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1. 发明授权

US08932858B2 Modified polysaccharide for cell culture and release 有权
标题翻译：用于细胞培养和释放的改性多糖
公开(公告)号：US08932858B2
公开(公告)日：2015-01-13
申请号：US12397809
申请日：2009-03-04
申请人： Wendy A. Baker , Dana C. Bookbinder , Theresa Chang , Robert R. Hancock, Jr.
发明人： Wendy A. Baker , Dana C. Bookbinder , Theresa Chang , Robert R. Hancock, Jr.
IPC分类号： C12N5/02 , C08B11/20 , C12N5/00
CPC分类号： C08B11/20 , C12N5/0068 , C12N2533/78
摘要： Hydrophobically modified polysaccharide compositions, articles incorporating the compositions, and methods for cell culture, automatic release of cells, and release of cell culture coating from a substrate or the cell culture articles incorporating the coating compositions, as defined herein.
摘要翻译：疏水性改性多糖组合物，掺入组合物的制品，细胞培养方法，细胞自动释放以及从底物或包含本文所定义的涂料组合物的细胞培养物质释放细胞培养物包衣。

2. 发明申请

US20090227024A1 MODIFIED POLYSACCHARIDE FOR CELL CULTURE AND RELEASE 有权
标题翻译：改良多糖用于细胞培养和释放
公开(公告)号：US20090227024A1
公开(公告)日：2009-09-10
申请号：US12397809
申请日：2009-03-04
申请人： Wendy A. Baker , Dana C. Bookbinder , Theresa Chang , Robert R. Hancock, JR.
发明人： Wendy A. Baker , Dana C. Bookbinder , Theresa Chang , Robert R. Hancock, JR.
IPC分类号： C12N5/00 , C07H1/00
CPC分类号： C08B11/20 , C12N5/0068 , C12N2533/78
摘要： Hydrophobically modified polysaccharide compositions, articles incorporating the compositions, and methods for cell culture, automatic release of cells, and release of cell culture coating from a substrate or the cell culture articles incorporating the coating compositions, as defined herein.
摘要翻译：疏水性改性多糖组合物，掺入组合物的制品，细胞培养方法，细胞自动释放以及从底物或包含本文所定义的涂料组合物的细胞培养物质释放细胞培养物包衣。

3. 发明申请

US20090227027A1 COATED CELL CULTURE SURFACES AND METHODS THEREOF 审中-公开
标题翻译：涂覆的细胞培养物表面及其方法
公开(公告)号：US20090227027A1
公开(公告)日：2009-09-10
申请号：US12390726
申请日：2009-02-23
申请人： Wendy A. Baker , Theresa Chang , Robert R. Hancock, JR. , Wanda J. Walczak
发明人： Wendy A. Baker , Theresa Chang , Robert R. Hancock, JR. , Wanda J. Walczak
IPC分类号： C12N5/00
CPC分类号： C08L1/08 , C08L1/28 , C08L1/32 , C08L3/04 , C08L5/00 , C12N5/0068 , C12N2533/70 , C08L2666/26
摘要： A composition for use, for example, in cell culture surface modification and in cell culture articles, as defined herein. Also disclosed are methods of making the compositions and articles, and methods of using the compositions and articles, as defined herein.
摘要翻译：用于例如细胞培养物表面改性的组合物和如本文所定义的细胞培养物品。还公开了制备组合物和制品的方法，以及如本文所定义的使用组合物和制品的方法。

4. 发明授权

US08883314B2 Coated articles with improved fingerprint resistance and methods of making same 有权
标题翻译：具有改进的指纹抗蚀性的涂层制品及其制造方法
公开(公告)号：US08883314B2
公开(公告)日：2014-11-11
申请号：US13351571
申请日：2012-01-17
申请人： Theresa Chang , Robert Randall Hancock, Jr.
发明人： Theresa Chang , Robert Randall Hancock, Jr.
IPC分类号： B05D3/00 , C09D143/04 , C09D133/14 , C03C17/30 , B05D5/08
CPC分类号： C03C17/30 , B05D5/083 , C09D133/14 , C09D143/04 , Y10T428/266 , Y10T428/3154 , Y10T428/31612 , Y10T428/31645 , Y10T428/31663 , Y10T428/31935 , C08L27/12
摘要： Described herein are various articles that have improved resistance to the adverse effects observed when tactilely-transferable residue is contacted therewith, along with methods for their manufacture and use. The articles and methods generally make use of an adhesion binder that can be used to form a polymer network around a solvent-soluble fluoropolymer to adhere the fluoropolymer to the surface of the article substrate.
摘要翻译：本文描述的是具有改善的耐受可触感残留物与之接触的不利影响的耐受性的各种制品及其制造和使用方法。制品和方法通常使用粘合粘合剂，其可用于在溶剂可溶性含氟聚合物周围形成聚合物网络，以将氟聚合物粘附到制品基材的表面。

5. 发明申请

US20100190255A1 CROSS-LINKED GUMS FOR HEPATOCYTE CULTURE 审中-公开
标题翻译： HEPATOCYTE文化的交叉关系
公开(公告)号：US20100190255A1
公开(公告)日：2010-07-29
申请号：US12500088
申请日：2009-07-09
申请人： Theresa Chang , Wageesha Senaratne , Lung-Ming Wu
发明人： Theresa Chang , Wageesha Senaratne , Lung-Ming Wu
IPC分类号： C12N5/071
CPC分类号： C12N5/0068 , C12N5/067 , C12N2533/70
摘要： This disclosure relates to cell culture surfaces derived from or contain gums including naturally occurring gums, plant gums, galactomannan gums or derivatives thereof including carboxyalkyl guar gum. Even more particularly, the disclosure relates to chemically or physically cross-linked modified gums where the gum surfaces are tuned to provide cell culture surfaces with physical and chemical characteristics particularly suited for hepatocyte culture. The disclosure also relates to articles of manufacture (e.g., cell culture vessels and labware) having such matrices, methods of making and providing the matrices to cell culture surfaces, and methods of using cell culture vessels having such matrices.
摘要翻译：本公开涉及源自或含有牙龈的细胞培养物表面，包括天然存在的树胶，植物胶，半乳甘露聚糖胶或其衍生物，包括羧烷基瓜耳胶。更具体地，本公开涉及化学或物理交联的改性胶，其中胶表面被调谐以提供特别适合于肝细胞培养的物理和化学特性的细胞培养物表面。本公开还涉及具有这种基质的制品（例如，细胞培养容器和实验器皿），制备和提供基质到细胞培养物表面的方法，以及使用具有这种基质的细胞培养容器的方法。

6. 发明申请

US20120189843A1 Coated Articles With Improved Fingerprint Resistance and Methods of Making Same 有权
标题翻译：具有改进指纹抗性的涂层制品及其制作方法
公开(公告)号：US20120189843A1
公开(公告)日：2012-07-26
申请号：US13351571
申请日：2012-01-17
申请人： Theresa Chang , Robert Randall Hancock, JR.
发明人： Theresa Chang , Robert Randall Hancock, JR.
IPC分类号： B32B3/00 , C09D143/04 , B05D3/10 , B32B17/10
CPC分类号： C03C17/30 , B05D5/083 , C09D133/14 , C09D143/04 , Y10T428/266 , Y10T428/3154 , Y10T428/31612 , Y10T428/31645 , Y10T428/31663 , Y10T428/31935 , C08L27/12
摘要： Described herein are various articles that have improved resistance to the adverse effects observed when tactilely-transferable residue is contacted therewith, along with methods for their manufacture and use. The articles and methods generally make use of an adhesion binder that can be used to form a polymer network around a solvent-soluble fluoropolymer to adhere the fluoropolymer to the surface of the article substrate.
摘要翻译：本文描述的是具有改善的耐受可触感残留物与之接触的不利影响的耐受性的各种制品及其制造和使用方法。制品和方法通常使用粘合粘合剂，其可用于在溶剂可溶性含氟聚合物周围形成聚合物网络，以将氟聚合物粘附到制品基材的表面。

7. 发明申请

US20110306136A1 LAMININ-ENTACTIN COMPLEX AND CELL CULTURE ARTICLE AND METHODS THEREOF 有权
标题翻译： LAMININ-ENTACTIN复合物和细胞培养物品及其方法
公开(公告)号：US20110306136A1
公开(公告)日：2011-12-15
申请号：US13111234
申请日：2011-05-19
申请人： Theresa Chang , Jin Liu , Odessa Natalie Petzold , Ruchirej Yongsunthon
发明人： Theresa Chang , Jin Liu , Odessa Natalie Petzold , Ruchirej Yongsunthon
IPC分类号： C12N5/071 , C12M3/00
CPC分类号： C12N5/0068 , C12M25/00 , C12N2533/50 , C12N2533/52
摘要： A cell culture system including: a substrate, a substrate coating, one or more live cells, and an overlay source. The substrate coating and overlay can be laminin, and laminin•entactin complex, respectively. Alternatively, the substrate coating and overlay can be laminin•entactin complex, and laminin, respectively. The cell culture system can further include liquid media and a protective cover. A method for making and using the system in cell culture articles and culture methods, as defined herein, is also disclosed.
摘要翻译：一种细胞培养系统，包括：底物，底物涂层，一个或多个活细胞和覆盖源。底物涂层和覆盖层可分别为层粘连蛋白和层粘连蛋白•内酰胺酶复合物。或者，基底涂层和覆盖层可以分别是层粘连蛋白·内含子复合物和层粘连蛋白。细胞培养系统还可以包括液体介质和保护盖。还公开了在本文定义的细胞培养物和培养方法中制备和使用该系统的方法。

8. 发明申请

US20070117197A1 LACTOBACILLI EXPRESSING BIOLOGICALLY ACTIVE POLYPEPTIDES AND USES THEREOF 有权
标题翻译： Lactobacilli表达生物活性多肽及其用途
公开(公告)号：US20070117197A1
公开(公告)日：2007-05-24
申请号：US11620588
申请日：2007-01-05
申请人： Chia-Hwa Chang , David Simpson , Theresa Chang , Qiang Xu , John Lewicki
发明人： Chia-Hwa Chang , David Simpson , Theresa Chang , Qiang Xu , John Lewicki
IPC分类号： C12N1/21 , C12N15/74
CPC分类号： C07K14/335 , A61K35/747 , A61K38/164 , A61K38/1774 , C12N15/74
摘要： The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.
摘要翻译：本发明涉及重组改变以表达生物活性蛋白质的乳杆菌属物种。本发明还涉及将细菌提供给阴道的方法。

9. 发明申请

US20110053270A1 Patterning Hydrogels 审中-公开
标题翻译：图案水凝胶
公开(公告)号：US20110053270A1
公开(公告)日：2011-03-03
申请号：US12862967
申请日：2010-08-25
申请人： Theresa Chang , Robert Randall Hancock, JR. , Trista Nicole Hesch , Michael Lesley Sorensen , Ruchirej Yongsunthon
发明人： Theresa Chang , Robert Randall Hancock, JR. , Trista Nicole Hesch , Michael Lesley Sorensen , Ruchirej Yongsunthon
IPC分类号： B05D3/06 , C12N5/00
CPC分类号： C12N5/0068 , C12N2533/78 , C12N2535/00 , G03F7/095 , G03F7/26
摘要： A method for forming a pattern-coated substrate includes disposing a composition comprising a polysaccharide-based polymer on a substrate to generate a coated substrate. The polysaccharide-based polymer composition is substantially free of cross-linking monomers. The method further includes exposing a portion of the coated substrate to a first dose of UV radiation to induce crosslinking of the polysaccharide-based polymer, wherein a portion of the substrate is shielded from the ionizing radiation. The UV exposed coated substrate may be washed or hydrated to remove uncross-linked polysaccharide-based polymer.
摘要翻译：形成图案涂布基板的方法包括在基材上设置包含多糖类聚合物的组合物以产生涂布的基材。多糖类聚合物组合物基本上不含交联单体。该方法还包括将涂覆的基底的一部分暴露于第一剂量的UV辐射以诱导多糖类聚合物的交联，其中基底的一部分与电离辐射屏蔽。紫外线曝光的涂覆的基底可以被洗涤或水合以除去未交联的多糖基聚合物。

10. 发明申请

US20120178162A1 POLYMER MATRICES FOR CELL CULTURE 有权
标题翻译：细胞培养的聚合物矩阵
公开(公告)号：US20120178162A1
公开(公告)日：2012-07-12
申请号：US13270357
申请日：2011-10-11
申请人： Wendy Annette Baker , Theresa Chang , Robert Randall Hancock, JR.
发明人： Wendy Annette Baker , Theresa Chang , Robert Randall Hancock, JR.
IPC分类号： C12N5/071 , C08B15/00 , B32B1/02 , C09D101/28 , B32B9/04 , B05D3/06 , C08B37/00 , C09D133/04
CPC分类号： C09D133/066 , C08J3/075 , C08J2301/26 , C08L1/26 , C08L1/284 , C09D101/26 , C09D101/284 , C09D133/14 , C12M23/20 , C12N5/0068 , C12N2533/10 , C12N2533/30 , C12N2533/78 , C12N2537/10 , Y10T428/13 , C08L33/066 , C08L33/14
摘要： Synthetic cell culture surfaces, including a hydrophobe modified cellulose or an hydroxylated acrylate polymer composition and optionally including a silica source, cell culture coating and cell culture articles incorporating the composition, and methods of making and using the articles for cell culture, as defined herein.
摘要翻译：合成细胞培养物表面，包括疏水改性纤维素或羟基化丙烯酸酯聚合物组合物，并且任选地包括二氧化硅源，细胞培养物包衣和掺入该组合物的细胞培养物，以及制备和使用本文定义的细胞培养物品的方法。

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