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1. 发明申请

US20150024024A1 Cell Lines That Produce Prostaglandin F2 Alpha (PGF2A) And Uses Thereof 审中-公开
标题翻译：产生前列腺素F2α（PGF2A）的细胞系及其用途
公开(公告)号：US20150024024A1
公开(公告)日：2015-01-22
申请号：US13265312
申请日：2010-04-21
申请人： Weng Tao , Konrad Kauper , Paul Francis Stabila , Vincent Ling
发明人： Weng Tao , Konrad Kauper , Paul Francis Stabila , Vincent Ling
IPC分类号： A61K9/48 , A61K35/30 , A61K38/18
CPC分类号： A61K9/4808 , A61F9/00 , A61K35/30 , A61K38/18 , C12N9/0083
摘要： Cells and cell lines that are genetically modified to express the hCox-2 enzyme, which results in the upregulation of prostaglandin F2 alpha (PGF2a) on the cells have been obtained. Encapsulated cell therapy devices containing such cells or cell lines that are capable of delivering PGF2a, as well as methods of using these devices to deliver PGF2a to the eye and to treat ophthalmic disorders in patients suffering therefrom are also described.
摘要翻译：已获得遗传修饰以表达hCox-2酶的细胞和细胞系，其导致细胞上的前列腺素F2α（PGF2a）的上调。还描述了包含能够递送PGF2a的这种细胞或细胞系的包封的细胞治疗装置，以及使用这些装置将PGF2a递送至眼睛并治疗患有眼部疾病的方法。

2. 发明申请

US20110111008A1 Use of PEDF in an Encapsulated Cell-Based Delivery System 审中-公开
标题翻译：在封装的基于细胞的递送系统中使用PEDF
公开(公告)号：US20110111008A1
公开(公告)日：2011-05-12
申请号：US12899026
申请日：2010-10-06
申请人： Weng Tao , Konrad Kauper , Paul Stabila , Vincent Ling
发明人： Weng Tao , Konrad Kauper , Paul Stabila , Vincent Ling
IPC分类号： A61F2/00 , A61K35/12 , C12N11/02 , A61F9/007
CPC分类号： A61F9/0017 , A61F2220/0008 , A61F2240/001 , A61F2250/0068 , A61K9/0051 , A61K38/00 , A61K2035/128 , C12N5/0621 , C12N2510/02 , Y02A50/401
摘要： The invention relates to a device for delivery of pigment epithelium derived factor (PEDF) to the eye utilizing encapsulated PEDF-secreting cells and related methods for the treatment and prevention of ophthalmic diseases and disorders.
摘要翻译：本发明涉及一种利用包封的PEDF分泌细胞向眼睛输送色素上皮衍生因子（PEDF）的装置，以及用于治疗和预防眼科疾病和病症的相关方法。

3. 发明申请

US20100272780A1 CELL LINES THAT PRODUCE PROSTAGLANDIN F2 ALPHA (PGF2a) AND USES THEREOF 审中-公开
标题翻译：生产PROSTAGLANDIN F2 ALPHA（PGF2a）的细胞系及其用途
公开(公告)号：US20100272780A1
公开(公告)日：2010-10-28
申请号：US12764575
申请日：2010-04-21
申请人： Vincent Ling , Weng Tao , Konrad Kauper , Paul Stabila
发明人： Vincent Ling , Weng Tao , Konrad Kauper , Paul Stabila
IPC分类号： A61F2/00 , C12N15/63 , C12N5/10 , A61P27/02 , A61K31/5575
CPC分类号： A61K9/4808 , A61F9/00 , A61K35/30 , A61K38/18 , C12N9/0083
摘要： The invention provides cells and cell lines the are genetically modified to express the hCox-2 enzyme, which, in turn, results in the upregulation of prostaglandin F2 alpha (PGF2a) production. The invention also provides encapsulated cell therapy devices containing such cells or cell lines that are capable of delivering PGF2a as well as methods of using these devices to deliver PGF2a to the eye and to treat ophthalmic disorders in patients suffering therefrom.
摘要翻译：本发明提供经遗传修饰以表达hCox-2酶的细胞和细胞系，其又导致前列腺素F2α（PGF2a）产生的上调。本发明还提供了包含能够递送PGF2a的这种细胞或细胞系的包封的细胞治疗装置以及使用这些装置将PGF2a递送至眼睛并治疗患有眼部疾病的患者的方法。

4. 发明授权

US09149427B2 Cell lines that secrete anti-angiogenic antibody-scaffolds and soluble receptors and uses thereof 有权
标题翻译：分泌抗血管生成抗体 - 支架和可溶性受体的细胞系及其用途
公开(公告)号：US09149427B2
公开(公告)日：2015-10-06
申请号：US13308264
申请日：2011-11-30
申请人： Vincent Ling , Arne M. Nystuen , Weng Tao , Paul Stabila , Konrad Kauper
发明人： Vincent Ling , Arne M. Nystuen , Weng Tao , Paul Stabila , Konrad Kauper
IPC分类号： C12N5/02 , C12N5/10 , A61K9/00 , A61L27/38 , A61K38/17 , A61K35/12 , C07K14/71 , A61K48/00
CPC分类号： A61K39/3955 , A61K9/0051 , A61K35/12 , A61K35/30 , A61K38/179 , A61K48/005 , A61L27/38 , A61L2430/16 , C07K14/71 , C07K2319/30 , C12N2830/46
摘要： The invention provides nucleic acid and polypeptide sequences encoding antibody based scaffolds such as full antibodies, antibody Fab fragments, single chain antibodies, soluble VEGF receptor-Fc fusion proteins, and/or anti-angiogenic PDGF receptors. Also encompassed are cell lines encoding such anti-angiogenic antibody scaffolds, VEGF receptors, and/or PDGF receptors. The invention also provides encapsulated cell therapy devices that are capable of delivering such anti-angiogenic antibody scaffolds, VEGF receptors, and/or PDGF receptors as well as methods of using these devices to deliver the anti-angiogenic antibody scaffolds, VEGF receptors, and/or PDGF receptors to medically treat disorders in patients, including ophthalmic, vascular, inflammatory, and cell proliferation diseases.
摘要翻译：本发明提供了编码基于抗体的支架例如全抗体，抗体Fab片段，单链抗体，可溶性VEGF受体-Fc融合蛋白和/或抗血管生成PDGF受体的核酸和多肽序列。还包括编码这种抗血管生成抗体支架，VEGF受体和/或PDGF受体的细胞系。本发明还提供能够递送此类抗血管生成抗体支架，VEGF受体和/或PDGF受体的封装的细胞治疗装置，以及使用这些装置递送抗血管生成抗体支架，VEGF受体和/ 或PDGF受体以医学治疗患者的疾病，包括眼睛，血管，炎症和细胞增殖疾病。

5. 发明申请

US20120141573A1 Cell Lines That Secrete Anti-Angiogenic Antibody-Scaffolds and Soluble Receptors and Uses Thereof 有权
标题翻译：分泌抗血管生成抗体支架和可溶性受体的细胞系及其用途
公开(公告)号：US20120141573A1
公开(公告)日：2012-06-07
申请号：US13308264
申请日：2011-11-30
申请人： Vincent Ling , Arne M. Nystuen , Weng Tao , Paul Stabila , Konard Kauper
发明人： Vincent Ling , Arne M. Nystuen , Weng Tao , Paul Stabila , Konard Kauper
IPC分类号： A61K9/48 , C12N15/85 , A61K48/00 , A61K9/00 , A61P35/00 , A61P9/10 , A61P27/06 , A61P7/00 , A61P29/00 , C12N5/10 , A61P27/02
CPC分类号： A61K39/3955 , A61K9/0051 , A61K35/12 , A61K35/30 , A61K38/179 , A61K48/005 , A61L27/38 , A61L2430/16 , C07K14/71 , C07K2319/30 , C12N2830/46
摘要： The invention provides nucleic acid and polypeptide sequences encoding antibody based scaffolds such as full antibodies, antibody Fab fragments, single chain antibodies, soluble VEGF receptor-Fc fusion proteins, and/or anti-angiogenic PDGF receptors. Also encompassed are cell lines encoding such anti-angiogenic antibody scaffolds, VEGF receptors, and/or PDGF receptors. The invention also provides encapsulated cell therapy devices that are capable of delivering such anti-angiogenic antibody scaffolds, VEGF receptors, and/or PDGF receptors as well as methods of using these devices to deliver the anti-angiogenic antibody scaffolds, VEGF receptors, and/or PDGF receptors to medically treat disorders in patients, including ophthalmic, vascular, inflammatory, and cell proliferation diseases.
摘要翻译：本发明提供了编码基于抗体的支架例如全抗体，抗体Fab片段，单链抗体，可溶性VEGF受体-Fc融合蛋白和/或抗血管生成PDGF受体的核酸和多肽序列。还包括编码这种抗血管生成抗体支架，VEGF受体和/或PDGF受体的细胞系。本发明还提供能够递送此类抗血管生成抗体支架，VEGF受体和/或PDGF受体的封装的细胞治疗装置，以及使用这些装置递送抗血管生成抗体支架，VEGF受体和/ 或PDGF受体以医学治疗患者的疾病，包括眼睛，血管，炎症和细胞增殖疾病。

6. 发明授权

US07601813B2 Anti-GL50 antibodies 失效
标题翻译：抗GL50抗体
公开(公告)号：US07601813B2
公开(公告)日：2009-10-13
申请号：US11311754
申请日：2005-12-19
申请人： Vincent Ling , Kyriaki Dunussi-Joannopoulos
发明人： Vincent Ling , Kyriaki Dunussi-Joannopoulos
IPC分类号： C07K16/28
CPC分类号： C07K14/70532 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated GL50 nucleic acid molecules, which encode novel GL50 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GL50 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GL50 gene has been introduced or disrupted. The invention still further provides isolated GL50 polypeptides, fusion proteins, antigenic peptides and anti-GL50 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的GL50多肽的分离的核酸分子，命名为GL50核酸分子。本发明还提供了反义核酸分子，含有GL50核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了GL50基因的非人转基因动物。本发明还进一步提供分离的GL50多肽，融合蛋白，抗原肽和抗GL50抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。

7. 发明申请

US20100055091A1 Novel GL-50 Molecules and Uses Therefor 失效
标题翻译：新型GL-50分子及其用途
公开(公告)号：US20100055091A1
公开(公告)日：2010-03-04
申请号：US12542901
申请日：2009-08-18
申请人： Vincent Ling , Kyriaki Dunussi-Joannopoulos
发明人： Vincent Ling , Kyriaki Dunussi-Joannopoulos
IPC分类号： A61K39/395
CPC分类号： C07K14/70532 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated GL50 nucleic acid molecules, which encode novel GL50 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GL50 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GL50 gene has been introduced or disrupted. The invention still further provides isolated GL50 polypeptides, fusion proteins, antigenic peptides and anti-GL50 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的GL50多肽的分离的核酸分子，命名为GL50核酸分子。本发明还提供了反义核酸分子，含有GL50核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了GL50基因的非人转基因动物。本发明还进一步提供分离的GL50多肽，融合蛋白，抗原肽和抗GL50抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。

8. 发明授权

US06521749B1 GL50 nucleic acids and uses therefor 失效
标题翻译： GL50核酸及其用途
公开(公告)号：US06521749B1
公开(公告)日：2003-02-18
申请号：US09667135
申请日：2000-09-21
申请人： Vincent Ling , Kyriaki Dunussi-Joannopoulos
发明人： Vincent Ling , Kyriaki Dunussi-Joannopoulos
IPC分类号： C07H2104
CPC分类号： C07K14/70532 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated GL50 nucleic acid molecules, which encode GL50 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GL50 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GL50 gene has been introduced or disrupted. The invention still further provides isolated GL50 polypeptides, fusion proteins, antigenic peptides and anti-GL50 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码GL50多肽的分离的核酸分子，命名为GL50核酸分子。本发明还提供了反义核酸分子，含有GL50核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了GL50基因的非人转基因动物。本发明还进一步提供分离的GL50多肽，融合蛋白，抗原肽和抗GL50抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。

9. 发明申请

US20060099635A1 Anti-GL50 antibodies 失效
公开(公告)号：US20060099635A1
公开(公告)日：2006-05-11
申请号：US11311754
申请日：2005-12-19
申请人： Vincent Ling , Kyriaki Dunussi-Joannopoulos
发明人： Vincent Ling , Kyriaki Dunussi-Joannopoulos
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , A61K39/395 , C07K16/28 , C07K14/705
CPC分类号： C07K14/70532 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated GL50 nucleic acid molecules, which encode novel GL50 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GL50 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GL50 gene has been introduced or disrupted. The invention still further provides isolated GL50 polypeptides, fusion proteins, antigenic peptides and anti-GL50 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

10. 发明授权

US07976840B2 Use of anti-GL50 antibodies for the downmodulation of an immune response 失效
标题翻译：使用抗GL50抗体进行免疫反应的下调
公开(公告)号：US07976840B2
公开(公告)日：2011-07-12
申请号：US12542901
申请日：2009-08-18
申请人： Vincent Ling , Kyriaki Dunussi-Joannopoulos
发明人： Vincent Ling , Kyriaki Dunussi-Joannopoulos
IPC分类号： A61K39/395
CPC分类号： C07K14/70532 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated GL50 nucleic acid molecules, which encode novel GL50 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GL50 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GL50 gene has been introduced or disrupted. The invention still further provides isolated GL50 polypeptides, fusion proteins, antigenic peptides and anti-GL50 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的GL50多肽的分离的核酸分子，命名为GL50核酸分子。本发明还提供了反义核酸分子，含有GL50核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了GL50基因的非人转基因动物。本发明还进一步提供分离的GL50多肽，融合蛋白，抗原肽和抗GL50抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。

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