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1. 发明授权

US08278309B2 Synthetic mimetics of host defense and uses thereof 有权
标题翻译：宿主防御的合成模拟物及其用途
公开(公告)号：US08278309B2
公开(公告)日：2012-10-02
申请号：US12605584
申请日：2009-10-26
申请人： William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
发明人： William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
IPC分类号： A01N43/54 , C07D239/02
CPC分类号： C07D403/14
摘要： The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译：本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。

2. 发明申请

US20100105703A1 Synthetic Mimetics Of Host Defense And Uses Thereof 有权
标题翻译：主机防御及其应用的合成模拟
公开(公告)号：US20100105703A1
公开(公告)日：2010-04-29
申请号：US12605584
申请日：2009-10-26
申请人： William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
发明人： William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
IPC分类号： A61K31/506 , C07D403/14 , A61P31/04
CPC分类号： C07D403/14
摘要： The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译：本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。

3. 发明授权

US08975262B2 Synthetic mimetics of host defense and uses thereof 有权
标题翻译：宿主防御的合成模拟物及其用途
公开(公告)号：US08975262B2
公开(公告)日：2015-03-10
申请号：US13563928
申请日：2012-08-01
申请人： William F. DeGrado , Haizhong Tang , Bozena Korczak , Dahui Liu , Richard W. Scott , Yongjiang Xu
发明人： William F. DeGrado , Haizhong Tang , Bozena Korczak , Dahui Liu , Richard W. Scott , Yongjiang Xu
IPC分类号： C07D403/14
CPC分类号： C07D403/14
摘要： The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译：本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。

4. 发明授权

US08455490B2 Facially amphiphilic polymers and oligomers and uses thereof 有权
标题翻译：表面两亲聚合物和低聚物及其用途
公开(公告)号：US08455490B2
公开(公告)日：2013-06-04
申请号：US13559065
申请日：2012-07-26
申请人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
发明人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
IPC分类号： A01N43/58 , A01N43/60 , A01N43/54 , A61K31/50 , A61K31/495 , C07D239/42 , C07D471/04 , C07D471/22 , C07D487/04
CPC分类号： A61K31/17 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/3225 , C08G73/028 , C08L75/02
摘要： The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
摘要翻译：本发明公开了使用表面两亲性聚合物和低聚物的方法，包括聚合物和低聚物作为抗微生物剂的药物用途和与肝素治疗相关的出血并发症的解毒剂。本发明还公开了新颖的表面两亲聚合物和低聚物及其组合物，包括药物组合物。本发明还公开了表面两亲聚合物和低聚物的设计和合成。

5. 发明申请

US20080176807A1 Facially amphiphilic polymers and oligomers and uses thereof 有权
标题翻译：表面两亲聚合物和低聚物及其用途
公开(公告)号：US20080176807A1
公开(公告)日：2008-07-24
申请号：US11980785
申请日：2007-10-31
申请人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
发明人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
IPC分类号： A61K38/07 , A61K38/05 , C07K5/10 , A61P31/04 , A61P31/12 , A01P1/00 , A61P31/10 , A01N37/44 , C07C233/64
CPC分类号： A61K31/17 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/3225 , C08G73/028 , C08L75/02
摘要： The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
摘要翻译：本发明公开了使用表面两亲性聚合物和低聚物的方法，包括聚合物和低聚物作为抗微生物剂的药物用途和与肝素治疗相关的出血并发症的解毒剂。本发明还公开了新颖的表面两亲聚合物和低聚物及其组合物，包括药物组合物。本发明还公开了表面两亲聚合物和低聚物的设计和合成。

6. 发明授权

US06677431B2 Design, preparation, and properties of antibacterial &bgr;-peptides 有权
标题翻译：抗菌β-肽的设计，制备和性质
公开(公告)号：US06677431B2
公开(公告)日：2004-01-13
申请号：US09732911
申请日：2000-12-11
申请人： William F. DeGrado , Yoshimoto Hamuro , Dahui Liu
发明人： William F. DeGrado , Yoshimoto Hamuro , Dahui Liu
IPC分类号： A61K3804
CPC分类号： C07C237/12 , A61K47/56 , A61K47/6903 , C07C271/22 , C07C2603/18
摘要： An antibacterial &bgr;-peptide having the following formula: wherein R1 is H, an alkyl group including 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl; R2 is an amine-containing alkyl group having the formula —(CH2)mNH2, wherein m=1, 2, 3, 4, or 5, (CH2)xNHC═NHNH2 wherein x is 1, 2, 3, 4, or 5, a pyridyl, an alkylpryidyl, an amidine-substituted benzyl, a phenyl group, or a cyclic amidine; R3 is H, an alkyl group including 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl; X is —NH2, —OH, —NHR, or OR where R is alkyl, aryl or acyl groups either free or polymer-supported, a carboxamide, a substituted carboxamide, or a polymer; Y is H, an alkyl group, an acyl group, an acyl-terminated polymer, a sulphonamide, an ether, a urea, a urethane, or a polymer; and n is 2, 3, 4, 5, 6, or 7.
摘要翻译：具有下式的抗菌β-肽：其中R 1是H，包含1-4个碳原子的烷基，苯基，杂芳基或烷基 - 芳基; R 2是具有式 - （CH 2）m NH 2的含胺烷基其中m = 1,2,3,4或5，（CH 2）x NHC = NHNH 2其中x为1,2,3,4或5，吡啶基，烷基基团，脒取代的苄基，苯基或环状脒; R 3为H，包含1-4个碳原子的烷基，苯基，杂芳基或烷基 - 芳基; X为-NH 2，-OH，-NHR或OR，其中R为烷基，芳基或 Y是H，烷基，酰基，酰基封端的聚合物，磺酰胺，醚，脲，氨基甲酸酯，氨基甲酸酯，氨基甲酸酯，或聚合物; andn是2,3,4,5,6或7。

7. 发明申请

US20130023561A1 Facially Amphiphilic Polymers and Oligomers and Uses Thereof 有权
标题翻译：两亲聚合物及其低聚物及其用途
公开(公告)号：US20130023561A1
公开(公告)日：2013-01-24
申请号：US13559065
申请日：2012-07-26
申请人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
发明人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
IPC分类号： A61K31/167 , A61K31/404 , A01N43/38 , A61K31/4545 , A01P1/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/00 , A01N37/24 , A01N43/40
CPC分类号： A61K31/17 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/3225 , C08G73/028 , C08L75/02
摘要： The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
摘要翻译：本发明公开了使用表面两亲性聚合物和低聚物的方法，包括聚合物和低聚物作为抗微生物剂的药物用途和与肝素治疗相关的出血并发症的解毒剂。本发明还公开了新颖的表面两亲聚合物和低聚物及其组合物，包括药物组合物。本发明还公开了表面两亲聚合物和低聚物的设计和合成。

8. 发明授权

US07173102B2 Facially amphiphilic polymers as anti-infective agents 有权
标题翻译：表面两亲性聚合物作为抗感染剂
公开(公告)号：US07173102B2
公开(公告)日：2007-02-06
申请号：US10471028
申请日：2002-03-07
申请人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan
发明人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan
IPC分类号： C08G18/00 , C08G63/00 , C08G69/02 , C08G71/02
CPC分类号： A61L15/44 , A01N25/10 , A01N37/18 , A01N37/22 , A01N37/24 , A01N37/28 , A01N37/30 , A01N37/42 , A01N47/22 , A01N47/30 , A01N47/44 , A61K31/74 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/20 , A61L2300/216 , A61L2300/404 , C08G18/2865 , C08G18/3225 , C08G61/02 , C08G61/10 , C08G61/122 , C08G69/26 , C08G73/028 , C08G73/22 , C08G2261/312 , Y10T428/193 , Y10T428/24207 , Y10T428/24446 , Y10T428/24455 , Y10T428/29 , Y10T428/31 , Y10T428/31504 , Y10T428/31678 , Y10T428/31725 , Y10T428/8305
摘要： Facially amphiphilic polymers and articles made therefrom having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a method to identify and optimize the facial amphiphilicity of polyamide, polyester, polyurea, polyurethane, polycarbonate and polyphenylene polymers. Utility as a contact disinfectant is disclosed.
摘要翻译：公开了两性聚合物和由其制成的制品具有杀生物面。聚合物可以抑制与表面或邻近所述杀生物表面的区域接触的微生物的生长。还公开了一种鉴定和优化聚酰胺，聚酯，聚脲，聚氨酯，聚碳酸酯和聚亚苯基聚合物的面部两亲性的方法。公开了作为接触消毒剂的效用。

9. 发明授权

US08222456B2 Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof 有权
标题翻译：表面两亲性聚芳基和聚芳基炔基聚合物和低聚物及其用途
公开(公告)号：US08222456B2
公开(公告)日：2012-07-17
申请号：US11038787
申请日：2005-01-21
申请人： William F. DeGrado , Dahui Liu , Gregory N. Tew , Michael L. Klein
发明人： William F. DeGrado , Dahui Liu , Gregory N. Tew , Michael L. Klein
IPC分类号： C07C211/27 , C07C279/06 , C07C233/77 , A61K31/135 , A61K31/155 , A61K31/16 , A61K31/132
CPC分类号： C07C279/12 , A61K31/74 , C07C211/27 , C07C217/58 , C07C233/78
摘要： The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.
摘要翻译：本发明公开了使用表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法，包括但不限于聚合物和低聚物作为抗微生物剂的药物用途和用于与肝素治疗相关的出血并发症的解毒剂。本发明还公开了新颖的表面两亲聚芳基和聚芳基炔基聚合物和低聚物，新型聚合物和低聚物的组合物，包括药物组合物，以及设计和合成表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法。

10. 发明授权

US09241917B2 Facially amphiphilic polymers and oligomers and uses thereof 有权
公开(公告)号：US09241917B2
公开(公告)日：2016-01-26
申请号：US10801951
申请日：2004-03-17
申请人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
发明人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
IPC分类号： C08G18/00 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/32 , C08G73/02 , C08L75/02
CPC分类号： A61K31/17 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/3225 , C08G73/028 , C08L75/02
摘要： The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.

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