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    • 6. 发明申请
    • Tibial cut guide assembly having rotatable cut guide body
    • 胫骨切割引导组件具有可旋转的切割引导体
    • US20070186738A1
    • 2007-08-16
    • US11343849
    • 2006-01-31
    • Shawn McGinleyMichael Schwartz
    • Shawn McGinleyMichael Schwartz
    • B26D7/06
    • B26D7/0006A61B17/157Y10T83/2042
    • A guide assembly including a riser and a guide body. Riser has first and second ends. First end has a first opening defining a first axis. First opening is defined by a wall and includes a shoulder extending about wall. First opening also has a channel defined in wall. Channel extends parallel to first axis. Cut guide body has a first bone engaging surface, an opposing second surface and opposing proximal and distal sides. Cut guide includes a post extending vertically from distal side and defining a post axis. Post is rotatably received within first opening of riser. Cut guide includes a boss extending from post at an angle to post axis. Boss is slidable within channel to enable post to be inserted into first opening. Post is rotatable about post axis and boss engages shoulder to prevent vertical movement of post in first opening.
    • 一种引导组件,其包括提升管和引导体。 立管具有第一和第二端。 第一端具有限定第一轴线的第一开口。 第一开口由壁限定,并且包括围绕壁延伸的肩部。 第一次开放也有一个定义在墙上的通道。 通道平行于第一轴延伸。 切割引导体具有第一骨接合表面,相对的第二表面和相对的近侧和远侧。 切割引导件包括从远端垂直延伸并且限定后轴的柱。 柱可旋转地容纳在提升管的第一开口内。 切割引导件包括一个凸台,其从后端以一角度延伸到后轴。 老板可以在通道内滑动,使柱可插入第一个开口。 柱可以围绕柱轴旋转并且凸台接合肩部以防止柱在第一开口中的垂直运动。
    • 7. 发明申请
    • Drug model explorer
    • 药物模型探险家
    • US20060161354A1
    • 2006-07-20
    • US11388660
    • 2006-03-23
    • Jacob MandemaMichael SchwartzTimothy SheinerJean-Max Vally
    • Jacob MandemaMichael SchwartzTimothy SheinerJean-Max Vally
    • G06F19/00
    • G16H50/50G06F19/3456G16H10/20G16H40/63
    • Computer systems and methods facilitate exploring results of drug candidate modeling. In one embodiment, the software is configured to receive raw data simulated by a probabilistic model of clinical safety, tolerability, and efficacy of a drug candidate. Index information is extracted from the raw data and then referenced to generate a metadata file, the structure of the metadata file,explicitly reflecting a hierarchical structure of the model. The metadata file is in turn used to convert the raw data into a binary file, the metadata file explicitly identifying locations within the binary file, of treatment scenario information types and output performance information types. The metadata file is also referenced to generate an interface configured to receive inputs from a non-expert audience, and in turn present relevant subsets of the binary file in a limited number of plot and tabular formats. By standardizing presentation and manipulation of data from different models, software and methods in accordance with the present invention facilitate meaningful interaction between a non-expert audience, and the complex abstract mathematical models predicting drug behavior. The heightened audience-model interaction afforded by the present invention in turn promotes uniform and consistent evaluation of modeled data in the process of drug development.
    • 计算机系统和方法有助于探索药物候选建模的结果。 在一个实施例中,软件被配置为接收由药物候选者的临床安全性,耐受性和功效的概率模型模拟的原始数据。 从原始数据中提取索引信息,然后引用生成元数据文件,元数据文件的结构,明确地反映模型的层次结构。 元数据文件又用于将原始数据转换为二进制文件,元数据文件明确地标识二进制文件中的位置,处理方案信息类型和输出性能信息类型。 还引用元数据文件来生成被配置为从非专家观众接收输入的接口,并且依次以有限数量的情节和表格格式呈现二进制文件的相关子集。 通过标准化来自不同模型的数据的呈现和操纵,根据本发明的软件和方法促进非专家观众之间的有意义的交互,以及预测药物行为的复杂抽象数学模型。 本发明提供的观众模式相互联系越来越强大地对药物开发过程中的建模数据进行了统一和一致的评估。