专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4330620A Method and reagent for the determination of creatine kinase MB 失效
标题翻译：用于测定肌酸激酶MB的方法和试剂
公开(公告)号：US4330620A
公开(公告)日：1982-05-18
申请号：US125318
申请日：1980-02-28
申请人： Wolfgang Gruber , Helmut Lenz , Siegfried Looser , Hans-Ralf Linke
发明人： Wolfgang Gruber , Helmut Lenz , Siegfried Looser , Hans-Ralf Linke
IPC分类号： C12N9/12 , A61K39/00 , C12Q1/50 , G01N33/573 , G01N33/70 , G01N33/54 , C12N9/99
CPC分类号： C12Q1/50 , G01N33/70 , Y10S435/962 , Y10S435/968
摘要： A method for the determination of creatine kinase-MB in serum by immunological exclusion of sub-unit M and measurement of the sub-unit B for the determination of creatine kinase, the improvement comprising, for the purpose of excluding the sub-unit M, adding to the reaction mixture comprising determination reagents and the creatine kinase-containing sample, monovalent fragments obtained from antibodies against the sub-unit M by proteolytic cleavage under reducing conditions.
摘要翻译：通过免疫排除子单元M和用于测定肌酸激酶的子单元B的测量来测定血清中的肌酸激酶-MB的方法，其改进包括为了排除子单元M，向包含测定试剂和含肌酸激酶的样品的反应混合物中加入通过在还原条件下通过蛋白水解切割从针对子单元M的抗体获得的单价片段。

2. 发明授权

US4423227A Process for the preparation of reactive, couplable derivatives of the thyroid hormones 失效
标题翻译：制备甲状腺激素的反应性，偶联性衍生物的方法
公开(公告)号：US4423227A
公开(公告)日：1983-12-27
申请号：US307141
申请日：1981-09-30
申请人： Hans-Georg Batz , Winfried Albert , Helmut Lenz , Hans-Ralf Linke , Fritz Stahler
发明人： Hans-Georg Batz , Winfried Albert , Helmut Lenz , Hans-Ralf Linke , Fritz Stahler
IPC分类号： C07C67/00 , C07C231/00 , C07C231/02 , C07C233/47 , C07C233/49 , C07D207/44 , C07D207/452 , C07F7/18 , G01N33/53 , G01N33/60 , G01N33/78 , C07F7/10
CPC分类号： C07D207/452 , G01N33/78
摘要： Process for the preparation of reactive, couplable derivatives of the thyroid hormones 3,3',5-triiodothyronine (T.sub.3) and 3,3',5,5'-tetraiodothyronine (T.sub.4) by reaction with reactive carboxylic acid derivatives, which process comprises sylylating all the functional groups of the thyroid hormone by reaction with a reactive triorganosylyl derivative and then reacting the persylylated derivative of the thyroid hormone thus obtained with an activated carboxylic acid derivative.
摘要翻译：通过与活性羧酸衍生物反应制备3,3'，5-三碘甲状腺原氨酸（T3）和3,3'，5,5'-四碘甲状腺原氨酸（T4）的活性，偶联衍生物的方法，该方法包括通过与反应性三有机基团衍生物反应来甲酰化甲状腺激素的所有官能团，然后使由此获得的甲状腺激素的透性衍生物与活化的羧酸衍生物反应。

3. 发明授权

US10663538B2 Monitoring of a temporal change in a magnetic field in a magnetic resonance device 有权
公开(公告)号：US10663538B2
公开(公告)日：2020-05-26
申请号：US15700124
申请日：2017-09-09
申请人： Wolfgang Bielmeier , Gerhard Brinker , Swen Campagna , Nikolaus Demharter , Bernd Erbe , Matthias Gebhardt , Helmut Lenz , Jürgen Nistler , Dominik Paul , Carsten Prinz , Gudrun Ruyters , Stephan Stöcker , Markus Vester
发明人： Wolfgang Bielmeier , Gerhard Brinker , Swen Campagna , Nikolaus Demharter , Bernd Erbe , Matthias Gebhardt , Helmut Lenz , Jürgen Nistler , Dominik Paul , Carsten Prinz , Gudrun Ruyters , Stephan Stöcker , Markus Vester
IPC分类号： G01R33/24 , G01R33/385 , G01R33/28
摘要： A method for monitoring a temporal change in a magnetic field in a magnetic resonance device, as well as an evaluation unit, a magnetic resonance device, and a computer program product for performing the method are provided. The method provides that a position-dependent magnetic field distribution that is produced by the plurality of gradient coils is provided with a plurality of monitoring points. In addition, time-dependent gradient values of the plurality of gradient coils are ascertained. Based on position-dependent magnetic field distribution and the time-dependent gradient values, the temporal change in the magnetic field is ascertained. The temporal change in the magnetic field is monitored by comparing the temporal change in the magnetic field with at least one limit value.

4. 发明申请

US20180074138A1 MONITORING OF A TEMPORAL CHANGE IN A MAGNETIC FIELD IN A MAGNETIC RESONANCE DEVICE 审中-公开
公开(公告)号：US20180074138A1
公开(公告)日：2018-03-15
申请号：US15700124
申请日：2017-09-09
申请人： Wolfgang Bielmeier , Gerhard Brinker , Swen Campagna , Nikolaus Demharter , Bernd Erbe , Matthias Gebhardt , Helmut Lenz , Jürgen Nistler , Dominik Paul , Carsten Prinz , Gudrun Ruyters , Stephan Stöcker , Markus Vester
发明人： Wolfgang Bielmeier , Gerhard Brinker , Swen Campagna , Nikolaus Demharter , Bernd Erbe , Matthias Gebhardt , Helmut Lenz , Jürgen Nistler , Dominik Paul , Carsten Prinz , Gudrun Ruyters , Stephan Stöcker , Markus Vester
IPC分类号： G01R33/24 , G01R33/385 , G01R33/28
CPC分类号： G01R33/24 , G01R33/288 , G01R33/385
摘要： A method for monitoring a temporal change in a magnetic field in a magnetic resonance device, as well as an evaluation unit, a magnetic resonance device, and a computer program product for performing the method are provided. The method provides that a position-dependent magnetic field distribution that is produced by the plurality of gradient coils is provided with a plurality of monitoring points. In addition, time-dependent gradient values of the plurality of gradient coils are ascertained. Based on position-dependent magnetic field distribution and the time-dependent gradient values, the temporal change in the magnetic field is ascertained. The temporal change in the magnetic field is monitored by comparing the temporal change in the magnetic field with at least one limit value.

5. 发明授权

US08664007B2 Immune complex-specific antibodies for increased sensitivity in immunoassay array tests 有权
标题翻译：免疫复合物特异性抗体，用于在免疫测定阵列测试中提高灵敏度
公开(公告)号：US08664007B2
公开(公告)日：2014-03-04
申请号：US11260938
申请日：2005-10-28
申请人： Ursula Klause , Helmut Lenz , Christine Markert-Hahn
发明人： Ursula Klause , Helmut Lenz , Christine Markert-Hahn
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , G01N33/6854
摘要： The invention concerns a method for determining antigen-specific antibodies of a particular immunoglobulin class in a sample by means of an immunoassay in an array format in which various binding partners Bnx are bound on different discrete areas on a support where Bnx in each case contain the various antigens that are able to specifically bind to the antibodies to be detected, by incubating the support with the sample and a binding partner B2 which carries a label and subsequently detecting the label on the respective discrete areas wherein B2 specifically binds antibodies of a certain immunoglobulin class that have been bound in an antigen-specific manner.
摘要翻译：本发明涉及通过以阵列格式的免疫测定来测定样品中特定免疫球蛋白类别的抗原特异性抗体的方法，其中各种结合配偶体Bnx结合在支架上的不同离散区域上，其中每种情况下Bnx包含能够通过将载体与样品一起孵育的各种抗原和携带标记的结合伴侣B2，随后检测各个离散区域上的标记，其中B2特异性结合某种免疫球蛋白的抗体已经以抗原特异性方式结合的类。

6. 发明申请

US20080012636A1 Electric Amplifier and Method for the Control Thereof 有权
标题翻译：电动放大器及其控制方法
公开(公告)号：US20080012636A1
公开(公告)日：2008-01-17
申请号：US11629442
申请日：2005-06-14
申请人： Helmut Lenz
发明人： Helmut Lenz
IPC分类号： H03F1/36
CPC分类号： G01R33/3852
摘要： A method for controlling an electric amplifier is provided. The method includes monitoring a closed-loop control signal of a regulator, which triggers an end stage of the amplifier; adjusting the closed-loop control signal as a function of an output signal of the end stage; comparing the closed-loop control signal with a reference signal; triggering the end stage when an amplitude limit value and a period length limit value are exceeded or undershot by the amplitude value and period length value, respectively, of the closed-loop control signal; and blocking an input side and/or the regulator when the end stage is triggered.
摘要翻译：提供了一种用于控制电放大器的方法。该方法包括监视调节器的闭环控制信号，其触发放大器的末级; 根据终端的输出信号调整闭环控制信号; 将闭环控制信号与参考信号进行比较; 当分别超过或低于闭环控制信号的振幅值和周期长度值的振幅限制值和周期长度限制值时，触发结束级; 并且当终端被触发时阻塞输入侧和/或调节器。

7. 发明申请

US20070262892A1 Method for generating a modulator input signal and premodulator 失效
标题翻译：用于产生调制器输入信号和预调制器的方法
公开(公告)号：US20070262892A1
公开(公告)日：2007-11-15
申请号：US11784047
申请日：2007-04-05
申请人： Helmut Lenz
发明人： Helmut Lenz
IPC分类号： H03M3/00
CPC分类号： H03F3/2173
摘要： A method for generating at least one modulator input signal from at least one regulator signal is provided. The method comprising: generating at least one dither signal based on the periodic output of elements of a discrete dither sequence of the basic form DF=0, 1, 2 . . . 2(m−n)−1; and adding the at least one dither signal to the regulator signal. The regulator signal comprises a digital regulator signal with a length of m bits, and the modulator input signal comprises a digital modulator input signal with a length of n bits, where m>n.
摘要翻译：提供了一种用于从至少一个调节器信号产生至少一个调制器输入信号的方法。该方法包括：基于基本形式DF = 0,1,2的离散抖动序列的元素的周期性输出来产生至少一个抖动信号。。。 2（m-n）-1; 以及将所述至少一个抖动信号添加到所述调节器信号。调节器信号包括长度为m位的数字调节器信号，并且调制器输入信号包括长度为n位的数字调制器输入信号，其中m> n。

8. 发明授权

US07091632B2 Stabilization circuit for compensating fluctuations in a voltage at a user 失效
公开(公告)号：US07091632B2
公开(公告)日：2006-08-15
申请号：US10266293
申请日：2002-10-08
申请人： Helmut Lenz
发明人： Helmut Lenz
IPC分类号： H02J3/24
CPC分类号： H02J3/1814 , H02J9/06 , Y02E40/18
摘要： A stabilization circuit wherein voltages of the secondary winding of a transformer are stabilized with respect to mains voltage fluctuations and load fluctuations, an auxiliary voltage is derived either from a secondary winding of the transformer or an auxiliary transformer. Together with the mains voltage portion of this auxiliary voltage acquired by pulse-width modulation forms the primary voltage of the transformer such that the desired stabilization is achieved.

9. 发明授权

US6060285A Process for the production of hetero-bispecific antibodies 失效
标题翻译：异源双特异性抗体的制备方法
公开(公告)号：US6060285A
公开(公告)日：2000-05-09
申请号：US500596
申请日：1990-03-22
申请人： Helmut Lenz , Ulrich Weidle
发明人： Helmut Lenz , Ulrich Weidle
IPC分类号： C07K16/46 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , C12R1/19 , C12R1/91 , C07H15/12 , C12N5/00 , C12N15/00 , C12P21/06
CPC分类号： C07K16/468 , Y10S435/972
摘要： For the production of hetero-bispecific monoclonal antibodies at least the genes for the light chain and for the variable part of the heavy chain are isolated from a hybridoma cell line which secretes an antibody with a desired specificity and they are inserted into a eukaryotic plasmid vector which contains a marker capable of selection together with a strong promoter, this expression vector is transfected into a hybridoma cell line which secretes antibodies with a second desired specificity, the cell line is cultured, the antibodies are obtained and the bispecific antibody is isolated.
摘要翻译：为了生产异双特异性单克隆抗体，至少将轻链基因和重链可变部分从杂交瘤细胞系中分离出来，所述杂交瘤细胞系将具有所需特异性的抗体分泌，并将其插入真核质粒载体其包含能够与强启动子一起选择的标记，将该表达载体转染到以第二所需特异性分泌抗体的杂交瘤细胞系中，培养细胞系，获得抗体并分离双特异性抗体。

10. 发明授权

US5965378A Antibody class-specific interference eliminating reagent 失效
标题翻译：抗体类特异性干扰消除试剂
公开(公告)号：US5965378A
公开(公告)日：1999-10-12
申请号：US809412
申请日：1997-04-24
申请人： Dittmar Schlieper , Helmut Lenz , Urban Schmitt , Volker Klemt
发明人： Dittmar Schlieper , Helmut Lenz , Urban Schmitt , Volker Klemt
IPC分类号： C07K16/06 , C07K16/42 , G01N33/53 , G01N33/531 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6854 , C07K16/065 , C07K16/4283 , G01N33/5306 , G01N33/54393 , C07K2317/55 , Y10S435/962 , Y10S435/965 , Y10S436/825 , Y10S530/829 , Y10S530/861 , Y10S530/862 , Y10S530/863 , Y10S530/864 , Y10S530/865 , Y10S530/866
摘要： The invention concerns a composition composed of several different antibodies or/and antibody fragments which is suitable as a reagent to reduce interferences in an immunological method for the class-specific detection of antibodies from one or several of the immunoglobulin classes G, M, A, D and E.
摘要翻译： PCT No.PCT / EP95 / 04307 Sec。 371日期1997年04月24日 102（e）日期1997年4月24日PCT提交1995年11月2日PCT公布。公开号WO96 / 14337 日期1996年5月17日本发明涉及由几种不同的抗体或/和抗体片段组成的组合物，其适合作为用于减少免疫学方法中针对来自一种或几种免疫球蛋白类别G的抗体类别特异性检测的干扰的试剂， M，A，D和E.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式