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1. 发明授权

US06640001B2 Method and apparatus for fast detection of lesions 失效
标题翻译：用于快速检测病变的方法和装置
公开(公告)号：US06640001B2
公开(公告)日：2003-10-28
申请号：US09907585
申请日：2001-07-17
申请人： Jimmy R. Roehrig , Harlan M. Romsdahl , Wei Zhang
发明人： Jimmy R. Roehrig , Harlan M. Romsdahl , Wei Zhang
IPC分类号： G06K900
CPC分类号： G06K9/4633 , A61B6/502 , G06K9/00 , G06K9/3233 , G06K9/4638 , G06K9/56 , G06K2209/05 , G06T7/0012 , G06T2207/30068
摘要： A method and apparatus for the fast detection of spiculated lesions in a digital mammogram, the method for use in a computer aided diagnosis system for assisting a radiologist in identifying and recognizing the spiculations among a multiplicity of lines corresponding to standard fibrous breast tissue. A line and direction image is created from a digital mammogram, and a region of potential intersection for substantially every pixel in the digital mammogram image is determined. The region of potential intersection for each pixel is a predetermined pattern, such as a high aspect ratio rectangle or trapezoid, positioned around the pixel and rotated in a direction corresponding to direction information for that pixel. The regions of potential intersection are accumulated among the pixels to produce a cumulative array, and information in the cumulative array is processed for identifying spiculations in the digital mammogram.
摘要翻译：一种用于在数字乳腺X线照片中快速检测打孔损伤的方法和装置，该方法用于计算机辅助诊断系统，用于辅助放射科医师识别并识别对应于标准纤维性乳房组织的多条线之间的突起。从数字乳房X线照片产生线和方向图像，并且确定数字乳房X线照片图像中基本上每个像素的电位交叉区域。每个像素的电位交叉区域是围绕像素定位并沿与该像素的方向信息相对应的方向旋转的预定图案，例如高宽高比矩形或梯形。在像素之间累积潜在的交叉点的区域以产生累积阵列，并且处理累积阵列中的信息以识别数字乳腺X线照片中的spiculations。

2. 发明授权

US06263092B1 Method and apparatus for fast detection of spiculated lesions in digital mammograms 失效
标题翻译：用于快速检测数字乳腺X线照片中的打孔病变的方法和装置
公开(公告)号：US06263092B1
公开(公告)日：2001-07-17
申请号：US09103290
申请日：1998-06-23
申请人： Jimmy R. Roehrig , Harlan M. Romsdahl , Wei Zhang
发明人： Jimmy R. Roehrig , Harlan M. Romsdahl , Wei Zhang
IPC分类号： G06K900
CPC分类号： G06K9/4633 , A61B6/502 , G06K9/00 , G06K9/3233 , G06K9/4638 , G06K9/56 , G06K2209/05 , G06T7/0012 , G06T2207/30068
摘要： A method and apparatus for the fast detection of spiculated lesions in a digital mammogram, the method for use in a computer aided diagnosis system for assisting a radiologist in identifying and recognizing the spiculations among a multiplicity of lines corresponding to standard fibrous breast tissue. A line and direction image is created from a digital mammogram, and a region of potential intersection for substantially every pixel in the digital mammogram image is determined. The region of potential intersection for each pixel is a predetermined pattern, such as a high aspect ratio rectangle or trapezoid, positioned around the pixel and rotated in a direction corresponding to direction information for that pixel. The regions of potential intersection are accumulated among the pixels to produce a cumulative array, and information in the cumulative array is processed for identifying spiculations in the digital mammogram.
摘要翻译：一种用于在数字乳腺X线照片中快速检测打孔损伤的方法和装置，该方法用于计算机辅助诊断系统，用于辅助放射科医师识别并识别对应于标准纤维性乳房组织的多条线之间的突起。从数字乳房X线照片产生线和方向图像，并且确定数字乳房X线照片图像中基本上每个像素的电位交叉区域。每个像素的电位交叉区域是围绕像素定位并沿与该像素的方向信息相对应的方向旋转的预定图案，例如高宽高比矩形或梯形。在像素之间累积潜在的交叉点的区域以产生累积阵列，并且处理累积阵列中的信息以识别数字乳腺X线照片中的spiculations。

3. 发明授权

US6014452A Method and system for using local attention in the detection of abnormalities in digitized medical images 失效
标题翻译：在数字化医学图像检测异常中使用局部注意力的方法和系统
公开(公告)号：US6014452A
公开(公告)日：2000-01-11
申请号：US901541
申请日：1997-07-28
申请人： Wei Zhang , Harlan M. Romsdahl , Jimmy R. Roehrig
发明人： Wei Zhang , Harlan M. Romsdahl , Jimmy R. Roehrig
IPC分类号： G06T7/00 , G06K9/00 , A61B6/04 , G06K9/62
CPC分类号： G06K9/342 , G06T7/0012 , G06K2209/05
摘要： A method an system for using a local attention threshold to aid in the detection of clustered abnormalities in digitized medical images is disclosed. The local attention threshold is applied to locate spots within a predetermined distance from previously identified spots. More specifically, seed pixels are identified by applying a first seed threshold function to the output of a shift-invariant neural network and adaptive threshold. The seed pixels are then segmented into spots by applying a segmentation threshold function to each seed pixel. False-positive spots are removed using various techniques. Additional seed pixels are then identified by applying a local attention threshold to pixels within a predetermined distance to previously identified spots. The local attention threshold disclosed is less selective for pixels which are closer to the nearest spot than for pixels which are further from the nearest spot. The new seed pixels are then segmented into spots, and potential abnormalities are identified in the medical image based in part on the closeness of the identified spots.
摘要翻译：公开了一种使用局部关注阈值来辅助检测数字化医学图像中的聚类异常的方法。应用局部注意阈值来定位距离先前识别的点的预定距离内的点。更具体地，通过对移位不变神经网络和自适应阈值的输出应用第一种子阈值函数来识别种子像素。然后通过对每个种子像素应用分割阈值函数将种子像素分割成点。使用各种技术去除假阳性斑点。然后通过对与先前识别的点的预定距离内的像素应用局部注意阈值来识别附加种子像素。所公开的局部注意阈值对于距离最近的点更靠近最近的像素的像素的选择性较小。然后将新的种子像素分割成斑点，并且部分地基于识别的斑点的接近度在医学图像中识别潜在的异常。

4. 发明授权

US5815591A Method and apparatus for fast detection of spiculated lesions in digital mammograms 失效
公开(公告)号：US5815591A
公开(公告)日：1998-09-29
申请号：US676660
申请日：1996-07-10
申请人： Jimmy R. Roehrig , Harlan M. Romsdahl , Wei Zhang
发明人： Jimmy R. Roehrig , Harlan M. Romsdahl , Wei Zhang
IPC分类号： A61B6/00 , G06K9/32 , G06K9/46 , G06K9/56 , G06K9/00 , A61B6/04
CPC分类号： G06K9/4633 , G06K9/3233 , G06K9/4638 , G06K9/56 , A61B6/502 , G06K2209/05
摘要： A method and apparatus for the fast detection of spiculated lesions in a digital mammogram, the method for use in a computer aided diagnosis system for assisting a radiologist in identifying and recognizing the spiculations among a multiplicity of lines corresponding to standard fibrous breast tissue. A line and direction image is created from a digital mammogram, and a region of potential intersection for substantially every pixel in the digital mammogram image is determined. The region of potential intersection for each pixel is a predetermined pattern, such as a high aspect ratio rectangle or trapezoid, positioned around the pixel and rotated in a direction corresponding to direction information for that pixel. The regions of potential intersection are accumulated among the pixels to produce a cumulative array, and information in the cumulative array is processed for identifying spiculations in the digital mammogram.

5. 发明授权

US08144959B2 Facilitating temporal comparison of medical images 失效
标题翻译：促进医学图像的时间比较
公开(公告)号：US08144959B2
公开(公告)日：2012-03-27
申请号：US13022609
申请日：2011-02-07
申请人： Gabriele Zingaretti , Jimmy R. Roehrig , Julian Marshall , Zhong Tao
发明人： Gabriele Zingaretti , Jimmy R. Roehrig , Julian Marshall , Zhong Tao
IPC分类号： G06K9/00
CPC分类号： G06T7/0014 , G06T2207/30068
摘要： Methods, systems, and computer program products for facilitating temporal comparison of medical images is provided, with one exemplary application being for breast mammograms. In one embodiment, prior and subsequent mammographic images of a breast acquired using at least partially different mammogram acquisition systems are displayed for simultaneous viewing on a same mammogram display at an identical tissue distance per unit display distance without requiring a scale-adjusting viewer input. Also described are other embodiments for optimally scaling, windowing and/or otherwise advantageously processing and/or displaying prior and subsequent mammographic image sets in manners that facilitate temporal comparison therebetween.
摘要翻译：提供了用于促进医学图像的时间比较的方法，系统和计算机程序产品，其中一个示例性应用是用于乳房X线照片。在一个实施例中，使用至少部分不同的乳房X线照片采集系统获取的乳房的先前和随后的乳房摄影图像被显示，以在相同的乳房X线照片显示器上以与每单位显示距离相同的组织距离同时观看，而不需要缩放调整观察者输入。还描述了其他实施例，用于以促进其之间的时间比较的方式最佳地缩放，加窗和/或以其他方式有利地处理和/或显示先前和随后的乳房照相图像集。

6. 发明申请

US20080118138A1 Facilitating comparison of medical images 失效
标题翻译：促进医学图像的比较
公开(公告)号：US20080118138A1
公开(公告)日：2008-05-22
申请号：US11602575
申请日：2006-11-21
申请人： Gabriele Zingaretti , Jimmy R. Roehrig , Julian Marshall , Vincenzo Velocci
发明人： Gabriele Zingaretti , Jimmy R. Roehrig , Julian Marshall , Vincenzo Velocci
IPC分类号： G06K9/00 , G06T17/00
CPC分类号： G06T7/0012 , G06T2200/24 , G06T2207/10116 , G06T2207/30068
摘要： Facilitating analysis of one or more mammography images on a review workstation is described. A point or region of interest is identified in a first mammography image of a human breast. The distance between the point or region of interest and a point of reference, preferably the breast nipple, on the first mammography image is determined. A locus of points in a second mammography image of the breast is calculated, the locus of points representing potential locations corresponding to the point or region of interest in the first mammography image, and the calculation being based at least in part on the distance between the point or region of interest and the point of reference. The locus of points is then highlighted a user so as to facilitate a determination by the user of one or more locations in the second mammography image corresponding to the point or region of interest in the first mammography image. The locus of points is preferably a circular section arc having a radius corresponding to the point or region of interest to nipple distance, and centered about the nipple in the second mammography image.
摘要翻译：描述了在审查工作站上促进对一个或多个乳房摄影图像的分析。感兴趣的点或区域在人乳房的第一乳房摄影图像中被识别。确定在第一乳房摄影图像上的感兴趣的点或区域与参考点之间的距离，优选乳房乳头。计算乳房的第二乳房X线照相图像中的点的轨迹，表示与第一乳房X线照相图像中的感兴趣点或区域相对应的潜在位置的点的轨迹，并且该计算至少部分地基于点或区域和参考点。点的轨迹然后突出显示用户，以便于用户确定与第一乳房X线照相图像中的感兴趣点或区域相对应的第二乳房摄影图像中的一个或多个位置。点的轨迹优选为具有对应于乳头距离的感兴趣点或区域的半径的圆形截面圆弧，并且位于第二乳房X射线摄影图像中的乳头的中心。

7. 发明授权

US06198838B1 Method and system for detection of suspicious lesions in digital mammograms using a combination of spiculation and density signals 有权
标题翻译：使用螺旋和密度信号的组合检测数字乳腺X线照片中的可疑病变的方法和系统
公开(公告)号：US06198838B1
公开(公告)日：2001-03-06
申请号：US09141289
申请日：1998-08-27
申请人： Jimmy R. Roehrig , Takeshi Doi , Nico Karssemeijer , Guido M. Te Brake
发明人： Jimmy R. Roehrig , Takeshi Doi , Nico Karssemeijer , Guido M. Te Brake
IPC分类号： G06K900
CPC分类号： G06K9/00 , A61B6/502 , G06K9/3233 , G06K9/4633 , G06K9/4638 , G06K9/56 , G06K2209/05 , G06T7/0012
摘要： A method and system for detecting suspicious portions of digital mammograms by using independently calculated mass and spiculation information is disclosed. The method is for use in a computer aided diagnosis system that is designed to bring suspicious or possibly cancerous lesions in fibrous breast tissue to the attention of a radiologist or other medical professional. In a preferred embodiment, spiculation information and mass information are independently calculated, with the computed spiculation information not being dependent on results of the mass information computation, thus leading to greater reliability. Systems according to a preferred embodiment also compute spiculation information either prior to, or concurrently with, the computation of mass information, thus allowing increased overall system speed.
摘要翻译：公开了一种通过使用独立计算的质量和刺激信息来检测数字乳腺X线照片的可疑部分的方法和系统。该方法用于计算机辅助诊断系统，该系统旨在将纤维性乳房组织中的可疑或可能的癌性病变引起放射科医师或其他医学专业人员的注意。在优选实施例中，独立地计算刺激信息和质量信息，计算的刺激信息不依赖于质量信息计算的结果，因此导致更高的可靠性。根据优选实施例的系统还可以在质量信息的计算之前或同时计算密码信息，从而允许增加的整体系统速度。

8. 发明授权

US08897564B2 Method and system for automatic identification and orientation of medical images 有权
标题翻译：医学图像自动识别和定向的方法和系统
公开(公告)号：US08897564B2
公开(公告)日：2014-11-25
申请号：US11634434
申请日：2006-12-05
申请人： Keith W. Hartman , Julian Marshall , Alexander C. Schneider , Jimmy R. Roehrig
发明人： Keith W. Hartman , Julian Marshall , Alexander C. Schneider , Jimmy R. Roehrig
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0042 , G06F19/00 , G06T7/0012 , G06T7/73 , G06T2207/30068
摘要： A method and system for computer-aided detection of abnormal lesions in digital mammograms is described, wherein digital films are processed using an automated and computerized method of detecting the order and orientation of a set of films. In one embodiment, anatomic features are used to detect the order, orientation and identification of a film series. In another embodiment of the invention, a technologist feeds films into the system in any order and orientation. After processing, the system provides an output on a display device to a radiologist that is in an order and orientation preferred by the radiologist. In yet another embodiment of the invention, films from one case are distinguished from films of another case. In this manner and through the use of a bulk loader, a large number of films can be stacked together and fed into the system at one time.
摘要翻译：描述了一种用于计算机辅助检测数字乳腺X线照片中的异常病变的方法和系统，其中使用检测一组膜的顺序和取向的自动化和计算机化方法处理数字膜。在一个实施例中，解剖特征用于检测胶片系列的顺序，取向和识别。在本发明的另一个实施例中，技术人员以任何顺序和方向将胶片送入系统。在处理之后，系统将显示设备上的输出提供给放射科医师的放射科医师，该放射科医师处于放射科医师优选的顺序和取向。在本发明的另一个实施例中，来自一种情况的膜与另一种情况的膜不同。以这种方式并通过使用散装装载机，可以将大量的薄膜堆叠在一起并一次进入系统。

9. 发明授权

US07885443B2 Facilitating temporal comparison of medical images 有权
标题翻译：促进医学图像的时间比较
公开(公告)号：US07885443B2
公开(公告)日：2011-02-08
申请号：US11600246
申请日：2006-11-14
申请人： Gabriele Zingaretti , Jimmy R. Roehrig , Julian Marshall , Zhong Tao
发明人： Gabriele Zingaretti , Jimmy R. Roehrig , Julian Marshall , Zhong Tao
IPC分类号： G06K9/00
CPC分类号： G06T7/0014 , G06T2207/30068
摘要： Methods, systems, and computer program products for facilitating temporal comparison of medical images is provided, with one exemplary application being for breast mammograms. In one embodiment, prior and subsequent mammographic images of a breast acquired using at least partially different mammogram acquisition systems are displayed for simultaneous viewing on a same mammogram display at an identical tissue distance per unit display distance without requiring a scale-adjusting viewer input. Also described are other embodiments for optimally scaling, windowing and/or otherwise advantageously processing and/or displaying prior and subsequent mammographic image sets in manners that facilitate temporal comparison therebetween.
摘要翻译：提供了用于促进医学图像的时间比较的方法，系统和计算机程序产品，其中一个示例性应用是用于乳房X线照片。在一个实施例中，使用至少部分不同的乳房X线照片采集系统获取的乳房的先前和随后的乳房摄影图像被显示，以在相同的乳房X线照片显示器上以与每单位显示距离相同的组织距离同时观看，而不需要缩放调整观察者输入。还描述了其他实施例，用于以促进其之间的时间比较的方式最佳地缩放，加窗和/或以其他方式有利地处理和/或显示先前和随后的乳房照相图像集。

10. 发明授权

US07616793B2 Medical image review workstation with integrated content-based resource retrieval 失效
标题翻译：具有集成内容资源检索功能的医学图像审查工作站
公开(公告)号：US07616793B2
公开(公告)日：2009-11-10
申请号：US11026603
申请日：2004-12-30
申请人： Julian Marshall , Keith W. Hartman , Jimmy R. Roehrig
发明人： Julian Marshall , Keith W. Hartman , Jimmy R. Roehrig
IPC分类号： G06K9/00 , A61B5/00 , G06F19/00 , G06F7/00 , G06F17/30
CPC分类号： G06Q50/24 , G06F19/00 , G06F19/321 , G16H40/63 , G16H50/20 , Y10S707/99936
摘要： A review workstation for facilitating interpretation of a medical image by a user is described. The review workstation comprises a display device displaying the medical image to the user, and an input device receiving a graphical identification of a region of interest (ROI) in the medical image that is interesting to the user. Responsive to the identification of the ROI, a content-based image comparison is performed between the ROI and a resource database, the resource database comprising a collection of resource images previously analyzed by human interpreters and textual information associated with those previous analyses. The content-based image comparison comprises identifying a subset of the resource images similar to the ROI with respect to a preselected set of computed features. The display device subsequently displays to the user at least one of the identified subset of resource images and its associated textual information simultaneously with the ROI.
摘要翻译：描述了用于便于用户解读医学图像的检查工作站。检查工作站包括向用户显示医学图像的显示装置，以及接收用户感兴趣的医学图像中感兴趣区域（ROI）的图形标识的输入装置。响应于ROI的识别，在ROI和资源数据库之间执行基于内容的图像比较，资源数据库包括先前由人类解释器分析的资源图像的集合以及与之前分析相关联的文本信息。基于内容的图像比较包括相对于预选的计算特征集合来识别类似于ROI的资源图像的子集。显示设备随后向用户显示所识别的资源图像子集中的至少一个及其与ROI相关联的文本信息。

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