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1. 发明授权

US5342646A Method for making carrier systems for biologically active materials 失效
标题翻译：制备生物活性物质载体体系的方法
公开(公告)号：US5342646A
公开(公告)日：1994-08-30
申请号：US979425
申请日：1992-11-19
申请人： Wolfgang Kleese , Dieter Kraemer , Hans-Ulrich Petereit , Klaus Lehmann , Werner Siol
发明人： Wolfgang Kleese , Dieter Kraemer , Hans-Ulrich Petereit , Klaus Lehmann , Werner Siol
IPC分类号： C07K17/08 , C12N11/08 , G01N33/545 , B05D7/00 , A61K9/16 , B05D1/12
CPC分类号： G01N33/545 , C07K17/08 , C12N11/08
摘要： What is disclosed is a method for preparing carrier systems, adaptable to the covalent bonding thereto of biologically active materials, consisting of a known solid support material having a surface coated with a polymer containing functional groups suitable for covalent bonding, by coating the support material with a film-forming polymer dispersion and a non-film-forming polymer dispersion, suitably in admixture, at least one of the two polymer dispersions containing a polymer having functional groups suitable for covalent bonding with a biologically active material.
摘要翻译：公开的是一种制备载体系统的方法，其适用于生物活性材料的共价键合，其由已知的固体支持材料组成，所述固体支持材料具有涂覆有包含适于共价键合的官能团的聚合物的表面，通过用一种成膜聚合物分散体和一种非成膜聚合物分散体，适当地混合两种聚合物分散体中的至少一种，其含有具有适于与生物活性材料共价键合的官能团的聚合物。

2. 发明授权

US06306428B1 Time-release laminar pharmaceutical composition 失效
标题翻译：时间释放层状药物组成
公开(公告)号：US06306428B1
公开(公告)日：2001-10-23
申请号：US09058951
申请日：1998-04-13
申请人： Klaus Lehmann , Hans-Ulrich Petereit
发明人： Klaus Lehmann , Hans-Ulrich Petereit
IPC分类号： A61K900
CPC分类号： A61K9/2095 , A61K9/2072 , A61K9/2086 , A61K9/7007
摘要： A time-release laminar pharmaceutical composition, comprised of rolled or folded layers of a polymer film, that contain a pharmaceutically active substance, in which the outer surface area of the polymer film which contains the active substance, and which is accessible to the digestive juices, amounts to at most 25% of the entire surface area in the rolled or folded state, and the rolled or folded layers adhere to one another in such a way that the laminar form of medication maintains its rolled or folded form for a period of at least one hour in the release test according to USP 23, Method A, apparatus 2, at 37° C. and 50 rpm, in artificial gastric juice, and at least 30% of the active substance contained in it is released in the rolled or folded state.
摘要翻译：包含聚合物膜的卷曲或折叠层的时间释放层状药物组合物，其含有药物活性物质，其中含有活性物质的聚合物膜的外表面积并且可被消化液接触相当于轧制或折叠状态下整个表面积的至多25％，并且卷起或折叠的层彼此粘合，使得层状形式的药物保持其卷曲或折叠形式一段时间根据USP 23，方法A，装置2在37℃和50rpm，在人造胃液中的释放试验中至少1小时，其中含有的至少30％的活性物质被释放在轧制或折叠状态。

3. 发明授权

US5292522A Aqueous film coating agent for solid medicaments 失效
标题翻译：固体药物水性膜包衣剂
公开(公告)号：US5292522A
公开(公告)日：1994-03-08
申请号：US998882
申请日：1992-12-28
申请人： Hans-Ulrich Petereit , Manfred Assmus , Klaus Lehmann
发明人： Hans-Ulrich Petereit , Manfred Assmus , Klaus Lehmann
IPC分类号： A61K9/28 , A61K9/50 , A61K9/16
CPC分类号： A61K9/5073 , A61K9/28 , A61K9/282 , A61K9/2846 , A61K9/5015 , A61K9/5026
摘要： A water insoluble lipophilic emulsifier having a hydrophile-lipophile balance (HLB) of 3.5 to 7, added to an aqueous dispersion containing a polymer comprising acrylic acid, methacrylic acid, their alkyl esters, and/or their alkylaminoalkyl esters, acts as a lubricant and parting agent when the resulting mixture is used for coating pharmaceutical dosage forms and prevents the pharmaceutical dosage forms being coated from sticking to one another and to the walls of the coating apparatus used.
摘要翻译：将亲水 - 亲油平衡（HLB）为3.5至7的水不溶性亲脂性乳化剂加入到含有丙烯酸，甲基丙烯酸，它们的烷基酯和/或它们的烷基氨基烷基酯的聚合物的水性分散体中，起润滑作用，当所得到的混合物用于涂覆药物剂型并防止药物剂型被涂覆时彼此粘附和使用的涂覆装置的壁分离剂。

4. 发明授权

US5730999A Dermal therapeutic system made of a meltable poly (meth) acrylate 失效
标题翻译：由可熔融的聚（甲基）丙烯酸酯混合物制成的皮肤治疗系统
公开(公告)号：US5730999A
公开(公告)日：1998-03-24
申请号：US650025
申请日：1996-05-17
申请人： Klaus Lehmann , Hans-Ulrich Petereit , Manfred Assmus
发明人： Klaus Lehmann , Hans-Ulrich Petereit , Manfred Assmus
IPC分类号： A61K9/70 , A61L15/44 , A61L15/58 , A61P17/00
CPC分类号： A61K9/7061 , A61L15/44 , A61L15/58 , A61L2300/40 , A61L2300/418 , A61L2300/434 , A61L2300/602
摘要： A dermal therapeutic system which exhibits a prolonged release of a drug comprising at least one pharmaceutical agent combined with poly(meth)acrylates in the form of at least one layer of the therapeutic system, the poly(meth)acrylates being a mixture, which is produced from a melt, comprising (1) at least one (meth)acrylic polymer containing functional groups and (2) at least one (meth)acrylic polymer which regulates the flow behavior of the poly(meth)acrylate mixture and which contains no functional groups or only insignificant amounts of functional groups.
摘要翻译：显示药物延长释放的真皮治疗系统，其包含至少一种药物剂，其与至少一层治疗系统形式的聚（甲基）丙烯酸酯组合，所述聚（甲基）丙烯酸酯是混合物，其为由（1）至少一种含有官能团的（甲基）丙烯酸聚合物和（2）调节聚（甲基）丙烯酸酯混合物的流动行为的至少一种（甲基）丙烯酸类聚合物，其不含功能性组或仅有微量的官能团。

5. 发明授权

US06420473B1 Acrylic enteric coating compositions 有权
标题翻译：丙烯酸肠溶组合物
公开(公告)号：US06420473B1
公开(公告)日：2002-07-16
申请号：US09501866
申请日：2000-02-10
申请人： Ramireddy Chittamuru , George Reyes , Thomas P. Farrell , Charles F. Vesey , Dev K. Mehra , Hans-Ulrich Petereit , Klaus Lehmann
发明人： Ramireddy Chittamuru , George Reyes , Thomas P. Farrell , Charles F. Vesey , Dev K. Mehra , Hans-Ulrich Petereit , Klaus Lehmann
IPC分类号： C08J312
CPC分类号： A61K9/2893 , A61K9/2813 , A61K9/2846 , A61K47/02
摘要： A non-toxic, edible, enteric film coating, dry powder composition for use in making an aqueous enteric suspension which may be used in coating pharmaceutical tablets comprises a) an acrylic resin, said resin comprising i) from 20 to 85 percent by weight of at least one alkyl acrylate or alkyl methacrylate moiety, ii) from 80 to 15 percent by weight of at least one vinyl or vinylidene moiety having a carboxylic acid group capable of salt formation, and iii) from 0 to 30 percent by weight of at least one other vinyl or vinylidene moiety copolymerizable with i) and ii), b) an alkalizing agent capable of reacting with the acrylic resin such that, after reaction, 0.1 to 10 mole percent of the acidic groups in 1a-ii) are present in the salt form, and c) a detackifier.
摘要翻译：可用于制备可用于包衣药物片剂的水性肠溶悬浮液的无毒，可食用的肠溶薄膜包衣干粉组合物包括a）丙烯酸树脂，所述树脂包含i）20至85重量％至少一种丙烯酸烷基酯或甲基丙烯酸烷基酯部分，ii）80至15重量％的至少一个具有能够形成盐的羧酸基团的乙烯基或亚乙烯基部分，和iii）至少0至30重量％可与i）和ii）共聚的另一个乙烯基或亚乙烯基部分，b）能够与丙烯酸类树脂反应的碱化剂，使得反应后，1a-ii）中的0.1〜10摩尔％的酸性基团存在于盐形式，和c）防粘剂。

6. 发明授权

US4520172A Method for coating medicaments 失效
标题翻译：药物涂敷方法
公开(公告)号：US4520172A
公开(公告)日：1985-05-28
申请号：US474469
申请日：1983-03-11
申请人： Klaus Lehmann , Dieter Dreher , Hubert Rauch , Werner Siol
发明人： Klaus Lehmann , Dieter Dreher , Hubert Rauch , Werner Siol
IPC分类号： A61K9/58 , A61K9/28 , A61K9/32 , A61K47/00 , A61K47/32 , C08F8/28 , C08F8/12 , C08F8/44
CPC分类号： A61K9/2846
摘要： What are disclosed are methods for dispersing a powdered salt-forming synthetic resin in water in the presence of an agent forming a salt with said resin, methods for coating pharmaceutical dosage forms with a dispersion made by such a method, and powdered mixtures of a salt forming resin and salt forming agent for dispersion in water.
摘要翻译：所公开的方法是在形成与所述树脂形成盐的试剂的存在下将粉状成盐合成树脂分散在水中的方法，用通过这种方法制备的分散体涂覆药物剂型的方法和盐的混合物形成用于分散在水中的树脂和成盐剂。

7. 发明授权

US4452862A Pharmaceutical coating materials soluble or swellable in gastric juice and pharmaceutical dosage forms coated therewith 失效
标题翻译：在胃液中可溶或溶胀的药物包衣材料和用其涂覆的药物剂型
公开(公告)号：US4452862A
公开(公告)日：1984-06-05
申请号：US345478
申请日：1982-02-03
申请人： Gerhard Markert , Dieter Dreher , Klaus Lehmann , Werner Siol , Hubert Rauch
发明人： Gerhard Markert , Dieter Dreher , Klaus Lehmann , Werner Siol , Hubert Rauch
IPC分类号： A61K9/58 , A61K9/28 , A61K9/32 , A61K47/32 , B32B5/16
CPC分类号： A61K9/2846 , Y10T428/2998
摘要： Coating materials for pharmaceutical dosage forms contain, besides the conventional liquid or solid additives for pharmaceutical coatings, a binder comprising a synthetic polymer, prepared by emulsion polymerization, having 5 to 100% by weight of units derived from monomers of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group, R.sub.2 is an alkylene or aralkylene group having at least 3 carbon atoms in the chain between the amino nitrogen and the ester oxygen atom of which at least one is tertiary or quaternary, and R.sub.3 and R.sub.4 are lower alkyl radicals or together with the amino-nitrogen atom form a heteroaliphatic ring, and, optionally, additional comonomer units.
摘要翻译：用于药物剂型的涂层材料除了用于药物涂层的常规液体或固体添加剂外，还包含通过乳液聚合制备的包含合成聚合物的粘合剂，其具有5至100重量％的衍生自下式的单体的单元：其中 R1是氢原子或低级烷基，R2是在氨基氮和酯氧原子之间的链中具有至少3个碳原子的亚烷基或亚芳基，其至少一个是叔或四价，R3和R4 是低级烷基或与氨基 - 氮原子一起形成杂脂族环，和任选的另外的共聚单体单元。

8. 发明授权

US4039413A Method of bonding a polypeptide to a macromolecular polymeric carrier by irradiation with light 失效
标题翻译：通过光照射将多肽与大分子聚合物载体结合的方法
公开(公告)号：US4039413A
公开(公告)日：1977-08-02
申请号：US426317
申请日：1973-12-19
申请人： Dieter Kraemer , Klaus Lehmann , Hermann Plainer
发明人： Dieter Kraemer , Klaus Lehmann , Hermann Plainer
IPC分类号： A61K39/44 , A61K41/00 , C07C67/00 , C07C231/00 , C07C231/12 , C07K17/08 , C12N11/08 , C12N11/12 , C12P21/04 , C08L1/00 , C08L3/00
CPC分类号： C12N11/08 , A61K39/44 , A61K41/0023
摘要： Methods for bonding a polypeptide to a macro-molecular carrier compound by irradiating an aqueous solution of the polypeptide, in the absence of oxygen and in the presence of said carrier compound, with ultraviolet light in the optional presence of a photosensitizer or with visible light in the presence of a photosensitizer and an organic peroxide.
摘要翻译：将多肽与大分子载体化合物结合的方法，其中在无氧的情况下，在所述载体化合物的存在下，在任选的光敏剂存在下，或在可见光下，用紫外光照射多肽的水溶液光敏剂和有机过氧化物的存在。

9. 发明授权

US4070348A Water-swellable, bead copolymer 失效
标题翻译：水溶胀性，珠粒共聚物
公开(公告)号：US4070348A
公开(公告)日：1978-01-24
申请号：US544830
申请日：1975-01-28
申请人： Dieter Kraemer , Klaus Lehmann , Horst Pennewiss , Hermann Plainer , Roland Schweder
发明人： Dieter Kraemer , Klaus Lehmann , Horst Pennewiss , Hermann Plainer , Roland Schweder
IPC分类号： C08F2/14 , C12N11/08 , C08F28/00 , C08F2/00 , C08F24/00 , C08G75/00
CPC分类号： C08F2/14 , C12N11/08 , Y10S435/897 , Y10S526/909 , Y10S526/91
摘要： Water-swellable, cross-linked, bead copolymers of (A) an ethylenically unsaturated monomer having a carboxylic acid anhydride, glycidyl or succinimide group, (B) a comonomer having at least two radical-polymerizable carbon double bonds, and (C) a radical-polymerizable water-soluble comonomer are disclosed to be excellent carriers capable of bonding with biologically active substances such as enzymes, enzyme substrates, inhibitors, hormones, antibiotics, antigens, and peptides.
摘要翻译：（A）具有羧酸酐的烯键式不饱和单体，缩水甘油基或琥珀酰亚胺基，（B）具有至少两个可自由基聚合的碳双键的共聚单体的水溶胀性，交联的珠粒共聚物，（C）可自由基聚合的水溶性共聚单体被公开为能够与酶，酶底物，抑制剂，激素，抗生素，抗原和肽等生物活性物质结合的优异载体。

10. 发明授权

US4388271A Rapid diagnostic agents 失效
标题翻译：快速诊断剂
公开(公告)号：US4388271A
公开(公告)日：1983-06-14
申请号：US300899
申请日：1981-09-10
申请人： Dieter Kraemer , Klaus Lehmann , Roland Hartl
发明人： Dieter Kraemer , Klaus Lehmann , Roland Hartl
IPC分类号： C12Q1/28 , G01N33/72
CPC分类号： G01N33/725 , C12Q1/28 , Y10S436/904
摘要： The invention relates to diagnostic agents for the rapid diagnostic detection of blood in excretions and body fluids, consisting essentially of a solid support which is charged with a chromogenic substance as indicator and impregnated with an acrylic and/or methacrylic resin.
摘要翻译：本发明涉及用于快速诊断检测排泄物和体液中的血液的诊断剂，其基本上由固体支持物组成，所述固体支持物装载有显色物质作为指示剂并用丙烯酸和/或甲基丙烯酸树脂浸渍。

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