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1. 发明申请

US20050158867A1 Method for screening biological samples for presence of the metabolic syndrome 审中-公开
标题翻译：用于筛选存在代谢综合征的生物样品的方法
公开(公告)号：US20050158867A1
公开(公告)日：2005-07-21
申请号：US10501563
申请日：2003-01-14
申请人： Wolfgang Petrich , Gerhard Werner , Reinhold Mischler , Johanna Frueh , Stephan Jacob
发明人： Wolfgang Petrich , Gerhard Werner , Reinhold Mischler , Johanna Frueh , Stephan Jacob
IPC分类号： G01N21/35 , G01N21/65 , G01N33/49 , G01N21/00
CPC分类号： G01N21/35
摘要： The present invention discloses a method and a system for screening biological samples for the presence of a metabolic syndrome in a sample donor.
摘要翻译：本发明公开了一种用于筛选样品供体中代谢综合征存在的生物样品的方法和系统。

2. 发明授权

US07369952B2 Quantification of disease progression by means of interpolation between parameters based on electromagnetic spectra 失效
标题翻译：通过基于电磁波谱的参数之间的插值来定量疾病进展
公开(公告)号：US07369952B2
公开(公告)日：2008-05-06
申请号：US10552248
申请日：2004-04-06
申请人： Wolfgang Petrich , Gerhard Werner , Heinz-Michael Hein , Hans-Juergen Kuhr
发明人： Wolfgang Petrich , Gerhard Werner , Heinz-Michael Hein , Hans-Juergen Kuhr
IPC分类号： G01R23/16 , G06F19/00
CPC分类号： G16H10/40 , G06F19/00 , G16H50/50
摘要： The invention relates to analysis methods for diagnosing diseases on human and animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeutic controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class, but it is classified in a data record based on the interpolation between different classes.
摘要翻译：本发明涉及用于诊断人和动物样品疾病的分析方法。本发明还涉及用于诊断疾病的各个阶段的评估方法，使得可以显示其进展。所述发明还能够以早期的方式鉴定疾病并进行治疗控制。本发明的方法在于实现用于分类样品的实际已知的多变量评价方法。然而，本发明的特征在于，没有将样本分配给某一类，而是基于不同类之间的插值将其分类到数据记录中。

3. 发明申请

US20060195296A1 Control for a disease progression 失效
标题翻译：控制疾病进展
公开(公告)号：US20060195296A1
公开(公告)日：2006-08-31
申请号：US10552248
申请日：2004-04-06
申请人： Wolfgang Petrich , Gerhard Werner , Heinz-Michael Hein , Hans-Juergen Kuhr
发明人： Wolfgang Petrich , Gerhard Werner , Heinz-Michael Hein , Hans-Juergen Kuhr
IPC分类号： G06F11/30 , G06F15/00
CPC分类号： G16H10/40 , G06F19/00 , G16H50/50
摘要： The invention relates to analysis methods for diagnosing diseases on human and animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeutic controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class, but it is classified in a data record based on the interpolation between different classes.
摘要翻译：本发明涉及用于诊断人和动物样品疾病的分析方法。本发明还涉及用于诊断疾病的各个阶段的评估方法，使得可以显示其进展。所述发明还能够以早期的方式鉴定疾病并进行治疗控制。本发明的方法在于实现用于分类样品的实际已知的多变量评价方法。然而，本发明的特征在于，没有将样本分配给某一类，而是基于不同类之间的插值将其分类到数据记录中。

4. 发明申请

US20120045842A1 ANALYSIS SYSTEM WITH CODING RECOGNITION 有权
标题翻译：具有编码识别的分析系统
公开(公告)号：US20120045842A1
公开(公告)日：2012-02-23
申请号：US13021356
申请日：2011-02-04
申请人： Wolfgang Petrich , Stefan Kalveram , Markus Serr
发明人： Wolfgang Petrich , Stefan Kalveram , Markus Serr
IPC分类号： G01N33/50 , G01N21/75
CPC分类号： G01N33/48764 , G01N35/00009 , G01N35/00663 , Y10T436/110833 , Y10T436/112499 , Y10T436/144444
摘要： An analysis system for detecting at least one analyte in a sample is proposed, in particular for detecting glucose in a bodily fluid. The analysis system is designed to detect the analyte using at least one test element. The test element has at least one analysis zone for detecting the analyte. The test element furthermore comprises at least one coding with at least one test element specific item of information and/or at least one position specific item of information. The analysis system comprises a detector and furthermore at least one transfer device which is designed to afford the detector the possibility of acquiring the analysis zone in at least a first position and to afford the detector the possibility of acquiring the coding in at least a second position which differs from the first position.
摘要翻译：提出了用于检测样品中至少一种分析物的分析系统，特别是用于检测体液中的葡萄糖。分析系统被设计成使用至少一个测试元件来检测分析物。测试元件具有至少一个用于检测分析物的分析区。测试元件还包括至少一个具有至少一个测试元件特定信息项和/或至少一个位置特定信息项的编码。该分析系统包括一个检测器，此外至少一个传送装置被设计成为检测器提供在至少第一位置获取分析区域的可能性，并且提供检测器在至少第二位置获取编码的可能性这与第一个位置不同。

5. 发明申请

US20120040386A1 FINE-GRAINED FILLER SUBSTANCES FOR PHOTOMETRIC REACTION FILMS 审中-公开
标题翻译：用于光学反应膜的细粒填充物质
公开(公告)号：US20120040386A1
公开(公告)日：2012-02-16
申请号：US13099601
申请日：2011-05-03
申请人： Wolfgang-Reinhold Knappe , Bernd Hiller , Ursula Lehr , Volker Zimmer , Wolfgang Petrich , Luis David Bedon-Gomez
发明人： Wolfgang-Reinhold Knappe , Bernd Hiller , Ursula Lehr , Volker Zimmer , Wolfgang Petrich , Luis David Bedon-Gomez
IPC分类号： C12Q1/32 , C12Q1/54 , B05D5/00 , B05D7/00 , C12Q1/02 , C12M1/40
摘要： There is proposed a diagnostic test element for detecting an analyte in a sample of a body fluid, more particularly in whole blood. The diagnostic test element comprises at least one test field having at least one detection reagent, wherein the detection reagent is set up to pass through at least one detectable change in the presence of the analyte, more particularly an optical change. The test field has at least one detection layer which comprises the detection reagent and which comprises particles. At least 90% of all particles of the detection layer have an actual particle size of less than 10 micrometers.
摘要翻译：提出了一种诊断测试元件，用于检测体液样品中的分析物，特别是在全血中。所述诊断测试元件包括至少一个具有至少一个检测试剂的测试场，其中所述检测试剂设置成在分析物存在下通过至少一个可检测的变化，更具体地说是光学变化。测试场具有至少一个检测层，其包括检测试剂并且包含颗粒。检测层的所有颗粒的至少90％具有小于10微米的实际颗粒尺寸。

6. 发明授权

US07708948B2 Test system for analyzing body fluids 失效
标题翻译：体液分析测试系统
公开(公告)号：US07708948B2
公开(公告)日：2010-05-04
申请号：US11468049
申请日：2006-08-29
申请人： Wolfgang Petrich
发明人： Wolfgang Petrich
IPC分类号： G01N33/48 , G01N21/00
CPC分类号： G01N35/00009 , A61B5/14532 , G01N33/48764 , G01N2035/00019 , Y10T436/144444
摘要： The invention relates to a test system for analyzing body fluids of the type comprising a test element tape carrying a plurality of test elements, a tape deflector for the test element tape for the selective application of body fluid, and a light source as well as a detector for optically analyzing test elements to which body fluid has been applied. The tape deflector has a rotatable optical element which acts as a deflection roller during transport of the test element tape. The optical element is positioned in the optical path between the light source and the detector.
摘要翻译：本发明涉及一种用于分析类型的体液的测试系统，其包括承载多个测试元件的测试元件带，用于选择性施加体液的测试元件带的带偏转器，以及光源用于光学分析已经施加体液的测试元件的检测器。带导向器具有可旋转的光学元件，其在传送测试元件带期间用作偏转辊。光学元件位于光源和检测器之间的光路中。

7. 发明授权

US06952603B2 Subcutaneous analyte sensor 失效
标题翻译：皮下分析物传感器
公开(公告)号：US06952603B2
公开(公告)日：2005-10-04
申请号：US09810635
申请日：2001-03-16
申请人： Martin Gerber , Matthias Essenpreis , Wolfgang Petrich
发明人： Martin Gerber , Matthias Essenpreis , Wolfgang Petrich
IPC分类号： G01N21/01 , A61B5/00 , A61B5/145 , A61B5/1459 , G01N21/41 , G01B9/02
CPC分类号： A61B5/1459 , A61B5/14532
摘要： Assembly and method for measuring the concentration of an analyte in a biological matrix. The assembly includes an implantable optical-sensing element that comprises a body, and a membrane mounted on the body in a manner such that the membrane and the body define a cavity. The membrane is permeable to the analyte, but is impermeable to background species in the biological matrix. A refractive element is positioned in the cavity. A light source transmits light of a first intensity onto the refractive element, and a light detector receives light of a second intensity that is reflected from the cavity. A controller device optically coupled to the detector compares the first and second light intensities, and relates the intensities to analyte concentration.
摘要翻译：用于测量生物基质中分析物浓度的装配和方法。组件包括可植入的光学感测元件，其包括主体和以使得膜和主体限定空腔的方式安装在主体上的膜。膜对分析物是可渗透的，但对于生物基质中的背景物质是不可渗透的。折射元件位于空腔中。光源将第一强度的光透射到折射元件上，并且光检测器接收从腔体反射的第二强度的光。光耦合到检测器的控制器设备比较第一和第二光强度，并将强度与分析物浓度相关联。

8. 发明申请

US20120064615A1 TEST ELEMENT FOR DETECTING AN ANALYTE IN A SAMPLE 有权
标题翻译：用于检测样品中分析物的测试元件
公开(公告)号：US20120064615A1
公开(公告)日：2012-03-15
申请号：US13102343
申请日：2011-05-06
申请人： Wolfgang Petrich , Luis David Bedon-Gomez
发明人： Wolfgang Petrich , Luis David Bedon-Gomez
IPC分类号： C12M1/40 , G01N21/75
CPC分类号： G01N21/6428 , B01L3/5027 , B01L3/502707 , B01L3/502746 , B01L2200/16 , B01L2300/0825 , B01L2400/0406 , B01L2400/084 , G01N21/8483 , G01N33/526 , G01N33/552
摘要： The invention relates to a test element for detecting at least one analyte in a sample, in particular for detecting at least one metabolite in a bodily fluid. The test element comprises at least one test field with a test field surface. The test field comprises at least one detection reagent that is adapted to undergo a detectable reaction in the presence of the analyte. The test element further comprises at least one distribution element that has at least one distribution surface facing the test field surface. Between the distribution surface and the test field surface is at least one capillary gap, wherein the capillary gap is adapted to allow a layer of the sample with a layer thickness of no more than 50 μm to form within the capillary gap.
摘要翻译：本发明涉及用于检测样品中至少一种分析物的测试元件，特别是用于检测体液中的至少一种代谢物。测试元件包括具有测试场表面的至少一个测试场。测试领域包括至少一种适于在分析物存在下经受可检测反应的检测试剂。测试元件还包括至少一个分布元件，其具有面向测试场表面的至少一个分布表面。在分布表面和测试场表面之间是至少一个毛细管间隙，其中毛细管间隙适于允许层厚度不大于50μm的样品层形成在毛细管间隙内。

9. 发明申请

US20110064618A1 FLUORESCENCE SPECTROSCOPY IN ABSORBING MEDIA 有权
标题翻译：吸收介质中的荧光光谱
公开(公告)号：US20110064618A1
公开(公告)日：2011-03-17
申请号：US12942356
申请日：2010-11-09
申请人： Wolfgang Petrich , Claudia Gaessler-Dietsche , Carina Horn , Kai Hebestreit , Jean-Michel Asfour , Klemens Bardelang , Gerrit Kocherscheidt
发明人： Wolfgang Petrich , Claudia Gaessler-Dietsche , Carina Horn , Kai Hebestreit , Jean-Michel Asfour , Klemens Bardelang , Gerrit Kocherscheidt
IPC分类号： G01N21/64 , G01J1/58
CPC分类号： C12Q1/008 , C12Q1/26 , C12Q1/32 , C12Q1/54 , G01N33/52 , G01N33/66 , Y10T436/144444
摘要： The invention relates to processes and devices for detecting an analyte in a sample by fluorescence measurement of a fluorophore, wherein the detection medium which contains a fluorophore or a precursor of the fluorophore is admixed with an absorber whose absorbance spectrum superimposes the fluorescence excitation range of the fluorophore. The system consisting of the fluorophore and the absorber, which is produced in the detection medium, has an altered effective fluorescence excitation range with an altered fluorescence excitation maximum. Illumination with fluorescence excitation light can take place within the range of this altered excitation maximum. The measured signal obtained from determining fluorescence emission exhibits only low dependence on the wavelength of the excitation light.
摘要翻译：本发明涉及通过荧光团的荧光测定来检测样品中分析物的方法和装置，其中将含有荧光团或荧光团前体的检测介质与吸收光谱与吸收光谱的荧光激发范围相加荧光团。由荧光团和在检测介质中产生的吸收体组成的系统具有改变的有效荧光激发范围，具有改变的荧光激发最大值。荧光激发光的照明可以在这种改变的激发最大值的范围内进行。从确定荧光发射获得的测量信号仅对激发光的波长的依赖性低。

10. 发明申请

US20100227348A1 METHOD AND DEVICE FOR DETERMINING THE CONCENTRATION OF AN ANALYTE USING FLUORESCENCE MEASUREMENT 审中-公开
标题翻译：使用荧光测量法确定分析仪浓度的方法和装置
公开(公告)号：US20100227348A1
公开(公告)日：2010-09-09
申请号：US12696665
申请日：2010-01-29
申请人： Wolfgang Petrich , Hans-Peter Haar , Joachim Hoenes , Carina Horn
发明人： Wolfgang Petrich , Hans-Peter Haar , Joachim Hoenes , Carina Horn
IPC分类号： C12Q1/54 , C12M1/34
CPC分类号： C12Q1/32 , C12Q1/54
摘要： A method is presented for determining the concentration of an analyte in a liquid sample using a reagent system. The reaction of the sample with the reagent system results in a change of the quantity of a fluorophore, the quantity of the fluorophore correlating with the concentration of the analyte, a characteristic measurement variable for the quantity of the fluorophore being measured, and the concentration of the analyte being determined using an evaluation algorithm on the basis of the measurement variable. The reagent system is integrated in an analysis system and the fluorescence lifetime of the fluorophore is used in the ascertainment of the concentration of the analyte.
摘要翻译：提出了一种使用试剂系统确定液体样品中分析物浓度的方法。样品与试剂系统的反应导致荧光团量的变化，荧光团的量与分析物的浓度相关，测量的荧光团的量的特征测量变量和浓度使用基于测量变量的评估算法确定分析物。试剂系统集成在分析系统中，荧光团的荧光寿命用于确定分析物的浓度。

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