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    • 1. 发明授权
    • Halovir, an antiviral marine natural product, and derivatives thereof
    • 抗病毒海洋天然产物Halovir及其衍生物
    • US06458766B1
    • 2002-10-01
    • US09211877
    • 1998-12-15
    • William FenicalPaul R. JensenDavid C. Rowley
    • William FenicalPaul R. JensenDavid C. Rowley
    • A61K3808
    • C07K7/06A61K38/00
    • The present invention provides a compound having the structure: wherein R1a and R1b are independently selected from the group consisting of —H, alkyl, lower-alkyl, substituted alkyl and substituted lower-alkyl; R2a and R2b are independently selected from the group consisting of —H, lower-alkyl, and substituted lower-alkyl; R3 is —H, lower-alkyl, substituted lower-alkyl and where R3 and R4 are attached together by a lower-alkyl or a substituted lower-alkyl moiety; R4 is —H, lower-alkyl, substituted lower-alkyl and where R3 and R4 are attached together form a lower-alkyl or substituted lower-alkyl bridge; R5, R7, R9 and R11 are independently selected from the group consisting of —H, lower-alkyl, and substituted lower-alkyl; R6 is —H, lower-alkyl and substituted lower-alkyl; R8 is —H, lower-alkyl and substituted lower-alkyl; R10 is —H, lower-alkyl and substituted lower-alkyl; R12 is —H, lower-alkyl and substituted lower-alkyl; and A is —C(O)—R13, wherein R13 is —H, —OH, alkyl, lower-alkyl, substituted lower-alkyl or —O(lower-alkyl); —CH2—OR14 wherein R14 is —H, —C(O)CH3, alkyl, lower-alkyl or substituted lower-alkyl; or —CH2—NR15R16, where R15 and R16 are independently selected from —H, lower-alkyl, alkyl, substituted lower-alkyl or substituted alkyl; a pharmaceutically acceptable salt or derivatives thereof, useful for preventing or treating viral and microbial infections.
    • 本发明提供具有以下结构的化合物:其中R1a和R1b独立地选自-H,烷基,低级烷基,取代的烷基和取代的低级烷基; R2a和R2b独立地选自 - H,低级烷基和取代的低级烷基; R 3是-H,低级烷基,取代的低级烷基,其中R 3和R 4通过低级烷基或取代的低级烷基部分连接在一起; R4是-H ,低级烷基取代的低级烷基,其中R3和R4连接在一起形成低级烷基或取代的低级烷基桥; R 5,R 7,R 9和R 11独立地选自-H,低级烷基 和取代的低级烷基; R 6为-H,低级烷基和取代的低级烷基; R 8为-H,低级烷基和取代的低级烷基; R 10为-H,低级烷基和取代的低级烷基; R 12 是-H,低级烷基和取代的低级烷基; 并且A是-C(O)-R 13,其中R 13是-H,-OH,烷基,低级烷基,取代的低级烷基或-O(低级 - 烷基); -CH2-OR14,其中R14是-H,-C(O)CH3,烷基,低级烷基或取代的低级烷基; 或-CH 2 -NR 15 R 16,其中R 15和R 16独立地选自-H,低级烷基,烷基,取代的低级烷基或取代的烷基;其药学上可接受的盐或其衍生物,可用于预防或治疗病毒和微生物感染。