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1. 发明授权

US5986176A Transgenic plants expressing biocidal proteins 失效
标题翻译：表达杀生物蛋白的转基因植物
公开(公告)号：US5986176A
公开(公告)日：1999-11-16
申请号：US777113
申请日：1996-12-30
申请人： Willem Frans Broekaert , Bruno Phillippe Angelo Cammue , Sarah Bronwen Rees , Jozef Vanderleyden
发明人： Willem Frans Broekaert , Bruno Phillippe Angelo Cammue , Sarah Bronwen Rees , Jozef Vanderleyden
IPC分类号： A01N65/20 , A01N65/32 , A01N65/38 , A01N65/44 , A61K38/00 , C07K14/415 , C12N15/82 , C12N5/14
CPC分类号： C12N15/8281 , A01N65/20 , A01N65/32 , A01N65/38 , A01N65/44 , C07K14/415 , C12N15/8282 , A61K38/00
摘要： Biocidal proteins capable of isolation from seeds have been characterized. The proteins have an amino acid sequence containing the common cysteine/glycine domain of Chitin-binding Plant Proteins but show substantially better activity against pathogenic fungi, a higher ratio of basic amino acids to acidic amino acids, and/or antifungal activity which results in increased hyphal branching. Antimicrobial proteins isolated from Amaranthus, Capsicum, Briza and related species are provided. The proteins show a wide range of antifungal activity and are active against Gram-positive bacteria. DNA encoding the proteins may be isolated and incorporated into vectors. Plants may be transformed with this DNA. The proteins find agricultural or pharmaceutical application as antifungal or antibacterial agents. Transgenic plants expressing the protein will show increased disease resistance.
摘要翻译：已经表征了能够从种子中分离的杀生物蛋白质。蛋白质具有含有几丁质结合植物蛋白质的共同半胱氨酸/甘氨酸结构域的氨基酸序列，但对病原真菌显示出更好的活性，碱性氨基酸与酸性氨基酸的比例更高，和/或抗真菌活性增加菌丝分枝。提供了从苋属，辣椒，Briza和相关物种分离的抗菌蛋白质。蛋白质显示出广泛的抗真菌活性，并且对革兰氏阳性菌具有活性。编码蛋白质的DNA可以被分离并并入载体中。可以用这种DNA转化植物。蛋白质发现农业或药物应用作为抗真菌剂或抗菌剂。表达蛋白质的转基因植物将显示出增加的抗病性。

2. 发明授权

US5691199A DNA encoding biocidal proteins 失效
标题翻译：编码杀生物蛋白的DNA
公开(公告)号：US5691199A
公开(公告)日：1997-11-25
申请号：US451566
申请日：1995-05-26
申请人： Willem Frans Broekaert , Bruno Philippe Angelo Cammue , Sarah Bronwen Rees , Jozef Vanderleyden
发明人： Willem Frans Broekaert , Bruno Philippe Angelo Cammue , Sarah Bronwen Rees , Jozef Vanderleyden
IPC分类号： A01N65/20 , A01N65/32 , A01N65/38 , A01N65/44 , A61K38/00 , C07K14/415 , C12N15/82 , C12N15/29
CPC分类号： C12N15/8281 , A01N65/20 , A01N65/32 , A01N65/38 , A01N65/44 , C07K14/415 , C12N15/8282 , A61K38/00
摘要： Biocidal proteins capable of isolation from seeds have been characterized. The proteins have an amino acid sequence containing the common cysteine/glycine domain of Chitin-binding Plant Proteins but show substantially better activity against pathogenic fungi, a higher ratio of basic amino acids to acidic amino acids, and/or antifungal activity which results in increased hyphal branching. Antimicrobial proteins isolated from Amaranthus, Capsicum, Briza and related species are provided. The proteins show a wide range of antifungal activity and are active against Gram-positive bacteria. DNA encoding the proteins may be isolated and incorporated into vectors. Plants may be transformed with this DNA. The proteins find agricultural or pharmaceutical application as antifungal or antibacterial agents. Transgenic plants expressing the protein will show increased disease resistance.
摘要翻译：已经表征了能够从种子中分离的杀生物蛋白质。蛋白质具有含有几丁质结合植物蛋白质的共同半胱氨酸/甘氨酸结构域的氨基酸序列，但对病原真菌显示出更好的活性，碱性氨基酸与酸性氨基酸的比例更高，和/或抗真菌活性增加菌丝分枝。提供了从苋属，辣椒，Briza和相关物种分离的抗菌蛋白质。蛋白质显示出广泛的抗真菌活性，并且对革兰氏阳性菌具有活性。编码蛋白质的DNA可以被分离并并入载体中。可以用这种DNA转化植物。蛋白质发现农业或药物应用作为抗真菌剂或抗菌剂。表达蛋白质的转基因植物将显示出增加的抗病性。

3. 发明授权

US5689048A Biocidal proteins 失效
标题翻译：杀生物蛋白
公开(公告)号：US5689048A
公开(公告)日：1997-11-18
申请号：US471329
申请日：1995-06-02
申请人： Miguel De Bolle , Willem Frans Broekaert , Bruno Philippe Angelo Cammue , Sarah Bronwen Rees , Jozef Vanderleyden
发明人： Miguel De Bolle , Willem Frans Broekaert , Bruno Philippe Angelo Cammue , Sarah Bronwen Rees , Jozef Vanderleyden
IPC分类号： A01H5/00 , A01N65/08 , A61K38/00 , A61P31/04 , C07K14/00 , C07K14/415 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/29 , C12N15/82 , C12P21/02 , C12N5/04
CPC分类号： C12N15/8282 , A01N65/08 , C07K14/415 , C12N15/8281
摘要： Biocidal proteins isolated from Mirabilis have been characterised. The proteins show a wide range of antifungal activity and are active against gram-positive bacteria. DNA encoding the proteins has been isolated and incorporated into vectors. Plants transformed with this DNA have been produced. The proteins find commercial application as antifungal or antibacterial agents; transformed plants will show increased disease-resistance.
摘要翻译：已经描述了从Mirabilis分离的杀生物蛋白质。蛋白质显示出广泛的抗真菌活性，并且对革兰氏阳性细菌具有活性。编码蛋白质的DNA已被分离并并入载体中。已经生产了用该DNA转化的植物。蛋白质作为抗真菌剂或抗菌剂找到商业应用; 转化的植物将显示增加的抗病性。

4. 发明授权

US5942663A Biocidal proteins 失效
标题翻译：杀生物蛋白
公开(公告)号：US5942663A
公开(公告)日：1999-08-24
申请号：US915142
申请日：1997-08-20
申请人： Miguel De Bolle , Willem Frans Broekaert , Bruno Philippe Angelo Cammue , Sarah Bronwen Rees , Jozef Vanderleyden
发明人： Miguel De Bolle , Willem Frans Broekaert , Bruno Philippe Angelo Cammue , Sarah Bronwen Rees , Jozef Vanderleyden
IPC分类号： A01H5/00 , A01N65/08 , A61K38/00 , A61P31/04 , C07K14/00 , C07K14/415 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/29 , C12N15/82 , C12P21/02 , C12N15/70 , C12N15/74
CPC分类号： C12N15/8282 , A01N65/08 , C07K14/415 , C12N15/8281
摘要： Biocidal proteins isolated from Mirabilis have been characterized. The proteins show a wide range of antifungal activity and are active against gram-positive bacteria. DNA encoding the proteins has been isolated and incorporated into vectors. Plants transformed with this DNA have been produced. The proteins find commercial application as antifungal or antibacterial agents; transformed plants will show increased disease-resistance.
摘要翻译：已经描述了从Mirabilis分离的杀生物蛋白质。蛋白质显示出广泛的抗真菌活性，并且对革兰氏阳性细菌具有活性。编码蛋白质的DNA已被分离并并入载体中。已经生产了用该DNA转化的植物。蛋白质作为抗真菌剂或抗菌剂找到商业应用; 转化的植物将显示增加的抗病性。

5. 发明授权

US06521590B1 Biocidal proteins 失效
标题翻译：杀生物蛋白
公开(公告)号：US06521590B1
公开(公告)日：2003-02-18
申请号：US09298574
申请日：1999-04-29
申请人： Willem Frans Broekaert , Bruno Philippe Angelo Cammue , Rupert William Osborn , Sarah Bronwen Rees , Jozef Vanderleyden
发明人： Willem Frans Broekaert , Bruno Philippe Angelo Cammue , Rupert William Osborn , Sarah Bronwen Rees , Jozef Vanderleyden
IPC分类号： A61K3808
CPC分类号： C12N15/8281 , A01N65/20 , A01N65/32 , A01N65/38 , A01N65/44 , A61K38/00 , C07K14/415 , C12N15/8282
摘要： Biocidal proteins capable of isolation from seeds have been characterized. The proteins have an amino acid sequence containing the common cysteine/glycine domain of Chitin-binding Plant Proteins but show substantially better activity against pathogenic fungi, a higher ratio of basic amino acids to acidic amino acids, and/or antifungal activity which results in increased hyphal branching. Antimicrobial proteins isolated from Amaranthus, Capsicum, Briza and related species are provided. The proteins show a wide range of antifungal activity and are active against Gram-positive bacteria. DNA encoding the proteins may be isolated and incorporated into vectors. Plants may be transformed with this DNA. The proteins find agricultural or pharmaceutical application as antifungal or antibacterial agents. Transgenic plants expressing the protein will show increased disease resistance.
摘要翻译：已经表征了能够从种子中分离的杀生物蛋白质。蛋白质具有含有几丁质结合植物蛋白质的共同半胱氨酸/甘氨酸结构域的氨基酸序列，但对病原真菌显示出更好的活性，碱性氨基酸与酸性氨基酸的比例更高，和/或抗真菌活性增加菌丝分枝。提供了从苋属，辣椒，Briza和相关物种分离的抗菌蛋白质。蛋白质显示出广泛的抗真菌活性，并且对革兰氏阳性菌具有活性。编码蛋白质的DNA可以被分离并并入载体中。可以用这种DNA转化植物。蛋白质发现农业或药物应用作为抗真菌剂或抗菌剂。表达蛋白质的转基因植物将显示出增加的抗病性。

6. 发明授权

US5597801A Biocidal proteins 失效
标题翻译：杀生物蛋白
公开(公告)号：US5597801A
公开(公告)日：1997-01-28
申请号：US451568
申请日：1995-05-26
申请人： Willem F. Broekaert , Bruno P. A. Cammue , Sarah B. Rees , Jozef Vanderleyden
发明人： Willem F. Broekaert , Bruno P. A. Cammue , Sarah B. Rees , Jozef Vanderleyden
IPC分类号： A01N65/20 , A01N65/32 , A01N65/38 , A01N65/44 , A61K38/00 , C07K14/415 , C12N15/82 , A01N63/00 , A01N65/00 , A61K38/16
CPC分类号： C12N15/8281 , A01N65/20 , A01N65/32 , A01N65/38 , A01N65/44 , C07K14/415 , C12N15/8282 , A61K38/00
摘要： Biocidal proteins capable of isolation from seeds have been characterized. The proteins have an amino acid sequence containing the common cysteine/glycine domain of Chitin-binding Plant Proteins but show substantially better activity against pathogenic fungi, a higher ratio of basic amino acids to acidic amino acids, and/or antifungal activity which results in increased hyphal branching. Antimicrobial proteins isolated from Amaranthus, Capsicum, Briza and related species are provided. The proteins show a wide range of antifungal activity and are active against Gram-positive bacteria. DNA encoding the proteins may be isolated and incorporated into vectors. Plants may be transformed with this DNA. The proteins find agricultural or pharmaceutical application as antifungal or antibacterial agents. Transgenic plants expressing the protein will show increased disease resistance.
摘要翻译：已经表征了能够从种子中分离的杀生物蛋白质。蛋白质具有含有几丁质结合植物蛋白质的共同半胱氨酸/甘氨酸结构域的氨基酸序列，但对病原真菌显示出更好的活性，碱性氨基酸与酸性氨基酸的比例更高，和/或抗真菌活性增加菌丝分枝。提供从苋属，辣椒，布里扎和相关物种分离的抗菌蛋白质。蛋白质显示出广泛的抗真菌活性，并且对革兰氏阳性菌具有活性。编码蛋白质的DNA可以被分离并并入载体中。可以用这种DNA转化植物。蛋白质发现农业或药物应用作为抗真菌剂或抗菌剂。表达蛋白质的转基因植物将显示出增加的抗病性。

7. 发明申请

US20130029981A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR CONTROLLING BIOFILMS 有权
标题翻译：化合物，组合物和控制生物体的方法
公开(公告)号：US20130029981A1
公开(公告)日：2013-01-31
申请号：US13526235
申请日：2012-06-18
申请人： Sigrid De Keersmaecker , Dirk De Vos , Denis Ermolatev , Hans Steenackers , Erik Van Der Eycken , Jozef Vanderleyden , Bharat S. Savaliya
发明人： Sigrid De Keersmaecker , Dirk De Vos , Denis Ermolatev , Hans Steenackers , Erik Van Der Eycken , Jozef Vanderleyden , Bharat S. Savaliya
IPC分类号： C07D233/88 , C07D487/04 , C07D405/12 , C07D403/12 , C07D409/14 , C07D413/14 , C07D239/42 , A61K31/4168 , A01N43/50 , A61K31/454 , A61K31/519 , A01N43/90 , A61K31/5377 , A01N43/84 , A61P31/00 , A01P1/00 , A61P31/04 , C07D401/12
CPC分类号： C07D233/88 , C07D405/12 , C07D409/04 , C07D487/04
摘要： The invention relates to substituted 2-aminoimidazoles and their imidazo[1,2-a]pyrimidinium salts precursors being active against biofilm formation. The invention also relates to imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent, and to substituted 2-aminoimidazoles wherein the amino group bears a terminal heterocyclic group such as a triazolyl group which are formed through azide-alkyne Huisgen cycloaddition starting from said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to a class of N-(azidoalkyl)pyrimidin-2-amines useful as starting materials for the synthesis of said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to antimicrobial compositions that include a microbial biofilm formation inhibiting amount of such substituted 2-aminoimidazoles or imidazo[1,2-a]pyrimidinium salts in combination with excipients. Methods for inhibiting or controlling microbial biofilm formation in a plant, a body part of a human or an animal, or a surface with which a human or an animal may come into contact are also disclosed.
摘要翻译：本发明涉及取代的2-氨基咪唑及其对生物膜形成有活性的咪唑并[1,2-a]嘧啶鎓盐前体。本发明还涉及带有叠氮基烷基取代基的咪唑并[1,2-a]嘧啶鎓盐以及取代的2-氨基咪唑，其中氨基具有通过叠氮基炔代Huisgen环加成反应形成的末端杂环基，例如三唑基由具有叠氮基烷基取代基的咪唑并[1,2-a]嘧啶鎓盐制得。本发明还涉及可用作合成具有叠氮基烷基取代基的所述咪唑并[1,2-a]嘧啶鎓盐的起始原料的一类N-（叠氮基烷基）嘧啶-2-胺。本发明还涉及抗微生物组合物，其包括微生物生物膜形成抑制量的这种取代的2-氨基咪唑或咪唑并[1,2-a]嘧啶鎓盐与赋形剂的组合。还公开了抑制或控制植物，人或动物的身体部位或人或动物可能接触的表面的微生物生物膜形成的方法。

8. 发明授权

US06187904B1 Biocidal proteins 失效
标题翻译：杀生物蛋白
公开(公告)号：US06187904B1
公开(公告)日：2001-02-13
申请号：US08971982
申请日：1997-11-17
申请人： Willem F. Broekaert , Bruno P. A. Cammue , Rupert W. Osborn , Sarah B. Rees , Franky R. G. Terras , Jozef Vanderleyden
发明人： Willem F. Broekaert , Bruno P. A. Cammue , Rupert W. Osborn , Sarah B. Rees , Franky R. G. Terras , Jozef Vanderleyden
IPC分类号： C07K1400
CPC分类号： A01N37/46 , A01N65/08 , A01N65/12 , C07K14/415 , C12N15/8281 , C12N15/8282
摘要： Biocidal proteins isolated from seeds have been characterised, in particular proteins isolated from members of the Brassicaceae, Compositae and Leguminosae families including Raphanus, Brassica, Sinapis, Arabidopsis, Dahlia, Cnicus, Lathyrus and Clitoria. The proteins show a wide range of antifungal activity and some are active against Gram-positive bacteria. All share a common amino acid sequence. DNA encoding the proteins has been isolated and incorporated into vectors. Plants transformed with this DNA may be produced. The proteins find commercial application as antifungal or antibacterial agents; transformed plants will show increased disease-resistance.
摘要翻译：已经表征了从种子中分离的杀生物蛋白质，特别是从甘蓝科，菊科和豆科科的成员中分离出的蛋白质，包括蔷薇属（Raphanus），芸苔属（Brassica），辛纳皮（Sinapis），拟南芥，拟南芥，大丽花，哥伦布，火山灰和枸杞子。蛋白质显示出广泛的抗真菌活性，一些对革兰氏阳性菌具有活性。全部共有氨基酸序列。编码蛋白质的DNA已被分离并并入载体中。可以生产用该DNA转化的植物。蛋白质作为抗真菌剂或抗菌剂找到商业应用; 转化的植物将显示增加的抗病性。

9. 发明授权

US5538525A Biocidal proteins 失效
标题翻译：杀生物蛋白
公开(公告)号：US5538525A
公开(公告)日：1996-07-23
申请号：US377687
申请日：1995-01-25
申请人： Willem F. Broekaert , Bruno P. A. Cammue , Rupert W. Osborn , Sarah B. Rees , Franky R. G. Terras , Jozef Vanderleyden
发明人： Willem F. Broekaert , Bruno P. A. Cammue , Rupert W. Osborn , Sarah B. Rees , Franky R. G. Terras , Jozef Vanderleyden
IPC分类号： A01N37/46 , A01N65/12 , A01N65/20 , C07K14/415 , C12N15/29 , C12N15/82 , A01N37/18
CPC分类号： A01N37/46 , A01N65/08 , A01N65/12 , C07K14/415 , C12N15/8281 , C12N15/8282
摘要： Biocidal proteins isolated from seeds have been characterised, in particular proteins isolated from members of the Brassicaceae, Compositae and Leguminosae families including Raphanus, Brassica, Sinapis, Arabidopsis, Dahlia, Cnicus, Lathyrus and Clitoria. The proteins show a wide range of antifungal activity and some are active against Gram-positive bacteria. All share a common amino acid sequence. DNA encoding the proteins has been isolated and incorporated into vectors. Plants transformed with this DNA may be produced. The proteins find commercial application as antifungal or antibacterial agents; transformed plants will show increased disease-resistance.
摘要翻译：已经表征了从种子中分离的杀生物蛋白质，特别是从甘蓝科，菊科和豆科科的成员中分离出的蛋白质，其中包括Raphanus，Brassica，Sinapis，Arabidopsis，Dahlia，Cnicus，Lathyrus和Clitoria。蛋白质显示出广泛的抗真菌活性，一些对革兰氏阳性菌具有活性。全部共有氨基酸序列。编码蛋白质的DNA已被分离并并入载体中。可以生产用该DNA转化的植物。蛋白质作为抗真菌剂或抗菌剂找到商业应用; 转化的植物将显示增加的抗病性。

10. 发明授权

US08906915B2 Compounds, compositions, and methods for controlling biofilms 有权
标题翻译：用于控制生物膜的化合物，组合物和方法
公开(公告)号：US08906915B2
公开(公告)日：2014-12-09
申请号：US13526235
申请日：2012-06-18
申请人： Sigrid De Keersmaecker , Dirk De Vos , Denis Ermolatev , Hans Steenackers , Erik Van Der Eycken , Jozef Vanderleyden , Bharat S. Savaliya
发明人： Sigrid De Keersmaecker , Dirk De Vos , Denis Ermolatev , Hans Steenackers , Erik Van Der Eycken , Jozef Vanderleyden , Bharat S. Savaliya
IPC分类号： A61K31/535 , C07D487/04 , C07D405/12 , C07D233/88 , C07D409/04
CPC分类号： C07D233/88 , C07D405/12 , C07D409/04 , C07D487/04
摘要： The invention relates to substituted 2-aminoimidazoles and their imidazo[1,2-a]pyrimidinium salts precursors being active against biofilm formation. The invention also relates to imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent, and to substituted 2-aminoimidazoles wherein the amino group bears a terminal heterocyclic group such as a triazolyl group which are formed through azide-alkyne Huisgen cycloaddition starting from said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to a class of N-(azidoalkyl)pyrimidin-2-amines useful as starting materials for the synthesis of said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to antimicrobial compositions that include a microbial biofilm formation inhibiting amount of such substituted 2-aminoimidazoles or imidazo[1,2-a]pyrimidinium salts in combination with excipients. Methods for inhibiting or controlling microbial biofilm formation in a plant, a body part of a human or an animal, or a surface with which a human or an animal may come into contact are also disclosed.
摘要翻译：本发明涉及取代的2-氨基咪唑及其对生物膜形成有活性的咪唑并[1,2-a]嘧啶鎓盐前体。本发明还涉及带有叠氮基烷基取代基的咪唑并[1,2-a]嘧啶鎓盐以及取代的2-氨基咪唑，其中氨基具有通过叠氮基炔代Huisgen环加成反应形成的末端杂环基，例如三唑基由具有叠氮基烷基取代基的咪唑并[1,2-a]嘧啶鎓盐制得。本发明还涉及可用作合成具有叠氮基烷基取代基的所述咪唑并[1,2-a]嘧啶鎓盐的起始原料的一类N-（叠氮基烷基）嘧啶-2-胺。本发明还涉及抗微生物组合物，其包括微生物生物膜形成抑制量的这种取代的2-氨基咪唑或咪唑并[1,2-a]嘧啶鎓盐与赋形剂的组合。还公开了抑制或控制植物，人或动物的身体部位或人或动物可能接触的表面的微生物生物膜形成的方法。

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