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    • 2. 发明授权
    • Treatment of tumors
    • 治疗肿瘤
    • US5602094A
    • 1997-02-11
    • US219506
    • 1994-03-29
    • David Goddard
    • David Goddard
    • A61K38/17A61K38/09
    • A61K38/1709
    • Malignant gliomas are treated by modifying the eicosanoid biosynthetic pathway with reduction of the inhibitory effect of prostanoids on the cytotoxic activity of NK and LAK cells. Synthetic peptides, corresponding to shared sequences with phospholipase activating protein (PLAP), having the capacity to activate phospholipase A.sub.2 (PLA.sub.2), when administered in a delayed release delivery system, such as with agarose beads induce release of PGE.sub.2, with significant tumor necrosis. A tumor model comprising an air pouch in the dorsum of rats is utilized for effective evaluation of the treatment, with tumor growth, treatment and evaluation of tumors grown therein.
    • 通过降低类前列腺素对NK细胞和LAK细胞的细胞毒活性的抑制作用,改变类花生酸生物合成途径,治疗恶性胶质瘤。 当在延迟释放递送系统(例如用琼脂糖珠)中施用时,具有活化磷脂酶A2(PLA2)的能力的磷脂酶活化蛋白(PLAP)的共有序列的合成肽诱导具有显着肿瘤坏死的PGE2释放。 使用包含大鼠背侧的空气囊的肿瘤模型,用于有效评估治疗,其中肿瘤生长,治疗和评估其中生长的肿瘤。