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1. 发明授权

US5857997A Catheter for electrophysiological procedures 失效
标题翻译：导管用于电生理程序
公开(公告)号：US5857997A
公开(公告)日：1999-01-12
申请号：US919137
申请日：1997-08-30
申请人： William W. Cimino , Robert Abrams , Miriam H. Taimisto , Marc Jenson , Patrick E. Macaulay
发明人： William W. Cimino , Robert Abrams , Miriam H. Taimisto , Marc Jenson , Patrick E. Macaulay
IPC分类号： A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61M25/01 , A61M37/00
CPC分类号： A61B5/6855 , A61B18/00 , A61B18/1492 , A61B5/0422 , A61M25/0136 , A61B2017/00044 , A61B2017/00292 , A61B2017/00853 , A61B2018/00916 , A61B2018/1253 , A61B2562/0209 , A61B2562/043 , A61M25/0144 , A61M25/0147
摘要： A catheter adapted to perform electrophysiological procedures comprises a body member, a manipulation handle attached to the proximal end of the body member for applying torque to the body member, the handle having a control knob adapted for control movements in a first plane and in a second plane simultaneously. A deflection control line is attached at its distal end to the distal portion of the catheter and its proximal end attached to the control device of the handle so that tension applied to the control line by sliding the control knob causes deflection of the distal portion of the catheter. A stiffening member is disposed within the body member of the catheter and is slidable, said stiffening member providing increased rigidity to the portion of the body member in which the stiffening member is located. Rotation of the control knob controls the position of the stiffening member in the body member. In a further aspect, a stiffening member in accordance with one embodiment includes a tapered distal end section with a ball formed on the distal tip, the tapered section terminating at the ball. In accordance with another aspect, the torsional rigidity of the catheter body is increased by use of a layer of aramid fibers mixed with an epoxy. In yet another feature, the handle and rotatable sliding element are symmetrically shaped to facilitate complete single-handed operation of the handle by the physician of all position control aspects of the catheter.
摘要翻译：适于执行电生理过程的导管包括身体构件，附接到身体构件的近端的操纵手柄，用于向身体构件施加扭矩，手柄具有适于控制第一平面中的运动的控制旋钮，飞机同时进行。偏转控制线在其远端附接到导管的远端部分，并且其近端附接到手柄的控制装置，使得通过滑动控制旋钮施加到控制线的张力导致远端部分的偏转导管。加强构件设置在导管的主体构件内并且可滑动，所述加强构件为加强构件所在的主体构件的部分提供增加的刚性。控制旋钮的旋转控制加强构件在主体构件中的位置。在另一方面，根据一个实施例的加强构件包括锥形远端部分，其具有形成在远侧末端上的球，锥形部分终止于球。根据另一方面，通过使用与环氧树脂混合的芳族聚酰胺纤维层来增加导管体的扭转刚度。在另一个特征中，手柄和可旋转的滑动元件是对称的，以便于医生对导管的所有位置控制方面的手柄的完全单手操作。

2. 发明授权

US5662606A Catheter for electrophysiological procedures 失效
标题翻译：导管用于电生理程序
公开(公告)号：US5662606A
公开(公告)日：1997-09-02
申请号：US339125
申请日：1994-11-14
申请人： William W. Cimino , Robert Abrams , Miriam H. Taimisto , Marc Jenson , Patrick E. Macaulay
发明人： William W. Cimino , Robert Abrams , Miriam H. Taimisto , Marc Jenson , Patrick E. Macaulay
IPC分类号： A61B5/0408 , A61B5/0402 , A61B5/042 , A61B5/0478 , A61B5/0492 , A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61M25/00 , A61M25/01 , A61M37/00
CPC分类号： A61B5/0422 , A61B18/00 , A61B18/1492 , A61B5/6852 , A61B5/6855 , A61M25/0136 , A61M25/0144 , A61M25/0147 , A61B2017/00039 , A61B2017/00044 , A61B2017/00292 , A61B2017/003 , A61B2017/00853 , A61B2018/0016 , A61B2018/00351 , A61B2018/00577 , A61B2018/00839 , A61B2018/0091 , A61B2018/00916 , A61B2018/00946 , A61B2018/1253 , A61B2562/0209 , A61B2562/043 , A61M25/0043 , A61M25/0054
摘要： A catheter adapted to perform electrophysiological procedures comprises a body member, a manipulation handle attached to the proximal end of the body member for applying torque to the body member, the handle having a control knob adapted for control movements in a first plane and in a second plane simultaneously. A deflection control line is attached at its distal end to the distal portion of the catheter and its proximal end attached to the control device of the handle so that tension applied to the control line by sliding the control knob causes deflection of the distal portion of the catheter. A stiffening member is disposed within the body member of the catheter and is slidable, said stiffening member providing increased rigidity to the portion of the body member in which the stiffening member is located. Rotation of the control knob controls the position of the stiffening member in the body member. In a further aspect, a stiffening member in accordance with one embodiment includes a tapered distal end section with a ball formed on the distal tip, the tapered section terminating at the ball. In accordance with another aspect, the torsional rigidity of the catheter body is increased by use of a layer of aramid fibers mixed with an epoxy. In yet another feature, the handle and rotatable sliding element are symmetrically shaped to facilitate complete single-handed operation of the handle by the physician of all position control aspects of the catheter.
摘要翻译：适于执行电生理过程的导管包括身体构件，附接到身体构件的近端的操纵手柄，用于向身体构件施加扭矩，手柄具有适于控制第一平面中的运动的控制旋钮，飞机同时进行。偏转控制线在其远端附接到导管的远端部分，并且其近端附接到手柄的控制装置，使得通过滑动控制旋钮施加到控制线的张力导致远端部分的偏转导管。加强构件设置在导管的主体构件内并且可滑动，所述加强构件为加强构件所在的主体构件的部分提供增加的刚性。控制旋钮的旋转控制加强构件在主体构件中的位置。在另一方面，根据一个实施例的加强构件包括锥形远端部分，其具有形成在远侧末端上的球，锥形部分终止于球。根据另一方面，通过使用与环氧树脂混合的芳族聚酰胺纤维层来增加导管体的扭转刚度。在另一个特征中，手柄和可旋转的滑动元件是对称的，以便于医生对导管的所有位置控制方面的手柄的完全单手操作。

3. 发明授权

US5364352A Catheter for electrophysiological procedures 失效
标题翻译：导管用于电生理程序
公开(公告)号：US5364352A
公开(公告)日：1994-11-15
申请号：US31249
申请日：1993-03-12
申请人： William W. Cimino , Robert Abrams , Miriam H. Taimisto , Marc Jensen , Patrick E. Macaulay
发明人： William W. Cimino , Robert Abrams , Miriam H. Taimisto , Marc Jensen , Patrick E. Macaulay
IPC分类号： A61B5/0408 , A61B5/0402 , A61B5/042 , A61B5/0478 , A61B5/0492 , A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61M25/00 , A61M25/01 , A61M37/00
CPC分类号： A61B5/0422 , A61B18/00 , A61B18/1492 , A61B5/6852 , A61B5/6855 , A61M25/0136 , A61M25/0144 , A61M25/0147 , A61B2017/00039 , A61B2017/00044 , A61B2017/00292 , A61B2017/003 , A61B2017/00853 , A61B2018/0016 , A61B2018/00351 , A61B2018/00577 , A61B2018/00839 , A61B2018/0091 , A61B2018/00916 , A61B2018/00946 , A61B2018/1253 , A61B2562/0209 , A61B2562/043 , A61M25/0043 , A61M25/0054
摘要： A catheter adapted to perform electrophysiological procedures comprises a body member, a manipulation handle attached to the proximal end of the body member for applying torque to the body member, the handle having a control knob adapted for control movements in a first plane and in a second plane simultaneously. A deflection control line is attached at its distal end to the distal portion of the catheter and its proximal end attached to the control device of the handle so that tension applied to the control line by sliding the control knob causes deflection of the distal portion of the catheter. A stiffening member is disposed within the body member of the catheter and is slidable, said stiffening member providing increased rigidity to the portion of the body member in which the stiffening member is located. Rotation of the control knob controls the position of the stiffening member in the body member. In a further aspect, a stiffening member in accordance with one embodiment includes a tapered distal end section with a ball formed on the distal tip, the tapered section terminating at the ball. In accordance with another aspect, the torsional rigidity of the catheter body is increased by use of a layer of aramid fibers mixed with an epoxy. In yet another feature, the handle and rotatable sliding element are symmetrically shaped to facilitate complete single-handed operation of the handle by the physician of all position control aspects of the catheter.
摘要翻译：适于执行电生理过程的导管包括身体构件，附接到身体构件的近端的操纵手柄，用于向身体构件施加扭矩，手柄具有适于控制第一平面中的运动的控制旋钮，飞机同时进行。偏转控制线在其远端附接到导管的远端部分，并且其近端附接到手柄的控制装置，使得通过滑动控制旋钮施加到控制线的张力导致远端部分的偏转导管。加强构件设置在导管的主体构件内并且可滑动，所述加强构件为加强构件所在的主体构件的部分提供增加的刚性。控制旋钮的旋转控制加强构件在主体构件中的位置。在另一方面，根据一个实施例的加强构件包括锥形远端部分，其具有形成在远侧末端上的球，锥形部分终止于球。根据另一方面，通过使用与环氧树脂混合的芳族聚酰胺纤维层来增加导管体的扭转刚度。在另一个特征中，手柄和可旋转的滑动元件是对称的，以便于医生对导管的所有位置控制方面的手柄的完全单手操作。

4. 发明申请

US20110283996A1 Enhanced semi-automatic emergency medication dose nebulizer 失效
标题翻译：增强型半自动应急药物剂量雾化器
公开(公告)号：US20110283996A1
公开(公告)日：2011-11-24
申请号：US13135292
申请日：2011-06-30
申请人： Robert Abrams
发明人： Robert Abrams
IPC分类号： A61M11/00
CPC分类号： A61M11/02 , A61M11/06 , A61M15/0028 , A61M15/0031 , A61M15/0038 , A61M15/0041 , A61M16/0063 , A61M16/06 , A61M16/101 , A61M2205/583 , A61M2205/587 , A61M2209/045 , A61M2209/082 , A61M2209/084 , A61M2209/086 , Y10T83/0596 , Y10T137/3112 , Y10T137/6123
摘要： A conventional respiratory nebulizer has an emergency medication dose storage system delivering the stored medication dose directly to the nebulizing chamber with a single impulse of force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The delivery system includes a plunger assembly having a pair of converging blades coming to a point for piercing a medication capsule held within a docking chamber adjacent to a nebulizing mixing chamber and a hollow needle connected to an air power source directing air through said needle, to force liquid medication from said pierced medication capsule into said nebulizing mixing chamber of said nebulizer.
摘要翻译：常规呼吸雾化器具有紧急药物剂量存储系统，其将存储的药物剂量直接输送到雾化室，其具有单个脉冲力到简单的机械输送系统，从而使雾化器可用于两个步骤：（a）打开药物胶囊用简单的开放动作; 和（b）吸入雾化药物。输送系统包括柱塞组件，该柱塞组件具有一对会聚叶片，该一对收敛叶片进入用于刺穿保持在与雾化混合室相邻的对接室内的药物胶囊的点，以及连接到空气动力源的中空针，空气动力源将空气引导通过所述针，将液体药物从所述刺穿的药物胶囊强力推入所述喷雾器的雾化混合室。

5. 发明申请

US20090133692A1 Semi-automatic emergency medication dose nebulizer 有权
标题翻译：半自动应急用药剂量雾化器
公开(公告)号：US20090133692A1
公开(公告)日：2009-05-28
申请号：US12321854
申请日：2009-01-26
申请人： Robert Abrams
发明人： Robert Abrams
IPC分类号： A61M11/00
CPC分类号： A61M11/02 , A61M15/0028 , A61M15/0031 , A61M15/0038 , A61M15/0041 , A61M16/0063 , A61M2205/583 , A61M2205/587 , A61M2209/045
摘要： A conventional respiratory nebulizer has an emergency medication dose storage system delivering the stored medication dose directly to the nebulizing chamber with a single impulse of manual force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The nebulizer can be operated without disassembling the nebulizer housing so as to expose the nebulizing chamber and without manually opening the liquid medication container and, without spillage and without manual pouring of the to liquid medication directly into the nebulizing chamber, and without reassembling the nebulizer housing before positioning the inhaler mouthpiece in the mouth so as to inhale the nebulized medication. The delivery system includes a slicing blade to sever the capsule and a looped paddle follower to move the severed portion out of the way of fluid flow.
摘要翻译：常规呼吸雾化器具有紧急药物剂量存储系统，其将存储的药物剂量直接输送到雾化室，其具有单个手动力的脉冲至简单的机械输送系统，从而使雾化器可以分两步使用：（a）打开药物胶囊具有简单的开启动作; 和（b）吸入雾化药物。喷雾器可以在不拆卸雾化器壳体的情况下操作，以便暴露雾化室，而不用手动打开液体药物容器，并且不会溢出并且没有手动将液体药物直接注入到雾化室中，并且不重新组装雾化器壳体之前将吸入器吸嘴定位在口中，以吸入雾化药物。输送系统包括用于切断胶囊的切片刀片和环形叶片从动件，以将切断的部分移出流体流动的方式。

6. 发明申请

US20050137647A1 Method of intravascularly delivering stimulation leads into direct contact with tissue 失效
标题翻译：血管内传递刺激的方法导致与组织的直接接触
公开(公告)号：US20050137647A1
公开(公告)日：2005-06-23
申请号：US10744853
申请日：2003-12-22
申请人： Michael Wallace , Kamal Ramzipoor , Robert Garabedian , Robert Abrams
发明人： Michael Wallace , Kamal Ramzipoor , Robert Garabedian , Robert Abrams
IPC分类号： A61N1/05 , A61N1/18
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method of treating a disorder in a patient is provided. The method comprises delivering a stimulation lead within a blood vessel, intralumenally puncturing a wall of the blood vessel to create an exit point, and then introducing the stimulation lead through the exit point into direct contact with tissue the stimulation of which treats the disorder. Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead to the implanted stimulation source. Using the stimulation lead, the tissue can then be stimulated in order to treat the disorder.
摘要翻译：提供了一种治疗患者疾病的方法。该方法包括在血管内递送刺激引线，腔内穿刺血管的壁以产生出口点，然后将刺激引线通过出口点直接接触组织，其刺激治疗病症。可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电耦合到植入的刺激源。使用刺激铅，然后可以刺激组织以治疗该疾病。

7. 发明申请

US20050027247A1 Apparatus and method for treating intravascular disease 失效
标题翻译：用于治疗血管内疾病的装置和方法
公开(公告)号：US20050027247A1
公开(公告)日：2005-02-03
申请号：US10629114
申请日：2003-07-29
申请人： Harold Carrison , Robert Abrams , Jesse Casados , Roger Farnholtz
发明人： Harold Carrison , Robert Abrams , Jesse Casados , Roger Farnholtz
IPC分类号： A61F2/958 , A61M25/00 , A61M29/00
CPC分类号： A61M25/1011 , A61M2025/0057 , A61M2025/1052
摘要： Medical devices and methods of treatment using medical devices, and more particularly, methods of treating a treatment site in a blood vessel and devices or apparatuses for use therewith. In some embodiments, a method and apparatus for treating a treatment site in a blood vessel using fluid movement or agitation adjacent the treatment site is disclosed. In some embodiments, an apparatus is provided including one or more deployable structures adapted to create fluid movement within the vessel. The apparatus is inserted into the vessel, and the deployable structure is positioned adjacent the treatment site. The deployable structure is used to create fluid movement adjacent to the treatment site. In some embodiments, a treatment material, such as a medicine or drug, is introduced into the vessel proximate the treatment site, and the deployable structure is used to create fluid movement or agitation adjacent the treatment site to create a better interface between the treatment site and the medicine, or to move the medicine into the treatment site. In some embodiments, the fluid movement created by the deployable member aids in removal of tissue or other material from the treatment site.
摘要翻译：医疗装置和使用医疗装置的治疗方法，更具体地，涉及治疗血管内的治疗部位的方法及其使用的装置或装置。在一些实施例中，公开了一种用于使用邻近治疗部位的流体移动或搅动来治疗血管中的治疗部位的方法和装置。在一些实施例中，提供了包括适于在容器内产生流体运动的一个或多个可部署结构的装置。将装置插入容器中，并且可部署结构定位在治疗部位附近。可部署结构用于在处理部位附近形成流体运动。在一些实施方案中，诸如药物或药物的处理材料被引入到处理部位附近的容器中，并且可部署结构用于在处理部位附近产生流体移动或搅动，从而在处理部位或药物，或将药物移入治疗部位。在一些实施例中，可展开构件产生的流体运动有助于从治疗部位移除组织或其它材料。

8. 发明授权

US08291902B2 Enhanced semi-automatic emergency medication dose nebulizer 失效
标题翻译：增强型半自动应急药物剂量雾化器
公开(公告)号：US08291902B2
公开(公告)日：2012-10-23
申请号：US13135292
申请日：2011-06-30
申请人： Robert Abrams
发明人： Robert Abrams
IPC分类号： A61M16/00 , A61M15/00 , A61M11/06
CPC分类号： A61M11/02 , A61M11/06 , A61M15/0028 , A61M15/0031 , A61M15/0038 , A61M15/0041 , A61M16/0063 , A61M16/06 , A61M16/101 , A61M2205/583 , A61M2205/587 , A61M2209/045 , A61M2209/082 , A61M2209/084 , A61M2209/086 , Y10T83/0596 , Y10T137/3112 , Y10T137/6123
摘要： A conventional respiratory nebulizer has an emergency medication dose storage system delivering the stored medication dose directly to the nebulizing chamber with a single impulse of force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The delivery system includes a plunger assembly having a pair of converging blades coming to a point for piercing a medication capsule held within a docking chamber adjacent to a nebulizing mixing chamber and a hollow needle connected to an air power source directing air through said needle, to force liquid medication from said pierced medication capsule into said nebulizing mixing chamber of said nebulizer.
摘要翻译：常规呼吸雾化器具有紧急药物剂量存储系统，其将存储的药物剂量直接输送到雾化室，其具有单个脉冲力到简单的机械输送系统，从而使雾化器可用于两个步骤：（a）打开药物胶囊用简单的开放动作; 和（b）吸入雾化药物。输送系统包括柱塞组件，该柱塞组件具有一对会聚叶片，该一对收敛叶片进入用于刺穿保持在与雾化混合室相邻的对接室内的药物胶囊的点，以及连接到空气动力源的中空针，空气动力源将空气引导通过所述针，将液体药物从所述刺穿的药物胶囊强力推入所述喷雾器的雾化混合室。

9. 发明申请

US20090071473A1 Semi-automatic emergency medication dose nebulizer 有权
标题翻译：半自动应急用药剂量雾化器
公开(公告)号：US20090071473A1
公开(公告)日：2009-03-19
申请号：US12217406
申请日：2008-07-03
申请人： Robert Abrams
发明人： Robert Abrams
IPC分类号： A61M15/00 , A61M11/00
CPC分类号： A61M11/02 , A61M15/0028 , A61M15/0031 , A61M15/0038 , A61M15/0041 , A61M15/0081 , A61M15/0083 , A61M16/0063 , A61M2205/583 , A61M2205/587 , A61M2209/045
摘要： A conventional respiratory nebulizer has an emergency medication dose storage system conveniently useable in an emergency to deliver the stored medication dose directly to the nebulizing chamber quickly, reliably, and with a single impulse of manual force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The nebulizer can be operated without disassembling the nebulizer housing so as to expose the nebulizing chamber and without manually opening the liquid medication container and, without spillage and without manual pouring of the liquid medication directly into the nebulizing chamber, and without reassembling the nebulizer housing before positioning the inhaler mouthpiece in the mouth so as to inhale the nebulized medication.
摘要翻译：传统的呼吸雾化器具有方便地在紧急情况下可用的紧急药物剂量存储系统，其将快速，可靠地将存储的药物剂量直接递送到雾化室，并且以单一的手动力冲击到简单的机械输送系统，从而使雾化器可用于两个步骤：（a）以简单的打开动作打开药物胶囊; 和（b）吸入雾化药物。雾化器可以在不拆卸雾化器壳体的情况下操作，以便暴露雾化室，而不用手动打开液体药物容器，并且不会溢出并且没有将液体药物直接注入雾化室中，并且没有在雾化器壳体之前重新组装将吸入器吸嘴定位在口中，以吸入雾化药物。

10. 发明申请

US20090071470A1 Emergency medication dose nebulizer 审中-公开
标题翻译：紧急用药剂量雾化器
公开(公告)号：US20090071470A1
公开(公告)日：2009-03-19
申请号：US11901628
申请日：2007-09-18
申请人： Robert Abrams
发明人： Robert Abrams
IPC分类号： A61M16/10
CPC分类号： A61M11/02 , A61M15/0028 , A61M15/0031 , A61M15/0038 , A61M15/0041 , A61M16/0063 , A61M2205/583 , A61M2205/587 , A61M2209/045
摘要： A conventional respiratory nebulizer has an emergency medication dose storage system conveniently useable in an emergency to deliver the stored medication dose directly to the nebulizing chamber quickly, reliably, and with a single impulse of manual force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) deploy the medication with a single stroke of force; and (b) inhale the nebulized medication. The nebulizer can be operated without disassembling the nebulizer housing so as to expose the nebulizing chamber and without manually opening the liquid medication container and, without spillage and without manual pouring of the liquid medication directly into the nebulizing chamber, and without reassembling the nebulizer housing before positioning the inhaler mouthpiece in the mouth so as to inhale the nebulized medication.
摘要翻译：传统的呼吸雾化器具有方便地在紧急情况下可用的紧急药物剂量存储系统，其将快速，可靠地将存储的药物剂量直接递送到雾化室，并且以单一的手动力冲击到简单的机械输送系统，从而使雾化器可用于两个步骤：（a）以单次力量部署药物; 和（b）吸入雾化药物。雾化器可以在不拆卸雾化器壳体的情况下操作，以便暴露雾化室，而不用手动打开液体药物容器，并且不会溢出并且没有将液体药物直接注入雾化室中，并且没有在雾化器壳体之前重新组装将吸入器吸嘴定位在口中，以吸入雾化药物。

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