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1. 发明授权

US6103720A Ketobenzamides as calpain inhibitors 有权
标题翻译：酮苯甲酰胺作为钙蛋白酶抑制剂
公开(公告)号：US6103720A
公开(公告)日：2000-08-15
申请号：US319511
申请日：1999-06-08
申请人： Wilfried Lubisch , Achim Moller , Hans-Jorg Treiber
发明人： Wilfried Lubisch , Achim Moller , Hans-Jorg Treiber
IPC分类号： C07D295/12 , A61K31/16 , A61K31/166 , A61K31/381 , A61K31/40 , A61K31/4164 , A61K31/4402 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4468 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/498 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/87 , C07C237/22 , C07C237/36 , C07C237/42 , C07C311/19 , C07C311/21 , C07D211/58 , C07D213/56 , C07D215/12 , C07D215/36 , C07D215/48 , C07D233/54 , C07D233/61 , C07D241/42 , C07D241/44 , C07D295/02 , C07D295/13 , C07D333/38 , C07D333/56 , C07D333/60 , C07D401/12 , C07D521/00 , C07K5/02 , A61K31/535 , A61K31/21 , C07D241/36
CPC分类号： C07D295/13 , C07C237/36 , C07C311/19 , C07C311/21 , C07D211/58 , C07D213/56 , C07D215/12 , C07D215/36 , C07D215/48 , C07D231/12 , C07D233/56 , C07D241/42 , C07D241/44 , C07D249/08 , C07D333/38 , C07D333/60 , C07K5/0205
摘要： The patent describes ketobenzamides of the formula ##STR1## where R1, R2, R3, R4, X and n have the meanings given in the description, and their preparation. The novel compounds are useful for controlling disorders.
摘要翻译： PCT No.PCT / EP97 / 06655 Sec。 371 1999年6月8日第 102（e）日期1999年6月8日PCT 1997年11月28日PCT公布。出版物WO98 / 25883 日期1998年6月18日该专利描述了下式的酮苯甲酰胺，其中R1，R2，R3，R4，X和n具有说明书中给出的含义及其制备。新化合物可用于控制疾病。

2. 发明申请

US20080113989A1 Novel substituted amides, their preparation and use 有权
标题翻译：新型取代酰胺，其制备和用途
公开(公告)号：US20080113989A1
公开(公告)日：2008-05-15
申请号：US11897057
申请日：2007-08-29
申请人： Wilfried Lubisch , Achim Moller , Hans-Jorg Treiber , Monika Knopp
发明人： Wilfried Lubisch , Achim Moller , Hans-Jorg Treiber , Monika Knopp
IPC分类号： A61K31/5375 , A61K31/195 , A61P19/02 , A61P25/28 , A61P35/00 , A61P37/00 , A61P9/10 , C07C233/76 , C07D265/30
CPC分类号： C07D213/82 , A61K31/195 , A61K31/5375 , C07C229/38 , C07C237/22 , C07C237/32 , C07C2601/14 , C07D295/155
摘要： An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts.
摘要翻译：式I的酰胺及其互变异构形式，可能的对映体和非对映体形式，E和Z形式以及可能的生理上耐受的盐。

3. 发明授权

US09062027B2 Carboxamide compounds and their use as calpain inhibitors V 有权
标题翻译：羧酰胺化合物及其作为钙蛋白酶抑制剂的用途
公开(公告)号：US09062027B2
公开(公告)日：2015-06-23
申请号：US13992582
申请日：2011-12-08
申请人： Andreas Kling , Katja Jantos , Helmut Mack , Achim Moller , Wilfried Hornberger , Yanbin Lao , Gisela Backfisch , Marjoleen Nijsen
发明人： Andreas Kling , Katja Jantos , Helmut Mack , Achim Moller , Wilfried Hornberger , Yanbin Lao , Gisela Backfisch , Marjoleen Nijsen
IPC分类号： C07D401/14 , C07D401/04 , A61K31/4439 , A61P25/28
CPC分类号： C07D401/04 , A61K31/4439 , C07D401/14 , Y02A50/411
摘要： The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R1, R2, R3, R4, X, m and n have the meanings mentioned in the claims and the description, the tautomers thereof, the hydrates thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein R1 is optionally substituted benzyl or hetaryl-methyl, X is a single bond or an oxygen atom, R2 is C1-C4-alkyl, C1-C4-haloalkyl, C2-C4-alkenyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C2-alkyl, C3-C6-heterocycloalkyl-C1-C2-alkyl, phenyl, phenyl-C1-C3-alkyl, pyridin-2-yl-C1-C3-alkyl or CH2—C(O)OCH3, R3 and R4 independently of one another are halogen, CN, CF3, CHF2, CH2F, C1-C2-alkyl or C1-C2-alkoxy, and m and n independently of one another are 0 or 1.
摘要翻译：本发明涉及新的羧酰胺化合物及其用于制备药物的用途。羧酰胺化合物是钙蛋白酶（钙依赖性半胱氨酸蛋白酶）的抑制剂。因此，本发明还涉及这些羧酰胺化合物用于治疗与升高的钙蛋白酶活性相关的病症的用途。羧酰胺化合物是通式（I）的化合物，其中R 1，R 2，R 3，R 4，X，m和n具有权利要求书和描述中所述的含义，其互变异构体，其水合物和药学上合适的盐其中。在这些化合物中，优选其中R 1为任选取代的苄基或杂芳基 - 甲基，X为单键或氧原子，R 2为C 1 -C 4烷基，C 1 -C 4卤代烷基，C 2 -C 4 - 烯基，C 3 -C 6 环烷基，C 3 -C 6环烷基-C 1 -C 2烷基，C 3 -C 6杂环烷基-C 1 -C 2烷基，苯基，苯基-C 1 -C 3 - 烷基，吡啶-2-基-C 1 -C 3 - 烷基或CH 2 -C（O）OCH 3，R 3和R 4彼此独立地是卤素，CN，CF 3，CHF 2，CH 2 F，C 1 -C 2 - 烷基或C 1 -C 2 - 烷氧基，m和n彼此独立地为0或1。

4. 发明授权

US5686175A Recycled wood product with platelets 失效
标题翻译：回收木制品与血小板
公开(公告)号：US5686175A
公开(公告)日：1997-11-11
申请号：US416759
申请日：1995-07-25
申请人： Achim Moller
发明人： Achim Moller
IPC分类号： B27L11/02 , B27N1/00 , B32B5/16 , B32C17/00
CPC分类号： B27L11/02 , B27N1/00 , Y10S241/38 , Y10T428/253
摘要： A recycled wood product is formed from wood products originally made from first cut wood. The recycled wood product is formed by removing external fittings, if any, projecting from the original, wood product and thereafter chipping the original wood product into platelets which are thereafter assembled in layers, glued together and then pressed together. Any excess formaldehyde in the original wood product is removed by the addition of urea. Machinery to practice the process includes a chipping tool which chips the original product into platelets as the original wood product is advanced against the chipping tool on a movable support structure.
摘要翻译：回收木材产品由原始由第一切割木材制成的木制品形成。回收的木制品通过从原始木制品中除去外部配件（如果有的话）而形成，然后将原始木制品切碎成小片，然后将其组装成层，粘合在一起然后压在一起。通过添加尿素来除去原始木制品中的任何多余的甲醛。实施该过程的机器包括一种切屑工具，当原始木制品在可移动支撑结构上抵靠切屑工具前进时，将原始产品切割成血小板。

5. 发明申请

US20140005227A1 CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V 有权
标题翻译：羧酰胺化合物及其作为钙抑制剂V
公开(公告)号：US20140005227A1
公开(公告)日：2014-01-02
申请号：US13992582
申请日：2011-12-08
申请人： Andreas Kling , Katja Jantos , Helmut Mack , Achim Moller , Wilfried Hornberger , Yanbin Lao , Gisela Backfisch , Marjoleen Nijsen
发明人： Andreas Kling , Katja Jantos , Helmut Mack , Achim Moller , Wilfried Hornberger , Yanbin Lao , Gisela Backfisch , Marjoleen Nijsen
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , A61K31/4439 , C07D401/14 , Y02A50/411
摘要： The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R1, R2, R3, R4, X, m and n have the meanings mentioned in the claims and the description, the tautomers thereof, the hydrates thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein R1 is optionally substituted benzyl or hetaryl-methyl, X is a single bond or an oxygen atom, R2 is C1-C4-alkyl, C1-C4-haloalkyl, C2-C4-alkenyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C2-alkyl, C3-C6-heterocycloalkyl-C1-C2-alkyl, phenyl, phenyl-C1-C3-alkyl, pyridin-2-yl-C1-C3-alkyl or CH2—C(O)OCH3, R3 and R4 independently of one another are halogen, CN, CF3, CHF2, CH2F, C1-C2-alkyl or C1-C2-alkoxy, and m and n independently of one another are 0 or 1.
摘要翻译：本发明涉及新的羧酰胺化合物及其用于制备药物的用途。羧酰胺化合物是钙蛋白酶（钙依赖性半胱氨酸蛋白酶）的抑制剂。因此，本发明还涉及这些羧酰胺化合物用于治疗与升高的钙蛋白酶活性相关的病症的用途。羧酰胺化合物是通式（I）的化合物，其中R 1，R 2，R 3，R 4，X，m和n具有权利要求书和描述中所述的含义，其互变异构体，其水合物和药学上合适的盐其中。在这些化合物中，优选其中R 1为任选取代的苄基或杂芳基 - 甲基，X为单键或氧原子，R 2为C 1 -C 4烷基，C 1 -C 4卤代烷基，C 2 -C 4 - 烯基，C 3 -C 6 环烷基，C 3 -C 6环烷基-C 1 -C 2烷基，C 3 -C 6杂环烷基-C 1 -C 2烷基，苯基，苯基-C 1 -C 3 - 烷基，吡啶-2-基-C 1 -C 3 - 烷基或CH 2 -C（O）OCH 3，R 3和R 4彼此独立地是卤素，CN，CF 3，CHF 2，CH 2 F，C 1 -C 2 - 烷基或C 1 -C 2 - 烷氧基，m和n彼此独立地为0或1。

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