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1. 发明授权

US07299134B2 Method for correlating gene expression profiles with protein expression profiles 失效
标题翻译：将基因表达谱与蛋白质表达谱相关联的方法
公开(公告)号：US07299134B2
公开(公告)日：2007-11-20
申请号：US10076967
申请日：2002-02-15
申请人： William E. Rich , T. William Hutchens
发明人： William E. Rich , T. William Hutchens
IPC分类号： G06F19/00 , G01N24/00
CPC分类号： C12Q1/6809 , Y10T436/24
摘要： The present invention relates to methods for correlating gene and protein expression in a cell.
摘要翻译：本发明涉及使细胞中的基因和蛋白质表达相关的方法。

2. 发明授权

US08173433B2 Platelet biomarkers for cancer 失效
标题翻译：癌症血小板生物标志物
公开(公告)号：US08173433B2
公开(公告)日：2012-05-08
申请号：US11658377
申请日：2005-04-22
申请人： Judah M. Folkman , Giannoula Klement , Tai-Tung Yip , William E. Rich , Vladimir N. Podust
发明人： Judah M. Folkman , Giannoula Klement , Tai-Tung Yip , William E. Rich , Vladimir N. Podust
IPC分类号： G01N33/48 , A61K35/14
CPC分类号： G01N33/6872 , G01N33/57484 , G01N2333/49 , G01N2333/503 , G01N2333/515 , G01N2800/24 , G01N2800/368
摘要： The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.
摘要翻译：本发明涉及免疫学和生物化学领域。特别地，本发明描述了用于早期检测具有全身血管生成活性相关变化，特别是癌症，炎性病症，感染以及与怀孕和流产有关的事件的临床病症的方法，装置和试剂盒。

3. 发明授权

US06765199B2 Time-dependent digital signal scaling process 失效
标题翻译：时间依赖的数字信号缩放过程
公开(公告)号：US06765199B2
公开(公告)日：2004-07-20
申请号：US10193349
申请日：2002-07-10
申请人： Michael G. Youngquist , Edward Gavin , William E. Rich
发明人： Michael G. Youngquist , Edward Gavin , William E. Rich
IPC分类号： H01J4940
CPC分类号： H01J49/0036 , H01J49/025 , H01J49/40
摘要： A method for processing time-dependent signal data is disclosed. The time-dependent signal data are received in a memory, wherein the time-dependent signal data represent a time-dependent signal, and wherein the time-dependent signal data include representations of time-of-flight values of ions, or values derived from time-of-flight values of ions. The time-dependent signal data are scaled with a time-dependent scaling function.
摘要翻译：公开了一种用于处理时间相关信号数据的方法。时间相关信号数据被接收在存储器中，其中时间相关信号数据表示时间相关信号，并且其中时间相关信号数据包括离子飞行时间值的表示，或从离子的飞行时间值。时间依赖的信号数据用时间依赖的缩放函数进行缩放。

4. 发明申请

US20090042229A1 PLATELET BIOMARKERS FOR CANCER 失效
标题翻译：癌症生物标志物
公开(公告)号：US20090042229A1
公开(公告)日：2009-02-12
申请号：US11658377
申请日：2005-04-22
申请人： Judah M. Folkman , Giannoula Klement , Tai-Tung Yip , William E. Rich , Vladimir N. Podust
发明人： Judah M. Folkman , Giannoula Klement , Tai-Tung Yip , William E. Rich , Vladimir N. Podust
IPC分类号： C12Q1/37 , G01N33/00 , G01N31/22 , G01N33/566
CPC分类号： G01N33/6872 , G01N33/57484 , G01N2333/49 , G01N2333/503 , G01N2333/515 , G01N2800/24 , G01N2800/368
摘要： The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.
摘要翻译：本发明涉及免疫学和生物化学领域。特别地，本发明描述了用于早期检测具有全身血管生成活性相关变化，特别是癌症，炎性病症，感染以及与怀孕和流产有关的事件的临床病症的方法，装置和试剂盒。

5. 发明授权

US07348184B2 Protein interaction difference mapping 有权
标题翻译：蛋白质相互作用差异作图
公开(公告)号：US07348184B2
公开(公告)日：2008-03-25
申请号：US10626493
申请日：2003-07-23
申请人： William E. Rich , Egisto Boschetti , Lee O. Lomas , Tai-Tung Yip
发明人： William E. Rich , Egisto Boschetti , Lee O. Lomas , Tai-Tung Yip
IPC分类号： G01N33/543
CPC分类号： C40B30/04 , G01N33/54306 , G01N33/6803
摘要： This invention provides methods and materials for mapping interaction characteristics between components of a multicomponent biological complex. The methods involve capturing a multicomponent complex on a solid support and washing the support with a series of elution washes forming a gradient of solute concentrations, and determining whether a particular elution wash eluted a particular component.
摘要翻译：本发明提供了用于映射多组分生物复合物的组分之间的相互作用特征的方法和材料。该方法包括在固体支持物上捕获多组分复合物，并用洗脱洗涤洗涤洗脱洗涤洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱洗脱特定组分。

6. 发明授权

US07479631B2 Probes for a gas phase ion spectrometer 有权
标题翻译：气相离子光谱仪探头
公开(公告)号：US07479631B2
公开(公告)日：2009-01-20
申请号：US11681377
申请日：2007-03-02
申请人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
发明人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
IPC分类号： H01J49/00 , B01D59/44 , G01N24/00
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.
摘要翻译：本发明提供一种探针和一种使探针可移除地插入到气相离子光谱仪中的探针，该探针包括在表面上具有表面和水凝胶材料的基底，该水凝胶材料包含用于与分析物结合的结合官能团可由气相离子光谱仪检测。本发明还提供了一种探针和一种使探针可移除地插入到气相离子分光计中的方法，该探针包括具有表面和表面上直径均匀的多个颗粒的基底，该颗粒包含结合用于与气相离子光谱仪可检测的分析物结合的功能。此外，本发明提供了一种包括本发明的探针和气相离子光谱仪的系统，该气相离子光谱仪包括将光引导到探针表面以解吸分析物的能量源和与检测解吸附的分析物的探针表面连通的检测器。本发明还提供了一种用于从探针表面解吸分析物的方法，该方法包括在允许分析物和结合官能团之间结合的条件下将结合功能暴露于含有分析物的样品，并通过气体从探针解吸分析物相离子光谱法。

7. 发明授权

US06897072B1 Probes for a gas phase ion spectrometer 有权
标题翻译：气相离子光谱仪探头
公开(公告)号：US06897072B1
公开(公告)日：2005-05-24
申请号：US09560715
申请日：2000-04-27
申请人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
发明人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
IPC分类号： H01J49/16 , C08F20/10 , C08F20/56 , G01N1/28 , G01N27/62 , G01N27/64 , H01J49/04 , H01J49/12 , G01N24/00
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.
摘要翻译：本发明提供一种探针和一种使探针可移除地插入到气相离子光谱仪中的探针，该探针包括在表面上具有表面和水凝胶材料的基底，该水凝胶材料包含用于与分析物结合的结合官能团可由气相离子光谱仪检测。本发明还提供了一种探针和一种使探针可移除地插入到气相离子分光计中的方法，该探针包括具有表面和表面上直径均匀的多个颗粒的基底，该颗粒包含结合用于与气相离子光谱仪可检测的分析物结合的功能。此外，本发明提供了一种包括本发明的探针和气相离子光谱仪的系统，该气相离子光谱仪包括将光引导到探针表面以解吸分析物的能量源和与检测解吸附的分析物的探针表面连通的检测器。本发明还提供了一种用于从探针表面解吸分析物的方法，该方法包括在允许分析物和结合官能团之间结合的条件下将包含分析物的样品的结合官能团暴露，并通过气体从探针解吸分析物相离子光谱法。

8. 发明授权

US07205156B2 Probes for a gas phase ion spectrometer 有权
标题翻译：气相离子光谱仪探头
公开(公告)号：US07205156B2
公开(公告)日：2007-04-17
申请号：US10960222
申请日：2004-10-06
申请人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
发明人： William E. Rich , Pil-Je Um , Kamen Voivodov , Tai-Tung Yip , Jody Beecher
IPC分类号： G01N24/00
CPC分类号： H01J49/0418 , H01J49/12 , Y10T428/261 , Y10T428/31504 , Y10T436/24
摘要： The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel material on the surface, the hydrogel material comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. The invention also provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a plurality of particles that are uniform in diameter on the surface, the particles comprising binding functionalities for binding with an analyte detectable by the gas phase ion spectrometer. Further, the invention provides a system comprising the probe of the present invention and a gas phase ion spectrometer comprising an energy source that directs light to the probe surface to desorb an analyte and a detector in communication with the probe surface that detects the desorbed analyte. The invention also provides a method for desorbing an analyte from a probe surface, the method comprising exposing the binding functionalities to a sample containing an analyte under conditions to allow binding between the analyte and the binding functionalities, and desorbing the analyte from the probe by gas phase ion spectrometry.
摘要翻译：本发明提供一种探针和一种使探针可移除地插入到气相离子光谱仪中的探针，该探针包括在表面上具有表面和水凝胶材料的基底，该水凝胶材料包含用于与分析物结合的结合官能团可由气相离子光谱仪检测。本发明还提供了一种探针和一种使探针可移除地插入到气相离子分光计中的方法，该探针包括具有表面和表面上直径均匀的多个颗粒的基底，该颗粒包含结合用于与气相离子光谱仪可检测的分析物结合的功能。此外，本发明提供了一种包括本发明的探针和气相离子光谱仪的系统，该气相离子光谱仪包括将光引导到探针表面以解吸分析物的能量源和与检测解吸附的分析物的探针表面连通的检测器。本发明还提供了一种用于从探针表面解吸分析物的方法，该方法包括在允许分析物和结合官能团之间结合的条件下将包含分析物的样品的结合官能团暴露，并通过气体从探针解吸分析物相离子光谱法。

9. 发明授权

US07027933B2 Method for analyzing mass spectra 失效
公开(公告)号：US07027933B2
公开(公告)日：2006-04-11
申请号：US10669499
申请日：2003-09-23
申请人： Chris D. Paulse , Edward J. Gavin , Leonid Braginsky , William E. Rich , Eric T. Fung
发明人： Chris D. Paulse , Edward J. Gavin , Leonid Braginsky , William E. Rich , Eric T. Fung
IPC分类号： G01R23/16
CPC分类号： H01J49/0036 , G06F19/18 , G06F19/24
摘要： A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.

10. 发明授权

US06675104B2 Method for analyzing mass spectra 失效
公开(公告)号：US06675104B2
公开(公告)日：2004-01-06
申请号：US09999081
申请日：2001-11-15
申请人： Chris D. Paulse , Edward J. Gavin , Leonid Braginsky , William E. Rich , Eric T. Fung
发明人： Chris D. Paulse , Edward J. Gavin , Leonid Braginsky , William E. Rich , Eric T. Fung
IPC分类号： G01N3100
CPC分类号： H01J49/0036 , G06F19/18 , G06F19/24
摘要： A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.

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