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    • 7. 发明授权
    • Heteroarylethanol-pyridylalkylamines for controlling animal growth
    • 用于控制动物生长的杂芳基乙醇 - 吡啶基烷基胺
    • US5028617A
    • 1991-07-02
    • US467593
    • 1990-01-19
    • Hans LindelWerner HallenbachFriedrich BerschauerHeinrich A. GreifeGernot Klotz
    • Hans LindelWerner HallenbachFriedrich BerschauerHeinrich A. GreifeGernot Klotz
    • A23K1/16A61K31/44A61K31/4402A61K31/4406A61K31/4409A61K31/4418A61P3/04C07D213/38C07D213/61C07D213/64C07D213/65C07D213/73C07D213/80
    • C07D213/64C07D213/38C07D213/61C07D213/65C07D213/73C07D213/80
    • A compound for promoting livestock production and for controlling obesity in humans and animals, of the formula ##STR1## in which A represents .dbd.CH-- or .dbd.N--,R.sup.0 represents hydrogen or methyl,R.sup.1 and R.sup.3 each independently represents hydrogen, hydroxyl, halogen, cyano, alkyl, halogenoalkyl, hydroxyalkyl, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, halogenoalkoxy, halogenoalkylthio, NHSO.sub.2 -alkyl,R.sup.2 represents hydrogen, hydroxyl, alkoxy or the radical --NR.sup.5 R.sup.6,R.sup.4 represents hydrogen, C.sub.1 -C.sub.10 -alkyl which is optionally substituted by hydroxyl, halogen, alkoxy, acyloxy or the radical --NH.sup.7 R.sup.8, or represents the radical COR.sup.9 or the radical --O--Z--R.sup.10,Z represents C.sub.1 -C.sub.10 -alkylene, -alkenylene or alkynylene,R.sup.5 represents hydrogen or alkyl,R.sup.6 represents hydrogen, alkyl, halogenoalkyl or acyl, or R.sup.5 and R.sup.6 together with the adjoining N atom form a saturated or unsaturated heterocyclic 4-, 5- or 6-membered ring,R.sup.7 and R.sup.8 each independently represents hydrogen, optionally substituted alkyl, optionally substituted aryl,R.sup.9 represents hydroxyl, alkoxy or the radical --NR.sup.7 R.sup.8,R.sup.10 represents hydroxyl, alkoxy, acyloxy, optionally substituted aryloxy or aralkyloxy,with the substituent R.sup.4 and the alkylamino group in the pyridyl ring of the formula I being in the p position with respect to one another, or a physiologically tolerated salt thereof, or, if A represents nitrogen, optionally the N-oxide thereof.
    • 一种用于促进家畜生产和控制人和动物肥胖的化合物,其中A表示= CH-或= N-,R0表示氢或甲基,R1和R3各自独立地表示氢, 羟基,卤素,氰基,烷基,卤代烷基,羟基烷基,烷氧基羰基,氨基羰基,一烷基氨基羰基和二烷基氨基羰基,烷氧基,卤代烷氧基,卤代烷硫基,NHSO2-烷基,R2代表氢,羟基,烷氧基或基-NR5R6,R4代表氢,C1- 任选被羟基,卤素,烷氧基,酰氧基或基团-NH 7 R 8取代的C 10 - 烷基,或表示基团COR 9或基团-OZ-R 10,Z表示C 1 -C 10 - 亚烷基, - 亚烯基或亚炔基,R 5表示氢 或烷基,R 6表示氢,烷基,卤代烷基或酰基,或R 5和R 6与相邻的N原子一起形成饱和或不饱和的4-,5-或6-元环,R 7和R 8各自独立地表示氢, 取代的烷基,任选取代的芳基,R 9表示羟基,烷氧基或基团-NR 7 R 8,R 10表示羟基,烷氧基,酰氧基,任选取代的芳氧基或芳烷氧基,式I的吡啶环中的取代基R4和烷基氨基在 相对于彼此的p位置或其生理上耐受的盐,或者如果A表示氮,则任选地其N-氧化物。
    • 9. 发明授权
    • (2-aminopropyl) pyridines useful as intermediates
    • (2-氨基丙基)吡啶可用作中间体
    • US5216170A
    • 1993-06-01
    • US677020
    • 1991-03-28
    • Hans LindelWerner HallenbachFriedrich BerschauerHeinrich A. GreifeGernot Klotz
    • Hans LindelWerner HallenbachFriedrich BerschauerHeinrich A. GreifeGernot Klotz
    • C07D213/38C07D213/61C07D213/64C07D213/65C07D213/73C07D213/80
    • C07D213/64C07D213/38C07D213/61C07D213/65C07D213/73C07D213/80
    • A compound for promoting livestock production and for controlling obesity in humans and animals, of the formula ##STR1## in which A represents .dbd.CH-- or .dbd.N--,R.sup.0 represents hydrogen or methyl,R.sup.1 and R.sup.3 each independently represents hydrogen, hydroxyl, halogen, cyano, alkyl, halogenoalkyl, hydroxyalkyl, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, halogenoalkoxy, halogenoalkylthio, NHSO.sub.2 -alkyl,R.sup.2 represents hydrogen, hydroxyl, alkoxy or the radical --NR.sup.5 R.sup.6,R.sup.4 represents hydrogen, C.sub.1 -C.sub.10 -alkyl which is optionally substituted by hydroxyl, halogen, alkoxy, acyloxy or the radical --NR.sup.7 R.sup.8, or represents the radical COR.sup.9 or the radical --O--Z--R.sup.10,Z represents C.sub.1 -C.sub.10 -alkylene, -alkenylene or alkynylene,R.sup.5 represents hydrogen or alkyl,R.sup.6 represents hydrogen, alkyl, halogenoalkyl or acyl, or R.sup.5 and R.sup.6 together with the adjoining N atom form a saturated or unsaturated heterocyclic 4-, 5- or 6-membered ring,R.sup.7 and R.sup.8 each independently represents hydrogen, optionally substituted alkyl, optionally substituted aryl,R.sup.9 represents hydroxyl, alkoxy or the radical --NR.sup.7 R.sup.8,R.sup.10 represents hydroxyl, alkoxy, acyloxy, optionally substituted aryloxy or aralkyloxy,with the substituent R.sup.4 and the alkylamino group in the pyridyl ring of the formula I being in the p position with respect to one another,or a physiologically tolerated salt thereof, or, if A represents nitrogen, optionally the N-oxide thereof.
    • 一种用于促进家畜生产和控制人和动物肥胖的化合物,其中A表示= CH-或= N-,R0表示氢或甲基,R1和R3各自独立地表示氢, 羟基,卤素,氰基,烷基,卤代烷基,羟基烷基,烷氧基羰基,氨基羰基,一烷基氨基羰基和二烷基氨基羰基,烷氧基,卤代烷氧基,卤代烷硫基,NHSO2-烷基,R2代表氢,羟基,烷氧基或基-NR5R6,R4代表氢,C1- 任选被羟基,卤素,烷氧基,酰氧基或基团-NR 7 R 8取代的C 10 - 烷基,或表示基团COR 9或基团-OZ-R 10,Z表示C 1 -C 10亚烷基, - 亚烯基或亚炔基,R 5表示氢 或烷基,R 6表示氢,烷基,卤代烷基或酰基,或R 5和R 6与相邻的N原子一起形成饱和或不饱和的4-,5-或6-元环,R 7和R 8各自独立地表示氢, 取代的烷基,任选取代的芳基,R 9表示羟基,烷氧基或基团-NR 7 R 8,R 10表示羟基,烷氧基,酰氧基,任选取代的芳氧基或芳烷氧基,式I的吡啶环中的取代基R4和烷基氨基在 相对于彼此的p位置或其生理上耐受的盐,或者如果A表示氮,则任选地其N-氧化物。