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1. 发明授权

US07193711B2 Imaging method and apparatus 有权
标题翻译：成像方法和装置
公开(公告)号：US07193711B2
公开(公告)日：2007-03-20
申请号：US10847736
申请日：2004-05-17
申请人： William Rassman , David Ralin , Robert A. Lieberman , Lothar U. Kempen , Herbert Shapiro
发明人： William Rassman , David Ralin , Robert A. Lieberman , Lothar U. Kempen , Herbert Shapiro
IPC分类号： G01J4/00
CPC分类号： G01N21/211 , G01N21/21 , G01N21/253 , G01N21/552 , G01N2021/212 , Y10S436/805
摘要： An imaging method and apparatus are provided, including a light source emitting a polarized light beam, and an optical assembly including a control layer and/or a light reflection surface. The control layer advantageously allows for control over the properties of a generated evanescent wave to optimize an image of a specimen array within the evanescent wave. The light reflection surface includes coupling means used to couple a receptor/capture agent advantageously allowing for flexible control over receptor specific regions.
摘要翻译：提供一种成像方法和装置，包括发射偏振光束的光源和包括控制层和/或光反射表面的光学组件。控制层有利地允许控制所产生的ev逝波的性质以优化ev逝波内的样本阵列的图像。光反射表面包括用于耦合受体/捕获剂的偶联装置，其有利地允许对受体特异性区域的灵活控制。

2. 发明授权

US07126688B2 Microarray scanning 有权
标题翻译：微阵列扫描
公开(公告)号：US07126688B2
公开(公告)日：2006-10-24
申请号：US10847754
申请日：2004-05-17
申请人： William Rassman , David Ralin , Robert A. Lieberman , Lothar U. Kempen , Herbert Shapiro
发明人： William Rassman , David Ralin , Robert A. Lieberman , Lothar U. Kempen , Herbert Shapiro
IPC分类号： G01J4/00
CPC分类号： G01N21/253 , G01N21/21 , G01N21/211 , G01N21/552 , G01N33/54373 , G01N2021/212
摘要： Methods and apparatus for scanning of a microarray to provide an image of the microarray are disclosed. Data related to change in polarization state of a scanning light beam for individual points or lines or other portion of the microarray are collected and processed to image the microarray at high resolution and speed.
摘要翻译：公开了用于扫描微阵列以提供微阵列图像的方法和装置。收集和处理与单个点或线或微阵列的其他部分的扫描光束的偏振状态变化相关的数据，以高分辨率和速度对微阵列进行成像。

3. 发明申请

US20050024642A1 Imaging method and apparatus 有权
标题翻译：成像方法和装置
公开(公告)号：US20050024642A1
公开(公告)日：2005-02-03
申请号：US10847736
申请日：2004-05-17
申请人： William Rassman , David Ralin , Robert Lieberman , Lothar Kempen , Herbert Shapiro
发明人： William Rassman , David Ralin , Robert Lieberman , Lothar Kempen , Herbert Shapiro
IPC分类号： G01J4/00 , G01N21/21 , G01N21/25 , G01N21/55
CPC分类号： G01N21/211 , G01N21/21 , G01N21/253 , G01N21/552 , G01N2021/212 , Y10S436/805
摘要： An imaging method and apparatus are provided, including a light source emitting a polarized light beam, and an optical assembly including a control layer and/or a light reflection surface. The control layer advantageously allows for control over the properties of a generated evanescent wave to optimize an image of a specimen array within the evanescent wave. The light reflection surface includes coupling means used to couple a receptor/capture agent advantageously allowing for flexible control over receptor specific regions.
摘要翻译：提供一种成像方法和装置，包括发射偏振光束的光源和包括控制层和/或光反射表面的光学组件。控制层有利地允许控制所产生的ev逝波的性质以优化ev逝波内的样本阵列的图像。光反射表面包括用于耦合受体/捕获剂的偶联装置，其有利地允许对受体特异性区域的灵活控制。

4. 发明申请

US20050030535A1 Microarray scanning 有权
标题翻译：微阵列扫描
公开(公告)号：US20050030535A1
公开(公告)日：2005-02-10
申请号：US10847754
申请日：2004-05-17
申请人： William Rassman , David Ralin , Robert Lieberman , Lothar Kempen , Herbert Shapiro
发明人： William Rassman , David Ralin , Robert Lieberman , Lothar Kempen , Herbert Shapiro
IPC分类号： G01J4/00 , G01N21/21 , G01N21/25 , G01N21/55
CPC分类号： G01N21/253 , G01N21/21 , G01N21/211 , G01N21/552 , G01N33/54373 , G01N2021/212
摘要： Methods and apparatus for scanning of a microarray to provide an image of the microarray are disclosed. Data related to change in polarization state of a scanning light beam for individual points or lines or other portion of the microarray are collected and processed to image the microarray at high resolution and speed.
摘要翻译：公开了用于扫描微阵列以提供微阵列图像的方法和装置。收集和处理与单个点或线或微阵列的其他部分的扫描光束的偏振状态变化相关的数据，以高分辨率和速度对微阵列进行成像。

5. 发明申请

US20060254343A1 Bacteria sensor and method 失效
标题翻译：细菌传感器及方法
公开(公告)号：US20060254343A1
公开(公告)日：2006-11-16
申请号：US11395849
申请日：2006-03-31
申请人： Indu Saxena , Herbert Shapiro
发明人： Indu Saxena , Herbert Shapiro
IPC分类号： G01N11/00
CPC分类号： G01N21/8507 , G01N21/6486 , G01N21/94 , G01N2021/6484
摘要： Bacteria accumulations on the interior walls of a fluid conduit are detected by placing a bacterial target substrate in the conduit. The substrate is structured to allow bacteria to colonize it at at least the rate of accumulation expected on the conduit walls or at an accelerated rate in order to preempt normal bacteria accumulation on the walls. A bacteria getter may be used to accelerate bacterial colonization of the substrate. An excitation signal interrogating the substrate causes autofluorescence in the presence of bacteria, specifically from NADH and/or NADPH present. The autofluorescent emission is transmitted to a detector and processor. In one system when the presence of bacteria at a preset level is detected there is initiated a diversion of the fluid into an auxiliary subsystem during which the primary subsystem is remediated. In one configuration, a wall portion is transparent and the biofilm target substrate is integral with the transparent wall portion and the sensor head is attached to the outside of the transparent wall portion. It can be made as a removable and/or disposable cell in which the transparent wall portion is a glass plug that fits into a hole in the conduit. The biofilm target substrate can be a getter affinity surface formed on the inside surface of the glass plug. Various means are used for obtaining accelerated biofilm growth.
摘要翻译：通过将细菌靶基质置于导管中来检测流体导管内壁上的细菌积聚。底物被构造成允许细菌以至少在导管壁上预期的积聚速率或以加速的速度将其定殖，以便预防正常的细菌积聚在壁上。可以使用细菌吸气剂来加速基质的细菌定植。询问底物的激发信号在细菌存在下，特别是存在于NADH和/或NADPH的情况下引起自发荧光。自发荧光发射被传送到检测器和处理器。在一个系统中，当检测到处于预设水平的细菌的存在时，开始将流体转移到辅助子系统中，在该辅助子系统中主要子系统被补救。在一种构造中，壁部是透明的，并且生物膜靶基板与透明壁部分成一体，并且传感器头部附接到透明壁部分的外侧。它可以制成可拆卸和/或一次性电池，其中透明壁部分是装配在导管中的孔中的玻璃塞。生物膜靶基材可以是形成在玻璃塞的内表面上的吸气剂亲合性表面。各种手段用于获得加速的生物膜生长。

6. 发明授权

US07741108B2 Bacteria sensor and method 失效
标题翻译：细菌传感器及方法
公开(公告)号：US07741108B2
公开(公告)日：2010-06-22
申请号：US11395849
申请日：2006-03-31
申请人： Indu Saxena , Herbert Shapiro
发明人： Indu Saxena , Herbert Shapiro
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N21/8507 , G01N21/6486 , G01N21/94 , G01N2021/6484
摘要： Bacteria accumulations on the interior walls of a fluid conduit are detected by placing a bacterial target substrate in the conduit. The substrate is structured to allow bacteria to colonize it at at least the rate of accumulation expected on the conduit walls or at an accelerated rate in order to preempt normal bacteria accumulation on the walls. A bacteria getter may be used to accelerate bacterial colonization of the substrate. An excitation signal interrogating the substrate causes autofluorescence in the presence of bacteria, specifically from NADH and/or NADPH present. The autofluorescent emission is transmitted to a detector and processor. In one system when the presence of bacteria at a preset level is detected there is initiated a diversion of the fluid into an auxiliary subsystem during which the primary subsystem is remediated. In one configuration, a wall portion is transparent and the biofilm target substrate is integral with the transparent wall portion and the sensor head is attached to the outside of the transparent wall portion. It can be made as a removable and/or disposable cell in which the transparent wall portion is a glass plug that fits into a hole in the conduit. The biofilm target substrate can be a getter affinity surface formed on the inside surface of the glass plug. Various means are used for obtaining accelerated biofilm growth.
摘要翻译：通过将细菌靶基质置于导管中来检测流体导管内壁上的细菌积聚。底物被构造成允许细菌以至少在导管壁上预期的积聚速率或以加速的速度将其定殖，以便预防正常的细菌积聚在壁上。可以使用细菌吸气剂来加速基质的细菌定植。询问底物的激发信号在细菌存在下，特别是存在于NADH和/或NADPH的情况下引起自发荧光。自发荧光发射被传送到检测器和处理器。在一个系统中，当检测到处于预设水平的细菌的存在时，开始将流体转移到辅助子系统中，在该辅助子系统中主要子系统被补救。在一种构造中，壁部是透明的，并且生物膜靶基板与透明壁部分成一体，并且传感器头部附接到透明壁部分的外侧。它可以制成可拆卸和/或一次性电池，其中透明壁部分是装配在导管中的孔中的玻璃塞。生物膜靶基材可以是形成在玻璃塞的内表面上的吸气剂亲合性表面。各种手段用于获得加速的生物膜生长。

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