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1. 发明申请

US20110160248A1 PYRAZOLE COMPOUNDS AND USES THEREOF 有权
标题翻译：吡咯化合物及其用途
公开(公告)号：US20110160248A1
公开(公告)日：2011-06-30
申请号：US12975862
申请日：2010-12-22
申请人： Xianbo Zhou , Roderick E.M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
发明人： Xianbo Zhou , Roderick E.M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
IPC分类号： A61K31/454 , A61P25/00 , A61P25/18 , A61P25/28 , A61P25/16 , A61P25/24
CPC分类号： C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要： The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译：本发明提供了式I化合物：其中R1-R6，X，Y和B具有本文所述的任何值，以及这些化合物的盐，包含这些化合物的组合物，以及包括施用这样的化合物的治疗方法化合物。这些化合物是MAO-B酶功能的抑制剂，可用于改善认知功能和治疗动物精神疾病。

2. 发明授权

US07919626B2 Pyrazole compounds and uses thereof 有权
标题翻译：吡唑化合物及其用途
公开(公告)号：US07919626B2
公开(公告)日：2011-04-05
申请号：US11679775
申请日：2007-02-27
申请人： Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
发明人： Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
IPC分类号： C07D211/00 , C07D295/00 , C07D211/30 , C07D211/32 , C07D211/20
CPC分类号： C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要： The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译：本发明提供了式I化合物：其中R1-R6，X，Y和B具有本文所述的任何值，以及这些化合物的盐，包含这些化合物的组合物，以及包括施用这样的化合物的治疗方法化合物。这些化合物是MAO-B酶功能的抑制剂，可用于改善认知功能和治疗动物精神疾病。

3. 发明授权

US08399487B2 Pyrazole compounds and uses thereof 有权
标题翻译：吡唑化合物及其用途
公开(公告)号：US08399487B2
公开(公告)日：2013-03-19
申请号：US12975862
申请日：2010-12-22
申请人： Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
发明人： Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
IPC分类号： A61K31/445
CPC分类号： C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要： The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译：本发明提供了式I化合物：其中R1-R6，X，Y和B具有本文所述的任何值，以及这些化合物的盐，包含这些化合物的组合物，以及包括施用这样的化合物的治疗方法化合物。这些化合物是MAO-B酶功能的抑制剂，可用于改善认知功能和治疗动物精神疾病。

4. 发明授权

US08791137B2 Therapeutic compounds 有权
标题翻译：治疗化合物
公开(公告)号：US08791137B2
公开(公告)日：2014-07-29
申请号：US12849418
申请日：2010-08-03
申请人： Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P Kaplan , Terence P Keenan , Andrew McRiner
发明人： Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P Kaplan , Terence P Keenan , Andrew McRiner
IPC分类号： A61K31/445 , C07D409/14
CPC分类号： C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要： The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译：本发明提供了式I化合物：其中R1-R6，X，Y和B具有本文所述的任何值，以及这些化合物的盐，包含这些化合物的组合物，以及包括施用这样的化合物的治疗方法化合物。这些化合物是MAO-B酶功能的抑制剂，可用于改善认知功能和治疗动物精神疾病。

5. 发明申请

US20100317648A1 THERAPEUTIC COMPOUNDS 有权
标题翻译：治疗化合物
公开(公告)号：US20100317648A1
公开(公告)日：2010-12-16
申请号：US12849418
申请日：2010-08-03
申请人： Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
发明人： Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
IPC分类号： A61K31/397 , A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/4439 , A61K31/4155 , C07D413/14 , C07D409/14 , C07D409/04 , A61P25/28 , A61P25/00 , A61P25/16
CPC分类号： C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要： The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译：本发明提供了式I化合物：其中R1-R6，X，Y和B具有本文所述的任何值，以及这些化合物的盐，包含这些化合物的组合物，以及包括施用这样的化合物的治疗方法化合物。这些化合物是MAO-B酶功能的抑制剂，可用于改善认知功能和治疗动物精神疾病。

6. 发明申请

US20070203154A1 Therapeutic Compounds 有权
标题翻译：治疗化合物
公开(公告)号：US20070203154A1
公开(公告)日：2007-08-30
申请号：US11679775
申请日：2007-02-27
申请人： Xianbo Zhou , Roderick Scott , Rusiko Bourtchouladze , Alan Kaplan , Terence Keenan , Andrew McRiner
发明人： Xianbo Zhou , Roderick Scott , Rusiko Bourtchouladze , Alan Kaplan , Terence Keenan , Andrew McRiner
IPC分类号： A61K31/496 , A61K31/454 , A61K31/4178 , A61K31/416 , A61K31/4152
CPC分类号： C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要： The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译：本发明提供式I化合物：其中R 1〜R 6，X，Y和B具有本文所述的任何值，以及其中的盐化合物，包含这些化合物的组合物和包含施用这些化合物的治疗方法。这些化合物是MAO-B酶功能的抑制剂，可用于改善认知功能和治疗动物精神疾病。

7. 发明授权

US07816499B2 Antibodies that selectively bind HDAC9 有权
标题翻译：选择性结合HDAC9的抗体
公开(公告)号：US07816499B2
公开(公告)日：2010-10-19
申请号：US11809899
申请日：2007-05-31
申请人： Victoria M. Richon , Xianbo Zhou , Richard A. Rifkind , Paul A. Marks
发明人： Victoria M. Richon , Xianbo Zhou , Richard A. Rifkind , Paul A. Marks
IPC分类号： C07K16/40
CPC分类号： C12N9/16 , C12N9/80
摘要： The present invention features, inter alia, purified antibodies that selectively bind an isolated or recombinant histone deacetylase polypeptide comprising the amino acid sequence as set forth in SEQ ID NO: 2, which comprises a histone deacetylase catalytic domain at amino acids 635 to 953 of SEQ ID NO: 2, purified antibodies that selectively bind a biologically active fragment of the polypeptide of SEQ ID NO: 2, which fragment exhibits histone deacetylase activity, transcription repression activity, and the ability to deacetylate cellular substrates, purified antibodies that selectively bind an isolated or recombinant histone deacetylase polypeptide encoded by a nucleotide sequence as set forth in SEQ ID NO: 1, purified antibodies that selectively bind an isolated or recombinant histone deacetylase polypeptide comprising the amino acid sequence as set forth in SEQ ID NO: 2 lacking a nuclear localization signal, and purified antibodies that selectively bind an isolated or recombinant histone deacetylase polypeptide having at least 95% amino acid sequence identity to SEQ ID NO: 2 and which exhibits histone deacetylase activity, transcription repression activity, and the ability to deacetylate cellular substrates.
摘要翻译：本发明特别地特征在于，选择性地结合包含如SEQ ID NO：2所示的氨基酸序列的分离或重组组蛋白脱乙酰酶多肽的纯化抗体，其包含SEQ ID NO：2的氨基酸635至953的组蛋白脱乙酰酶催化结构域 ID NO：2，选择性结合SEQ ID NO：2的多肽的生物活性片段的纯化抗体，该片段表现出组蛋白脱乙酰酶活性，转录抑制活性和脱乙酰化细胞底物的能力，选择性结合分离的或由SEQ ID NO：1所示的核苷酸序列编码的重组组蛋白脱乙酰酶多肽，其选择性地结合包含缺失核定位的SEQ ID NO：2所示的氨基酸序列的分离或重组组蛋白脱乙酰酶多肽的纯化抗体信号和纯化的抗体，其选择性地结合分离的或重组的h 具有与SEQ ID NO：2具有至少95％氨基酸序列同一性并且表现出组蛋白脱乙酰酶活性，转录抑制活性和脱乙酰化细胞底物的能力的异黄酮脱乙酰酶多肽。

8. 发明授权

US07063973B2 HDAC9 polypeptides and polynucleotides and uses thereof 失效
公开(公告)号：US07063973B2
公开(公告)日：2006-06-20
申请号：US10173539
申请日：2002-06-14
申请人： Victoria M. Richon , Xianbo Zhou , Richard A. Rifkind , Paul A. Marks
发明人： Victoria M. Richon , Xianbo Zhou , Richard A. Rifkind , Paul A. Marks
IPC分类号： C12N9/16 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/16 , C12N9/80
摘要： The present invention features substantially pure HDAC9, HDAC9a, HDAC9(ΔNLS), HDAC9a(ΔNLS), an HDRP(ΔNLS) polypeptides, and isolated nucleic acid molecules encoding those polypeptides. The present invention also features vectors containing HDAC9, HDAC9a, HDAC9(ΔNLS), HDAC9a(ΔNLS), and HDRP(ΔNLS) nucleic acid sequences, and cells containing those vectors.

9. 发明申请

US20060030019A1 HDAC9 polypeptides and polynucleotides and uses thereof 有权
标题翻译： HDAC9多肽及其多核苷酸及其用途
公开(公告)号：US20060030019A1
公开(公告)日：2006-02-09
申请号：US11202268
申请日：2005-08-10
申请人： Victoria Richon , Xianbo Zhou , Richard Rifkind , Paul Marks
发明人： Victoria Richon , Xianbo Zhou , Richard Rifkind , Paul Marks
IPC分类号： C07H21/04 , C12P21/06 , C12N9/16
CPC分类号： C12N9/16 , C12N9/80
摘要： The present invention features substantially pure HDAC9, HDAC9a, HDAC9(ΔNLS), HDAC9a(ΔNLS), an HDRP(ΔNLS) polypeptides, and isolated nucleic acid molecules encoding those polypeptides. The present invention also features vectors containing HDAC9, HDAC9a, HDAC9(ΔNLS), HDAC9a(ΔNLS), and HDRP(ΔNLS) nucleic acid sequences, and cells containing those vectors.
摘要翻译：本发明具有基本上纯的HDAC9，HDAC9a，HDAC9（DeltaNLS），HDAC9a（DeltaNLS），HDRP（DeltaNLS）多肽以及编码这些多肽的分离的核酸分子。本发明还包含含有HDAC9，HDAC9a，HDAC9（DeltaNLS），HDAC9a（DeltaNLS）和HDRP（ΔNLS）核酸序列的载体和含有这些载体的细胞。

10. 发明申请

US20080221308A1 HDAC9 polypeptides and polynucleotides and uses thereof 有权
标题翻译： HDAC9多肽及其多核苷酸及其用途
公开(公告)号：US20080221308A1
公开(公告)日：2008-09-11
申请号：US11809899
申请日：2007-05-31
申请人： Victoria M. Richon , Xianbo Zhou , Richard A. Rifkind , Paul A. Marks
发明人： Victoria M. Richon , Xianbo Zhou , Richard A. Rifkind , Paul A. Marks
IPC分类号： C07K16/18
CPC分类号： C12N9/16 , C12N9/80
摘要： The present invention features substantially pure HDAC9, HDAC9a, HDAC9(ΔNLS), HDAC9a(ΔNLS), an HDRP(ΔNLS) polypeptides, and isolated nucleic acid molecules encoding those polypeptides. The present invention also features vectors containing HDAC9, HDAC9a, HDAC9(ΔNLS), HDAC9a(ΔNLS), and HDRP(ΔNLS) nucleic acid sequences, and cells containing those vectors.
摘要翻译：本发明具有基本上纯的HDAC9，HDAC9a，HDAC9（DeltaNLS），HDAC9a（DeltaNLS），HDRP（DeltaNLS）多肽以及编码这些多肽的分离的核酸分子。本发明还包含含有HDAC9，HDAC9a，HDAC9（DeltaNLS），HDAC9a（DeltaNLS）和HDRP（ΔNLS）核酸序列的载体和含有这些载体的细胞。

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