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1. 发明授权

US06420430B1 Use of inhibitors of the sodium-hydrogen exchanger for preparing a medicament for preventing age-related disorders, and for prolonging life 失效
标题翻译：使用钠氢交换器的抑制剂来制备用于预防年龄相关疾病和延长寿命的药物
公开(公告)号：US06420430B1
公开(公告)日：2002-07-16
申请号：US09469299
申请日：1999-12-22
申请人： Wolfgang Linz , Hans-Jochen Lang , Bela Kelety , Peter Schmid
发明人： Wolfgang Linz , Hans-Jochen Lang , Bela Kelety , Peter Schmid
IPC分类号： A61K31155
CPC分类号： A61K31/155
摘要： Inhibitors of the cellular sodium-hydrogen exchanger are employed for preparing a medicament for preventing age-related functional disorders and dysfuntional changes of organs of the body and for preventing age-related diorders and for prolonging life while maintaining an improved quality of life. Typical representatives of NHE inhibitors are cariporide and eniporide
摘要翻译：细胞钠氢交换器的抑制剂用于制备用于预防年龄相关功能障碍和身体器官功能障碍变化的药物，并用于防止与年龄有关的异常并延长寿命，同时保持改善的生活质量。 NHE抑制剂的典型代表是卡立泊和恩哌立德

2. 发明授权

US08026069B2 Process for identification of compounds for modulating the activity of sodium/calcium exchange transporter 有权
标题翻译：用于鉴定调节钠/钙交换转运蛋白活性的化合物的方法
公开(公告)号：US08026069B2
公开(公告)日：2011-09-27
申请号：US11573762
申请日：2005-08-10
申请人： Henning Vollert , Sven Geibel , Bela Kelety , Wolfgang Doerner , Andreas Haase , Natalie Watzke , Kerstin Diekert
发明人： Henning Vollert , Sven Geibel , Bela Kelety , Wolfgang Doerner , Andreas Haase , Natalie Watzke , Kerstin Diekert
IPC分类号： G01N33/53 , C07K14/00
CPC分类号： G01N33/6872 , G01N2500/00
摘要： The invention refers to a cell free assay for determining the activity of a Na+/Ca2+ exchanger (NCX) protein by means of a cell free electrophysiological sensor chip, a kit of parts comprising the sensor chip with a NCX protein as well as the manufacturing and use of the kit of parts.
摘要翻译：本发明是指通过无细胞电生理学传感器芯片测定Na + / Ca 2+交换剂（NCX）蛋白的活性的无细胞测定法，包含具有NCX蛋白的传感器芯片的试剂盒，以及制造和使用套件的零件。

3. 发明申请

US20080248486A1 Type Pept1 Protein Assay 审中-公开
标题翻译：类型Pept1蛋白测定
公开(公告)号：US20080248486A1
公开(公告)日：2008-10-09
申请号：US11664541
申请日：2005-09-30
申请人： Natalie Watzke , Maarten Ruitenberg , Wolfgang Dorner , Renate Gauss , Bela Kelety , Joanna Tobien
发明人： Natalie Watzke , Maarten Ruitenberg , Wolfgang Dorner , Renate Gauss , Bela Kelety , Joanna Tobien
IPC分类号： G01N33/53 , A61K38/54
CPC分类号： C12Q1/001
摘要： The present invention relates to a type PepT1 protein assay and in particular a process for identifying a substrate and/or a modulator of the PepT1 protein.
摘要翻译：本发明涉及一种PepT1型蛋白质测定法，特别涉及用于鉴定PepT1蛋白质的底物和/或调节剂的方法。

4. 发明申请

US20080211485A1 Process for Identification of Compounds for Modulating the Activity of Sodium/Calcium Exchange Transporter 有权
标题翻译：用于调节钠/钙交换转运蛋白活性的化合物的鉴定方法
公开(公告)号：US20080211485A1
公开(公告)日：2008-09-04
申请号：US11573762
申请日：2005-08-10
申请人： Henning Vollert , Sven Geibel , Bela Kelety , Wolfgang Doerner , Andreas Haase , Natalie Watzke , Kerstin Diekert
发明人： Henning Vollert , Sven Geibel , Bela Kelety , Wolfgang Doerner , Andreas Haase , Natalie Watzke , Kerstin Diekert
IPC分类号： G01N33/48 , G01R19/00
CPC分类号： G01N33/6872 , G01N2500/00
摘要： The invention refers to a cell free assay for determining the activity of a Na+/Ca2+ exchanger (NCX) protein by means of a cell free electrophysiological sensor chip, a kit of parts comprising the sensor chip with a NCX protein as well as the manufacturing and use of the kit of parts.
摘要翻译：本发明是指通过无细胞电生理学传感器芯片测定Na + / ATP 2 +交换剂（NCX）蛋白的活性的无细胞测定法，包含传感器芯片和NCX蛋白质的部件套件以及部件套件的制造和使用。

5. 发明申请

US20090184006A1 METHOD FOR THE DETERMINATION OF THE ACTIVITY OF THE ORGANIC CATION TRANSPORTER 审中-公开
标题翻译：用于确定有机载体运输机活性的方法
公开(公告)号：US20090184006A1
公开(公告)日：2009-07-23
申请号：US12162833
申请日：2007-01-22
申请人： Henning Vollert , Sven Geibel , Bela Kelety , Klaus Fendler , Petra Arndt , Olga Gaiko , Ingo Janausch
发明人： Henning Vollert , Sven Geibel , Bela Kelety , Klaus Fendler , Petra Arndt , Olga Gaiko , Ingo Janausch
IPC分类号： G01N33/50 , G01N27/26
CPC分类号： G01N33/5438 , G01N33/6842 , G01N33/6872 , G01N2333/4703 , G01N2500/00
摘要： The present invention refers to a method for determining the activity of the organic cation transporter (OCT), a method for determining the activity of or identifying a chemical compound that modulates the activity of OCT with the help of a cell free electrophysiological sensor chip containing a solid-supported sensor electrode and a lipid layer containing the OCT located in the immediate spatial vicinity to the sensor electrode, whereas the sensor electrode is electrically insulated relative to the solutions used and to the lipid layer, as well as to the sensor chip itself and a kit containing same.
摘要翻译：本发明涉及一种用于测定有机阳离子转运蛋白（OCT）的活性的方法，一种用于测定调节OCT活性的活性或鉴定化学化合物的方法，借助于无细胞电生理学传感器芯片，其含有固体支持的传感器电极和含有OCT的脂质层位于传感器电极的紧邻空间附近，而传感器电极相对于所使用的溶液和脂质层以及传感器芯片本身和一个包含相同的套件

6. 发明申请

US20070021805A1 Biocompatible sensor electrode assembly and method for the production thereof 审中-公开
标题翻译：生物相容性传感器电极组件及其制造方法
公开(公告)号：US20070021805A1
公开(公告)日：2007-01-25
申请号：US10556422
申请日：2004-05-10
申请人： Bela Kelety
发明人： Bela Kelety
IPC分类号： A61N1/00
CPC分类号： C12Q1/001 , G01N33/5438
摘要： The invention relates to a biocompatible sensor electrode arrangement and to a process for its manufacture, at least one carrier substrate area (22), at least one intermediate substrate area (26) on the surface area (22a) of the carrier substrate area (22) and a biomaterial area (24) on the top side surface area (26a) of the intermediate substrate area (26) being provided. The biomaterial area (24) consists of at least one biologically compatible material component. The carrier substrate area (22) with the intermediate substrate area (26) is formed in the form or the manner of a wafer element or a printed circuit, as photolithographically processed structure, as structure bonded on or laminated on and/or as structure processed by printing, in particular on the carrier substrate (22) in each case.
摘要翻译：本发明涉及一种生物相容的传感器电极装置及其制造方法，至少一个载体衬底区域（22），载体衬底区域的表面区域（22a）上的至少一个中间衬底区域（26） 22）和设置在中间基板区域（26）的顶侧表面区域（26a）上的生物材料区域（24）。生物材料区域（24）由至少一种生物相容的材料组分组成。具有中间基板区域（26）的载体基板区域（22）以晶片元件或印刷电路的形式或方式形成为光刻处理结构，结构结合在其上并且/或作为结构处理通过在各种情况下特别是在载体基板（22）上进行印刷。

7. 发明申请

US20060283706A1 Biosensor arrangement and method for producing it 审中-公开
标题翻译：生物传感器布置及其生产方法
公开(公告)号：US20060283706A1
公开(公告)日：2006-12-21
申请号：US11454494
申请日：2006-06-16
申请人： Bela Kelety , Wolfgang Dorner , Robin Krause
发明人： Bela Kelety , Wolfgang Dorner , Robin Krause
IPC分类号： G01N33/487
CPC分类号： G01N27/3277
摘要： A biosensor arrangement and a method for producing a biosensor arrangement. The biosensor arrangement comprises at least one electrode substrate with a surface which forms an electrode of the biosensor arrangement. At least one biomaterial area is formed which is provided in and/or on the surface of the electrode substrate. The electrode substrate is formed with or of a synthetic material or with or of a polymer material, which in turn is electrically conductive.
摘要翻译：生物传感器装置和生物传感器装置的制造方法。生物传感器装置包括具有形成生物传感器装置的电极的表面的至少一个电极基板。形成至少一个生物材料区域，其设置在电极基板的表面和/或表面上。电极基板由合成材料形成，或由聚合物材料形成，或者由聚合物材料形成，而聚合物材料又是导电的。

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