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    • 4. 发明申请
    • Manufacture of trimethylhydroquinone diacylates
    • 三甲基氢醌二酰胺的制造
    • US20050038286A1
    • 2005-02-17
    • US10498626
    • 2002-12-07
    • Werner BonrathMichael Schneider
    • Werner BonrathMichael Schneider
    • C07B61/00C07C67/00C07C67/08C07C69/017C07C69/16
    • C07C67/00C07C69/017C07C69/16
    • A process for the manufacture of 2,3,5-trimethylhydroquinone diacylate comprising reacting ketoisophorone with an acylating agent in the presence of a NH- or CH-acidic catalyst, particularly certain bis (perfluorinated hydrocarbyl sulphonyl) imides and metal salts thereof and, respectively, certain tris (perfluoroakanesulphonyl or pentafluorobenzenesulphonyl) methanes and metal salts thereof. Thc acylating agent is particularly an acid anhydride, an acyl halide or an enol ester. The so-obtained 2,3,5-trimethylhydroquinone diacylate can be converted into (all-rac)-α-tocopherol by transesterification to yield 2,3,5-trimethylhydroquinone and reaction of the latter with isophytol. (all-rac )-α-Tocopherol itself is the most active member of the vitamin E group.
    • 包括制备2,3,5-三甲基氢醌二酸酯的方法,其包括在NH-或CH-酸性催化剂,特别是某些双(全氟化烃基磺酰基)酰亚胺及其金属盐的存在下使酮异二氢酮与酰化剂反应,和 ,某些三(全氟烷基磺酰基或五氟苯磺酰基)甲烷及其金属盐。 酰化剂特别是酸酐,酰基卤或烯醇酯。 如此获得的2,3,5-三甲基氢醌二酸酯可以通过酯交换反应转化成(全脱色)-α-生育酚,得到2,3,5-三甲基氢醌并将其与异麦芽糖醇反应。 (全消旋)-al-生育酚本身是维生素E组中最活跃的成员。
    • 5. 发明授权
    • Manufacture of trimethylhydroquinone diacylates
    • 三甲基氢醌二酰胺的制造
    • US07153994B2
    • 2006-12-26
    • US10498626
    • 2002-12-07
    • Werner BonrathMichael Schneider
    • Werner BonrathMichael Schneider
    • C07C69/00
    • C07C67/00C07C69/017C07C69/16
    • A process for the manufacture of 2,3,5-trimethylhydroquinone diacylate comprising reacting ketoisophorone with an acylating agent in the presence of a NH- or CH-acidic catalyst, particularly certain bis(perfluorinated hydrocarbyl sulphonyl) imides and metal salts thereof and, respectively, certain tris(perfluoroalkanesulphonyl or pentafluorobenzenesulphonyl) methanes and metal salts thereof. The acylating agent is particularly an acid anhydride, an acyl halide or an enol ester. The so-obtained 2,3,5-trimethylhydroquinone diacylate can be converted into (all-rac)-α-tocopherol by transesterification to yield 2,3,5-trimethylhydroquinone and reaction of the latter with isophytol. (all-rac)-α-Tocopherol itself is the most active member of the vitamin E group.
    • 包括制备2,3,5-三甲基氢醌二酸酯的方法,其包括在NH-或CH-酸性催化剂,特别是某些双(全氟化烃基磺酰基)酰亚胺及其金属盐的存在下使酮异二氢酮与酰化剂反应,和 ,某些三(全氟烷基磺酰基或五氟苯磺酰基)甲烷及其金属盐。 酰化剂特别是酸酐,酰基卤或烯醇酯。 如此获得的2,3,5-三甲基氢醌二酸酯可以通过酯交换反应转化成(全脱色)-α-生育酚,得到2,3,5-三甲基氢醌并将其与异麦芽糖醇反应。 (全消旋)-al-生育酚本身是维生素E组中最活跃的成员。