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1. 发明授权

US07428724B2 Interactive interface for engineering standard work 有权
标题翻译：互动界面，用于工程标准工作
公开(公告)号：US07428724B2
公开(公告)日：2008-09-23
申请号：US10881733
申请日：2004-06-30
申请人： William R. Pike , Keith R. Boislard , Brian Wylie , Stephen V. Glynn , Michael McCarthy , Roger Paolillo , John Hardy
发明人： William R. Pike , Keith R. Boislard , Brian Wylie , Stephen V. Glynn , Michael McCarthy , Roger Paolillo , John Hardy
IPC分类号： G06F9/44
CPC分类号： G06Q10/06
摘要： A method and system for managing complex projects uses a framework having workflow maps containing activity blocks that provide detailed, easily accessible information within the framework about the project. The framework links functional groups, their associated activities, and the dependences between activities. Images of the workflow maps are converted into an interactive interface by linking location information associated with objects in the workflow map with their associated data in the database. Selecting a given object in the workflow map retrieves the data associated with the location of the selected object. Implementing the framework as a web-based application allows easy access to the framework as well as data entered into the framework for future analysis.
摘要翻译：用于管理复杂项目的方法和系统使用框架，该框架具有包含活动块的工作流映射，在框架内提供关于项目的详细，易于访问的信息。框架链接功能组，其相关活动以及活动之间的依赖关系。通过将与工作流映射中的对象相关联的位置信息与数据库中的关联数据相链接，将工作流映射的映像转换为交互式界面。在工作流程图中选择给定的对象将检索与所选对象的位置相关联的数据。将框架实现为基于Web的应用程序可以轻松访问框架以及输入到框架中的数据以供将来分析。

2. 发明申请

US20060005158A1 Interactive interface for engineering standard work 有权
标题翻译：互动界面，用于工程标准工作
公开(公告)号：US20060005158A1
公开(公告)日：2006-01-05
申请号：US10881733
申请日：2004-06-30
申请人： William Pike , Keith Boislard , Brian Wylie , Stephen Glynn , Michael McCarthy , Roger Paolillo , John Hardy
发明人： William Pike , Keith Boislard , Brian Wylie , Stephen Glynn , Michael McCarthy , Roger Paolillo , John Hardy
IPC分类号： G06F9/44
CPC分类号： G06Q10/06
摘要： A method and system for managing complex projects uses a framework having workflow maps containing activity blocks that provide detailed, easily accessible information within the framework about the project. The framework links functional groups, their associated activities, and the dependences between activities. Images of the workflow maps are converted into an interactive interface by linking location information associated with objects in the workflow map with their associated data in the database. Selecting a given object in the workflow map retrieves the data associated with the location of the selected object. Implementing the framework as a web-based application allows easy access to the framework as well as data entered into the framework for future analysis.
摘要翻译：用于管理复杂项目的方法和系统使用框架，该框架具有包含活动块的工作流映射，在框架内提供关于项目的详细，易于访问的信息。框架链接功能组，其相关活动以及活动之间的依赖关系。通过将与工作流映射中的对象相关联的位置信息与数据库中的关联数据相链接，将工作流映射的映像转换为交互式界面。在工作流程图中选择给定的对象将检索与所选对象的位置相关联的数据。将框架实现为基于Web的应用程序可以轻松访问框架以及输入到框架中的数据以供将来分析。

3. 发明申请

US20060239765A1 Joint with application in electrochemical devices 有权
标题翻译：联合应用于电化学装置
公开(公告)号：US20060239765A1
公开(公告)日：2006-10-26
申请号：US11112122
申请日：2005-04-22
申请人： K. Weil , John Hardy
发明人： K. Weil , John Hardy
IPC分类号： F16B7/10
CPC分类号： H01M8/1253 , H01M8/0273 , H01M8/0282 , H01M8/0297 , H01M2008/1293 , Y02E60/525 , Y02P70/56 , Y10T403/31
摘要： A joint for use in electrochemical devices, such as solid oxide fuel cells (SOFCs), oxygen separators, and hydrogen separators, that will maintain a hermetic seal at operating temperatures of greater than 600° C., despite repeated thermal cycling excess of 600° C. in a hostile operating environment where one side of the joint is continuously exposed to an oxidizing atmosphere and the other side is continuously exposed to a wet reducing gas. The joint is formed of a metal part, a ceramic part, and a flexible gasket. The flexible gasket is metal, but is thinner and more flexible than the metal part. As the joint is heated and cooled, the flexible gasket is configured to flex in response to changes in the relative size of the metal part and the ceramic part brought about by differences in the coefficient of thermal expansion of the metal part and the ceramic part, such that substantially all of the tension created by the differences in the expansion and contraction of the ceramic and metal parts is absorbed and dissipated by flexing the flexible gasket.
摘要翻译：用于电化学装置的接头，例如固体氧化物燃料电池（SOFC），氧气分离器和氢气分离器，其将在高于600℃的工作温度下保持气密密封，尽管重复的热循环超过600° C.在恶劣的操作环境中，接头的一侧连续暴露于氧化气氛，另一侧连续暴露于湿的还原气体。接头由金属部件，陶瓷部件和柔性衬垫形成。柔性垫片是金属，但比金属部件更薄，更柔韧。当接头被加热和冷却时，柔性衬垫被配置为响应于由于金属部件和陶瓷部件的热膨胀系数的差异而导致的金属部件和陶瓷部件的相对尺寸的变化而弯曲，使得由陶瓷和金属部件的膨胀和收缩的差异产生的基本上所有的张力通过弯曲柔性垫片被吸收和消散。

4. 发明申请

US20060063057A1 High strength insulating metal-to-metal joints for solid oxide fuel cells and other high temperature applications and method of making 审中-公开
标题翻译：用于固体氧化物燃料电池的高强度绝缘金属 - 金属接头和其他高温应用和制造方法
公开(公告)号：US20060063057A1
公开(公告)日：2006-03-23
申请号：US10948359
申请日：2004-09-22
申请人： K. Weil , Lawrence Chick , Christopher Coyle , John Hardy , Guanguang Xia , Kerry Meinhardt , Vincent Sprenkle , Dean Paxton
发明人： K. Weil , Lawrence Chick , Christopher Coyle , John Hardy , Guanguang Xia , Kerry Meinhardt , Vincent Sprenkle , Dean Paxton
IPC分类号： H01M2/02
CPC分类号： H01M8/0282 , C03C8/24 , C03C29/00 , H01M8/0286 , H01M8/1246 , Y02E60/525 , Y02P70/56
摘要： A seal formed between a metal part and a second part that will remain gas tight in high temperature operating environments which experience frequent thermal cycling, which is particularly useful as an insulating joint in solid oxide fuel cells. A first metal part is attached to a reinforcing material. A glass forming material in the positioned in between the first metal part and the second part, and a seal is formed between the first metal part and the second part by heating the glass to a temperature suitable to melt the glass forming materials. The glass encapsulates and bonds at least a portion of the reinforcing material, thereby adding tremendous strength to the overall seal. A ceramic material may be added to the glass forming materials, to assist in forming an insulating barrier between the first metal part and the second part and to regulating the viscosity of the glass during the heating step.
摘要翻译：形成在金属部件和第二部件之间的密封件，其将在经受频繁热循环的高温操作环境中保持气密，这在固体氧化物燃料电池中作为绝缘接头特别有用。第一金属部件附接到增强材料。定位在第一金属部分和第二部分之间的玻璃形成材料，并且通过将玻璃加热到适于熔化玻璃形成材料的温度，在第一金属部分和第二部分之间形成密封。玻璃封装并粘合至少一部分增强材料，从而为整个密封件增加了巨大的强度。陶瓷材料可以添加到玻璃形成材料中，以有助于在第一金属部分和第二部分之间形成绝缘屏障，并且在加热步骤期间调节玻璃的粘度。

5. 发明申请

US20060060633A1 High strength insulating metal-to-ceramic joints for solid oxide fuel cells and other high temperature applications and method of making 审中-公开
标题翻译：用于固体氧化物燃料电池的高强度绝缘金属 - 陶瓷接头和其他高温应用和制造方法
公开(公告)号：US20060060633A1
公开(公告)日：2006-03-23
申请号：US10948346
申请日：2004-09-22
申请人： K. Weil , Lawrence Chick , Christopher Coyle , John Hardy , Guanguang Xia , Kerry Meinhardt , Vincent Sprenkle , Dean Paxton
发明人： K. Weil , Lawrence Chick , Christopher Coyle , John Hardy , Guanguang Xia , Kerry Meinhardt , Vincent Sprenkle , Dean Paxton
IPC分类号： H01M2/02
CPC分类号： C04B37/023 , B32B2311/22 , B32B2311/30 , C04B35/01 , C04B35/013 , C04B37/025 , C04B2235/3246 , C04B2235/3279 , C04B2235/424 , C04B2235/6025 , C04B2237/10 , C04B2237/34 , C04B2237/405 , C04B2237/406 , H01J49/025 , H01M8/0271 , H01M8/0282 , H01M8/0286 , Y02P70/56
摘要： A seal formed between a metal part and a second part that will remain gas tight in high temperature operating environments which experience frequent thermal cycling, which is particularly useful as an insulating joint in solid oxide fuel cells. A first metal part is attached to an reinforcing material. A glass forming material in the positioned in between the first metal part and the second part, and a seal is formed between the first metal part and the second part by heating the glass to a temperature suitable to melt the glass forming materials. The glass encapsulates and bonds at least a portion of the reinforcing material, thereby adding tremendous strength to the overall seal. A ceramic material may be added to the glass forming materials, to assist in forming an insulating barrier between the first metal part and the second part and to regulating the viscosity of the glass during the heating step.
摘要翻译：形成在金属部件和第二部件之间的密封件，其将在经受频繁热循环的高温操作环境中保持气密，这在固体氧化物燃料电池中作为绝缘接头特别有用。第一金属部件附接到增强材料。定位在第一金属部分和第二部分之间的玻璃形成材料，并且通过将玻璃加热到适于熔化玻璃形成材料的温度，在第一金属部分和第二部分之间形成密封。玻璃封装并粘合至少一部分增强材料，从而为整个密封件增加了巨大的强度。陶瓷材料可以添加到玻璃形成材料中，以有助于在第一金属部分和第二部分之间形成绝缘屏障，并且在加热步骤期间调节玻璃的粘度。

6. 发明授权

US06942379B2 Clock assembly having an adjustable configuration 失效
标题翻译：时钟组件具有可调配置
公开(公告)号：US06942379B2
公开(公告)日：2005-09-13
申请号：US10139698
申请日：2002-05-03
申请人： John Hardy
发明人： John Hardy
IPC分类号： G04B37/14 , G04B37/00
CPC分类号： G04B37/1413
摘要： The present invention provides a modular clock assembly comprising a body portion having a clock face and an exterior surface extending peripherally around the clock face, a clock mechanism secured to the body portion, a clock magnet affixed to the exterior surface of the body portion, a moveable member having a plurality of member surfaces, and at least one member magnet affixed to a member surface so that the moveable member is attachable to the exterior surface of the body portion by aligning the member magnet with the clock magnet.
摘要翻译：本发明提供了一种模块化时钟组件，其包括主体部分，其具有钟表面和在钟表面周围延伸的外表面，固定到主体部分的时钟机构，固定到主体部分的外表面的时钟磁体，具有多个构件表面的可移动构件和固定到构件表面的至少一个构件磁体，使得可移动构件可通过使构件磁体与时钟磁体对准而附接到主体部分的外表面。

7. 发明授权

US6083694A Method for elucidation and detection of polymorphisms, splice variants, and proximal coding mutations using intronic sequences of the alzheimer's S182 gene 失效
标题翻译：使用阿尔茨海默氏症S182基因的内含子序列来阐明和检测多态性，剪接变体和近端编码突变的方法
公开(公告)号：US6083694A
公开(公告)日：2000-07-04
申请号：US738381
申请日：1996-10-25
申请人： John Hardy , Alison M. Goate
发明人： John Hardy , Alison M. Goate
IPC分类号： C12N15/09 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q1/683 , C12Q1/6869 , C12Q2600/156
摘要： A method of detecting polymorphisms in the S182 gene by detecting mutations in the S182 gene using selected mismatched PCR primers comprising sequences derived from intronic sequences of the S182 gene is provided. A method of identifying an individual susceptible to late onset Alzheimer's Disease is also provided.
摘要翻译：提供了通过使用包含来自S182基因的内含子序列的序列的选择的错配PCR引物检测S182基因中的突变来检测S182基因中的多态性的方法。还提供了鉴定易患迟发性阿尔茨海默病的个体的方法。

8. 发明授权

US09896729B2 Method for diagnosing a neurodegenerative disease 有权
公开(公告)号：US09896729B2
公开(公告)日：2018-02-20
申请号：US14241646
申请日：2012-08-31
申请人： Stuart Pickering-Brown , Bryan Traynor , Andrew B. Singleton , Huw Morris , Peter Heutink , John Hardy , Pentti Tienari
发明人： Stuart Pickering-Brown , Bryan Traynor , Andrew B. Singleton , Huw Morris , Peter Heutink , John Hardy , Pentti Tienari
IPC分类号： C07H21/04 , C12Q1/68 , A61K38/17 , G01N33/50 , G01N33/68
CPC分类号： C12Q1/6883 , A61K38/1709 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/502 , G01N33/5088 , G01N33/6896 , G01N2333/47 , G01N2800/2814 , G01N2800/2835
摘要： The present invention relates to methods of assessing whether a subject has or is likely to develop a neurodegenerative disease comprising determining whether the subject has a mutation in the C9orf72 gene wherein said mutation prevents or disrupts C9orf72 expression relative to expression in a reference from subjects without the mutation.

9. 发明申请

US20150252421A1 METHOD FOR DIAGNOSING A NEURODEGENERATIVE DISEASE 有权
标题翻译：诊断神经病变疾病的方法
公开(公告)号：US20150252421A1
公开(公告)日：2015-09-10
申请号：US14241646
申请日：2012-08-31
申请人： Stuart Pickering-Brown , Bryan Traynor , Andrew B. Singleton , Huw Morris , Peter Heutink , John Hardy , Pentti Tienari
发明人： Stuart Pickering-Brown , Bryan Traynor , Andrew B. Singleton , Huw Morris , Peter Heutink , John Hardy , Pentti Tienari
IPC分类号： C12Q1/68 , G01N33/68 , G01N33/50 , A61K38/17
CPC分类号： C12Q1/6883 , A61K38/1709 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/502 , G01N33/5088 , G01N33/6896 , G01N2333/47 , G01N2800/2814 , G01N2800/2835
摘要： The present invention relates to methods of assessing whether a subject has or is likely to develop a neurodegenerative disease comprising determining whether the subject has a mutation in the C9orf72 gene wherein said mutation prevents or disrupts C9orf72 expression relative to expression in a reference from subjects without the mutation.
摘要翻译：本发明涉及评价受试者是否具有或可能发展神经变性疾病的方法，包括确定受试者是否具有C9orf72基因中的突变，其中所述突变阻止或破坏C9orf72表达相对于来自没有突变。

10. 发明申请

US20150099609A1 AGILITY TRAINING APPARATUS AND METHOD OF AGILITY TRAINING 审中-公开
标题翻译：能力培训设备和能力培训方法
公开(公告)号：US20150099609A1
公开(公告)日：2015-04-09
申请号：US14472360
申请日：2014-08-28
申请人： John White , Adam White , John Hardy
发明人： John White , Adam White , John Hardy
IPC分类号： A63B17/00 , A63B69/00
CPC分类号： A63B17/00 , A63B69/0028 , A63B2024/0065 , A63B2209/08 , A63B2209/10 , A63B2210/50
摘要： The present invention relates to the field of exercise apparatuses that provide exercises which are used for speed and agility training as well as strength training, with an emphasis on plyometric training, comprising a multi-directional, multi-configurable, and adjustable system of ladders.
摘要翻译：本发明涉及提供用于速度和敏捷性训练以及力量训练的锻炼的锻炼设备领域，其中强调聚类训练，包括多方向，多可配置且可调节的梯子系统。

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