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1. 发明申请

US20090210012A1 Laminoplasty devices and methods 审中-公开
标题翻译：椎板成形术装置及方法
公开(公告)号：US20090210012A1
公开(公告)日：2009-08-20
申请号：US12386892
申请日：2009-04-24
申请人： William B. Null , Robert W. Weakley , Gregory C. Marik , John G. Heller , Jeffrey C. Wang
发明人： William B. Null , Robert W. Weakley , Gregory C. Marik , John G. Heller , Jeffrey C. Wang
IPC分类号： A61B17/80
CPC分类号： A61B17/7059 , A61B17/7071
摘要： Laminoplasty plates are engageable to at least one portion of a divided lamina to maintain a desired spacing relative to the spinal canal. The laminoplasty plates include a spacer portion having a first end and a second end that spans a gap formed by at least one of a divided lamina portion. The laminoplasty plates can include a lamina engagement portion at one end for engagement with the divided lamina portion.
摘要翻译：椎板成形术板可接合至分裂片的至少一部分以保持相对于椎管的期望间隔。椎板成形术板包括间隔部分，该间隔部分具有第一端和第二端，该第二端跨越由分开的椎板部分中的至少一个形成的间隙。椎板成形术板可以包括在一端的椎板接合部分，用于与分开的椎板部分接合。

2. 发明授权

US08105366B2 Laminoplasty plate with flanges 有权
标题翻译：椎板成形术板与法兰
公开(公告)号：US08105366B2
公开(公告)日：2012-01-31
申请号：US10447126
申请日：2003-05-28
申请人： William B. Null , Robert W. Weakley , Gregory C. Marik , John G. Heller , Jeffrey C. Wang
发明人： William B. Null , Robert W. Weakley , Gregory C. Marik , John G. Heller , Jeffrey C. Wang
IPC分类号： A61B17/80
CPC分类号： A61B17/7059 , A61B17/7071
摘要： Laminoplasty plates are engageable to at least one portion of a divided lamina to maintain a desired spacing relative to the spinal canal. The laminoplasty plates include a spacer portion having a first end and a second end that spans a gap formed by at least one of a divided lamina portion. The laminoplasty plates can include a lamina engagement portion at one end for engagement with the divided lamina portion.
摘要翻译：椎板成形术板可接合至分裂片的至少一部分以保持相对于椎管的期望间隔。椎板成形术板包括间隔部分，该间隔部分具有第一端和第二端，该第二端跨越由分开的椎板部分中的至少一个形成的间隙。椎板成形术板可以包括在一端的椎板接合部分，用于与分开的椎板部分接合。

3. 发明授权

US08962569B2 Compositions comprising spp24 peptide fragments 有权
标题翻译：包含spp24肽片段的组合物
公开(公告)号：US08962569B2
公开(公告)日：2015-02-24
申请号：US13699288
申请日：2011-05-25
申请人： Samuel S. Murray , Elsa J. Murray , Jeffrey C. Wang
发明人： Samuel S. Murray , Elsa J. Murray , Jeffrey C. Wang
IPC分类号： C07K14/00 , C07K9/00 , A61K38/04 , A61K38/16 , A61K38/17
CPC分类号： A61K38/1709 , A61K2300/00
摘要： Provided herein is tumor suppression composition and methods of making and using the same.
摘要翻译：本文提供了肿瘤抑制组合物及其制备和使用方法。

4. 发明授权

US08182518B2 Static and dynamic cervical plates and cervical plate constructs 有权
标题翻译：静态和动态的宫颈板和宫颈板构造
公开(公告)号：US08182518B2
公开(公告)日：2012-05-22
申请号：US11022504
申请日：2004-12-21
申请人： Michael S. Butler , Jeffrey C. Wang
发明人： Michael S. Butler , Jeffrey C. Wang
IPC分类号： A61B17/80
CPC分类号： A61B17/8047 , A61B17/7059 , A61B17/8023 , A61B17/8042
摘要： A cervical bone plate includes a graft window that allows access to and/or visualization of a bone graft area of the cervical spine after attachment of the present cervical plate to the vertebrae. The window is preferably, but not necessarily, sized for maximum exposure of the graft area and/or the vertebral body without compromising plate strength, particularly with respect to federal standards for such devices. The window is centrally positioned on the plate and is sized to provide alignment of the plate onto the vertebrae at the base of the vertebra fastener or screw holes of the plate. In a dynamic form of this cervical bone plate, the graft window expands and contracts with respective expansion and contraction of the dynamic plate after attachment to the vertebrae (i.e. “dynamizes”). In another form, a three-component dynamic bone plate is configured such that a middle component accepts an identical end component at both ends of the middle component. The end component is a 180° interchangeable part. The middle component and the end component have cooperating configurations and complementarily configured grooves that allow sliding movement between the middle component and the end components. A two-pillar construction provides a central window.
摘要翻译：宫颈骨板包括移植窗口，其在将本颈椎板附接到椎骨之后允许进入和/或可视化颈椎骨移植区域。窗口优选地但不一定地被设定成能够最大限度地暴露移植物区域和/或椎体而不损害板的强度，特别是关于这种装置的联邦标准。窗口位于板的中心位置，其尺寸适于提供板在椎骨紧固件的底部或板的螺钉孔的椎骨上的对准。在这种子宫颈骨板的动态形式中，移植窗口在附着到椎骨之后（即“动态化”）的动态板的各自的膨胀和收缩扩张和收缩。在另一种形式中，三分量动态骨板被配置为使得中间部件在中间部件的两端接受相同的端部部件。端部部件是180°可互换部件。中间部件和端部部件具有配合构造和互补配置的凹槽，允许中间部件和端部部件之间滑动。一个双柱建筑提供了一个中心窗口。

5. 发明申请

US20110087328A1 CENTRALLY DRIVEN EXPANDABLE IMPLANT AND METHOD 审中-公开
标题翻译：中心驱动可扩展的植入物和方法
公开(公告)号：US20110087328A1
公开(公告)日：2011-04-14
申请号：US12970649
申请日：2010-12-16
申请人： Andrew M. Dickson , James S. Harrop , Dean G. Karahalios , Eric A. Potts , Christopher I. Shaffrey , Jeffrey C. Wang
发明人： Andrew M. Dickson , James S. Harrop , Dean G. Karahalios , Eric A. Potts , Christopher I. Shaffrey , Jeffrey C. Wang
IPC分类号： A61F2/44
CPC分类号： A61F2/44 , A61F2/30744 , A61F2/4611 , A61F2002/2835 , A61F2002/30062 , A61F2002/3008 , A61F2002/30235 , A61F2002/30354 , A61F2002/30522 , A61F2002/3055 , A61F2002/30551 , A61F2002/30601 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30787 , A61F2002/30841 , A61F2002/4475 , A61F2002/449 , A61F2002/4627 , A61F2002/4628 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0069 , A61F2250/0098 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179
摘要： Embodiments of the invention include expandable, implantable devices and methods. Devices expand linearly to provide secure fixation between or among anatomical structures. In some embodiments, an implant replaces one or more vertebral bodies of the spine.
摘要翻译：本发明的实施例包括可扩展的可植入装置和方法。设备线性扩展以在解剖结构之间或之间提供牢固的固定。在一些实施例中，植入物代替脊柱的一个或多个椎体。

6. 发明申请

US20130143811A1 Tumor Suppression Compositions 有权
标题翻译：肿瘤抑制组合物
公开(公告)号：US20130143811A1
公开(公告)日：2013-06-06
申请号：US13699288
申请日：2011-05-25
申请人： Samuel S. Murray , Elsa J. Murray , Jeffrey C. Wang
发明人： Samuel S. Murray , Elsa J. Murray , Jeffrey C. Wang
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K2300/00
摘要： Provided herein is tumor suppression composition and methods of making and using the same.
摘要翻译：本文提供了肿瘤抑制组合物及其制备和使用方法。

7. 发明授权

US08415302B2 Surgical applications for BMP binding protein 有权
公开(公告)号：US08415302B2
公开(公告)日：2013-04-09
申请号：US12448497
申请日：2007-12-26
申请人： Samuel S. Murray , Elsa J. Brochmann-Murray , Keyvan Behnam , Jeffrey C. Wang
发明人： Samuel S. Murray , Elsa J. Brochmann-Murray , Keyvan Behnam , Jeffrey C. Wang
IPC分类号： A61K38/10 , A61K38/12 , A61K38/18 , C07K4/12 , C07K5/12 , C07K14/51 , C07K14/495
CPC分类号： A61K38/12 , A61K35/12 , A61K35/32 , A61K38/10 , A61K38/1841 , A61K38/1875 , C07K7/64 , C07K14/47 , C07K14/51 , A61K2300/00
摘要： The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.

8. 发明授权

US07879096B2 Centrally driven expandable implant 有权
标题翻译：集中驱动的可扩张植入物
公开(公告)号：US07879096B2
公开(公告)日：2011-02-01
申请号：US11412751
申请日：2006-04-27
申请人： Andrew M. Dickson , James S. Harrop , Dean G. Karahalios , Eric A. Potts , Christopher I. Shaffrey , Jeffrey C. Wang
发明人： Andrew M. Dickson , James S. Harrop , Dean G. Karahalios , Eric A. Potts , Christopher I. Shaffrey , Jeffrey C. Wang
IPC分类号： A61F2/44
CPC分类号： A61F2/44 , A61F2/30744 , A61F2/4611 , A61F2002/2835 , A61F2002/30062 , A61F2002/3008 , A61F2002/30235 , A61F2002/30354 , A61F2002/30522 , A61F2002/3055 , A61F2002/30551 , A61F2002/30601 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30787 , A61F2002/30841 , A61F2002/4475 , A61F2002/449 , A61F2002/4627 , A61F2002/4628 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0069 , A61F2250/0098 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179
摘要： An expandable medical implant for supporting skeletal structures. The medical implant having a length along its expandable dimension. The implant having a first tubular member with a connection end, an opposite skeletal interface end, and a central expansion instrument opening. Also, the implant has a second tubular member with a connection end configured to engage with the connection end of the first tubular member. The second tubular member having an opposite skeletal interface end. Additionally, an expansion instrument is insertable through the central expansion instrument opening and expandable against the first tubular member and the connection end of the second tubular member to expand the medical implant. The combined first and second tubular members are of a greater dimension along the length of the implant than the combined first and second tubular members are in any dimension perpendicular to their length.
摘要翻译：用于支撑骨骼结构的可扩展医用植入物。医疗植入物沿其可扩张尺寸具有长度。所述植入物具有具有连接端的第一管状构件，相对的骨架界面端和中心扩张器械开口。此外，植入物具有第二管状构件，其具有构造成与第一管状构件的连接端接合的连接端。第二管状构件具有相对的骨架界面端。此外，膨胀仪器可以通过中央膨胀仪器开口插入并且能够抵靠第一管状构件和第二管状构件的连接端膨胀以扩展医用植入物。组合的第一和第二管状构件沿着植入物的长度具有更大的尺寸，而不是组合的第一和第二管状构件在任何尺寸上垂直于它们的长度。

9. 发明申请

US20090047360A1 Bone morphogenic protein binding peptide 有权
标题翻译：骨形态发生蛋白结合肽
公开(公告)号：US20090047360A1
公开(公告)日：2009-02-19
申请号：US11985745
申请日：2007-11-16
申请人： Samuel S. Murray , Elsa J. Murray , Jeffrey C. Wang , Keyvan Behnam
发明人： Samuel S. Murray , Elsa J. Murray , Jeffrey C. Wang , Keyvan Behnam
IPC分类号： A61K35/12 , C07K7/00 , A61P19/00 , C07H21/00
CPC分类号： A61L27/227 , A61K35/28 , A61K38/12 , A61K38/1841 , A61K38/1875 , A61L27/3821 , A61L27/3834 , A61L27/54 , A61L2400/18 , A61L2430/02 , C07K7/08 , C07K14/51 , C12N5/0668 , C12N2501/15 , C12N2501/155 , A61K2300/00
摘要： A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
摘要翻译：称为BMP结合肽（BBP）的环化肽是与内生形式的BBP一样强烈地结合rhBMP-2的合成肽，并且物种之间的序列保守性导致各种有用的BBP组合物。 BBP增加rhBMP-2的整体成骨活性，增加rhBMP-2诱导骨形成的速率，BBP单独诱导钙化。包括BBP的组合物和底物以及使用BBP的方法可用于需要钙化和成骨的治疗，诊断和临床应用。

10. 发明授权

US08193312B2 Bone morphogenic protein binding peptide 有权
标题翻译：骨形态发生蛋白结合肽
公开(公告)号：US08193312B2
公开(公告)日：2012-06-05
申请号：US11985745
申请日：2007-11-16
申请人： Samuel S. Murray , Elsa J. Murray , Jeffrey C. Wang , Keyvan Behnam
发明人： Samuel S. Murray , Elsa J. Murray , Jeffrey C. Wang , Keyvan Behnam
IPC分类号： C07K4/12 , C07K5/12 , C07K14/51 , C07K14/495 , A61K38/10 , A61K38/12 , A61K38/18 , A61F2/26 , A61P19/00
CPC分类号： A61L27/227 , A61K35/28 , A61K38/12 , A61K38/1841 , A61K38/1875 , A61L27/3821 , A61L27/3834 , A61L27/54 , A61L2400/18 , A61L2430/02 , C07K7/08 , C07K14/51 , C12N5/0668 , C12N2501/15 , C12N2501/155 , A61K2300/00
摘要： A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
摘要翻译：称为BMP结合肽（BBP）的环化肽是与内生形式的BBP一样强烈地结合rhBMP-2的合成肽，并且物种之间的序列保守性导致各种有用的BBP组合物。 BBP增加rhBMP-2的整体成骨活性，增加rhBMP-2诱导骨形成的速率，BBP单独诱导钙化。包括BBP的组合物和底物以及使用BBP的方法可用于需要钙化和成骨的治疗，诊断和临床应用。

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