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1. 发明授权

US4677918A Railroad car with retractable closure track held down by bridge plate 失效
标题翻译：铁路车辆，可伸缩闭合轨道由桥板压住
公开(公告)号：US4677918A
公开(公告)日：1987-07-07
申请号：US768805
申请日：1985-08-23
申请人： William R. Baker , Walter J. Marulic , James C. Robertson
发明人： William R. Baker , Walter J. Marulic , James C. Robertson
IPC分类号： B61D3/18 , B61D17/06 , B61D19/00 , E05D13/00
CPC分类号： B61D3/187 , B61D17/06 , B61D19/007 , Y10T16/379
摘要： A railroad car for transporting vehicles such as automobiles and trucks has a pair of door assemblies which close each end of the railroad car. The lower end of the door assemblies are guided in a track and the track has vertically retractable sections located where the vehicle tires roll so as to provide added load height when the car ends are open and vehicles are being loaded or unloaded. An embodiment with a pivotal, counterweighted Z-shaped member upon which the retractable track section is mounted is disclosed along with an embodiment utilizing a vertically displaceable tubular member and a coil spring.
摘要翻译：用于运输诸如汽车和卡车的车辆的铁路车辆具有关闭铁路车辆两端的一对门组件。门组件的下端被引导在轨道中，并且轨道具有位于车辆轮胎滚动的位置的竖直可伸缩部分，以便当汽车端部打开并且车辆被加载或卸载时提供附加的负载高度。公开了具有枢转的，配重的Z形构件的可伸缩轨道部分安装在该实施例上的实施例以及利用可垂直移位的管状构件和螺旋弹簧的实施例。

2. 发明授权

US4836726A Vehicle wheel chock for securing vehicles during transport 失效
标题翻译：运输过程中车辆固定车辆的车轮轴承座
公开(公告)号：US4836726A
公开(公告)日：1989-06-06
申请号：US213188
申请日：1988-06-29
申请人： James C. Robertson , William R. Baker
发明人： James C. Robertson , William R. Baker
IPC分类号： B60P3/077 , B61D45/00
CPC分类号： B61D45/004 , B60P3/077 , B61D45/001
摘要： A chock block for a vehicle transported on a deck to secure the vehicle against longitudinal movement; the chock block having a first member and a longitudinal second member lateral to the first member; the first member nesting with a track on the deck and removable from such nesting by upward displacement; the second member extending along and terminating beyond the tread face of a vehicle tire; a pin on the chock block for removably securing the first member to the track to prevent the chock block from horizontal and upward movement; the second member having a longitudinal center when viewed from the top; the chock block being essentially symmetrical about the second member longitudinal center; and the pin having a handle observable and manually operable from both sides of the second member longitudinal center to withdraw the pin forward end from a track hole to remove the chock block from the track and to help position the pin forward end in a track hole.
摘要翻译：在甲板上运输的车辆的轴承座，用于固定车辆纵向运动; 所述阻塞块具有第一构件和横向于所述第一构件的纵向第二构件; 第一个成员与甲板上的轨道嵌套，并通过向上移位而从这种嵌套中移除; 所述第二构件沿着车辆轮胎的胎面延伸并且终止于车辆轮胎的胎面; 轴承座上的销子，用于可拆卸地将第一构件固定到轨道上，以防止阻塞块水平和向上移动; 所述第二构件从所述顶部观察时具有纵向中心; 所述阻塞块基本上关于所述第二构件纵向中心对称; 并且销具有可观察并且可从第二构件纵向中心的两侧手动操作的手柄，以将销的前端从轨道孔撤回，以将轨道块从轨道移除并帮助将销前端定位在轨道孔中。

3. 发明申请

US20130012504A1 BI-FUNCTIONAL QUINOLINE ANALOGS 审中-公开
标题翻译：双功能喹啉类似物
公开(公告)号：US20130012504A1
公开(公告)日：2013-01-10
申请号：US13619636
申请日：2012-09-14
申请人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Jennifer Alissa Loyer-Drew , Stephane Perreault , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
发明人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Jennifer Alissa Loyer-Drew , Stephane Perreault , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
IPC分类号： C07D215/54 , C07D401/14 , A61K31/496 , C07D413/12 , A61K31/538 , A61K31/4706 , C07D409/14 , A61P29/00 , A61P31/00 , A61P37/08 , A61P11/00 , A61P11/08 , A61P11/06 , A61P11/10 , A61P11/02 , A61K31/4709
CPC分类号： C07D215/54 , C07D401/12 , C07D409/14 , C07D413/12
摘要： Provided are compounds of Formula I: R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring, and all other variables are as defined herein, as well as their use in treating pulmonary inflammation or bronchoconstriction and compositions comprising and processes for preparing the same.
摘要翻译：提供式I化合物：R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，并且所有其它变量如本文所定义，以及它们在治疗肺部炎症或支气管收缩和组合物中的用途包括及其制备方法。

4. 发明申请

US20110275622A1 BI-FUNCTIONAL QUINOLINE ANALOGS 失效
标题翻译：双功能喹啉类似物
公开(公告)号：US20110275622A1
公开(公告)日：2011-11-10
申请号：US13103577
申请日：2011-05-09
申请人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Jennifer Alissa Loyer-Drew , Stephane Perreault , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
发明人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Jennifer Alissa Loyer-Drew , Stephane Perreault , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
IPC分类号： A61K31/4709 , C07D401/14 , C07D413/12 , A61K31/496 , A61K31/538 , A61P29/00 , A61K31/475 , A61P11/00 , A61P11/06 , A61P11/08 , A61P3/00 , C07D215/54 , A61K31/4706
CPC分类号： C07D215/54 , C07D401/12 , C07D409/14 , C07D413/12
摘要： Provided are compounds of Formula I: wherein X is: R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring, and all other variables are as defined herein, as well as their use in treating pulmonary inflammation or bronchoconstriction and compositions comprising and processes for preparing the same.
摘要翻译：提供式I的化合物：其中X是：R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，并且所有其它变量如本文所定义，以及它们在治疗肺部炎症中的用途或支气管收缩剂及其组合物及其制备方法。

5. 发明申请

US20090318396A1 CORTICOSTEROID LINKED BETA-AGONIST COMPOUNDS FOR USE IN THERAPY 审中-公开
标题翻译：用于治疗的角质层连接的抗原激动剂化合物
公开(公告)号：US20090318396A1
公开(公告)日：2009-12-24
申请号：US12481364
申请日：2009-06-09
申请人： William R. Baker , Musong Kim , Alexander Rudolph , Marcin Stasiak , Josh Van Veldhuizen
发明人： William R. Baker , Musong Kim , Alexander Rudolph , Marcin Stasiak , Josh Van Veldhuizen
IPC分类号： A61K31/58 , C07J71/00 , A61P11/00
CPC分类号： C07J71/0031 , C07J51/00
摘要： New chemical entities which comprise corticosteroids and phosphorylated β-agonists for use in therapy and compositions comprising and processes for preparing the same.
摘要翻译：包含用于治疗的皮质类固醇和磷酸化β-激动剂的新化学实体及其制备方法及其制备方法。

6. 发明授权

US5541320A Process for the preparation of a substituted diaminoalcohol 失效
公开(公告)号：US5541320A
公开(公告)日：1996-07-30
申请号：US413659
申请日：1995-03-30
申请人： William R. Baker , John K. Pratt , Daniel W. Norbeck , Chen Zhao
发明人： William R. Baker , John K. Pratt , Daniel W. Norbeck , Chen Zhao
IPC分类号： C07D211/76 , C07D211/86 , C07D213/69 , C07D213/26
CPC分类号： C07D213/69 , C07D211/76 , C07D211/86
摘要： A process is disclosed for the preparation of a substituted diaminoalcohol of the formula: ##STR1##

7. 发明授权

US5244910A Renin inhibitors 失效
标题翻译：肾素抑制剂
公开(公告)号：US5244910A
公开(公告)日：1993-09-14
申请号：US736364
申请日：1991-07-31
申请人： William R. Baker , Steven A. Boyd , Anthony K. L. Fung , Herman H. Stein , Jon F. Denissen , Charles W. Hutchins
发明人： William R. Baker , Steven A. Boyd , Anthony K. L. Fung , Herman H. Stein , Jon F. Denissen , Charles W. Hutchins
IPC分类号： A61K31/495 , A61K31/535 , A61K38/55 , C07D211/46 , C07D401/12 , C07D405/12 , C07D413/12 , C07D451/06 , C07D451/14
CPC分类号： C07D451/06 , A61K31/495 , A61K31/535 , A61K38/553 , C07D211/46 , C07D401/12 , C07D405/12 , C07D413/10 , C07D451/14
摘要： A renin inhibiting compound of the formula: ##STR1## wherein X is O NH or S and G is a mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof; with the proviso that the compound is not N-(3-(4-Morpholino)propyl)-5(S)-(2(S)-(1(S)-(4-(methoxymethoxy)piperidin-1-yl)carbonyl-2- phenyl)ethoxyhexanamido)-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanamide.
摘要翻译：下式的肾素抑制化合物：其中X是O NH或S，G是血管紧张素原的Leu-Val切割位点的模拟物; 或其药学上可接受的盐，酯或前药; 条件是该化合物不是N-（3-（4-吗啉代）丙基）-5（S） - （2（S） - （1（S） - （4-（甲氧基甲氧基）哌啶-1-基）羰基-2-苯基）乙氧基己酰氨基）-6-环己基-4（S） - 羟基-2（S） - 异丙基己酰胺。

8. 发明授权

US5164388A Heterocyclic peptide renin inhibitors 失效
标题翻译：杂环肽肾素抑制剂
公开(公告)号：US5164388A
公开(公告)日：1992-11-17
申请号：US678266
申请日：1991-04-18
申请人： Biswanath De , Thomas N. Zydowsky , William R. Baker , Joseph F. Dellaria , Saul H. Rosenberg , Hwan S. Jae
发明人： Biswanath De , Thomas N. Zydowsky , William R. Baker , Joseph F. Dellaria , Saul H. Rosenberg , Hwan S. Jae
IPC分类号： A61K38/00 , C07D211/14 , C07D211/76 , C07D213/74 , C07D233/54 , C07D239/42 , C07D241/04 , C07D241/08 , C07D243/08 , C07D263/10 , C07D263/22 , C07D295/15 , C07D403/06 , C07D413/04 , C07D413/06 , C07D413/14 , C07D417/06 , C07K5/078
CPC分类号： C07D233/64 , C07D211/14 , C07D211/76 , C07D213/74 , C07D239/42 , C07D241/04 , C07D241/08 , C07D243/08 , C07D263/10 , C07D263/22 , C07D295/15 , C07D403/06 , C07D413/04 , C07D413/06 , C07D413/14 , C07D417/06 , C07K5/06139 , A61K38/00 , C07C2101/14
摘要： A renin inhibiting compound of the formula ##STR1## wherein X is N, O or CH; R.sub.1 is absent or a functional group; A and L are independently selected from absent, C.dbd.O, SO.sub.2 and CH.sub.2 ; D is C.dbd.O, SO.sub.2 or CH.sub.2 ; Y is N or CH; R.sub.2 is hydrogen, loweralkyl or substituted alkyl; Z is a functional group; R.sub.3 is loweralkyl or substituted alkyl; n is 0 or 1; and T is a mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.
摘要翻译：其中X是N，O或CH的式（Ⅰ）的肾素抑制化合物; R1不存在或官能团; A和L独立地选自C = O，SO 2和CH 2; D是C = O，SO 2或CH 2; Y为N或CH; R2是氢，低级烷基或取代的烷基; Z是功能组; R3是低级烷基或取代的烷基; n为0或1; T是模拟血管紧张素原的Leu-Val切割位点; 或其药学上可接受的盐，酯或前药。

9. 发明授权

US4017578A Method for producing laser targets 失效
标题翻译：激光靶产生方法
公开(公告)号：US4017578A
公开(公告)日：1977-04-12
申请号：US586459
申请日：1975-06-12
申请人： Thomas R. Jarboe , William R. Baker
发明人： Thomas R. Jarboe , William R. Baker
IPC分类号： F25J1/00 , H05H1/22 , B02C18/02 , G21B1/02
CPC分类号： F25J1/0221 , F25J1/001 , F25J1/0276 , G21B1/19 , F25J2205/20 , F25J2210/42 , F25J2290/42 , Y02E30/16 , Y10S376/916
摘要： An apparatus and method for producing deuterium targets or pellets of 25.mu. to 75.mu. diameter. The pellets are sliced from a continuously spun solid deuterium thread at a rate of up to 10 pellets/second. The pellets after being sliced from the continuous thread of deuterium are collimated and directed to a point of use, such as a laser activated combustion or explosion chamber wherein the pellets are imploded by laser energy or laser produced target plasmas for neutral beam injection.
摘要翻译：一种制造直径25〜75μm的氘靶或丸粒的装置及方法。将颗粒从持续纺丝的固体氘丝以最多10个丸粒/秒的速率切片。从连续的氘丝线切片后的颗粒被准直并且被引导到使用点，例如激光活化燃烧或爆炸室，其中颗粒被激光能量或激光产生的靶等离子体用于中性束注入。

10. 发明授权

US08450490B2 Bi-functional pyrazolopyridine compounds 失效
标题翻译：双功能吡唑并吡啶化合物
公开(公告)号：US08450490B2
公开(公告)日：2013-05-28
申请号：US13619792
申请日：2012-09-14
申请人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
发明人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
IPC分类号： C07D513/02
CPC分类号： C07D471/04
摘要： This invention provides compounds of the formula: wherein X is wherein R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring and all other variables are as defined herein, their use in pulmonary inflammation or bronchoconstriction therapy and compositions comprising and processes for preparing the same are provided.
摘要翻译：本发明提供下式的化合物：其中X是其中R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，所有其它变量如本文所定义，它们在肺部炎症或支气管收缩治疗中的用途，以及提供了组合物及其制备方法。

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