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1. 发明授权

US3931268A Methylhydrazinomethyl-substituted benzoic acid amides 失效
标题翻译：甲基肼基甲基取代的苯甲酸酰胺
公开(公告)号：US3931268A
公开(公告)日：1976-01-06
申请号：US35292
申请日：1970-05-06
申请人： Werner Bollag , Hugo Gutmann , Balthasar Hegedus , Ado Kaiser , Albert Langemann , Marcel Muller , Paul Zeller
发明人： Werner Bollag , Hugo Gutmann , Balthasar Hegedus , Ado Kaiser , Albert Langemann , Marcel Muller , Paul Zeller
IPC分类号： C07C233/00 , C07C233/12 , C07C243/38 , C07C103/76 , C07C103/22 , C07C103/78 , C07C103/82
CPC分类号： C07C243/38 , C07C233/00 , C07C243/00
摘要： Benzene-ring substituted (2-methylhydrazino)methylbenzene compounds and intermediates therefor are described. The former compounds are useful as cytostatic agents.
摘要翻译：描述了苯环取代的（2-甲基肼基）甲苯化合物及其中间体。前一种化合物可用作细胞抑制剂。

2. 发明授权

US3969397A Process for the preparation of l-dopa 失效
标题翻译：制备多巴的方法
公开(公告)号：US3969397A
公开(公告)日：1976-07-13
申请号：US884333
申请日：1969-12-11
申请人： Ado Kaiser , Marcel Scheer , Werner Hausermann , Leo Marti
发明人： Ado Kaiser , Marcel Scheer , Werner Hausermann , Leo Marti
IPC分类号： C07C227/34 , A61K31/195 , C07C227/36 , C07C229/36 , C07D263/42 , E04C1/39 , C07C63/50
CPC分类号： A61K31/195 , C07D263/42 , E04C1/39
摘要： The present invention is directed to preparing L-Dopa, an agent effective in the treatment of Parkinson's Disease, from a D,L-N-benzoyl-3-(4-hydroxy-3-methoxyphenyl) alanine utilizing dehydroabietylamine as a resolving agent and intermediates in this process.
摘要翻译：本发明涉及使用脱氢枞胺作为拆分剂从D，LN-苯甲酰基-3-（4-羟基-3-甲氧基苯基）丙氨酸制备有效治疗帕金森病的药物L-多巴，这个过程。

3. 发明授权

US4256748A Imidazo[2,1-b]quinazolin-2(3H)-ones and pharmaceutical compositions for treatment and prophylaxis of cardiac insufficiency and cardiac failure 失效
标题翻译：咪唑并[2,1-b]喹唑啉-2（3H） - 酮和用于治疗和预防心功能不全和心力衰竭的药物组合物
公开(公告)号：US4256748A
公开(公告)日：1981-03-17
申请号：US50395
申请日：1979-06-20
申请人： Madhukar S. Chodnekar , Ado Kaiser
发明人： Madhukar S. Chodnekar , Ado Kaiser
IPC分类号： A61K31/505 , A61P7/02 , A61P9/04 , C07D233/68 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of the formula ##STR1## wherein R.sup.1,R.sup.2,R.sup.3 and R.sup.4 are as hereinafter described, tautomers and salts thereof, are disclosed. The foregoing compounds inhibit the aggregation of blood platelets which renders them useful as therapeutic agents in the prophylaxis of thromboses. Furthermore, they are useful for the treatment and prophylaxis of cardiac insufficiency and cardiac failure, due to their inotropic activity without substantial tachycardia.
摘要翻译：公开了其中R 1，R 2，R 3和R 4如下文所述的式Ⅰa化合物的互变异构体及其盐。上述化合物抑制血小板聚集，使其可用作预防血栓形成的治疗剂。此外，它们可用于治疗和预防心功能不全和心力衰竭，因为它们的肌力活动而没有实质性的心动过速。

4. 发明授权

US4581172A Substituted pyrimido[6,1-a]isoquinolin-4-ones,pyrimido[6,1-a]benzozepin-4-ones and pyrimido[6,1-a]benzodiazepin-4-ones useful for prevention of thromboses and treating hypertension 失效
标题翻译：取代的嘧啶并[6,1-a]异喹啉-4-酮，嘧啶并[6,1-a]苯并氮杂-4-酮和嘧啶并[6,1-a]苯并二氮杂-4-酮可用于预防血栓形成和治疗高血压
公开(公告)号：US4581172A
公开(公告)日：1986-04-08
申请号：US603793
申请日：1984-04-25
申请人： Ado Kaiser , Frank Kienzle
发明人： Ado Kaiser , Frank Kienzle
IPC分类号： C07D239/62 , C07D471/04 , C07D487/04 , C07D491/14 , A61K31/505
CPC分类号： C07D471/04 , C07D239/62 , C07D487/04 , C07D491/14
摘要： Pyrimidone derivatives of the formula ##STR1## wherein n is the integer 1 or 0; A.sup.1 and A.sup.2 are independently methylene or mono-lower alkyl or di-lower alkyl methylene; X is methylene, mono-lower alkyl or di-lower alkyl methylene, nitrogen or lower alkyl nitrogen; R is hydrogen or lower alkyl; and Y and Z taken together are the group .dbd.NR.sup.5, or R and Z taken together form a N--C--bond and Y is a group --N(H)R.sup.5 ; R.sup.1, R.sup.2 and R.sup.3 are hydrogen, lower alkyl or lower alkoxy, or R.sup.1 and R.sup.2 or R.sup.2 and R.sup.3 taken together are methylenedioxy or ethylenedioxy; R.sup.4 is hydrogen or lower-alkyl; R.sup.5 is phenyl or phenyl substituted by one or more of R.sup.6, R.sup.7 and R.sup.8 which, independently, are chlorine, fluorine, bromine, lower-alkyl or lower-alkoxy; and provided that at least one of the methylene groups A.sup.1 and A.sup.2 is mono-lower alkyl or di-lower alkyl methylene, when R.sup.4 is hydrogen and n is 0,and physiologically compatible salts thereof which have blood platelet aggregation-inhibiting activity or have activity on the circulatory system, are described.The compounds of formula I are obtained starting from corresponding chlorinated or brominated pyrimidone derivatives.
摘要翻译：式（I）其中n为整数1或0的吡嗪酮衍生物; A1和A2独立地是亚甲基或单低级烷基或二低级烷基亚甲基; X是亚甲基，单低级烷基或二低级烷基亚甲基，氮或低级烷基氮; R是氢或低级烷基; Y和Z一起为基团= NR5，或R和Z一起形成N-C键，Y为-N（H）R 5基团; R 1，R 2和R 3是氢，低级烷基或低级烷氧基，或者R 1和R 2或R 2和R 3一起是亚甲二氧基或亚乙二氧基; R4是氢或低级烷基; R5是被R6，R7和R8中的一个或多个取代的苯基或苯基，其独立地是氯，氟，溴，低级烷基或低级烷氧基; 并且条件是当R4是氢并且n是0时，亚甲基A1和A2中的至少一个是单低级烷基或二低级烷基亚甲基，以及其具有血小板聚集抑制活性或具有活性的生理上相容的盐在循环系统上进行了描述。从相应的氯化或溴化嘧啶衍生物开始获得式I化合物。

5. 发明授权

US4390540A Imidazoquinazolines having pharmaceutical activity 失效
标题翻译：咪唑喹唑啉具有药物活性
公开(公告)号：US4390540A
公开(公告)日：1983-06-28
申请号：US292315
申请日：1981-08-12
申请人： Madhukar S. Chodnekar , Ado Kaiser , Frank Kienzle
发明人： Madhukar S. Chodnekar , Ado Kaiser , Frank Kienzle
IPC分类号： C07D239/84 , C07D487/04 , C07D491/147 , A61K31/505
CPC分类号： C07D487/04 , C07D239/84
摘要： Imidazoquinazolines of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are hydrogen, halogen, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy or C.sub.2-5 -alkoxyalkyl; or two of R.sup.1, R.sup.2 and R.sup.3 on adjacent carbon atoms taken together are methylenedioxy or ethylenedioxy; and R.sup.4 and R.sup.5 are hydrogen or C.sub.1-4 -alkyl,and their tautomers, as well as their physiologically compatible acid addition salts, are described.The compounds of formula I inhibit the aggregation of the blood platelets, as well as gastric acid secretion, and have activity on the circulatory system.
摘要翻译：其中R 1，R 2和R 3是氢，卤素，C 1-4 - 烷基，C 1-4 - 烷氧基或C 2-5 - 烷氧基烷基的式I的咪唑并喹唑啉; 或相邻碳原子上的R 1，R 2和R 3中的两个是亚甲二氧基或亚乙二氧基; R4和R5是氢或C1-4烷基，它们的互变异构体以及它们的生理相容的酸加成盐被描述。式I的化合物抑制血小板聚集以及胃酸分泌，并且对循环系统具有活性。

6. 发明授权

US3933859A Dihydrocoumarin derivatives 失效
标题翻译：二氢香豆素衍生物
公开(公告)号：US3933859A
公开(公告)日：1976-01-20
申请号：US478654
申请日：1974-06-12
申请人： Ado Kaiser , Wolfgang Koch , Marcel Scheer , Uwe Wolcke
发明人： Ado Kaiser , Wolfgang Koch , Marcel Scheer , Uwe Wolcke
IPC分类号： C07D311/20 , C07F5/04
CPC分类号： C07F5/04 , C07D311/20
摘要： Process for obtaining 5,6 or 6,7 or 7,8 dihydroxy coumarin or derivatives thereof, which are useful for lower blood pressure and for chemical sympathectomy by oxidizing 2,3 or 3,4 or 4,5 dihydroxyphenyl-propionic acid or derivatives thereof, and novel coumarin derivatives of the process.
摘要翻译：用于获得5,6或6,7或7,8二羟基香豆素或其衍生物的方法，其可用于降低血压和通过氧化2,3或3,4或4,5-二羟基苯基 - 丙酸或衍生物进行化学交感神经切断以及该方法的新型香豆素衍生物。

7. 发明授权

US4202832A Thiocarbamoylthio fatty acids 失效
标题翻译：硫代氨基甲酰硫代脂肪酸
公开(公告)号：US4202832A
公开(公告)日：1980-05-13
申请号：US953720
申请日：1978-10-20
申请人： Ulf Fischer , Ado Kaiser
发明人： Ulf Fischer , Ado Kaiser
IPC分类号： C07C333/18 , C07D295/18 , C07C155/08 , C07D207/12 , C07D211/30
CPC分类号： C07D295/18 , C07C333/18
摘要： Thiocarbamoylthio fatty acid derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Y and n are as hereinafter set forth, are described. The compounds of formula I are useful as lipid-lowering agents.
摘要翻译：其中R 1，R 2，A，Y和n如下文所述，其结构式为“IMAGE”I的硫代氨基甲酰硫代脂肪酸衍生物被描述。式I的化合物可用作降脂剂。

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