专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07923250B2 Methods of expressing LIM mineralization protein in non-osseous cells 有权
标题翻译：在非骨细胞中表达LIM矿化蛋白的方法
公开(公告)号：US07923250B2
公开(公告)日：2011-04-12
申请号：US10292951
申请日：2002-11-13
申请人： William F. McKay , Scott Boden , Sangwook T. Yoon
发明人： William F. McKay , Scott Boden , Sangwook T. Yoon
IPC分类号： C12N15/00
CPC分类号： A61K48/005 , A61K35/12 , A61K35/13 , A61K48/00 , A61K2121/00 , A61L27/3804 , A61L27/3856 , C07K14/47 , C07K14/4702 , C07K14/78 , C07K16/18 , C12N2799/022
摘要： Methods of expressing LIM mineralization protein in non-osseous mammalian cells, such as stem cells or intervertebral disc cells (e.g., cells of the annulus fibrosus, or cells of the nucleus pulposus) are described. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. Transfection may be accomplished ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. Expression of the LIM mineralization protein can stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycyan and/or collagen. Methods for treating disc disease associated with trauma or disc degeneration are also described.
摘要翻译：描述了在非骨骼哺乳动物细胞中表达LIM矿化蛋白的方法，例如干细胞或椎间盘细胞（例如纤维环的细胞或髓核的细胞）。所述方法涉及用分离的核酸转染细胞，所述分离的核酸包含可操作地连接到启动子的编码LIM矿化蛋白的核苷酸序列。转染可以通过直接注射病毒或裸露DNA或非病毒载体如质粒在体内或体内完成。 LIM矿化蛋白的表达可以刺激能够产生蛋白多糖和/或胶原的细胞中的蛋白聚糖和/或胶原产生。还描述了与创伤或椎间盘退变相关的椎间盘疾病的治疗方法。

2. 发明授权

US5891147A Minimally invasive spinal surgical methods & instruments 失效
标题翻译：微创脊柱手术方法与仪器
公开(公告)号：US5891147A
公开(公告)日：1999-04-06
申请号：US939848
申请日：1997-09-29
申请人： Peter A. Moskovitz , Scott Boden , William F. McKay , Joseph Moctezuma
发明人： Peter A. Moskovitz , Scott Boden , William F. McKay , Joseph Moctezuma
IPC分类号： A61B17/00 , A61B17/02 , A61B17/16 , A61B17/32 , A61B18/14 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/44 , A61F2/46 , A61F5/00
CPC分类号： A61F2/4611 , A61B17/02 , A61B17/0206 , A61B17/025 , A61B17/1604 , A61B17/1606 , A61B17/1608 , A61B17/1637 , A61F2/4455 , A61F2/4601 , A61B18/1442 , A61B2017/00261 , A61B2017/0042 , A61B2017/0256 , A61B2017/320044 , A61F2002/2835 , A61F2002/30062 , A61F2002/30153 , A61F2002/30261 , A61F2002/4623 , A61F2002/4635 , A61F2002/4649 , A61F2210/0004 , A61F2230/0019 , A61F2230/0082 , A61F2310/00293 , Y10S606/907
摘要： Minimally invasive spinal surgical techniques and tools are provided. The methods include separating the iliocostalis lumborum muscle from the anterior leaf of the thoracolumbar fascia to create a channel from the patient's skin to the intertransverse interval. In one embodiment, the method also includes delivering graft material through the channel to the intertransverse interval. A device according to one aspect of the present invention includes a retraction portion having a flattened plate configured to atraumatically retract tissue to create a working space within an endosurgical site and a curved shaft attached to the retraction portion. The shaft includes a bend having a radius of preferably 160 degrees. A gripping portion is attached to the shaft and is configured for manually gripping and manipulating the device.
摘要翻译：提供微创脊柱外科技术和工具。这些方法包括从胸腰肌筋膜前叶分离髂骨肌肉肌肉，以创建从患者皮肤到横向间隔的通道。在一个实施方案中，该方法还包括将移植材料通过该通道输送到跨越间隔。根据本发明的一个方面的装置包括具有扁平板的收缩部分，所述扁平板被构造成无损伤地收缩组织以在外科手术部位内产生工作空间，以及附接到所述缩回部分的曲轴。轴包括具有优选为160度的半径的弯曲部。抓握部分附接到轴上并被构造成手动地夹持和操纵装置。

3. 发明授权

US5885291A Minimally invasive spinal surgical methods and instruments 失效
标题翻译：微创脊柱手术方法和手段
公开(公告)号：US5885291A
公开(公告)日：1999-03-23
申请号：US939791
申请日：1997-09-29
申请人： Peter A. Moskovitz , Scott Boden , William F. McKay , Joseph Moctezuma
发明人： Peter A. Moskovitz , Scott Boden , William F. McKay , Joseph Moctezuma
IPC分类号： A61B17/00 , A61B17/02 , A61B17/16 , A61B17/32 , A61B18/14 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/44 , A61F2/46
CPC分类号： A61F2/4611 , A61B17/02 , A61B17/0206 , A61B17/025 , A61B17/1604 , A61B17/1606 , A61B17/1608 , A61B17/1637 , A61F2/4455 , A61F2/4601 , A61B18/1442 , A61B2017/00261 , A61B2017/0042 , A61B2017/0256 , A61B2017/320044 , A61F2002/2835 , A61F2002/30062 , A61F2002/30153 , A61F2002/30261 , A61F2002/4623 , A61F2002/4635 , A61F2002/4649 , A61F2210/0004 , A61F2230/0019 , A61F2230/0082 , A61F2310/00293 , Y10S606/907
摘要： Minimally invasive spinal surgical techniques and tools are provided. The methods include separating the iliocostalis lumborum muscle from the anterior leaf of the thoracolumbar fascia to create a channel from the patient's skin to the intertransverse interval. In one embodiment, the method also includes delivering graft material through the channel to the intertransverse interval. A device according to one aspect of the present invention includes a retraction portion having a flattened plate configured to atraumatically retract tissue to create a working space within an endosurgical site and a curved shaft attached to the retraction portion. The shaft includes a bend having a radius of preferably 160 degrees. A gripping portion is attached to the shaft and is configured for manually gripping and manipulating the device.
摘要翻译：提供微创脊柱外科技术和工具。这些方法包括从胸腰肌筋膜前叶分离髂骨肌肉肌肉，以创建从患者皮肤到横向间隔的通道。在一个实施方案中，该方法还包括将移植材料通过该通道输送到跨越间隔。根据本发明的一个方面的装置包括具有扁平板的收缩部分，所述扁平板被构造成无损伤地收缩组织以在外科手术部位内产生工作空间，以及附接到所述缩回部分的曲轴。轴包括具有优选为160度的半径的弯曲部。抓握部分附接到轴上并被构造成手动地夹持和操纵装置。

4. 发明授权

US5741261A Minimally invasive spinal surgical methods and instruments 失效
公开(公告)号：US5741261A
公开(公告)日：1998-04-21
申请号：US670351
申请日：1996-06-25
申请人： Peter A. Moskovitz , Scott Boden , William F. McKay , Joseph Moctezuma
发明人： Peter A. Moskovitz , Scott Boden , William F. McKay , Joseph Moctezuma
IPC分类号： A61B17/00 , A61B17/02 , A61B17/16 , A61B17/32 , A61B18/14 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/44 , A61F2/46 , A61B17/56
CPC分类号： A61F2/4611 , A61B17/02 , A61B17/0206 , A61B17/025 , A61B17/1604 , A61B17/1606 , A61B17/1608 , A61B17/1637 , A61F2/4455 , A61F2/4601 , A61B18/1442 , A61B2017/00261 , A61B2017/0042 , A61B2017/0256 , A61B2017/320044 , A61F2002/2835 , A61F2002/30062 , A61F2002/30153 , A61F2002/30261 , A61F2002/4623 , A61F2002/4635 , A61F2002/4649 , A61F2210/0004 , A61F2230/0019 , A61F2230/0082 , A61F2310/00293 , Y10S606/907
摘要： Minimally invasive spinal surgical techniques and tools are provided. The methods include separating the iliocostalis lumborum muscle from the anterior leaf of the thoracolumbar fascia to create a channel from the patient's skin to the intertransverse interval. In one embodiment, the method also includes delivering graft material through the channel to the intertransverse interval. A device according to one aspect of the present invention includes a retraction portion having a flattened plate configured to atraumatically retract tissue to create a working space within an endosurgical site and a curved shaft attached to the retraction portion. The shaft includes a bend having a radius of preferably 160 degrees. A gripping portion is attached to the shaft and is configured for manually gripping and manipulating the device.

5. 发明授权

US5885292A Minimally invasive spinal surgical methods and instruments 失效
公开(公告)号：US5885292A
公开(公告)日：1999-03-23
申请号：US939796
申请日：1997-09-29
申请人： Peter A. Moskovitz , Scott Boden , William F. McKay , Joseph Moctezuma
发明人： Peter A. Moskovitz , Scott Boden , William F. McKay , Joseph Moctezuma
IPC分类号： A61B17/00 , A61B17/02 , A61B17/16 , A61B17/32 , A61B18/14 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/44 , A61F2/46 , A61B17/56
CPC分类号： A61F2/4611 , A61B17/02 , A61B17/0206 , A61B17/025 , A61B17/1604 , A61B17/1606 , A61B17/1608 , A61B17/1637 , A61F2/4455 , A61F2/4601 , A61B18/1442 , A61B2017/00261 , A61B2017/0042 , A61B2017/0256 , A61B2017/320044 , A61F2002/2835 , A61F2002/30062 , A61F2002/30153 , A61F2002/30261 , A61F2002/4623 , A61F2002/4635 , A61F2002/4649 , A61F2210/0004 , A61F2230/0019 , A61F2230/0082 , A61F2310/00293 , Y10S606/907
摘要： Minimally invasive spinal surgical techniques and tools are provided. The methods include separating the iliocostalis lumborum muscle from the anterior leaf of the thoracolumbar fascia to create a channel from the patient's skin to the intertransverse interval. In one embodiment, the method also includes delivering graft material through the channel to the intertransverse interval. A device according to one aspect of the present invention includes a retraction portion having a flattened plate configured to atraumatically retract tissue to create a working space within an endosurgical site and a curved shaft attached to the retraction portion. The shaft includes a bend having a radius of preferably 160 degrees. A gripping portion is attached to the shaft and is configured for manually gripping and manipulating the device.

6. 发明授权

US09616153B2 Rigid bone graft substitute 有权
公开(公告)号：US09616153B2
公开(公告)日：2017-04-11
申请号：US12104564
申请日：2008-04-17
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61F2/28 , A61L27/56 , A61L27/40 , A61L27/54 , A61F2/30
CPC分类号： A61L27/56 , A61F2/2803 , A61F2002/2817 , A61F2002/30062 , A61F2002/3092 , A61F2002/3096 , A61F2210/0004 , A61F2310/00293 , A61F2310/00365 , A61L27/40 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： A bone graft substitute includes a porous matrix at least partially covered by a reinforcing outer layer. The porous matrix may be a collagen-ceramic composite, and the reinforcing outer layer may be formed from highly cross-linked collagen. The implant may also include one or more reinforcement ribs, which may be made from calcium phosphate or dense collagen. In addition, the bone graft substitute preferably includes an effective amount of a bioactive agent, such as BMP-2, rhBMP-2, or functional fragments thereof. The bioactive agent is preferably disposed within the porous matrix.

7. 发明授权

US09163212B2 Osteogenic cell delivery matrix 有权
标题翻译：成骨细胞递送基质
公开(公告)号：US09163212B2
公开(公告)日：2015-10-20
申请号：US12692940
申请日：2010-01-25
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61K9/14 , A61K33/42 , A61K47/02 , A61K35/12 , A61P19/00 , C12N5/00 , A61L27/42 , A61L27/56
CPC分类号： A61L27/44 , A61L27/365 , A61L27/3834 , A61L27/3847 , A61L27/425 , A61L27/54 , A61L27/56 , A61L2300/102 , A61L2300/112 , A61L2300/412 , A61L2300/64 , A61L2430/02 , C12N5/0068 , C12N2533/14
摘要： Compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) within a matrix provided. By adding calcium and/or phosphate ions to the matrix, one may foster greater bone regeneration.
摘要翻译：通过在提供的基质内施用分离的人间充质干细胞（hMSCs）来增加骨形成的组合物和方法。通过向基质中加入钙和/或磷酸根离子，可以促进更大的骨再生。

8. 发明授权

US09161903B2 Flowable composition that hardens on delivery to a target tissue site beneath the skin 有权
标题翻译：可流动的组合物在皮肤递送至目标组织部位时变硬
公开(公告)号：US09161903B2
公开(公告)日：2015-10-20
申请号：US12262705
申请日：2008-10-31
申请人： Susan J. Drapeau , William F. McKay , Nelson Scarborough
发明人： Susan J. Drapeau , William F. McKay , Nelson Scarborough
IPC分类号： A61K51/00 , A61K9/00 , A61K9/14 , A61K47/34
CPC分类号： A61K9/0024 , A61K9/0085 , A61K9/16 , A61K31/573 , A61K47/10 , A61K47/34 , A61K51/1213
摘要： Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent and (ii) an effective amount of the therapeutic agent, the flowable composition being capable of hardening to form a drug depot at a physiological temperature or as solvent contacts bodily fluid at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal. In some embodiments, an implantable drug depot for delivering a therapeutic agent is provided, the implantable drug depot comprising (i) a chamber; and (ii) a flowable composition comprising an effective amount of a therapeutic agent disposed within the chamber of the drug depot, the flowable composition capable of hardening when the drug depot is delivered at or near the target tissue site.
摘要翻译：提供可流动的组合物和方法用于在患者皮肤下方的靶组织部位处或附近递送治疗剂，所述可流动组合物包含（i）溶剂和（ii）有效量的治疗剂，所述可流动组合物为能够在生理温度下硬化形成药物贮库，或者作为溶剂与目标组织部位处或附近的体液接触，其中药物贮库能够在至少一天的时间内释放治疗剂，并且靶组织部位包括至少一个肌肉，韧带，肌腱，软骨，脊椎盘，脊神经根附近的脊椎孔隙空间，小面或滑膜关节或椎管。在一些实施方案中，提供了用于递送治疗剂的可植入药物贮库，所述可植入药物贮库包括（i）室; 和（ii）可流动组合物，其包含设置在所述药物贮库的所述室内的有效量的治疗剂，所述可流动组合物能够在所述药物贮库在所述靶组织部位处或附近递送时硬化。

9. 发明授权

US09107983B2 Osteoconductive matrices comprising statins 有权
标题翻译：包含他汀类的骨诱导性基质
公开(公告)号：US09107983B2
公开(公告)日：2015-08-18
申请号：US12913237
申请日：2010-10-27
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61L27/44 , A61L27/54 , A61K9/00 , A61K35/32
CPC分类号： A61L27/446 , A61L27/54 , A61L2300/412 , A61L2430/02
摘要： Osteoconductive matrices and methods are provided that have one or more statins disposed therein. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustain release of the statin and facilitate bone formation and repair of the fracture site.
摘要翻译：提供具有一个或多个他汀类药物的骨诱导性基质和方法。可将基质注入骨折部位。提供的骨传导性基质允许他汀类维生素的释放并促进骨形成部位的骨形成和修复。

10. 发明授权

US08998854B2 Catheter devices and drainage systems for delivering therapeutic agents 有权
标题翻译：用于输送治疗剂的导管装置和排水系统
公开(公告)号：US08998854B2
公开(公告)日：2015-04-07
申请号：US12695899
申请日：2010-01-28
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61M5/178 , A61M27/00 , A61M25/00 , A61M1/00
CPC分类号： A61M27/00 , A61M1/0084 , A61M25/0026 , A61M25/003 , A61M25/007 , A61M2025/0031 , A61M2025/0036 , A61M2025/004
摘要： A catheter for drainage of a wound and delivery of a therapeutic agent at or near the wound of a patient is provided. The catheter comprises: a proximal end configured to receive the therapeutic agent and permit passage of bodily fluid, the proximal end configured to be coupled to a drainage tube and/or a therapeutic agent delivery device; a distal end for insertion at or near the wound; and a body disposed between the proximal end and distal end of the catheter and configured to receive the therapeutic agent from the proximal end of the catheter, the body having a first set of holes configured to allow passage of the therapeutic agent from the proximal end to a site at or near the wound and the body having a second set of holes configured to allow drainage of bodily fluid from the wound into the catheter.
摘要翻译：提供了用于在患者的伤口处或伤口附近引导伤口和递送治疗剂的导管。所述导管包括：近端构造成容纳所述治疗剂并允许体液通过，所述近端构造成联接到排液管和/或治疗剂递送装置; 用于插入伤口处或附近的远端; 以及设置在所述导管的所述近端和远端之间并且构造成从所述导管的近端接收所述治疗剂的主体，所述主体具有第一组孔，所述第一组孔构造成允许所述治疗剂从所述近端通过至伤口处或附近的部位和身体具有第二组孔，其被配置为允许体液从伤口排出到导管中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式