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1. 发明申请

US20110137205A1 ANALYSIS SYSTEM AND METHOD FOR DETERMINING AN ANALYTE IN A BODY FLUID 有权
标题翻译：用于确定体液中分析物的分析系统和方法
公开(公告)号：US20110137205A1
公开(公告)日：2011-06-09
申请号：US12962000
申请日：2010-12-07
申请人： Stephan-Michael Frey , Hans List , Andrea Rittinghaus , Volker Zimmer , Guenter Ihle , Wolfgang Roedel
发明人： Stephan-Michael Frey , Hans List , Andrea Rittinghaus , Volker Zimmer , Guenter Ihle , Wolfgang Roedel
IPC分类号： A61B5/151
CPC分类号： A61B5/157 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/15113 , A61B5/15123 , A61B5/1513 , A61B5/15146 , A61B5/15151 , A61B5/15163
摘要： A system for determining an analyte in a body fluid includes a magazine comprising two partial magazines, one including chambers containing analysis elements having a sample contact zone and a reagent system containing a reagent, whose reaction with the body fluid results in a change of a variable, and another including chambers containing puncturing elements having a tip having a capillary channel, which forms a fluid connection between the tip and a sample transfer zone of the puncturing element. The system may also include an analysis instrument having a puncturing drive for driving a puncturing element on a movement path, a mounting for receiving the magazine such that one chamber of the magazine at a time is located in a functional position, in which a puncturing element in the chamber can be moved by the puncturing drive, and a measuring and evaluation apparatus for measuring the change of the variable.
摘要翻译：用于确定体液中的分析物的系统包括：包含两个部分杂志的盒，一个包括具有样品接触区的分析元件的腔室和含有试剂的试剂系统，其与体液的反应导致变量，另一个包括具有具有毛细通道的尖端的穿刺元件的腔室，其形成尖端和穿刺元件的样品转移区域之间的流体连接。该系统还可以包括具有用于在移动路径上驱动穿刺元件的穿刺驱动器的分析仪器，用于接收盒子的安装件，使得一次一次的仓库位于功能位置，其中穿刺元件可以通过穿刺驱动器移动腔室，以及用于测量变量的变化的测量和评估装置。

2. 发明申请

US20110092854A1 Instruments and system for producing a sample of a body fluid and for analysis thereof 审中-公开
标题翻译：用于生产体液样品并用于分析的仪器和系统
公开(公告)号：US20110092854A1
公开(公告)日：2011-04-21
申请号：US12582277
申请日：2009-10-20
申请人： Uwe Kraemer , Volker Zimmer , Wolfgang Roedel , Hans List , Stephan-Michael Frey , Christian Hoerauf , Paul Patel
发明人： Uwe Kraemer , Volker Zimmer , Wolfgang Roedel , Hans List , Stephan-Michael Frey , Christian Hoerauf , Paul Patel
IPC分类号： A61B5/151
CPC分类号： A61B5/1519 , A61B5/1411 , A61B5/14532 , A61B5/1459 , A61B5/150022 , A61B5/150068 , A61B5/150183 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/150809 , A61B5/150816 , A61B5/150954 , A61B5/15109 , A61B5/15123 , A61B5/15128 , A61B5/15142 , A61B5/15186 , A61B5/15194 , A61B5/157 , A61B2562/0295
摘要： An instrument for producing a sample of body fluid for analysis by piercing the skin with a lancing element having a piercing tip is disclosed. The instrument can comprise a housing and a lancing drive for driving a lancing element connected thereto in a puncturing movement. A pressure ring can surround a skin contact opening and can be adapted for pressing against the skin such that the skin can bulge into the skin contact opening for promoting expression of body fluid. The skin contact opening can have a circular opening with a diameter of at least about 3 mm and at most about 8 mm. The instrument can comprise a pressing force control device for controlling the pressing force between the pressure ring and the skin at the time of triggering the puncturing movement, to be at least about 3 N and at most about 8 N.
摘要翻译：公开了一种用于通过用具有穿刺尖端的穿刺元件刺穿皮肤来生产用于分析的体液样品的仪器。仪器可以包括壳体和穿刺驱动器，用于在穿刺运动中驱动与其连接的穿刺元件。压力环可以围绕皮肤接触开口，并且可以适于压在皮肤上，使得皮肤可以凸出到皮肤接触开口中，以促进体液的表达。皮肤接触开口可以具有直径为至少约3mm且至多约8mm的圆形开口。仪器可以包括用于在触发穿刺运动时控制压力环和皮肤之间的按压力的按压力控制装置，至少约3N且至多约8N。

3. 发明授权

US09439591B2 Analysis system and method for determining an analyte in a body fluid 有权
标题翻译：用于测定体液中分析物的分析系统和方法
公开(公告)号：US09439591B2
公开(公告)日：2016-09-13
申请号：US12962000
申请日：2010-12-07
申请人： Stephan-Michael Frey , Hans List , Andrea Rittinghaus , Volker Zimmer , Guenter Ihle , Wolfgang Roedel
发明人： Stephan-Michael Frey , Hans List , Andrea Rittinghaus , Volker Zimmer , Guenter Ihle , Wolfgang Roedel
IPC分类号： A61B5/157 , A61B5/15 , A61B5/145 , A61B5/1455 , A61B5/151
CPC分类号： A61B5/157 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/15113 , A61B5/15123 , A61B5/1513 , A61B5/15146 , A61B5/15151 , A61B5/15163
摘要： A system for determining an analyte in a body fluid includes a magazine comprising two partial magazines, one including chambers containing analysis elements having a sample contact zone and a reagent system containing a reagent, whose reaction with the body fluid results in a change of a variable, and another including chambers containing puncturing elements having a tip having a capillary channel, which forms a fluid connection between the tip and a sample transfer zone of the puncturing element. The system may also include an analysis instrument having a puncturing drive for driving a puncturing element on a movement path, a mounting for receiving the magazine such that one chamber of the magazine at a time is located in a functional position, in which a puncturing element in the chamber can be moved by the puncturing drive, and a measuring and evaluation apparatus for measuring the change of the variable.
摘要翻译：用于确定体液中的分析物的系统包括：包含两个部分杂志的盒，一个包括具有样品接触区的分析元件的腔室和含有试剂的试剂系统，其与体液的反应导致变量，另一个包括具有具有毛细通道的尖端的穿刺元件的腔室，其形成尖端和穿刺元件的样品转移区域之间的流体连接。该系统还可以包括具有用于在移动路径上驱动穿刺元件的穿刺驱动器的分析仪器，用于接收盒子的安装件，使得一次一次的仓库位于功能位置，其中穿刺元件可以通过穿刺驱动器移动腔室，以及用于测量变量的变化的测量和评估装置。

4. 发明申请

US20120276565A1 STABILIZATION OF ENZYMES WITH STABLE COENZYMES 有权
标题翻译：用稳定的聚苯乙烯稳定酶
公开(公告)号：US20120276565A1
公开(公告)日：2012-11-01
申请号：US13400209
申请日：2012-02-20
申请人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
发明人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
IPC分类号： C12N9/96 , G01N27/26 , G01N21/76 , C12Q1/32 , C12Q1/26
CPC分类号： C12N9/96 , C12N9/0006 , C12N9/0036 , C12Q1/26 , C12Q1/32 , C12Y101/01001 , C12Y101/01002 , C12Y101/01047 , C12Y101/01049 , C12Y106/05002 , C12Y106/99
摘要： Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization.
摘要翻译：公开了通过在稳定的辅酶的存在下储存酶来稳定酶的方法。此外，还公开了用稳定的辅酶稳定的酶以及其用于检测分析物的测试元件中的用途。其他方面包括独特的组合物，方法，技术，涉及酶稳定化的系统和装置。

5. 发明申请

US20120197158A1 Handheld analysis device 审中-公开
标题翻译：手持式分析仪
公开(公告)号：US20120197158A1
公开(公告)日：2012-08-02
申请号：US13196970
申请日：2011-08-03
申请人： Wolfgang Roedel
发明人： Wolfgang Roedel
IPC分类号： A61B5/151
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150717 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15146
摘要： A handheld medical device for body fluid analysis such as to measure an analyte concentration, for example glucose, in a body fluid such as blood or interstitial fluid by a patient or caregiver. The device comprises a mechanical assembly having a transport unit for consumable analytical elements, a display unit, a sensor for analyzing a body fluid sample obtained by a lancet prick, a memory for storing a series of measurement results, a first actuating element, the actuation of which transfers the device into a first active state, activates the mechanical assembly and prepares a measurement. In the first active state, a measurement is started by the actuation of one of the actuating elements, and a second actuating element, the actuation of which transfers the device into a second active state. The display unit is switched on by the actuation of the second actuating element, without activating the mechanical assembly.
摘要翻译：一种用于体液分析的手持式医疗装置，例如由患者或看护者测量体液如血液或间质液中的分析物浓度，例如葡萄糖。该装置包括具有用于消耗性分析元件的输送单元的机械组件，显示单元，用于分析由柳叶刀刺针获得的体液样本的传感器，用于存储一系列测量结果的存储器，第一致动元件，致动器其中的装置将装置转移到第一活动状态，激活机械装配并准备测量。在第一活动状态下，通过致动所述致动元件中的一个开始测量，以及第二致动元件，其致动将所述设备传送到第二激活状态。通过第二致动元件的致动来打开显示单元，而不启动机械组件。

6. 发明授权

US09540702B2 Stabilization of enzymes with stable coenzymes 有权
标题翻译：用稳定的辅酶稳定酶
公开(公告)号：US09540702B2
公开(公告)日：2017-01-10
申请号：US13400209
申请日：2012-02-20
申请人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
发明人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
IPC分类号： C12N9/04
CPC分类号： C12N9/96 , C12N9/0006 , C12N9/0036 , C12Q1/26 , C12Q1/32 , C12Y101/01001 , C12Y101/01002 , C12Y101/01047 , C12Y101/01049 , C12Y106/05002 , C12Y106/99
摘要： Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization.
摘要翻译：公开了通过在稳定的辅酶的存在下储存酶来稳定酶的方法。此外，还公开了用稳定的辅酶稳定的酶以及其用于检测分析物的测试元件中的用途。其他方面包括独特的组合物，方法，技术，涉及酶稳定化的系统和装置。

7. 发明授权

US06676970B2 Subcutaneous osteoporosis compositions 有权
标题翻译：皮下骨质疏松症组合物
公开(公告)号：US06676970B2
公开(公告)日：2004-01-13
申请号：US09848638
申请日：2001-05-03
申请人： Rainer Bader , Petra Bastian , Achim Goepferich , Wolfgang Roedel , Gerhard Winter
发明人： Rainer Bader , Petra Bastian , Achim Goepferich , Wolfgang Roedel , Gerhard Winter
IPC分类号： A61K4738
CPC分类号： A61K9/0024 , A61K9/0019 , A61K31/663 , A61K47/32 , A61K47/36 , A61K47/38
摘要： The invention is concerned with a pharmaceutical preparation for subcutaneous, parenteral administration, which contains bisphosphonic acids or their salts as the active substance, as well as the production of this preparation. By means of the preparation in accordance with the invention it is possible to administer locally relatively high concentrations of bisphosphonates without the occurrence of incompatibilities.
摘要翻译：本发明涉及皮下，肠胃外给药的药物制剂，其包含双膦酸或其作为活性物质的盐以及该制剂的制备。通过根据本发明的制备，可以在不发生不相容性的情况下施用局部相对高浓度的双膦酸盐。

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