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1. 发明授权

US06548555B1 Basic drug compositions with enhanced bioavailability 有权
标题翻译：具有增强的生物利用度的基本药物组合物
公开(公告)号：US06548555B1
公开(公告)日：2003-04-15
申请号：US09495438
申请日：2000-01-31
申请人： William J. Curatolo , James A. S. Nightingale , Ravi M. Shanker , Steven C. Sutton
发明人： William J. Curatolo , James A. S. Nightingale , Ravi M. Shanker , Steven C. Sutton
IPC分类号： A61K4732
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1652 , A61K9/2054 , A61K9/4866 , Y10S977/915
摘要： A composition comprising a basic drug, a drug which forms a zwitterion, or a salt of either entity, admixed with a polymer selected from hydroxypropylmethylcellulose acetate succinate (HPMCAS), cellulose acetate trimellitate (CAT), cellulose acetate phthalate (CAP), hydroxypropylcellulose acetate phthalate (HPCAP), hydroxypropylmethylcellulose acetate phthalate (HPMCAP), and methylcellulose acetate phthalate (MCAP). The compositions having improved solubility, hence bioavailability, in the small intestine; Processes for testing such compositions, and methods of using such compositions. The compositions comprise the basic drug, zwitterion, or salt and one or more of the aforementioned polymers. The invention further relates to a method for increasing the bioavailability of a basic or a zwitterionic drug comprising co-administering the basic drug, the zwitterionic drug, or the salt, with one or more of the aforementioned polymers.
摘要翻译：包含碱性药物，形成两性离子的药物或任一实体的盐，与选自羟丙基甲基纤维素乙酸酯琥珀酸酯（HPMCAS），醋酸偏苯三酸纤维素（CAT），乙酸邻苯二甲酸纤维素（CAP），羟丙基纤维素乙酸酯邻苯二甲酸酯（HPCAP），羟丙基甲基纤维素乙酸邻苯二甲酸酯（HPMCAP）和甲基纤维素乙酸邻苯二甲酸酯（MCAP）。所述组合物在小肠中具有改善的溶解度，因此具有生物利用度; 用于测试这些组合物的方法，以及使用这些组合物的方法。组合物包含碱性药物，两性离子或盐和一种或多种上述聚合物。本发明还涉及增加碱性或两性离子药物的生物利用度的方法，包括将一种或多种上述聚合物共同给予碱性药物，两性离子药物或盐。

2. 发明授权

US08236328B2 Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers 有权
标题翻译：与聚合物混合的无定形药物的分散体的药物组合物
公开(公告)号：US08236328B2
公开(公告)日：2012-08-07
申请号：US12217700
申请日：2008-07-08
申请人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West
发明人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West
IPC分类号： A61K9/00 , A61K9/14
CPC分类号： A61K9/146
摘要： A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
摘要翻译：药物组合物包含包含低溶解度药物和与浓度增强聚合物组合的基质的分散体。至少大部分药物在分散体中是无定形的。组合物改善药物在分散体中的稳定性和/或药物在使用环境中的浓度。

3. 发明授权

US08202912B2 Pharmaceutical compositions providing enhanced drug concentrations 有权
标题翻译：提供增强药物浓度的药物组合物
公开(公告)号：US08202912B2
公开(公告)日：2012-06-19
申请号：US13208305
申请日：2011-08-11
申请人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz
发明人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz
IPC分类号： A61K47/32 , A61K9/14 , A61K9/16 , A61K9/22
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1629 , A61K9/1652 , A61K31/135 , A61K31/404 , A61K31/4178 , A61K31/4375 , A61K31/496 , A61K31/517
摘要： A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
摘要翻译：将溶解度改善形式的药物与足够量的浓度增强聚合物组合，使得组合在使用环境中相对于包含相同量的相同溶解度改善形式的药物的对照提供了显着增强的药物浓度没有浓度增强聚合物。

4. 发明授权

US08026286B2 Pharmaceutical compositions providing enhanced drug concentrations 有权
标题翻译：提供增强药物浓度的药物组合物
公开(公告)号：US08026286B2
公开(公告)日：2011-09-27
申请号：US09742785
申请日：2000-12-20
申请人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz
发明人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz
IPC分类号： A61K47/32 , A61K9/14 , A61K9/16 , A61K9/22
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1629 , A61K9/1652 , A61K31/135 , A61K31/404 , A61K31/4178 , A61K31/4375 , A61K31/496 , A61K31/517
摘要： A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
摘要翻译：将溶解度改善形式的药物与足够量的浓度增强聚合物组合，使得组合在使用环境中相对于包含相同量的相同溶解度改善形式的药物的对照提供了显着增强的药物浓度没有浓度增强聚合物。

5. 发明授权

US08501231B2 Pharmaceutical compositions providing enhanced drug concentrations 有权
公开(公告)号：US08501231B2
公开(公告)日：2013-08-06
申请号：US13527536
申请日：2012-06-19
申请人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz
发明人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz
IPC分类号： A61K9/14 , A61K9/16 , A61K9/22 , A61K47/32
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1629 , A61K9/1652 , A61K31/135 , A61K31/404 , A61K31/4178 , A61K31/4375 , A61K31/496 , A61K31/517
摘要： A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.

6. 发明申请

US20120295988A1 Pharmaceutical Compositions of Dispersions of Amorphous Drugs Mixed with Polymers 有权
标题翻译：与聚合物混合的无定形药物分散体的药物组合物
公开(公告)号：US20120295988A1
公开(公告)日：2012-11-22
申请号：US13563536
申请日：2012-07-31
申请人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West
发明人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West
IPC分类号： A61K47/38 , A61P25/22 , A61P7/02 , A61P25/08 , A61P25/28 , A61P35/00 , A61P29/00 , A61P25/18 , A61P3/04 , A61P31/04 , A61P9/12 , A61P11/14
CPC分类号： A61K9/146
摘要： A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
摘要翻译：药物组合物包含包含低溶解度药物和与浓度增强聚合物组合的基质的分散体。至少大部分药物在分散体中是无定形的。组合物改善药物在分散体中的稳定性和/或药物在使用环境中的浓度。

7. 发明授权

US07235259B2 Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors 失效
标题翻译：胆固醇酯转运蛋白抑制剂的药物组合物
公开(公告)号：US07235259B2
公开(公告)日：2007-06-26
申请号：US10066091
申请日：2002-02-01
申请人： Marshall D. Crew , William J. Curatolo , Dwayne T. Friesen , Michael Jon Gumkowski , Douglas A. Lorenz , James A. S. Nightingale , Roger B. Ruggeri , Ravi M. Shanker
发明人： Marshall D. Crew , William J. Curatolo , Dwayne T. Friesen , Michael Jon Gumkowski , Douglas A. Lorenz , James A. S. Nightingale , Roger B. Ruggeri , Ravi M. Shanker
IPC分类号： A61K9/14 , A61K31/47
CPC分类号： A61K31/4196 , A61K9/146 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K31/41 , A61K31/47
摘要： A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
摘要翻译：药物组合物包含胆固醇酯转移蛋白抑制剂和浓度增强聚合物的固体无定形分散体。

8. 发明授权

US07115279B2 Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors 失效
公开(公告)号：US07115279B2
公开(公告)日：2006-10-03
申请号：US09918127
申请日：2001-07-30
申请人： William J. Curatolo , Dwayne T. Friesen , Michael J. Gumkowski , Douglas A. Lorenz , James A. S. Nightingale , Roger B. Ruggeri , Ravi M. Shanker
发明人： William J. Curatolo , Dwayne T. Friesen , Michael J. Gumkowski , Douglas A. Lorenz , James A. S. Nightingale , Roger B. Ruggeri , Ravi M. Shanker
IPC分类号： A61K9/14 , A61K31/47
CPC分类号： A61K9/1652 , A61K9/146 , A61K9/1635 , A61K31/4196 , A61K31/47
摘要： A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.

9. 发明授权

US08703196B2 Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers 有权
标题翻译：与聚合物混合的无定形药物的分散体的药物组合物
公开(公告)号：US08703196B2
公开(公告)日：2014-04-22
申请号：US13563536
申请日：2012-07-31
申请人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West
发明人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West
IPC分类号： A61K9/14 , A61K47/38
CPC分类号： A61K9/146
摘要： A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
摘要翻译：药物组合物包含包含低溶解度药物和与浓度增强聚合物组合的基质的分散体。至少大部分药物在分散体中是无定形的。组合物改善药物在分散体中的稳定性和/或药物在使用环境中的浓度。

10. 发明授权

US08389011B2 Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors 有权
公开(公告)号：US08389011B2
公开(公告)日：2013-03-05
申请号：US13494668
申请日：2012-06-12
申请人： Marshall D. Crew , William J. Curatolo , Dwayne T. Friesen , Michael Jon Gumkowski , Douglas A. Lorenz , James A. S. Nightingale , Roger B. Ruggeri , Ravi M. Shanker
发明人： Marshall D. Crew , William J. Curatolo , Dwayne T. Friesen , Michael Jon Gumkowski , Douglas A. Lorenz , James A. S. Nightingale , Roger B. Ruggeri , Ravi M. Shanker
IPC分类号： A61K9/14 , A61K31/135 , A61K31/47 , A61K47/32
CPC分类号： A61K9/1652 , A61K9/146 , A61K9/1635 , A61K31/4196 , A61K31/47
摘要： A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.

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