施例涉及一种称为“纳米颗粒铁磁共振加热”的技术，其中使用除RF热疗处理之外的铁磁共振加热以引起细胞凋亡和坏死。用于进行肿瘤的铁磁共振加热处理的装置包括包含在肿瘤内部的超顺磁性颗粒的体积浓度，其浓度范围为约0.1％至约1％; 磁场源，被配置为向所述肿瘤的区域递送梯度DC磁场; 以及能量源，其被配置为以大约100至200MHz的频率向所述肿瘤递送RF场。 2.根据权利要求1所述的设备，其中所述超顺磁性颗粒选自由以下物质组成的组：基于磁赤铁矿（γ-Fe 2 O 3 O 3）的化合物和钇铁石榴石（Y 3 5 12 12）基的化合物。

2. 发明授权

US07704923B2 High throughput screening of catalysts using spin resonance 失效
标题翻译：使用自旋共振的催化剂的高通量筛选
公开(公告)号：US07704923B2
公开(公告)日：2010-04-27
申请号：US11299034
申请日：2005-12-08
申请人： Xiao-Dong Xiang , Haitao Yang , Gang Wang , Jonathan Melman
发明人： Xiao-Dong Xiang , Haitao Yang , Gang Wang , Jonathan Melman
IPC分类号： C40B30/00
CPC分类号： G01N33/542 , G01N24/087 , G01N24/088 , G01N2500/00 , G01R33/323 , G01R33/34 , G01R33/34053 , G01R33/3456 , G01R33/44 , G01R33/46 , G01R33/48 , G01R33/60 , G06F19/16
摘要： High throughput screening of catalyst libraries may be performed using spin resonance techniques, and an evanescent wave probe developed by the present inventors. The probe may operate using either nuclear magnetic resonance or electron spin resonance techniques. In one configuration, a scanning evanescent wave spin resonance probe is used in conjunction with a library of catalysts or other materials, and localized detection of spin resonance is carried out at each library address. In another configuration, the evanescent wave probe is used in a micro-reactor array assay.
摘要翻译：催化剂文库的高通量筛选可以使用自旋共振技术和由本发明人开发的ev逝波探针进行。探针可以使用核磁共振或电子自旋共振技术进行操作。在一种配置中，扫描ev逝波自旋共振探针与催化剂或其他材料的文库结合使用，并且在每个文库地址进行自旋共振的局部检测。在另一种配置中，ev逝波探针用于微反应器阵列测定。

3. 发明申请

US20060160136A1 High throughput screening of catalysts using spin resonance 失效
标题翻译：使用自旋共振的催化剂的高通量筛选
公开(公告)号：US20060160136A1
公开(公告)日：2006-07-20
申请号：US11299034
申请日：2005-12-08
申请人： Xiao-Dong Xiang , Haitao Yang , Gang Wang , Jonathan Melman
发明人： Xiao-Dong Xiang , Haitao Yang , Gang Wang , Jonathan Melman
IPC分类号： C40B40/02 , C40B50/02
CPC分类号： G01N33/542 , G01N24/087 , G01N24/088 , G01N2500/00 , G01R33/323 , G01R33/34 , G01R33/34053 , G01R33/3456 , G01R33/44 , G01R33/46 , G01R33/48 , G01R33/60 , G06F19/16
摘要： High throughput screening of catalyst libraries may be performed using spin resonance techniques, and an evanescent wave probe developed by the present inventors. The probe may operate using either nuclear magnetic resonance or electron spin resonance techniques. In one configuration, a scanning evanescent wave spin resonance probe is used in conjunction with a library of catalysts or other materials, and localized detection of spin resonance is carried out at each library address. In another configuration, the evanescent wave probe is used in a micro-reactor array assay.
摘要翻译：可以使用自旋共振技术和由本发明人开发的ev逝波探针来进行催化剂文库的高通量筛选。探针可以使用核磁共振或电子自旋共振技术进行操作。在一种配置中，扫描ev逝波自旋共振探针与催化剂或其他材料的文库结合使用，并且在每个文库地址进行自旋共振的局部检测。在另一种配置中，ev逝波探针用于微反应器阵列测定。

4. 发明授权

US07945335B2 Remotely RF powered conformable thermal applicators 有权
标题翻译：远程射频功率一致的热敷设器
公开(公告)号：US07945335B2
公开(公告)日：2011-05-17
申请号：US11601083
申请日：2006-11-16
申请人： Xiao-Dong Xiang , Gang Wang , Haitao Yang , Jonathan Melman , Gerald Francis Dionne
发明人： Xiao-Dong Xiang , Gang Wang , Haitao Yang , Jonathan Melman , Gerald Francis Dionne
IPC分类号： A61F2/00
CPC分类号： A61N1/406 , A61K41/0052 , A61K49/1818
摘要： Embodiments of the present invention are generally related to apparatus and methodology of thermal applicators in cancer therapy. In particular, the present embodiments are directed to a technique called “nanoparticle ferromagnetic resonance heating,” where ferromagnetic resonance heating in addition to an RF hyperthermia treatment is used to cause cell apoptosis and necrosis. An apparatus for carrying out a ferromagnetic resonance heating treatment of a tumor, comprises a volume concentration of super paramagnetic particles contained within the interior of the tumor, the concentration ranging from about 0.1 to about 1 percent; a magnetic field source configured to deliver a gradient DC magnetic field to the region of the tumor; and an energy source configured to deliver to the tumor an RF field at a frequency ranging from about 100 to 200 MHz. The apparatus of claim 1, wherein the super paramagnetic particles are selected from the group consisting of maghemite (γ-Fe2O3) based compounds, and yttrium iron garnet (Y3Fe5O12) based compounds.
摘要翻译：本发明的实施例通常涉及癌症治疗中的热敷装置的装置和方法。特别地，本实施例涉及一种称为“纳米颗粒铁磁共振加热”的技术，其中使用除RF热疗处理之外的铁磁共振加热以引起细胞凋亡和坏死。用于进行肿瘤的铁磁共振加热处理的装置包括包含在肿瘤内部的超顺磁性颗粒的体积浓度，其浓度范围为约0.1％至约1％; 磁场源，被配置为向所述肿瘤的区域递送梯度DC磁场; 以及能量源，其被配置为以大约100至200MHz的频率向所述肿瘤递送RF场。 2.根据权利要求1所述的装置，其中所述超顺磁性粒子选自由以磁赤铁矿（γ-Fe2O3）为基础的化合物和基于钇铁石榴石（Y 3 Fe 5 O 12）的化合物组成的组。

5. 发明申请

US20070269611A1 Systems and methods of combinatorial synthesis 审中-公开
标题翻译：组合合成的系统和方法
公开(公告)号：US20070269611A1
公开(公告)日：2007-11-22
申请号：US11726742
申请日：2007-03-22
申请人： Xiao-Dong Xiang , Gang Wang , Wei Shan , Jonathan Melman
发明人： Xiao-Dong Xiang , Gang Wang , Wei Shan , Jonathan Melman
IPC分类号： C23C14/00 , G01N21/29 , G01N31/22 , B05D3/00 , C23C14/30 , C23C14/28 , B29C71/04 , C23C16/00
CPC分类号： G01N21/1717
摘要： Disclosed are methods to synthesize new functional materials in an effective and efficient way. These methods include physical vapor deposition and laser-assisted epitaxial growth capable of synthesizing materials comprising a plurality of precursors with similar or dissimilar chemical and/or physical properties. The designed materials are formed during the combinatorial synthesis without the necessity of post-deposition furnace heating to thermally activate simultaneous reaction and diffusion of precursor multilayers. Modulated photoreflectance spectroscopy may be used to screen regions of the library to assess deposition conditions.
摘要翻译：公开了以有效和高效的方式合成新功能材料的方法。这些方法包括物理气相沉积和激光辅助外延生长，其能够合成包含具有相似或不同化学和/或物理性质的多种前体的材料。所设计的材料在组合合成期间形成，而不需要后沉积炉加热以热激活前体多层的同时反应和扩散。可以使用调制光反射光谱来筛选文库的区域以评估沉积条件。

6. 发明申请

US20070238132A1 Screening of combinatorial libraries using radioactivity 审中-公开
标题翻译：使用放射性筛选组合库
公开(公告)号：US20070238132A1
公开(公告)日：2007-10-11
申请号：US11732521
申请日：2007-04-03
申请人： Xiao-Dong Xiang , Jonathan Melman , Gang Wang
发明人： Xiao-Dong Xiang , Jonathan Melman , Gang Wang
IPC分类号： C40B30/06 , C40B40/04
CPC分类号： C40B40/00 , G01N33/60
摘要： The combinatorial approach to materials synthesis can create vast libraries of materials. Some luminescent materials can be activated by the application of electrical current. Additionally, these materials can be activated by the application of an electron gun or some other electron source, such as a β-emitter. In its simplest form, a library of materials can be screened for luminescence by placing the library in a position to collect beta particles emitted from radioactive β-emitters.
摘要翻译：材料合成的组合方法可以创建大量的材料库。一些发光材料可以通过施加电流而被激活。此外，这些材料可以通过施加电子枪或一些其他电子源（例如β-发射体）而被激活。在其最简单的形式中，可以通过将文库放置在收集从放射性β-发射体发射的β粒子的位置来筛选发光库。

7. 发明申请

US20070243431A1 Hydrogen-generating solid fuel cartridge 审中-公开
标题翻译：产氢固体燃料盒
公开(公告)号：US20070243431A1
公开(公告)日：2007-10-18
申请号：US11707501
申请日：2007-02-15
申请人： Guang-Hui Zhu , Xiao-Dong Xiang , Jonathan Melman
发明人： Guang-Hui Zhu , Xiao-Dong Xiang , Jonathan Melman
IPC分类号： H01M8/18
CPC分类号： C01B3/065 , C01B3/501 , C01B2203/02 , C01B2203/041 , C01B2203/0495 , C01B2203/1041 , C01B2203/1047 , C01B2203/1052 , C01B2203/1058 , C01B2203/1076 , C01B2203/1205 , H01M8/04208 , H01M8/04216 , H01M8/04291 , H01M8/065 , H01M2008/1095 , H01M2250/30 , Y02B90/18 , Y02E60/362
摘要： Disclosed herein is a novel hydrogen-generating, solid fuel cartridge which may be used to provide hydrogen to a proton exchange membrane (PEM) fuel cell. The cartridge contains a mixture of the hydrogen-generating solid fuel and a catalyst. The solid fuel/catalyst mixture has a packing fraction greater than about 55 percent. Throughout the fuel/catalyst mixture is means for distributing the liquid reactant; there is also a network of hydrogen-collecting, gas permeable membranes for removing the hydrogen product from the cartridge. The hydrogen-generating solid fuel cartridge may further include a liquid reactant distribution plate for distributing the liquid reactant to the solid fuel/catalyst mixture in a substantially uniform manner. The distribution plate has distribution channels arranged in a fractal pattern.
摘要翻译：本文公开了一种新颖的产氢固体燃料盒，其可用于向质子交换膜（PEM）燃料电池提供氢。筒包含产生氢的固体燃料和催化剂的混合物。固体燃料/催化剂混合物的填充率大于约55％。整个燃料/催化剂混合物是用于分配液体反应物的装置; 还有一个用于从盒中除去氢产物的氢气收集透气膜网络。产氢固体燃料盒还可以包括液体反应物分配板，用于以基本均匀的方式将液体反应物分配到固体燃料/催化剂混合物。分布板具有以分形图案布置的分配通道。

8. 发明申请

US20120086034A1 SOLID-STATE LIGHT EMITTING DEVICES AND SIGNAGE WITH PHOTOLUMINESCENCE WAVELENGTH CONVERSION 有权
标题翻译：固态发光器件和具有光致变化波长变换的信号
公开(公告)号：US20120086034A1
公开(公告)日：2012-04-12
申请号：US13253031
申请日：2011-10-04
申请人： Xianglong Yuan , Jonathan Melman , Bing Dai , Gang Wang , Charles Edwards
发明人： Xianglong Yuan , Jonathan Melman , Bing Dai , Gang Wang , Charles Edwards
IPC分类号： H01L33/50 , F21V7/00
CPC分类号： H01L33/504 , F21K9/232 , F21K9/64 , F21V3/061 , F21V3/062 , F21Y2115/10 , F21Y2115/30 , H01L33/507 , H01L2933/0091
摘要： A solid-state light emitting device having a solid-state light emitter (LED) operable to generate excitation light and a wavelength conversion component including a mixture of particles of a photoluminescence material and particles of a light reflective material. In operation the phosphor absorbs at least a portion of the excitation light and emits light of a different color. The emission product of the device comprises the combined light generated by the LED and the phosphor. The wavelength conversion component can be light transmissive and comprise a light transmissive substrate on which the mixture of phosphor and reflective materials is provided as a layer or homogeneously distributed throughout the volume of the substrate. Alternatively the wavelength conversion component can be light reflective with the mixture of phosphor and light reflective materials being provided as a layer on the light reflective surface.
摘要翻译：一种具有可操作以产生激发光的固态光发射器（LED）和包括光致发光材料的颗粒和光反射材料的颗粒的混合物的波长转换组件的固态发光器件。在操作中，荧光体吸收至少一部分激发光并发射不同颜色的光。该器件的发射产物包括由LED和磷光体产生的组合光。波长转换组件可以是透光的并且包括透光基底，磷光体和反射材料的混合物在其上提供为层或均匀地分布在基底的整个体积中。或者，波长转换组件可以是光反射的，荧光体和光反射材料的混合物被提供为光反射表面上的层。

9. 发明授权

US08610340B2 Solid-state light emitting devices and signage with photoluminescence wavelength conversion 有权
标题翻译：固态发光器件和标牌具有光致发光波长转换
公开(公告)号：US08610340B2
公开(公告)日：2013-12-17
申请号：US13253031
申请日：2011-10-04
申请人： Xianglong Yuan , Jonathan Melman , Bing Dai , Gang Wang , Charles Edwards
发明人： Xianglong Yuan , Jonathan Melman , Bing Dai , Gang Wang , Charles Edwards
IPC分类号： H01J5/16
CPC分类号： H01L33/504 , F21K9/232 , F21K9/64 , F21V3/061 , F21V3/062 , F21Y2115/10 , F21Y2115/30 , H01L33/507 , H01L2933/0091
摘要： A solid-state light emitting device having a solid-state light emitter (LED) operable to generate excitation light and a wavelength conversion component including a mixture of particles of a photoluminescence material and particles of a light reflective material. In operation the phosphor absorbs at least a portion of the excitation light and emits light of a different color. The emission product of the device comprises the combined light generated by the LED and the phosphor. The wavelength conversion component can be light transmissive and comprise a light transmissive substrate on which the mixture of phosphor and reflective materials is provided as a layer or homogeneously distributed throughout the volume of the substrate. Alternatively the wavelength conversion component can be light reflective with the mixture of phosphor and light reflective materials being provided as a layer on the light reflective surface.
摘要翻译：一种具有可操作以产生激发光的固态光发射器（LED）和包括光致发光材料的颗粒和光反射材料的颗粒的混合物的波长转换组件的固态发光器件。在操作中，荧光体吸收至少一部分激发光并发射不同颜色的光。该器件的发射产物包括由LED和磷光体产生的组合光。波长转换组件可以是透光的并且包括透光基底，磷光体和反射材料的混合物在其上提供为层或均匀地分布在基底的整个体积中。或者，波长转换组件可以是光反射的，荧光体和光反射材料的混合物被提供为光反射表面上的层。

10. 发明授权

US08227276B2 Manufacture of light emitting devices with phosphor wavelength conversion 有权
标题翻译：制造具有磷光体波长转换的发光器件
公开(公告)号：US08227276B2
公开(公告)日：2012-07-24
申请号：US12782857
申请日：2010-05-19
申请人： Jonathan Melman
发明人： Jonathan Melman
IPC分类号： H01L33/00 , H01L21/00
CPC分类号： H01L33/50 , H01L33/0095 , H01L33/54 , H01L33/62 , H01L2224/32245 , H01L2224/48247 , H01L2224/48465 , H01L2224/49107 , H01L2224/73265 , H01L2224/8592 , H01L2924/01322 , H01L2924/181 , H01L2933/0041 , H01L2933/0066 , H01L2224/48091 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
摘要： A method of manufacturing a light emitting device comprises: depositing over substantially the entire surface of a LED wafer having a array of LEDs formed on a surface thereof a mixture of at least one phosphor and a polymer material, wherein the polymer material is transmissive to light generated by the LEDs and to light generated by the at least one phosphor material; using laser ablation to selectively make apertures in the phosphor/polymer material corresponding to electrode contact pads of each LED thereby enabling access to each electrode contact pad; and dividing the wafer into individual light emitting devices. The method can further comprise, prior to dividing the wafer, cutting slots in the phosphor/polymer material which are configured to pass between individual LEDs. The slots are configured such that a layer of phosphor/polymer material remains on the edges of each LED after division of the wafer into individual light emitting devices.
摘要翻译：一种制造发光器件的方法包括：在具有在其表面上形成有LED的阵列的LED晶片的基本上整个表面上沉积至少一种磷光体和聚合物材料的混合物，其中所述聚合物材料对光透射由所述LED产生的光和由所述至少一种荧光体材料产生的光; 使用激光烧蚀来选择性地使磷光体/聚合物材料中的孔对应于每个LED的电极接触焊盘，从而使得能够接近每个电极接触焊盘; 并将晶片分成单独的发光器件。该方法还可以包括在分割晶片之前，在配置成在各个LED之间通过的磷光体/聚合物材料中的切割槽。槽被构造成使得在将晶片分成单独的发光器件之后，荧光体/聚合物材料层保留在每个LED的边缘上。

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