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1. 发明申请

US20130324542A1 [1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF 审中-公开
标题翻译： [1,2,4]三唑[4,3-B] [1,2,4]三嗪化合物，其制备方法及其用途
公开(公告)号：US20130324542A1
公开(公告)日：2013-12-05
申请号：US13992048
申请日：2011-12-08
申请人： Wenhu Duan , Meiyu Geng , Fang Chen , Jing Ai , Yi Chen , Zhengsheng Zhan , Yongcong Lv , Ying Wang , Jian Ding
发明人： Wenhu Duan , Meiyu Geng , Fang Chen , Jing Ai , Yi Chen , Zhengsheng Zhan , Yongcong Lv , Ying Wang , Jian Ding
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to a structurally novel [1,2,4]triazolo[4,3-b][1,2,4]triazine compounds represented by formula (I) or formula (II), pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates or solvates thereof, and also relates to a preparation method of the compounds, a pharmaceutical composition including a therapeutically effective amount of the compounds, as well as the use thereof as protein tyrosine kinase inhibitors, particularly as c-Met inhibitors, in the preparation of medicaments for the prevention and/or treatment of diseases associated with c-Met abnormality.
摘要翻译：本发明涉及由式（I）或式（II）表示的结构上新的[1,2,4]三唑并[4,3-b] [1,2,4]三嗪化合物，其药学上可接受的盐，前体药物其还涉及本发明化合物的制备方法，包含治疗有效量的化合物的药物组合物，以及其作为蛋白酪氨酸激酶抑制剂，特别是作为c-Met抑制剂的用途，制备用于预防和/或治疗与c-Met异常有关的疾病的药物。

2. 发明申请

US20160145244A1 CERTAIN PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：某些蛋白激酶抑制剂
公开(公告)号：US20160145244A1
公开(公告)日：2016-05-26
申请号：US14945426
申请日：2015-11-19
申请人： Weibo Wang , Meiyu Geng , Jian Ding , Xingdong Zhao , Jing Ai , Huajie Zhang , Xia Peng
发明人： Weibo Wang , Meiyu Geng , Jian Ding , Xingdong Zhao , Jing Ai , Huajie Zhang , Xia Peng
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： Provided are certain ALK inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
摘要翻译：提供某些ALK抑制剂，其药物组合物及其用途。

3. 发明申请

US20140296216A1 PYRIMIDO[4,5-D]PYRIMIDINYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：吡咯二酮[4,5-D]吡啶化合物，药物组合物及其用途
公开(公告)号：US20140296216A1
公开(公告)日：2014-10-02
申请号：US14125304
申请日：2011-12-21
申请人： Ke Ding , Shaohua Chang , Shilin Xu , Lianwen Zhang , Zhengchao Tu , Jian Ding , Meiyu Geng , Yi Chen
发明人： Ke Ding , Shaohua Chang , Shilin Xu , Lianwen Zhang , Zhengchao Tu , Jian Ding , Meiyu Geng , Yi Chen
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551
摘要： A compound of formula (I) or (II) and use of the compound in the preparation of drugs for treating cancer are disclosed. The study shows that the compounds can inhibit the growth of many kinds of tumor cells, can be used for targeting epidermal growth factor receptor (EGFR), and particularly can inhibit tumor cells with single or multiple mutations of EGFR (T790M). Therefore, the compound can be used as EGFR inhibitor to treat cancer and has a relatively large application value.
摘要翻译：公开了式（I）或（II）的化合物和该化合物在制备用于治疗癌症的药物中的用途。该研究表明，该化合物可抑制多种肿瘤细胞的生长，可用于靶向表皮生长因子受体（EGFR），特别是可以单独或多次EGFR（T790M）突变抑制肿瘤细胞。因此，该化合物可用作EGFR抑制剂治疗癌症，具有较大的应用价值。

4. 发明申请

US20150105344A1 ALGIN OLIGOSACCHARIDES AND THE DERIVATIVES THEREOF AS WELL AS THE MANUFACTURE AND THE USE OF THE SAME 有权
标题翻译： ALGIN OLIGOSACCHARIDES及其衍生物及其制造方法及其使用
公开(公告)号：US20150105344A1
公开(公告)日：2015-04-16
申请号：US14482610
申请日：2014-09-10
申请人： Meiyu Geng , Huashi Guan , Xianliang Xin , Zhao Yang , Guangqiang Sun
发明人： Meiyu Geng , Huashi Guan , Xianliang Xin , Zhao Yang , Guangqiang Sun
IPC分类号： C07H3/06
CPC分类号： A61K31/715 , C07H3/04 , C07H3/06 , C08B37/0024 , C08B37/0084
摘要： The invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of β-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedure that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2˜6 and the temperature of 100˜120° C., and adjusted pH to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.
摘要翻译：本发明提供藻酸盐寡糖及其衍生物，其聚合度范围为2至22.藻酸盐寡糖由与1,4糖苷键连接的β-甘露糖醛酸组成。羧基位置1末端的衍生物可以通过氧化降解制备。本发明还提供了一种制备藻酸盐寡糖及其衍生物的方法，其包括藻酸盐溶液在高压釜中在pH 2〜6和温度为100〜120℃下反应2〜6小时的方法，以及在反应停止后将pH调至7，之后在氧化剂存在下氧化得到的寡糖，得到氧化产物。本发明的藻酸盐寡糖及其衍生物可用于制备用于预防和治疗AD和糖尿病的药物。

5. 发明授权

US08835403B2 Algin oligosaccharides and the derivatives thereof as well as the manufacture and the use of the same 有权
标题翻译：藻酸寡糖及其衍生物以及其制备和用途
公开(公告)号：US08835403B2
公开(公告)日：2014-09-16
申请号：US10594100
申请日：2005-02-25
申请人： Meiyu Geng , Huashi Guan , Xianliang Xin , Zhao Yang , Guangqiang Sun
发明人： Meiyu Geng , Huashi Guan , Xianliang Xin , Zhao Yang , Guangqiang Sun
IPC分类号： A61K31/7016 , A61K31/702 , A61K31/734 , A61P25/28 , C07H3/04 , C07H3/06 , C08B37/04 , C08B37/00 , A61P5/50
CPC分类号： A61K31/715 , C07H3/04 , C07H3/06 , C08B37/0024 , C08B37/0084
摘要： The present invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of β-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The present invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedures that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2-6 and the temperature of 100-120° C., and pH is adjusted to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative degradation product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.
摘要翻译：本发明提供了聚合度范围为2至22的藻酸盐寡糖及其衍生物。藻酸盐寡糖由与1,4糖苷键连接的β-甘露糖醛酸组成。羧基位置1末端的衍生物可以通过氧化降解制备。本发明还提供了一种制备藻酸盐寡糖及其衍生物的方法，其包括藻酸盐溶液在高压釜中在pH2-6和温度为100-120℃下反应2至6小时的程序，在反应停止后将pH调节至7，然后在氧化剂存在下氧化得到的寡糖，得到氧化降解产物。本发明的藻酸盐寡糖及其衍生物可用于制备用于预防和治疗AD和糖尿病的药物。

6. 发明申请

US20070254848A1 Algin Oligosaccharides and the Derivatives thereof as Well as the Manufacture and the Use of the Same 有权
标题翻译：藻糖及其衍生物以及其制造和使用
公开(公告)号：US20070254848A1
公开(公告)日：2007-11-01
申请号：US10594100
申请日：2005-02-25
申请人： Meiyu Geng , Xianliang Xin , Guangqing Sun
发明人： Meiyu Geng , Xianliang Xin , Guangqing Sun
IPC分类号： A61K31/70 , A61P25/28 , C07H15/00
CPC分类号： A61K31/715 , C07H3/04 , C07H3/06 , C08B37/0024 , C08B37/0084
摘要： The present invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of β-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The present invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedures that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2-6 and the temperature of 100-120° C., and pH is adjusted to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative degradation product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.
摘要翻译：本发明提供了聚合度范围为2至22的藻酸盐寡糖及其衍生物。藻酸盐寡糖由通过1,4糖苷键连接的β-D-甘露糖醛酸组成。羧基位置1末端的衍生物可以通过氧化降解制备。本发明还提供了一种制备藻酸盐寡糖及其衍生物的方法，其包括藻酸盐溶液在高压釜中在pH2-6和温度为100-120℃下反应2至6小时的程序，在反应停止后将pH调节至7，然后在氧化剂存在下氧化得到的寡糖，得到氧化降解产物。本发明的藻酸盐寡糖及其衍生物可用于制备用于预防和治疗AD和糖尿病的药物。

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