专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100234445A1 Patterns of known and novel small RNAS in human cervical cancer 审中-公开
标题翻译：已知和新型小RNAS在人宫颈癌中的模式
公开(公告)号：US20100234445A1
公开(公告)日：2010-09-16
申请号：US12459409
申请日：2009-06-30
申请人： Weng Onn Lui , Nader Pourmand , Bruce K. Patterson , Andrew Fire
发明人： Weng Onn Lui , Nader Pourmand , Bruce K. Patterson , Andrew Fire
IPC分类号： A61K31/713 , C12Q1/68 , C40B30/00 , A61P35/00
CPC分类号： A61K31/713 , C12Q1/6809 , C12Q1/6883 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207
摘要： Small RNA sequences that are differentially expressed in SCCC cells are provided. The sequences find use in diagnosis of cancer, and classification of cancer cells according to expression profiles. The methods are useful for detecting cervical cancer cells, facilitating diagnosis of cervical cancer and the severity of the cancer (e.g., tumor grade, tumor burden, and the like) in a subject, facilitating a determination of the prognosis of a subject, and assessing the responsiveness of the subject to therapy.
摘要翻译：提供了在SCCC细胞中差异表达的小RNA序列。这些序列用于诊断癌症，根据表达谱分类癌细胞。该方法可用于检测子宫颈癌细胞，促进子宫颈癌的诊断和癌症的严重性（例如，肿瘤分级，肿瘤负荷等），促进受试者的预后的确定，以及评估受试者对治疗的反应。

2. 发明授权

US10011884B2 Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (CIN) lesion from a suspension sample of cervical cells 有权
公开(公告)号：US10011884B2
公开(公告)日：2018-07-03
申请号：US13294101
申请日：2011-11-10
申请人： Bruce K. Patterson
发明人： Bruce K. Patterson
IPC分类号： G01N33/53 , G01N33/52 , G01N33/48 , C12Q1/70 , G01N33/574 , G01N33/50 , G06F19/20 , G06F19/00
CPC分类号： C12Q1/708 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/5091 , G01N33/57411 , G06F19/00 , G16B25/00 , G16H50/20
摘要： Methods of predicting whether a subject has a cervical intraepithelial neoplasia (CIN) lesion are provided. Aspects of the methods include obtaining both morphometric and biomarker data from a liquid cervical cellular sample and then using both types of data to predict whether the subject has a CIN lesion. Also provided are systems that find use in practicing the methods. The methods and systems find use in a variety of applications, including cervical cancer screening applications.

3. 发明授权

US08653250B2 HPV E6, E7 MRNA assay and methods of use thereof 有权
标题翻译： HPV E6，E7 MRNA测定及其使用方法
公开(公告)号：US08653250B2
公开(公告)日：2014-02-18
申请号：US12645202
申请日：2009-12-22
申请人： Bruce K. Patterson
发明人： Bruce K. Patterson
IPC分类号： C07H21/04
CPC分类号： C12Q1/708 , C12Q1/6841 , C12Q2600/158 , G06F19/00
摘要： Provided is an HPV E6, E7 mRNA assay, referenced herein as the “In Cell HPV Assay,” that is capable of sensitive and specific detection of normal cervical cells undergoing malignant transformation as well as abnormal cervical cells with pre-malignant or malignant lesions. The In Cell HPV Assay identifies HPV E6, E7 mRNA via in situ hybridization with oligonucleotides specific for HPV E6, E7 mRNA and quantitates the HPV E6, E7 mRNA via flow cytometry. The In Cell HPV Assay can be carried out in less than three hours directly from liquid-based cervical (“LBC”) cytology specimens. The In Cell HPV Assay provides an efficient and highly sensitive alternative to the Pap smear for determining abnormal cervical cytology.
摘要翻译：提供了HPV E6，E7mRNA测定法，其在本文中被称为“In Cell HPV Assay”，其能够敏感和特异性检测经历恶性转化的正常宫颈细胞以及具有恶性前或恶性病变的异常宫颈细胞。 In Cell HPV Assay通过与HPV E6，E7 mRNA特异性寡核苷酸的原位杂交鉴定HPV E6，E7 mRNA，并通过流式细胞术定量HPV E6，E7 mRNA。 In Cell HPV Assay可以在不到三个小时的时间内直接从液体宫颈（“LBC”）细胞学标本中进行。 In Cell HPV Assay提供了一种有效和高度敏感的替代方法，用于确定宫颈细胞学异常的Pap涂片。

4. 发明申请

US20100120021A1 HPV E6, E7 MRNA Assay and Methods of Use Thereof 有权
标题翻译： HPV E6，E7 MRNA测定及其使用方法
公开(公告)号：US20100120021A1
公开(公告)日：2010-05-13
申请号：US12645202
申请日：2009-12-22
申请人： Bruce K. Patterson
发明人： Bruce K. Patterson
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C12Q1/6841 , C12Q2600/158 , G06F19/00
摘要： Provided is an HPV E6, E7 mRNA assay, referenced herein as the “In Cell HPV Assay,” that is capable of sensitive and specific detection of normal cervical cells undergoing malignant transformation as well as abnormal cervical cells with pre-malignant or malignant lesions. The In Cell HPV Assay identifies HPV E6, E7 mRNA via in situ hybridization with oligonucleotides specific for HPV E6, E7 mRNA and quantitates the HPV E6, E7 mRNA via flow cytometry. The In Cell HPV Assay can be carried out in less than three hours directly from liquid-based cervical (“LBC”) cytology specimens. The In Cell HPV Assay provides an efficient and highly sensitive alternative to the Pap smear for determining abnormal cervical cytology.
摘要翻译：提供了HPV E6，E7mRNA测定法，其在本文中被称为“In Cell HPV Assay”，其能够敏感和特异性检测经历恶性转化的正常宫颈细胞以及具有恶性前或恶性病变的异常宫颈细胞。 In Cell HPV Assay通过与HPV E6，E7 mRNA特异性寡核苷酸的原位杂交鉴定HPV E6，E7 mRNA，并通过流式细胞术定量HPV E6，E7 mRNA。 In Cell HPV Assay可以在不到三个小时的时间内直接从液体宫颈（“LBC”）细胞学标本中进行。 In Cell HPV Assay提供了一种有效和高度敏感的替代方法，用于确定宫颈细胞学异常的Pap涂片。

5. 发明授权

US06939687B2 Method of testing adequacy of cells in a specimen 有权
标题翻译：测试样本中细胞充分性的方法
公开(公告)号：US06939687B2
公开(公告)日：2005-09-06
申请号：US10341094
申请日：2003-01-13
申请人： Bruce K. Patterson
发明人： Bruce K. Patterson
IPC分类号： G01N15/14 , G01N33/50 , C12Q1/04 , C12N13/00 , C12Q1/02
CPC分类号： G01N33/5005 , G01N15/14
摘要： The present invention provides a device and method for determining the adequacy of squamous (ectocervical) cells, columnar (endocervical) cells, neutrophils, and noncellular material in a liquid based cytology specimen. The invention first analyzes a liquid based cytology specimen using light scatter to create a light scatter characteristic representing a predetermined cell. Next the invention determines the presence of squamous (ectocervical) cells versus columnar (endocervical) cells versus neutrophils versus noncellular material using the results of the light scatter. The light scatter characteristic that may be used may be forward light scatter, side light scatter, or both side and forward light scatter.
摘要翻译：本发明提供了一种用于确定液体细胞学样本中鳞状（宫颈外）细胞，柱状（宫颈内）细胞，嗜中性粒细胞和非细胞材料的适宜性的装置和方法。本发明首先分析使用光散射的基于液体的细胞学标本，以产生表示预定细胞的光散射特性。接下来，本发明使用光散射的结果确定鳞状（宫颈外）细胞与柱状（子宫颈内）细胞对嗜中性粒细胞与非细胞材料的存在。可以使用的光散射特性可以是向前的光散射，侧面光散射或者两侧和向前的光散射。

6. 发明申请

US20210063399A1 Methods of Assaying Neoplastic and Neoplasia-Related Cells and Uses Thereof 有权
公开(公告)号：US20210063399A1
公开(公告)日：2021-03-04
申请号：US16959355
申请日：2019-01-02
申请人： Bruce K. PATTERSON , Amanda Noel CHARGIN , Keith SHULTS , IncellDx, Inc.
发明人： Bruce K. Patterson , Amanda Noel Chargin , Keith Shults
IPC分类号： G01N33/574 , C12Q1/6886 , G01N15/14
摘要： Methods are provided for assaying neoplastic cells and/or neoplasia-related cells. Aspects of the methods involve de-tecting heterogeneity, per cell programmed-death ligand 1 (PD-L1) expression, and/or proliferation of neoplasia and/or neoplasia-re-lated cells. Aspects of the methods include cytometrically assaying a labeled cell suspension to quantify per cell heterogeneity, per cell PD-L1 expression, proliferation, and/or other parameters to detect whether a neoplastic cell is present in the neoplasia sample. Aspects of the provided methods also include treating a subject based on the outcome of such an assay. In addition, kits that find use in practicing the subject methods are also provided.

7. 发明申请

US20090220945A1 HPV E6, E7 mRNA ASSAY AND METHODS OF USE THEREOF 有权
标题翻译： HPV E6，E7 mRNA测定及其使用方法
公开(公告)号：US20090220945A1
公开(公告)日：2009-09-03
申请号：US12391634
申请日：2009-02-24
申请人： Bruce K. Patterson
发明人： Bruce K. Patterson
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C12Q1/6841 , C12Q2600/158 , G06F19/00
摘要： Provided is an HPV E6, E7 mRNA assay, referenced herein as the “In Cell HPV Assay,” that is capable of sensitive and specific detection of normal cervical cells undergoing malignant transformation as well as abnormal cervical cells with pre-malignant or malignant lesions. The In Cell HPV Assay identifies HPV E6, E7 mRNA via in situ hybridization with oligonucleotides specific for HPV E6, E7 mRNA and quantitates the HPV E6, E7 mRNA via flow cytometry. The In Cell HPV Assay can be carried out in less than three hours directly from liquid-based cervical (“LBC”) cytology specimens. The In Cell HPV Assay provides an efficient and highly sensitive alternative to the Pap smear for determining abnormal cervical cytology.
摘要翻译：提供了HPV E6，E7mRNA测定法，其在本文中被称为“In Cell HPV Assay”，其能够敏感和特异性检测经历恶性转化的正常宫颈细胞以及具有恶性前或恶性病变的异常宫颈细胞。 In Cell HPV Assay通过与HPV E6，E7 mRNA特异性寡核苷酸的原位杂交鉴定HPV E6，E7 mRNA，并通过流式细胞术定量HPV E6，E7 mRNA。 In Cell HPV Assay可以在不到三个小时的时间内直接从液体宫颈（“LBC”）细胞学标本中进行。 In Cell HPV Assay提供了一种有效和高度敏感的替代方法，用于确定宫颈细胞学异常的Pap涂片。

8. 发明授权

US06329167B1 Method of testing adequacy of cells in a specimen 有权
标题翻译：测试样本中细胞充分性的方法
公开(公告)号：US06329167B1
公开(公告)日：2001-12-11
申请号：US09730223
申请日：2000-12-05
申请人： Bruce K. Patterson
发明人： Bruce K. Patterson
IPC分类号： C12Q104
CPC分类号： G01N33/5005 , G01N15/14
摘要： The present invention relates to an appartus and method for use in pre-screening or determining the adequacy of target cells in specimen prior to conducting further diagnostic testing or analysis of the specimen. More specifically, the present invention concerns a device and method which uses light scatter techniques to detect the presence of a target cell in a specimen.
摘要翻译：本发明涉及一种用于在进行进一步诊断测试或分析样本之前预筛选或确定样品中靶细胞的充分性的用途和方法。更具体地，本发明涉及使用光散射技术来检测样本中目标细胞的存在的装置和方法。

9. 发明申请

US20120122078A1 METHODS AND SYSTEMS FOR PREDICTING WHETHER A SUBJECT HAS A CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN) LESION FROM A SUSPENSION SAMPLE OF CERVICAL CELLS 有权
标题翻译：方法和系统，用于预测主体是否存在来自宫颈细胞悬浮液样品的神经内膜神经元（CIN）
公开(公告)号：US20120122078A1
公开(公告)日：2012-05-17
申请号：US13294101
申请日：2011-11-10
申请人： Bruce K. Patterson
发明人： Bruce K. Patterson
IPC分类号： G01N33/569 , C12M1/34
CPC分类号： C12Q1/708 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/5091 , G01N33/57411 , G06F19/00 , G06F19/20 , G16H50/20
摘要： Methods of predicting whether a subject has a cervical intraepithelial neoplasia (CIN) lesion are provided. Aspects of the methods include obtaining both morphometric and biomarker data from a liquid cervical cellular sample and then using both types of data to predict whether the subject has a CIN lesion. Also provided are systems that find use in practicing the methods. The methods and systems find use in a variety of applications, including cervical cancer screening applications.
摘要翻译：提供预测受试者是否患有子宫颈上皮内瘤变（CIN）病变的方法。方法的方面包括从液体宫颈细胞样品获得形态测定和生物标志物数据，然后使用两种类型的数据来预测受试者是否具有CIN病变。还提供了在实践方法中使用的系统。该方法和系统可用于各种应用，包括宫颈癌筛查应用。

10. 发明申请

US20120020914A1 LEUKEMIA INHIBITORY FACTOR (LIF) FOR USE IN REPRESSING HUMAN PAPILLOMAVIRUS (HPV) TRANSCRIPTION 审中-公开
标题翻译：用于代谢人乳头瘤病毒（HPV）的转录因子的低密度脂蛋白抑制因子（LIF）
公开(公告)号：US20120020914A1
公开(公告)日：2012-01-26
申请号：US13167404
申请日：2011-06-23
申请人： Joseph M. Bay , Bruce K. Patterson , Nelson Teng
发明人： Joseph M. Bay , Bruce K. Patterson , Nelson Teng
IPC分类号： A61K38/19 , A61P15/00 , A61P35/00 , A61P31/20
CPC分类号： A61K38/2093
摘要： Embodiments of the invention are related to leukemia inhibitory factor (LIF) for use in repressing human papillomavirus (HPV) transcription. Processes and related kits are described for treating a HPV-associated papillomatous proliferation, for treating a HPV-associated genital, anal, vulvar, penile, oral, or laryngeal wart, for treating HPV-associated cervical dysplasia or cervical cancer, and for repressing HPV transcription, by administering LIF to a patient in need thereof. A related embodiment is treatment of HPV-16 by use of LIF.
摘要翻译：本发明的实施方案涉及用于抑制人乳头状瘤病毒（HPV）转录的白血病抑制因子（LIF）。描述了治疗HPV相关性乳头状瘤增生，用于治疗HPV相关的生殖器，肛门，外阴，阴茎，口腔或喉疣的方法和相关试剂盒，用于治疗HPV相关宫颈发育不良或子宫颈癌，以及抑制HPV 通过向有需要的患者施用LIF来转录。相关实施例是通过使用LIF治疗HPV-16。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式