专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090176229A1 Methods and compositions for the identification of insect repellent compounds 有权
标题翻译：用于鉴定驱虫剂的方法和组合物
公开(公告)号：US20090176229A1
公开(公告)日：2009-07-09
申请号：US12283670
申请日：2008-09-15
申请人： William D. Tracey, JR. , Nancy Stearns , Lixian Zhong , Yifan Xu , Jason Caldwell , Allison Weaver , Angela Hofhine
发明人： William D. Tracey, JR. , Nancy Stearns , Lixian Zhong , Yifan Xu , Jason Caldwell , Allison Weaver , Angela Hofhine
IPC分类号： C12Q1/68 , C40B30/06 , C12N5/06
CPC分类号： C07K14/43581
摘要： Methods for identifying a candidate compound with an ability to modulate cation transport through a transient receptor potential (TRP) channel in a cell are disclosed. The methods can include (a) providing a cell expressing a recombinant nucleic acid sequence encoding an transient receptor potential (TRP) channel gene product or a functional fragment or derivative thereof; (b) contacting the cell with the candidate compound; (c) comparing cation transport in the cell in the absence of the candidate compound with cation transport in the cell in the presence of the candidate compound; and (d) identifying a candidate compound through the comparing step that modulates cation transport in the cell through the transient receptor potential (TRP) channel. Also disclosed are nucleic acid and amino acid sequences for insect TRP channel gene products, antibodies that bind to the disclosed TRP channels, and recombinant host cells the include the disclosed biosequences.
摘要翻译：公开了用于鉴定具有调节通过细胞中的瞬时受体电位（TRP）通道的阳离子转运能力的候选化合物的方法。所述方法可以包括（a）提供表达编码瞬时受体电位（TRP）通道基因产物或其功能片段或衍生物的重组核酸序列的细胞; （b）使细胞与候选化合物接触; （c）比较在不存在候选化合物的情况下在候选化合物存在下细胞中阳离子转运与细胞中阳离子转运的比较; 和（d）通过比较步骤鉴定候选化合物，所述比较步骤通过瞬时受体电位（TRP）通道调节细胞中的阳离子转运。还公开了昆虫TRP通道基因产物的核酸和氨基酸序列，结合所公开的TRP通道的抗体，以及重组宿主细胞，其包括所公开的生物。

2. 发明授权

US08017316B2 Methods and compositions for the identification of insect repellent compounds 有权
标题翻译：用于鉴定驱虫剂的方法和组合物
公开(公告)号：US08017316B2
公开(公告)日：2011-09-13
申请号：US12283670
申请日：2008-09-15
申请人： William D. Tracey, Jr. , Nancy Stearns , Lixian Zhong , Yifan Xu , Jason Caldwell , Allison Weaver , Angela Hofhine
发明人： William D. Tracey, Jr. , Nancy Stearns , Lixian Zhong , Yifan Xu , Jason Caldwell , Allison Weaver , Angela Hofhine
IPC分类号： C12Q1/00 , C12Q1/68 , C07K14/435
CPC分类号： C07K14/43581
摘要： Methods for identifying a candidate compound with an ability to modulate cation transport through a transient receptor potential (TRP) channel in a cell are disclosed. The methods can include (a) providing a cell expressing a recombinant nucleic acid sequence encoding an transient receptor potential (TRP) channel gene product or a functional fragment or derivative thereof; (b) contacting the cell with the candidate compound; (c) comparing cation transport in the cell in the absence of the candidate compound with cation transport in the cell in the presence of the candidate compound; and (d) identifying a candidate compound through the comparing step that modulates cation transport in the cell through the transient receptor potential (TRP) channel. Also disclosed are nucleic acid and amino acid sequences for insect TRP channel gene products, antibodies that bind to the disclosed TRP channels, and recombinant host cells the include the disclosed biosequences.
摘要翻译：公开了用于鉴定具有调节通过细胞中的瞬时受体电位（TRP）通道的阳离子转运能力的候选化合物的方法。所述方法可以包括（a）提供表达编码瞬时受体电位（TRP）通道基因产物或其功能片段或衍生物的重组核酸序列的细胞; （b）使细胞与候选化合物接触; （c）比较在不存在候选化合物的情况下在候选化合物存在下细胞中阳离子转运与细胞中阳离子转运的比较; 和（d）通过比较步骤鉴定候选化合物，所述比较步骤通过瞬时受体电位（TRP）通道调节细胞中的阳离子转运。还公开了昆虫TRP通道基因产物的核酸和氨基酸序列，与所公开的TRP通道结合的抗体，以及重组宿主细胞，包括所公开的生物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式