专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4085852A Method and apparatus for determining the covering of a coke wharf with quenched coke 失效
标题翻译：用焦炭确定焦炭码头覆盖的方法和装置
公开(公告)号：US4085852A
公开(公告)日：1978-04-25
申请号：US729020
申请日：1976-10-04
申请人： Wolfgang Teschner , Hans-Jurgen VON Massow
发明人： Wolfgang Teschner , Hans-Jurgen VON Massow
IPC分类号： C10B39/18
CPC分类号： C10B39/18
摘要： A wharf for receiving glowing coke, comprises an inclined receiving ramp which has a plurality of non-conducting areas and conductive plates interposed in the conductive areas at spaced locations. An electrical circuit control means is connected to each of the plates and provides a potential on the plates which will vary in accordance with the presence of coke over the plates. The electrical circuit also includes a control for effecting a control pulse in accordance with the potential sensed for carrying out a subsequent operation, such as the positioning or withdrawal of a rake element at the bottom of the wharf which supports the coke. With the method, by subjecting the conductive plates to an electrical potential, and by sensing the change in the potential, it is possible to regulate the amount of covering of the coke on the wharf.
摘要翻译：用于接收发光焦炭的码头包括倾斜的接收斜面，其具有多个非导电区域，并且在间隔的位置插入在导电区域中的导电板。电路控制装置连接到每个板，并且在板上提供将根据板上存在焦炭而变化的电位。电路还包括用于根据感测用于执行后续操作的电位来实现控制脉冲的控制，例如在支撑焦炭的码头底部定位或撤回耙式元件。利用该方法，通过使导电板处于电位，并且通过感测电位的变化，可以调节码头上的焦炭的覆盖量。

2. 发明授权

US08795658B2 Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral pH 有权
标题翻译：在弱酸性至中性pH下通过组氨酸的水性制剂稳定免疫球蛋白
公开(公告)号：US08795658B2
公开(公告)日：2014-08-05
申请号：US13235314
申请日：2011-09-16
申请人： Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Wolfgang Teschner , Hans-Peter Schwarz
发明人： Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Wolfgang Teschner , Hans-Peter Schwarz
IPC分类号： A61K39/395 , A61K47/02 , A61K47/18 , A61K9/00
CPC分类号： A61K39/39591 , A61K9/0019 , A61K47/02 , A61K47/183
摘要： The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of immunoglobulins at mildly acidic to neutral pH useful for parenteral administration.
摘要翻译：除其他方面之外，本发明提供了在轻度酸性至中性pH下具有组氨酸的免疫球蛋白的储存稳定水性制剂。本发明还提供了通过在轻度酸性至中性pH下配制组氨酸来稳定免疫球蛋白组合物的方法。有利地，本文提供的方法和制剂允许稳定的免疫球蛋白水溶液组合物，其具有适用于胃肠外给药的中等pH至中性pH。

3. 发明申请

US20110293594A1 REMOVAL OF SERINE PROTEASES BY TREATMENT WITH FINELY DIVIDED SILICON DIOXIDE 有权
标题翻译：用精细二氧化硅二氧化硅处理去除丝氨酸蛋白
公开(公告)号：US20110293594A1
公开(公告)日：2011-12-01
申请号：US13117028
申请日：2011-05-26
申请人： Wolfgang Teschner , Hans-Peter Schwarz , Ruth Madlener , Sonja Svatos , Azra Pljevljakovic , Alfred Weber
发明人： Wolfgang Teschner , Hans-Peter Schwarz , Ruth Madlener , Sonja Svatos , Azra Pljevljakovic , Alfred Weber
IPC分类号： A61K38/46 , C07K1/36 , A61K38/17 , A61P7/00 , C12N9/18 , A61K38/57 , A61K38/38 , C07K14/47 , C07K1/14 , C07K14/76
CPC分类号： C07K16/065 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K39/39525 , A61K47/183 , B01D15/12 , B01D15/362 , B01D15/363 , B01D15/424 , C07K1/30 , C07K1/36
摘要： The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.
摘要翻译：本发明提供了用于降低血浆来源的蛋白质组合物的丝氨酸蛋白酶和/或丝氨酸蛋白酶酶原含量的新方法。还提供了制备具有降低的丝氨酸蛋白酶和/或丝氨酸蛋白酶酶原含量的血浆衍生蛋白质组合物的方法。在其它方面中，本发明提供具有降低的丝氨酸蛋白酶和/或丝氨酸蛋白酶酶原含量的血浆衍生蛋白质的水性和冻干组合物。还有其它方面包括用于治疗，控制和/或预防疾病的方法，所述疾病包括施用具有降低的丝氨酸蛋白酶或丝氨酸蛋白酶酶原含量的血浆衍生的蛋白质组合物。

4. 发明授权

US06889712B2 Device for fixing a cable in a pipe 失效
标题翻译：将电缆固定在管道中的装置
公开(公告)号：US06889712B2
公开(公告)日：2005-05-10
申请号：US10180303
申请日：2002-06-27
申请人： Klaus Nothofer , Hans-Detlef Leppert , Wolfgang Teschner
发明人： Klaus Nothofer , Hans-Detlef Leppert , Wolfgang Teschner
IPC分类号： G02B6/50 , H02G1/08 , H02G9/06 , F16L55/00
CPC分类号： G02B6/508 , H02G1/08 , H02G9/06
摘要： For the purpose of repairing supply lines such as a waste-water pipe, a plastic hose has been developed which, in the clear state, has a diameter which is the same size as, or larger than, the diameter of the pipe in which it is to be inserted. This plastic hose is used to fix optical or electric cables against the inner wall of the pipe. For this purpose, the plastic hose is introduced into the waste-water pipe in a collapsed state, together with the cable, and is released when the desired positioning has been reached. The collapsed plastic hose will then regain its original shape and thereby fix the cable against the inner wall of the waste-water pipe.
摘要翻译：为了修理诸如废水管的供应管线，已经开发了一种塑料软管，其在清洁状态下具有与其中的管的直径相同或大于其直径的直径被插入。该塑料软管用于将光缆或电缆固定在管道的内壁上。为此，将塑料软管与电缆一起以折叠状态引入废水管中，并且在达到所需的定位时被释放。收缩的塑料软管然后将恢复其原始形状，从而将电缆固定在废水管的内壁上。

5. 发明授权

US09084743B2 Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof 有权
标题翻译：透明质酸酶和免疫球蛋白的稳定共配方及其使用方法
公开(公告)号：US09084743B2
公开(公告)日：2015-07-21
申请号：US12807991
申请日：2010-09-16
申请人： Wolfgang Teschner , Sonja Svatos , Leopold Bruckschwaiger , Alfred Weber , Hans-Peter Schwarz , Laura Lei
发明人： Wolfgang Teschner , Sonja Svatos , Leopold Bruckschwaiger , Alfred Weber , Hans-Peter Schwarz , Laura Lei
IPC分类号： A61K39/395 , A61K39/00 , A61K9/00 , A61K47/42 , C07K16/00 , C07K16/06 , C12N9/26
CPC分类号： A61K39/00 , A61K9/0021 , A61K39/39591 , A61K47/42 , A61K2039/505 , C07K16/00 , C07K16/06 , C07K2317/21 , C12N9/2474 , C12Y302/01035 , Y02A50/464
摘要： Provided herein are stable co-formulations of immunoglobulin and hyaluronidase that are stable to storage in liquid form at room temperature for at least 6 months and at standard refrigerator temperatures for 1-2 years. Such co-formulations can be used in methods of treating IG-treatable diseases or conditions by subcutaneous administration.
摘要翻译：本文提供了免疫球蛋白和透明质酸酶的稳定共配方，其在室温下以液体形式储存至少6个月，并在标准冰箱温度下保存1-2年。这种共同制剂可用于通过皮下给药治疗IG治疗性疾病或病症的方法。

6. 发明申请

US20130058961A1 METHOD FOR REDUCING THE THROMBOEMBOLIC POTENTIAL OF A PLASMA-DERIVED IMMUNOGLOBULIN COMPOSITION 有权
标题翻译：降低等离子体衍生的免疫球蛋白组成的血栓形成潜力的方法
公开(公告)号：US20130058961A1
公开(公告)日：2013-03-07
申请号：US13595967
申请日：2012-08-27
申请人： Wolfgang Teschner , Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Hans-Peter Schwarz
发明人： Wolfgang Teschner , Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Hans-Peter Schwarz
IPC分类号： A61K39/395 , A61P29/00 , A61P31/00 , A61P37/06
CPC分类号： C07K16/065
摘要： The present invention provides methods for reducing the amidolytic and anti-complement activity (ACA) content of an immunoglobulin composition through the use of cation exchange chromatography. In a specific embodiment, the invention provides methods for reducing the Factor XI and/or Factor XIa and/or ACA content of an immunoglobulin composition by collecting the leading portion of a cation exchange eluate. The present invention also provides immunoglobulin composition having reduced levels of amidolytic activity, Factor XI, and/or Factor XIa, and/or ACA content.
摘要翻译：本发明提供了通过使用阳离子交换色谱法降低免疫球蛋白组合物的酰胺分解和抗补体活性（ACA）含量的方法。在具体实施方案中，本发明提供通过收集阳离子交换洗脱液的前导部分来减少免疫球蛋白组合物的因子XI和/或因子XIa和/或ACA含量的方法。本发明还提供了具有降低的酰胺分解活性水平，因子XI和/或因子XIa和/或ACA含量的免疫球蛋白组合物。

7. 发明申请

US20110293598A1 METHOD TO PRODUCE AN IMMUNOGLOBULIN PREPARATION WITH IMPROVED YIELD 有权
公开(公告)号：US20110293598A1
公开(公告)日：2011-12-01
申请号：US13085056
申请日：2011-04-12
申请人： Leopold Bruckschwaiger , Sonja Svatos , Julia Nürnberger , Wolfgang Teschner , Harald Arno Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenburger , Azra Pljevljakovic
发明人： Leopold Bruckschwaiger , Sonja Svatos , Julia Nürnberger , Wolfgang Teschner , Harald Arno Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenburger , Azra Pljevljakovic
IPC分类号： A61K39/395 , A61P31/00 , A61P37/00 , C07K16/00 , A61P37/04
CPC分类号： C07K1/14 , C07K1/18 , C07K1/30 , C07K1/34 , C07K1/36 , C07K16/065
摘要： The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.

8. 发明申请

US20110021432A1 MANUFACTURE OF FACTOR H (FH) AND FH-DERIVATIVES FROM PLASMA 有权
标题翻译：因子H（FH）和FH衍生物从等离子体的制备
公开(公告)号：US20110021432A1
公开(公告)日：2011-01-27
申请号：US12842944
申请日：2010-07-23
申请人： Shawn F. BAIRSTOW , Richard J. Johnson , Sindhu Ramachandran , Ruth Madlener , Wolfgang Teschner , Hans-Peter Schwarz
发明人： Shawn F. BAIRSTOW , Richard J. Johnson , Sindhu Ramachandran , Ruth Madlener , Wolfgang Teschner , Hans-Peter Schwarz
IPC分类号： A61K38/17 , A61P9/10 , A61P9/00 , A61P13/12 , A61P13/00 , A61P27/02
CPC分类号： C07K14/472 , A61K38/1709 , A61K38/1725 , C07K1/36
摘要： The present invention provides compositions and pharmaceutical formulations of Factor H derived from plasma. Also provided are methods for the manufacture of the Factor H compositions and formulations, as well as methods for the treatment of diseases associated with Factor H dysfunction.
摘要翻译：本发明提供衍生自血浆的因子H的组合物和药物制剂。还提供了用于制备因子H组合物和制剂的方法，以及用于治疗与因子H功能障碍相关的疾病的方法。

9. 发明申请

US20100226907A1 PURIFICATION OF BUTYRYLCHOLINESTERASE USING MEMBRANE ADSORPTION 有权
标题翻译：使用膜吸附法纯化丁基胆碱酯酶
公开(公告)号：US20100226907A1
公开(公告)日：2010-09-09
申请号：US12617578
申请日：2009-11-12
申请人： Alexander Zaydenberg , Susan Weber , Patrick Gavit , Laura Lei , Wolfgang Teschner , Harald A. Butterweck , Ursula Mais-Paul , Hans-Peter Schwarz
发明人： Alexander Zaydenberg , Susan Weber , Patrick Gavit , Laura Lei , Wolfgang Teschner , Harald A. Butterweck , Ursula Mais-Paul , Hans-Peter Schwarz
IPC分类号： A61K38/46 , A61P39/02
CPC分类号： C12N9/18
摘要： The present invention relates to purification of butyrylcholinesterase using anion exchange material, where the butyrylcholinesterase content is enriched at least 10 fold per total protein in the composition.
摘要翻译：本发明涉及使用阴离子交换材料纯化丁酰胆碱酯酶，其中丁酰胆碱酯酶含量在组合物中富集至少10倍于总蛋白。

10. 发明申请

US20050249815A1 Process for producing a plasma protein-containing medicament 有权
标题翻译：用于制备含血浆蛋白的药物的方法
公开(公告)号：US20050249815A1
公开(公告)日：2005-11-10
申请号：US11151295
申请日：2005-06-14
申请人： Wolfgang Teschner , Yendra Linnau , Sonja Svatos , Herwig Igel
发明人： Wolfgang Teschner , Yendra Linnau , Sonja Svatos , Herwig Igel
IPC分类号： A61K35/14 , A61K38/00 , A61K38/17 , C07K14/76 , C07K16/06 , A61K35/16
CPC分类号： A61K35/16 , A61K38/1709 , C07K14/76 , C07K16/06
摘要： There is disclosed a method of preparing a plasma-protein-containing medicament from citrated plasma or from a citrate-containing plasma fraction, the medicament being substantially free from undesired metals, which method comprises the following steps: exchanging the citrate and optionally citrate-bound metals in a plasma-protein-containing solution for a water-soluble mono- or dicarboxylate or for an organic mono- or dicarboxylic acid under non-precipitating conditions, recovering the plasma protein or the plasma proteins, and finishing the medicament.
摘要翻译：公开了一种从柠檬酸盐血浆或含柠檬酸盐血浆级分制备含血浆蛋白的药物的方法，该药物基本上不含不期望的金属，该方法包括以下步骤：将柠檬酸盐和任选的柠檬酸盐结合用于水溶性单羧酸盐或二羧酸盐的含血浆蛋白的溶液中的金属或非沉淀条件下的有机单羧酸或二羧酸的金属，回收血浆蛋白或血浆蛋白，以及整理药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式