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1. 发明申请

US20060199796A1 Substituted benzofused heterocycles 有权
公开(公告)号：US20060199796A1
公开(公告)日：2006-09-07
申请号：US11203562
申请日：2005-08-12
申请人： Xi Chen , Xiaoqi Chen , Richard Connors , Kang Dai , Ying Fu , Juan Jaen , Yong-Jae Kim , Leping Li , Mike Lizarzaburu , Jeffrey Mihalic , Stephen Shuttleworth
发明人： Xi Chen , Xiaoqi Chen , Richard Connors , Kang Dai , Ying Fu , Juan Jaen , Yong-Jae Kim , Leping Li , Mike Lizarzaburu , Jeffrey Mihalic , Stephen Shuttleworth
IPC分类号： A61K31/553 , A61K31/5513 , A61K31/4709
CPC分类号： C07D417/06 , C07D217/24 , C07D223/16 , C07D243/14 , C07D401/06 , C07D401/12 , C07D487/04 , C07D491/10
摘要： The present invention relates to the compounds of Formula I, their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for example, for the treatment and prevention of obesity, obesity-related disorders and eating disorders.

2. 发明申请

US20050148617A1 Fused heterocyclic compounds 失效
标题翻译：稠合杂环化合物
公开(公告)号：US20050148617A1
公开(公告)日：2005-07-07
申请号：US10928029
申请日：2004-08-26
申请人： Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Mike Lizarzaburu , Jeffrey Mihalic , Stephen Shuttleworth
发明人： Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Mike Lizarzaburu , Jeffrey Mihalic , Stephen Shuttleworth
IPC分类号： A61P3/04 , A61P25/22 , A61P25/24 , C07D471/04 , C07D471/02 , A61K31/4745 , A61K31/55
CPC分类号： C07D471/04
摘要： Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
摘要翻译：提供了可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症的化合物，组合物和方法。特别地，本发明的化合物可用于治疗和/或预防进食障碍，肥胖症，焦虑障碍和情绪障碍。

3. 发明申请

US20080058365A1 Fused heterocyclic compounds 审中-公开
标题翻译：稠合杂环化合物
公开(公告)号：US20080058365A1
公开(公告)日：2008-03-06
申请号：US11881805
申请日：2007-07-26
申请人： Xi Chen , Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Jeffrey Mihalic
发明人： Xi Chen , Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Jeffrey Mihalic
IPC分类号： A61K31/4353 , A61P3/04
CPC分类号： C07D471/04
摘要： Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
摘要翻译：提供了可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症的化合物，组合物和方法。特别地，本发明的化合物可用于治疗和/或预防进食障碍，肥胖，焦虑障碍和情绪障碍。

4. 发明授权

US06809104B2 Fused heterocyclic compounds 失效
标题翻译：稠合杂环化合物
公开(公告)号：US06809104B2
公开(公告)日：2004-10-26
申请号：US10289933
申请日：2002-11-06
申请人： Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Mike Lizarzaburu , Jeffrey Thomas Mihalic , Stephen Joseph Shuttleworth
发明人： Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Mike Lizarzaburu , Jeffrey Thomas Mihalic , Stephen Joseph Shuttleworth
IPC分类号： C07D47104
CPC分类号： C07D471/04
摘要： Compounds having the formula: wherein L is a bond or (C1-C4)alkylene, R″ is hydrogen or (C1-C8)alkyl, and R1, R2, R4, R, R′, and the subscript n are as described herein, are provided, which are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor, such as eating disorders, obesity, anxiety disorders and mood disorders, are also provided.
摘要翻译：具有下式的化合物：其中L是一个键或（C 1 -C 4）亚烷基，R“是氢或（C 1 -C 8）烷基，R 1，R 2，R 4，R，R '和下标n如本文所述，其可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症。还提供了使用这些化合物治疗和/或预防由G蛋白偶联受体介导的病症或病症的药物组合物和方法，例如进食障碍，肥胖症，焦虑障碍和情绪障碍。

5. 发明授权

US07125885B2 Fused heterocyclic compounds 失效
标题翻译：稠合杂环化合物
公开(公告)号：US07125885B2
公开(公告)日：2006-10-24
申请号：US10928029
申请日：2004-08-26
申请人： Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Mike Lizarzaburu , Jeffrey Thomas Mihalic , Stephen Joseph Shuttleworth
发明人： Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Mike Lizarzaburu , Jeffrey Thomas Mihalic , Stephen Joseph Shuttleworth
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention provides compounds having the formula: wherein R1, R2, R, R′ and the subscript p are described herein. The compounds are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor, such as eating disorder, obesity, anxiety disorders and mood disorders are also provided.
摘要翻译：本发明提供具有下式的化合物：其中R 1，R 2，R 2，R 3'和下标p在本文中描述。该化合物可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症。还提供了使用这些化合物治疗和/或预防由G蛋白偶联受体介导的病症或病症（如进食障碍，肥胖症，焦虑症和情绪障碍）的药物组合物和方法。

6. 发明授权

US07253179B2 Fused heterocyclic compounds 失效
标题翻译：稠合杂环化合物
公开(公告)号：US07253179B2
公开(公告)日：2007-08-07
申请号：US10705173
申请日：2003-11-06
申请人： Xi Chen , Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Jeffrey Thomas Mihalic
发明人： Xi Chen , Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Jeffrey Thomas Mihalic
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
摘要翻译：提供了可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症的化合物，组合物和方法。特别地，本发明的化合物可用于治疗和/或预防进食障碍，肥胖症，焦虑障碍和情绪障碍。

7. 发明申请

US20050043330A1 Antiinflammation agents 失效
公开(公告)号：US20050043330A1
公开(公告)日：2005-02-24
申请号：US10928784
申请日：2004-08-26
申请人： Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
发明人： Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
IPC分类号： A61K31/4709 , A61K31/4745 , A61K31/5377 , A61P3/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D471/04 , C12N15/25 , C12N15/28 , A61K31/519 , A61K31/517 , C07D487/02 , C07D43/02
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

8. 发明申请

US20070155777A1 Antiinflammation agents 失效
标题翻译：抗炎剂
公开(公告)号：US20070155777A1
公开(公告)日：2007-07-05
申请号：US11709895
申请日：2007-02-21
申请人： Simon Burkitt , Mario Cardozo , Timothy Cushing , Michael DeGraffeneid , Christopher Farthing , Xiaolin Hao , Juan Jaen , Xian Jiao , David Kopecky , Marc Labelle , Sarah Lively , Dustin McMinn , Sven Rasmussen , Youngsook Shin , Andrew Smith , Marie-Louise Smith
发明人： Simon Burkitt , Mario Cardozo , Timothy Cushing , Michael DeGraffeneid , Christopher Farthing , Xiaolin Hao , Juan Jaen , Xian Jiao , David Kopecky , Marc Labelle , Sarah Lively , Dustin McMinn , Sven Rasmussen , Youngsook Shin , Andrew Smith , Marie-Louise Smith
IPC分类号： A61K31/4743 , C07D498/02
CPC分类号： C07D231/56 , C07D239/74 , C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.
摘要翻译：本文提供了可用于治疗炎症，免疫调节，代谢，感染和细胞增殖性疾病或病症的化合物，组合物和方法。特别地，本发明提供调节参与炎症，代谢，感染和细胞增殖的蛋白质的表达和/或功能的化合物。主题化合物含有稠合的杂双环。

9. 发明申请

US20070135464A1 Antiinflammation agents 审中-公开
公开(公告)号：US20070135464A1
公开(公告)日：2007-06-14
申请号：US11650268
申请日：2007-01-05
申请人： Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
发明人： Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
IPC分类号： A61K31/519 , A61K31/4709 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

10. 发明申请

US20060035928A1 Combination therapeutic compositions and methods of use 失效
标题翻译：组合治疗组合物和使用方法
公开(公告)号：US20060035928A1
公开(公告)日：2006-02-16
申请号：US11258817
申请日：2005-10-26
申请人： Juan Jaen , Jin-Long Chen
发明人： Juan Jaen , Jin-Long Chen
IPC分类号： A61K31/47 , A61K31/165
CPC分类号： A61K45/06 , A61K31/00 , A61K31/165 , A61K31/47 , Y10S514/866 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, α-glucosidase inhibitors, potassium channel antagonists, aldose reductase inhibitors, glucagon antagonists, activators of RXR, insulin therapy or other anti-obesity agent. The methods include the administration of the combination of compound of Formula I with antidiabetic agent where the two components are delivered in a simultaneous manner, where the compound of Formula I is administered first, followed by the antidiabetic agent, as well as wherein the antidiabetic agent is delivered first followed by the compound of Formula I.
摘要翻译：本发明提供了使用组合疗法治疗糖尿病的药物组合物和方法。组合物涉及式I化合物和抗糖尿病药如磺酰脲类，双胍类，格列酮，α-葡糖苷酶抑制剂，钾通道拮抗剂，醛糖还原酶抑制剂，胰高血糖素拮抗剂，RXR的激活剂，胰岛素治疗或其它抗肥胖剂。所述方法包括施用式I化合物与抗糖尿病药物的组合，其中两种成分以同时方式递送，其中首先给予式I化合物，然后是抗糖尿病药，以及其中抗糖尿病药首先交付，然后是式I的化合物。

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