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1. 发明授权

US6017866A Lipases with improved surfactant resistance 失效
标题翻译：具有改善的表面活性剂抵抗力的脂肪酶
公开(公告)号：US6017866A
公开(公告)日：2000-01-25
申请号：US732412
申请日：1996-10-22
申请人： Wolfgang Aehle , Gijsbert Gerritse , Hermanus B. M. Lenting
发明人： Wolfgang Aehle , Gijsbert Gerritse , Hermanus B. M. Lenting
IPC分类号： C12N15/09 , C11D3/386 , C12N9/20 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/20 , C11D3/38627 , Y10S435/874
摘要： The present invention provides mutant lipases which retain lipase activity, but have improved surfactant resistance and are thus highly advantageous for use in detergent compositions. Preferred lipases of this type include modified functional forms of a lipase of Pseudomonas alcaligenes having one or more amino acid substitutions at or near the surface of the lipase which effect interaction of the hydrophobic portions of surfactant molecules with initiation sites on the enzyme for surfactant denaturation.
摘要翻译： PCT No.PCT / EP95 / 01687 Sec。 371日期1996年10月22日第 102（e）日期1996年10月22日PCT提交1995年4月28日PCT公布。 WO95 / 30744PC PCT出版物日期1995年11月16日本发明提供了保留脂肪酶活性但具有改善的表面活性剂抗性的突变脂肪酶，因此在洗涤剂组合物中的使用非常有利。这种类型的优选脂肪酶包括在脂肪酶表面处或附近具有一个或多个氨基酸取代的产碱假单胞菌的脂肪酶的修饰的功能形式，其影响表面活性剂分子的疏水部分与用于表面活性剂变性的酶的起始位点的相互作用。

2. 发明授权

US09469848B2 Variants of glucoamylase 有权
标题翻译：葡糖淀粉酶的变体
公开(公告)号：US09469848B2
公开(公告)日：2016-10-18
申请号：US13806398
申请日：2011-06-30
申请人： Peter Edvard Degn , Richard R. Bott , Casper Willem Vroemen , Martijn Silvan Scheffers , Wolfgang Aehle , Elin Petersen
发明人： Peter Edvard Degn , Richard R. Bott , Casper Willem Vroemen , Martijn Silvan Scheffers , Wolfgang Aehle , Elin Petersen
IPC分类号： C12P19/20 , C12N9/34 , C07H21/04 , C07K1/00 , C12N9/26 , A23L1/09 , C12C5/00 , C12C7/04 , C12P19/02 , C13K1/06
CPC分类号： C12N9/2408 , A23L29/35 , C12C5/004 , C12C7/04 , C12N9/2428 , C12P19/02 , C12P19/20 , C12Y302/01003 , C13K1/06 , Y02P20/52
摘要： The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly, the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.
摘要翻译：本发明涉及母体葡糖淀粉酶的组合变体，其在淀粉水解期间具有降低缩合产物合成的性质。因此，母体葡糖淀粉酶的变体是适合的，例如用于酿造和葡萄糖浆生产中。还公开了编码在宿主细胞中产生葡糖淀粉酶变体的变体和方法的DNA构建体。

3. 发明申请

US20120149087A1 GLUCOAMYLASE VARIANTS WITH ALTERED PROPERTIES 有权
标题翻译：具有更改属性的葡萄糖酶变体
公开(公告)号：US20120149087A1
公开(公告)日：2012-06-14
申请号：US13251116
申请日：2011-09-30
申请人： Wolfgang Aehle , Richard R. Bott , Martijn Scheffers , Piet Van Solingen , Casper Vroemen
发明人： Wolfgang Aehle , Richard R. Bott , Martijn Scheffers , Piet Van Solingen , Casper Vroemen
IPC分类号： C12N9/34 , C12N15/63 , C12N1/19 , C12N1/15 , C12N5/10 , C12N15/56 , C12N1/21
CPC分类号： C12N9/2428 , C12P7/06 , C12P19/02 , C12P19/14 , Y02E50/17
摘要： The present disclosure relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present disclosure provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions and cleaning compositions. The disclosure also relates to DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.
摘要翻译：本公开涉及具有改变的性质（例如改善的热稳定性和/或比活性）的母体葡糖淀粉酶的变体。特别地，本公开提供了包含变体葡糖淀粉酶的组合物，包括淀粉水解组合物和清洁组合物。本公开还涉及编码在宿主细胞中产生葡糖淀粉酶变体的变体和方法的DNA构建体。

4. 发明申请

US20100267114A1 Glucoamylase Variants with Altered Properties 有权
标题翻译：具有改变特性的葡糖淀粉酶变体
公开(公告)号：US20100267114A1
公开(公告)日：2010-10-21
申请号：US12443255
申请日：2007-10-09
申请人： Wolfgang Aehle , Piet Van Solingen , Martin S. Scheffers , Richard R. Bott
发明人： Wolfgang Aehle , Piet Van Solingen , Martin S. Scheffers , Richard R. Bott
IPC分类号： C12N9/24 , C07H21/04 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10
CPC分类号： C12N9/2428 , C12N15/09 , C12Y302/01003 , Y02E50/17
摘要： The present invention relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present invention provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions, animal feed compositions and cleaning compositions. The invention also relates to DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.
摘要翻译：本发明涉及具有改变的性质（例如改善的热稳定性和/或比活性）的母体葡糖淀粉酶的变体。特别地，本发明提供包含变体葡糖淀粉酶，包括淀粉水解组合物，动物饲料组合物和清洁组合物的组合物。本发明还涉及编码在宿主细胞中产生葡糖淀粉酶变体的变体和方法的DNA构建体。

5. 发明申请

US20080063774A1 Multiple mutation variants of serine protease 有权
标题翻译：丝氨酸蛋白酶的多重突变变体
公开(公告)号：US20080063774A1
公开(公告)日：2008-03-13
申请号：US11809104
申请日：2007-05-31
申请人： Wolfgang Aehle , David Estell , Ronaldus Hommes , Brian Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran Poulose , Andrew Shaw , Wilhelmus Van Der Kley , Leonardus Van Marrewijk
发明人： Wolfgang Aehle , David Estell , Ronaldus Hommes , Brian Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran Poulose , Andrew Shaw , Wilhelmus Van Der Kley , Leonardus Van Marrewijk
IPC分类号： A23K1/00 , C07H21/00 , C11D7/42 , C12N1/00 , C12N1/15 , C12N1/21 , C12N15/63 , C12N9/50 , D06M16/00
CPC分类号： C12N9/52 , A23K20/189 , A23K50/75 , C11D3/386 , C12N9/96 , C12Y304/21 , D06M16/003
摘要： The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications.
摘要翻译：本发明提供了具有多个取代的新型微球菌spp丝氨酸蛋白酶。特别地，本发明提供了具有多个取代的丝氨酸蛋白酶，编码这些蛋白酶的DNA，包含编码蛋白酶的DNA的载体，用载体DNA转化的宿主细胞和由宿主细胞产生的酶。本发明还提供了清洁组合物（例如洗涤剂组合物），动物饲料组合物以及包含这些丝氨酸蛋白酶变体的纺织和皮革加工组合物。在特别优选的实施方案中，本发明提供衍生自本文所述的野生型蛋白酶的突变体（即，变体）蛋白酶。这些变体蛋白酶也可用于许多应用。

6. 发明授权

US6072015A Lignin based paint 有权
标题翻译：木质素基油漆
公开(公告)号：US6072015A
公开(公告)日：2000-06-06
申请号：US207302
申请日：1998-12-08
申请人： Rob Bolle , Wolfgang Aehle
发明人： Rob Bolle , Wolfgang Aehle
IPC分类号： C09D197/00 , C08H5/02 , C08K5/00
CPC分类号： C09D197/005
摘要： A method is provided for producing a painted article comprising: (a) preparing a lignin solution comprising lignin and a dye or pigment; (b) mixing the lignin solution with a phenol oxidizing enzyme; (c) incubating the mixture from said step (b) under conditions and for a time sufficient to form a solution of a desired viscosity; (d) contacting or spreading the mixture from the step (c) on an article to be painted; and (e) allowing the mixture to set onto the article by subjecting the article to conditions and for a time sufficient to form a paint on the surface of the article.
摘要翻译：提供了一种用于生产涂漆制品的方法，包括：（a）制备包含木质素和染料或颜料的木质素溶液; （b）将木质素溶液与酚氧化酶混合; （c）将所述步骤（b）的混合物在足以形成所需粘度的溶液的条件下培养一段时间; （d）将来自步骤（c）的混合物接触或铺展在待涂漆的物品上; 和（e）通过使制品经受物品表面上足以形成油漆的条件和时间使混合物置于物品上。

7. 发明授权

US08679816B2 Cellulase variants with improved expression, activity and stability, and use thereof 有权
标题翻译：具有改善的表达，活性和稳定性的纤维素酶变体及其用途
公开(公告)号：US08679816B2
公开(公告)日：2014-03-25
申请号：US13321928
申请日：2010-06-03
申请人： Wolfgang Aehle , Richard R. Bott , Benjamin Bower , Jonathan Caspi , David A. Estell , Frits Goedegebuur , Ronaldus W. J. Hommes , Thijs Kaper , Bradley Kelemen , Slavko Kralj , Johan Van Lieshout , Igor Nikolaev , Sander Van Stigt Thans , Louise Wallace , Gudrun Vogtentanz , Mats Sandgren
发明人： Wolfgang Aehle , Richard R. Bott , Benjamin Bower , Jonathan Caspi , David A. Estell , Frits Goedegebuur , Ronaldus W. J. Hommes , Thijs Kaper , Bradley Kelemen , Slavko Kralj , Johan Van Lieshout , Igor Nikolaev , Sander Van Stigt Thans , Louise Wallace , Gudrun Vogtentanz , Mats Sandgren
IPC分类号： C12N9/42 , C12P19/00 , C12P19/02 , C07H21/04
CPC分类号： C12N9/2437 , C12Y302/01091 , Y02E50/17
摘要： The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.
摘要翻译：本公开涉及纤维素酶变体。特别地，本公开涉及具有改善的表达，活性和/或稳定性的纤维素酶变体。还描述了编码纤维素酶变体的核酸，包含纤维素酶变体的组合物及其使用方法。

8. 发明授权

US08455234B2 Multiple mutation variants of serine protease 失效
标题翻译：丝氨酸蛋白酶的多重突变变体
公开(公告)号：US08455234B2
公开(公告)日：2013-06-04
申请号：US13162104
申请日：2011-06-16
申请人： Wolfgang Aehle , David A. Estell , Ronaldus W. J. Hommes , Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Andrew Shaw , Wilhelmus A. H. van der Kley , Leonardus P. M. van Marrewijk
发明人： Wolfgang Aehle , David A. Estell , Ronaldus W. J. Hommes , Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Andrew Shaw , Wilhelmus A. H. van der Kley , Leonardus P. M. van Marrewijk
IPC分类号： C12N9/48
CPC分类号： C12N9/52 , A23K20/189 , A23K50/75 , C11D3/386 , C12N9/96 , C12Y304/21 , D06M16/003
摘要： The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications.
摘要翻译：本发明提供了具有多个取代的新型微球菌spp丝氨酸蛋白酶。特别地，本发明提供了具有多个取代的丝氨酸蛋白酶，编码这些蛋白酶的DNA，包含编码蛋白酶的DNA的载体，用载体DNA转化的宿主细胞和由宿主细胞产生的酶。本发明还提供了清洁组合物（例如洗涤剂组合物），动物饲料组合物以及包含这些丝氨酸蛋白酶变体的纺织和皮革加工组合物。在特别优选的实施方案中，本发明提供衍生自本文所述的野生型蛋白酶的突变体（即，变体）蛋白酶。这些变体蛋白酶也可用于许多应用。

9. 发明申请

US20120164695A1 COMBINATORIAL VARIANTS OF GLUCOAMYLASE WITH IMPROVED SPECIFIC ACTIVITY AND/OR THERMOSTABILITY 审中-公开
标题翻译：具有改善的特异活性和/或热稳定性的葡萄糖酸酶的组合变体
公开(公告)号：US20120164695A1
公开(公告)日：2012-06-28
申请号：US13390381
申请日：2010-08-18
申请人： Wolfgang Aehle , Richard R. Bott , Martijn Silvan Scheffers , Casper Vroeman
发明人： Wolfgang Aehle , Richard R. Bott , Martijn Silvan Scheffers , Casper Vroeman
IPC分类号： C12N9/34 , C12N15/63 , C12P19/14 , C12N5/10 , C12N1/15 , C12N1/21 , C12N1/19 , C12N15/56 , C12P7/02
CPC分类号： C12P19/14 , A23L29/35 , C12N9/2428 , C12P7/06 , C12Y302/01003 , C13K1/06 , Y02E50/17
摘要： Presently provided are variant glucoamylases displaying altered properties, such as improved thermostability and/or specific activity. Also disclosed are DNA sequences coding for the variants, vectors and host cells incorporating the DNA sequence, enzyme compositions, and methods of using the variants in various applications.
摘要翻译：目前提供的是显示改变的性质的变体葡糖淀粉酶，例如改善的热稳定性和/或比活性。还公开了编码掺入DNA序列的变体，载体和宿主细胞的DNA序列，酶组合物和在各种应用中使用变体的方法。

10. 发明申请

US20120135500A1 CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF 有权
标题翻译：具有改进的表达，活性和稳定性的纤维素酶变体及其用途
公开(公告)号：US20120135500A1
公开(公告)日：2012-05-31
申请号：US13321928
申请日：2010-06-03
申请人： Wolfgang Aehle , Richard R. Bott , Benjamin Bower , Jonathan Caspi , David A. Estell , Frits Goedegebuur , Ronaldus W.J. Hommes , Thijs Kaper , Bradley Kelemen , Slavko Kralj , Johan Van Lieshout , Igor Nikolaev , Sander Van Stigt Thans , Louise Wallace , Gudrun Vogtentanz , Mats Sandgren
发明人： Wolfgang Aehle , Richard R. Bott , Benjamin Bower , Jonathan Caspi , David A. Estell , Frits Goedegebuur , Ronaldus W.J. Hommes , Thijs Kaper , Bradley Kelemen , Slavko Kralj , Johan Van Lieshout , Igor Nikolaev , Sander Van Stigt Thans , Louise Wallace , Gudrun Vogtentanz , Mats Sandgren
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12Y302/01091 , Y02E50/17
摘要： The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.
摘要翻译：本公开涉及纤维素酶变体。特别地，本公开涉及具有改善的表达，活性和/或稳定性的纤维素酶变体。还描述了编码纤维素酶变体的核酸，包含纤维素酶变体的组合物及其使用方法。

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