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1. 发明授权

US07621636B2 Working distance and alignment sensor for a fundus camera 失效
标题翻译：眼底相机的工作距离和对准传感器
公开(公告)号：US07621636B2
公开(公告)日：2009-11-24
申请号：US11621943
申请日：2007-01-10
申请人： Wei Su , Yan Zhou , Qing Chun Zhao , Yeou-Yen Cheng
发明人： Wei Su , Yan Zhou , Qing Chun Zhao , Yeou-Yen Cheng
IPC分类号： A61B3/14 , A61B3/10
CPC分类号： A61B3/12 , A61B3/102 , A61B3/152
摘要： In embodiments of optical arrangements of a working distance sensor in a fundus camera that can improve the determination of a correct working distance as well as the transverse positioning of the camera a number of near infrared light sources are arranged to project a number of near infrared illumination beams into the visible light illumination path of the fundus camera and a live view of the retina under near infrared illumination is captured and displayed on a monitor. These embodiments of optical arrangements and associated methods will enable an operator to directly determine if there is any undesirable flare or other artifact appearing within a designated region on the infrared retina view as a result of a wrong alignment of the fundus camera with respect to the eye in terms of not only the working distance but also the horizontal and vertical positions. Pattern recognition algorithms can be used to further enhance the positioning sensitivity of the working distance sensor. An additional iris alignment sensor can be added to achieve a coarse alignment and also function as a measure to determine if the dilation of the iris size is sufficient for different mode of fundus imaging.
摘要翻译：在眼底照相机中的工作距离传感器的光学布置的实施例中，其可以改善确定正确的工作距离以及相机的横向定位，并且布置多个近红外光源以投射多个近红外照明光束进入眼底照相机的可见光照明路径，并且在近红外照明下的视网膜的实时图像被捕获并显示在监视器上。光学布置和相关方法的这些实施例将使得操作者能够直接确定由于眼底照相机相对于眼睛错误对准的结果，在红外线视网膜视图上的指定区域内是否存在任何不期望的耀斑或其他伪像不仅在于工作距离，还包括水平和垂直位置。模式识别算法可用于进一步提高工作距离传感器的定位灵敏度。可以添加附加的虹膜对准传感器以实现粗略对准，并且还用作确定虹膜尺寸的扩张是否足够用于不同的眼底成像模式的措施。

2. 发明授权

US07621638B2 Delivering a short Arc lamp light for eye imaging 失效
标题翻译：为眼睛成像提供短弧灯
公开(公告)号：US07621638B2
公开(公告)日：2009-11-24
申请号：US11606597
申请日：2006-11-29
申请人： Wei Su , Yan Zhou , Yeou-Yen Cheng , Qing Chun Zhao
发明人： Wei Su , Yan Zhou , Yeou-Yen Cheng , Qing Chun Zhao
IPC分类号： A61B3/10 , F21V7/00
CPC分类号： A61B3/0008 , A61B3/12
摘要： A light delivery technique includes optical configurations as well as the associated methods that generate a ring beam from a linear light source. In one embodiment, a remote light source module delivers illumination light to a fundus camera and/or slit lamp. In another embodiment, an arrangement combines the use of a light pipe homogenizer and a ring beam transformer for efficiently collecting light from a substantially axially linear light source, homogenizing the collected light that lacks low angle flux relative to the optical axis, and transforming the light into a ring beam with a substantially improved low angle flux distribution. In still another embodiment, light emitted from a substantially axially linear light source is directly collected by a curved surface mirror and spatially filtered into a ring beam. The ring illumination beam can be co-axially projected on a sample such as the pupil of a human eye and at the same time the light beam also has a large enough relatively uniform angular flux distribution so that a wide area on the retina of the eye can be uniformly illuminated.
摘要翻译：光输送技术包括光学配置以及从线性光源产生环形光束的相关方法。在一个实施例中，远程光源模块将照明光传送到眼底照相机和/或裂隙灯。在另一个实施例中，一种布置结合了光管均质器和环形光束变换器的使用，用于有效地收集来自基本轴向线性光源的光，使收集到的光相互均匀化，所述光相对于光轴缺少低角度通量，以及将光转换成为具有基本上改进的低角度通量分布的环形梁。在另一个实施例中，从基本轴向线性光源发射的光直接由弯曲表面镜收集，并在空间上过滤成环形光束。环形照明光束可以同轴地投射在诸如人眼的瞳孔的样品上，并且同时光束也具有足够大的相对均匀的角度通量分布，使得眼睛的视网膜上的广泛区域可以均匀照明。

3. 发明申请

US20080165322A1 WORKING DISTANCE AND ALIGNMENT SENSOR FOR A FUNDUS CAMERA 失效
标题翻译： FUNDUS CAMERA的工作距离和对准传感器
公开(公告)号：US20080165322A1
公开(公告)日：2008-07-10
申请号：US11621943
申请日：2007-01-10
申请人： Wei Su , Yan Zhou , Qing Chun Zhao , Yeou-Yen Cheng
发明人： Wei Su , Yan Zhou , Qing Chun Zhao , Yeou-Yen Cheng
IPC分类号： A61B3/12
CPC分类号： A61B3/12 , A61B3/102 , A61B3/152
摘要： In embodiments of optical arrangements of a working distance sensor in a fundus camera that can improve the determination of a correct working distance as well as the transverse positioning of the camera a number of near infrared light sources are arranged to project a number of near infrared illumination beams into the visible light illumination path of the fundus camera and a live view of the retina under near infrared illumination is captured and displayed on a monitor. These embodiments of optical arrangements and associated methods will enable an operator to directly determine if there is any undesirable flare or other artifact appearing within a designated region on the infrared retina view as a result of a wrong alignment of the fundus camera with respect to the eye in terms of not only the working distance but also the horizontal and vertical positions. Pattern recognition algorithms can be used to further enhance the positioning sensitivity of the working distance sensor. An additional iris alignment sensor can be added to achieve a coarse alignment and also function as a measure to determine if the dilation of the iris size is sufficient for different mode of fundus imaging.
摘要翻译：在眼底照相机中的工作距离传感器的光学布置的实施例中，其可以改善确定正确的工作距离以及相机的横向定位，并且布置多个近红外光源以投射多个近红外照明光束进入眼底照相机的可见光照明路径，并且在近红外照明下的视网膜的实时图像被捕获并显示在监视器上。光学布置和相关方法的这些实施例将使得操作者能够直接确定由于眼底照相机相对于眼睛错误对准的结果，在红外线视网膜视图上的指定区域内是否存在任何不期望的耀斑或其他伪像不仅在于工作距离，还包括水平和垂直位置。模式识别算法可用于进一步提高工作距离传感器的定位灵敏度。可以添加附加的虹膜对准传感器以实现粗略对准，并且还用作确定虹膜尺寸的扩张是否足够用于不同的眼底成像模式的措施。

4. 发明申请

US20080123052A1 Delivering a short Arc lamp light for eye imaging 失效
标题翻译：为眼睛成像提供短弧灯
公开(公告)号：US20080123052A1
公开(公告)日：2008-05-29
申请号：US11606597
申请日：2006-11-29
申请人： Wei Su , Yan Zhou , Yeou-Yen Cheng , Qing Chun Zhao
发明人： Wei Su , Yan Zhou , Yeou-Yen Cheng , Qing Chun Zhao
IPC分类号： A61B3/10
CPC分类号： A61B3/0008 , A61B3/12
摘要： A light delivery technique includes optical configurations as well as the associated methods that generate a ring beam from a linear light source. In one embodiment, a remote light source module delivers illumination light to a fundus camera and/or slit lamp. In another embodiment, an arrangement combines the use of a light pipe homogenizer and a ring beam transformer for efficiently collecting light from a substantially axially linear light source, homogenizing the collected light that lacks low angle flux relative to the optical axis, and transforming the light into a ring beam with a substantially improved low angle flux distribution. In still another embodiment, light emitted from a substantially axially linear light source is directly collected by a curved surface mirror and spatially filtered into a ring beam. The ring illumination beam can be co-axially projected on a sample such as the pupil of a human eye and at the same time the light beam also has a large enough relatively uniform angular flux distribution so that a wide area on the retina of the eye can be uniformly illuminated.
摘要翻译：光输送技术包括光学配置以及从线性光源产生环形光束的相关方法。在一个实施例中，远程光源模块将照明光传送到眼底照相机和/或裂隙灯。在另一个实施例中，一种布置结合了光管均质器和环形光束变换器的使用，用于有效地收集来自基本轴向线性光源的光，使收集到的光相互均匀化，所述光相对于光轴缺少低角度通量，以及将光转换成为具有基本上改进的低角度通量分布的环形梁。在另一个实施例中，从基本轴向线性光源发射的光直接由弯曲表面镜收集，并在空间上过滤成环形光束。环形照明光束可以同轴地投射在诸如人眼的瞳孔的样品上，并且同时光束也具有足够大的相对均匀的角度通量分布，使得眼睛的视网膜上的广泛区域可以均匀照明。

5. 发明授权

US07445335B2 Sequential wavefront sensor 有权
标题翻译：顺序波前传感器
公开(公告)号：US07445335B2
公开(公告)日：2008-11-04
申请号：US11335980
申请日：2006-01-20
申请人： Wei Su , Yan Zhou , Qing Chun Zhao
发明人： Wei Su , Yan Zhou , Qing Chun Zhao
IPC分类号： A61B3/10
CPC分类号： G01J9/00 , A61B3/1015 , A61B3/14 , G01J1/0414 , G01J1/0437
摘要： A sequential wavefront sensor comprises a light beam scanning module, a sub-wavefront focusing lens, a detector with more than one photosensitive area and a processor for calculating the sequentially obtained centroids of a number focused light spots from the sub-wavefronts to determine the aberration of the input wavefront. A sequential wavefront sensing method comprises the steps of; sequentially projecting a number of sub-wavefronts onto a sub-wavefront focusing lens and a detector with more than one photosensitive areas, calculating the centroid of the focused light spot from each sub-wavefront, and processing the centroid information to determine the aberration of the wavefront. In particular, a method for auto-focusing and/or auto-astigmatism-correction comprises the steps of sequentially projecting a number of sub-wavefronts around an annular ring of a wavefront to a sub-wavefront focusing lens and a detector, calculating the centroid of focused light spot from each sub-wavefront to figure out the centroid trace and hence the defocus and/or astigmatism, adjusting the focus and/or astigmatism of the optical imaging system before the wavefront sensor so that the measured defocus and/or astigmatism is minimized.
摘要翻译：顺序波前传感器包括光束扫描模块，子波前聚焦透镜，具有多于一个感光区域的检测器和用于计算来自子波前的数量聚焦光点的顺序获得的质心的处理器，以确定像差的输入波前。顺序波前感测方法包括以下步骤：顺序地将多个子波前投影到子波前聚焦透镜和具有多于一个感光区域的检测器，计算来自每个子波前的聚焦光点的质心，以及处理质心信息以确定波前。特别地，一种用于自动聚焦和/或自动像散校正的方法包括以下步骤：将多个子波前围绕波前的环形环顺序地投影到子波前聚焦透镜和检测器，计算质心来自每个子波前的聚焦光点，以计算出质心轨迹，从而计算散焦和/或散光，调整光学成像系统在波前传感器之前的焦点和/或散光，使得测量的散焦和/或散光为最小化。

6. 发明申请

US20100118270A1 ADAPTOR FOR MOUNTING A GONIO LENS ONTO A HAND-HELD EYE EXAMINATION DEVICE 审中-公开
标题翻译：用于将手持镜头安装在手持式眼睛检查装置上的适配器
公开(公告)号：US20100118270A1
公开(公告)日：2010-05-13
申请号：US12606993
申请日：2009-10-27
申请人： William Shea , Yeou-Yen Cheng , Shelly Reed , Willem Crone , Barry Linder , Phillip Baker , Yan Zhou
发明人： William Shea , Yeou-Yen Cheng , Shelly Reed , Willem Crone , Barry Linder , Phillip Baker , Yan Zhou
IPC分类号： A61B3/117
CPC分类号： A61B3/117
摘要： An apparatus and method is disclosed that provides a means for mounting a separate optical element, such as a gonio lens, to a hand-held eye imaging device. In this way, the doctor only needs to use one hand to hold the imaging apparatus while the other hand can be freed to open the patient eye lid and also maintain a safe relative distance of the gonio lens with respect to the patient's eye. The gonio lens and adaptor can each or both be made disposable and also mechanically switchable relative to each other as well as relative to the handheld eye imaging device so that different portions of the patient eye can be imaged sequentially without the need to rotate the hand held eye imaging device.
摘要翻译：公开了一种设备和方法，其提供用于将单独的光学元件（例如gonio透镜）安装到手持式眼睛成像装置的装置。以这种方式，医生只需要用一只手来保持成像装置，另一只手可以被释放以打开患者眼罩，并且还保持角膜透镜相对于患者眼睛的安全的相对距离。角膜透镜和适配器可以各自或两者都被制成一次性的并且也可以相对于彼此以及相对于手持式眼睛成像装置机械地切换，使得患者眼睛的不同部分可以顺序成像，而不需要旋转手持眼睛成像装置。

7. 发明授权

US08328356B2 Enabling measurement with a handheld eye imaging device 有权
标题翻译：使用手持式眼睛成像装置实现测量
公开(公告)号：US08328356B2
公开(公告)日：2012-12-11
申请号：US12606041
申请日：2009-10-26
申请人： Yeou-Yen Cheng , Barry Linder , Willem Crone , Yan Zhou
发明人： Yeou-Yen Cheng , Barry Linder , Willem Crone , Yan Zhou
IPC分类号： A61B3/14 , A61B3/10
CPC分类号： A61B5/107 , A61B3/10 , A61B3/15
摘要： An apparatus and method is disclosed that enables an existing handheld eye imaging device to do direct measurement on images taken from the patient eye. In a preferred embodiment, a reticle is arranged in the handheld eye imaging device so that a reticle image is superimposed on the object image. In addition to allowing the user to make measurements, the reticle superimposed eye image can also be used to align the eye with the handheld eye imaging device, be used for registering images taken at different times, and also be used for finding previously recorded points on the images for comparison purposes.
摘要翻译：公开了一种使现有的手持式眼睛成像装置能够对从患者眼睛拍摄的图像进行直接测量的装置和方法。在优选实施例中，在手持式眼睛成像装置中布置了掩模版，使得掩模版图像叠加在物体图像上。除了允许用户进行测量之外，还可以使用掩模版叠加的眼睛图像来将眼睛与手持式眼睛成像装置对准，用于记录在不同时间拍摄的图像，并且还可以用于查找先前记录的点图像用于比较。

8. 发明申请

US20100110378A1 ENABLING MEASUREMENT WITH A HANDHELD EYE IMAGING DEVICE 有权
标题翻译：使用手持式眼睛成像装置实现测量
公开(公告)号：US20100110378A1
公开(公告)日：2010-05-06
申请号：US12606041
申请日：2009-10-26
申请人： Yeou-Yen Cheng , Barry Linder , Willem Crone , Yan Zhou
发明人： Yeou-Yen Cheng , Barry Linder , Willem Crone , Yan Zhou
IPC分类号： A61B3/15
CPC分类号： A61B5/107 , A61B3/10 , A61B3/15
摘要： An apparatus and method is disclosed that enables an existing handheld eye imaging device to do direct measurement on images taken from the patient eye. In a preferred embodiment, a reticle is arranged in the handheld eye imaging device so that a reticle image is superimposed on the object image. In addition to allowing the user to make measurements, the reticle superimposed eye image can also be used to align the eye with the handheld eye imaging device, be used for registering images taken at different times, and also be used for finding previously recorded points on the images for comparison purposes.
摘要翻译：公开了一种使现有的手持式眼睛成像装置能够对从患者眼睛拍摄的图像进行直接测量的装置和方法。在优选实施例中，在手持式眼睛成像装置中布置了掩模版，使得掩模版图像叠加在物体图像上。除了允许用户进行测量之外，还可以使用掩模版叠加的眼睛图像来将眼睛与手持式眼睛成像装置对准，用于记录在不同时间拍摄的图像，并且还可以用于查找先前记录的点图像用于比较。

9. 发明申请

US20110164220A1 Adaptive Sequential Wavefront Sensor with Variable Aperture 有权
标题翻译：具有可变光圈的自适应顺序波前传感器
公开(公告)号：US20110164220A1
公开(公告)日：2011-07-07
申请号：US13048806
申请日：2011-03-15
申请人： Wei Su , Yan Zhou
发明人： Wei Su , Yan Zhou
IPC分类号： A61B3/10 , A61B3/18
CPC分类号： G01J9/00 , A61B3/1015 , A61B3/14 , G01J1/0414 , G01J1/0437
摘要： One embodiment is a machine comprising a sequential wavefront scanner, a variable aperture, a position sensing device and a controller. The controller is coupled to the variable aperture and sequential wavefront scanning device and configured to coordinate the operation of the variable aperture and the sequential wavefront scanning device.
摘要翻译：一个实施例是包括顺序波前扫描器，可变孔径，位置感测装置和控制器的机器。控制器耦合到可变孔径和顺序波前扫描装置，并且被配置为协调可变孔径和顺序波前扫描装置的操作。

10. 发明申请

US20070171366A1 Sequential wavefront sensor 有权
标题翻译：顺序波前传感器
公开(公告)号：US20070171366A1
公开(公告)日：2007-07-26
申请号：US11335980
申请日：2006-01-20
申请人： Wei Su , Yan Zhou , Qing Zhao
发明人： Wei Su , Yan Zhou , Qing Zhao
IPC分类号： A61B3/10
CPC分类号： G01J9/00 , A61B3/1015 , A61B3/14 , G01J1/0414 , G01J1/0437
摘要： A sequential wavefront sensor comprises a light beam scanning module, a sub-wavefront focusing lens, a detector with more than one photosensitive area and a processor for calculating the sequentially obtained centroids of a number focused light spots from the sub-wavefronts to determine the aberration of the input wavefront. A sequential wavefront sensing method comprises the steps of; sequentially projecting a number of sub-wavefronts onto a sub-wavefront focusing lens and a detector with more than one photosensitive areas, calculating the centroid of the focused light spot from each sub-wavefront, and processing the centroid information to determine the aberration of the wavefront. In particular, a method for auto-focusing and/or auto-astigmatism-correction comprises the steps of sequentially projecting a number of sub-wavefronts around an annular ring of a wavefront to a sub-wavefront focusing lens and a detector, calculating the centroid of focused light spot from each sub-wavefront to figure out the centroid trace and hence the defocus and/or astigmatism, adjusting the focus and/or astigmatism of the optical imaging system before the wavefront sensor so that the measured defocus and/or astigmatism is minimized.
摘要翻译：顺序波前传感器包括光束扫描模块，子波前聚焦透镜，具有多于一个感光区域的检测器和用于计算来自子波前的数量聚焦光点的顺序获得的质心的处理器，以确定像差的输入波前。顺序波前感测方法包括以下步骤：顺序地将多个子波前投影到子波前聚焦透镜和具有多于一个感光区域的检测器，计算来自每个子波前的聚焦光点的质心，以及处理质心信息以确定波前。特别地，一种用于自动聚焦和/或自动像散校正的方法包括以下步骤：将多个子波前围绕波前的环形环顺序地投影到子波前聚焦透镜和检测器，计算质心来自每个子波前的聚焦光点，以计算出质心轨迹，从而计算散焦和/或散光，调整光学成像系统在波前传感器之前的焦点和/或散光，使得测量的散焦和/或散光为最小化。

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