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    • 3. 发明申请
    • Hook nut connector assembly
    • 钩形螺母连接器总成
    • US20050123377A1
    • 2005-06-09
    • US10759877
    • 2004-01-16
    • John BoylandWei TongLaszlo BarthaOystein Krogen
    • John BoylandWei TongLaszlo BarthaOystein Krogen
    • F16B5/02F16B21/09F16B21/18F16B37/04F16B33/00
    • F16B37/042F16B5/0291F16B21/09F16B21/18F16B37/041
    • The present invention provides an apparatus that fastens elements of a frame assembly. The frame assembly implements fasteners as independent elements from both a housing and a corresponding housing cover. Exemplary embodiments of such fasteners may include the hook nut fasteners disclosed herein. Generally, such fasteners include a central portion providing a contact area disposed in the plane of a housing fastening aperture, an extension tab providing a contact area on a housing interior wall, and an extension block providing a contact area on a housing exterior wall. The extension block may include a hollow portion configured to receive a securing bolt. One advantageous application of the invention relates to automobile motor assembly housings. Specifically, in that embodiment the hook nut fastening assembly reinforces the motor housing and provides additional support to the assembly by reinforcing the joints between an end-cover and a motor assembly main body.
    • 本发明提供一种紧固框架组件的元件的装置。 框架组件从壳体和相应的壳体盖两者实现紧固件作为独立元件。 这种紧固件的示例性实施例可以包括本文公开的钩形螺母紧固件。 通常,这种紧固件包括提供设置在壳体紧固孔的平面中的接触区域的中心部分,提供壳体内壁上的接触区域的延伸突出部以及在壳体外壁上提供接触区域的延伸块。 延伸块可以包括构造成接收固定螺栓的中空部分。 本发明的一个有利的应用涉及汽车电机组件外壳。 具体地,在该实施例中,钩螺母紧固组件加强了电动机壳体,并且通过加强端盖和电动机组件主体之间的接头而为组件提供额外的支撑。
    • 8. 发明授权
    • 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents
    • 6 - [(取代的)苯基]三唑并嘧啶作为抗癌剂
    • US07507739B2
    • 2009-03-24
    • US10950543
    • 2004-09-24
    • Nan ZhangSemiramis Ayral-KaloustianThai NguyenYanzhong WuWei Tong
    • Nan ZhangSemiramis Ayral-KaloustianThai NguyenYanzhong WuWei Tong
    • C07D487/04A61K31/519A61P35/04
    • C07D487/04
    • This invention relates to certain 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. The present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.
    • 本发明涉及某些6 - [(取代的)苯基]三唑并嘧啶化合物或其药学上可接受的盐,以及含有所述化合物或其药学上可接受的盐的组合物,其中所述化合物是可用于治疗哺乳动物癌症的抗癌剂。 本发明还涉及治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法,并进一步提供了治疗或预防表达多重耐药性(MDR)或耐多药耐药性的癌性肿瘤的方法 在有需要的哺乳动物中,所述方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。 本发明涉及通过促进微管聚合来治疗或抑制有需要的哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法,其包括对所述哺乳动物施用有效量的所述化合物及其药学上可接受的盐。