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1. 发明申请

US20060166955A1 Production process for 16-dehydropregnenoneol and its analogs 审中-公开
标题翻译： 16-脱氢孕烯醇及其类似物的生产工艺
公开(公告)号：US20060166955A1
公开(公告)日：2006-07-27
申请号：US10561164
申请日：2004-06-14
申请人： Weisheng Tian , Xin Xu , Shanshan Liu , Junwei Shen , Xiujing Wu
发明人： Weisheng Tian , Xin Xu , Shanshan Liu , Junwei Shen , Xiujing Wu
IPC分类号： A61K31/56 , C07J5/00
CPC分类号： C07J7/00 , C07J71/00
摘要： The present invention relates to a clean process for the degradation of steroidal sapogenin to produce 16-dehydropregnenolone and its analogs. The pure or the crude pseudo steroidal sapogenin, derived from steroidal sapogenin, dissolved in organic solvent, reacts with hydrogen peroxide with or without metal compound and acid as catalyst, and the crude products directly go through elimination and hydrolization in the presence of base to give 16-Dehydropregnenolone or its analog, accompanied with the other product 4R(or S)-methyl-5-hydroxy-pentate, which is converted to 4R(or S)-methyl-δ-pentyl lactone after acidification and extraction from the water layer. This technology improved the utilizing degree of steroidal sapogenin, improved the yield, and cleared up the chromium pollution in the former technique. In a word, the method disclosed in this invention is more suitable for manufacture.
摘要翻译：本发明涉及一种用于降解甾体皂苷元以产生16-脱氢孕烯醇酮及其类似物的清洁方法。衍生自甾体皂苷元的纯的或粗制的假甾体皂苷元，溶于有机溶剂中，与或不与金属化合物和酸作为催化剂与过氧化氢反应，粗产物在碱存在下直接进行消除和水解，得到伴随着另一种产物4R（或S） - 甲基-5-羟基 - 戊酸酯，其在酸化并从水层中提取后转化成4R（或S） - 甲基-δ-戊基内酯。该技术提高了甾体皂苷元的利用程度，提高了产量，并清除了前一种技术中的铬污染。总而言之，本发明公开的方法更适合于制造。

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