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1. 发明授权

US09250249B2 Autophagy and phospholipidosis pathway assays 有权
标题翻译：自噬和磷脂通路测定
公开(公告)号：US09250249B2
公开(公告)日：2016-02-02
申请号：US12584958
申请日：2009-09-14
申请人： Wayne Forrest Patton , Jack Coleman , Yuejun Xiang , Praveen Pande , Zaiguo Li
发明人： Wayne Forrest Patton , Jack Coleman , Yuejun Xiang , Praveen Pande , Zaiguo Li
IPC分类号： G01N33/68 , G01N33/50 , G01N33/58 , G01N33/94
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
摘要翻译：提供用于检测和监测自噬和磷脂病的测定，包括溶酶体贮积病的进展。可以监测溶酶体储存疾病的药物和治疗溶酶体贮积病条件的有效性。药物候选人和疑似毒素也可以筛选对细胞，组织和器官的毒性。还提供了区分磷脂肪激活剂和自噬途径扰动剂的方法。

2. 发明申请

US20100093004A1 Autophagy and phospholipidosis pathway assays 有权
标题翻译：自噬和磷脂通路测定
公开(公告)号：US20100093004A1
公开(公告)日：2010-04-15
申请号：US12584958
申请日：2009-09-14
申请人： Wayne Forrest Patton , Jack Coleman , Yuejun Xiang , Praveen Pande , Zaiguo Li
发明人： Wayne Forrest Patton , Jack Coleman , Yuejun Xiang , Praveen Pande , Zaiguo Li
IPC分类号： G01N33/53 , C12Q1/02
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
摘要翻译：提供用于检测和监测自噬和磷脂病的测定，包括溶酶体贮积病的进展。可以监测溶酶体储存疾病的药物和治疗溶酶体贮积病条件的有效性。药物候选人和疑似毒素也可以筛选对细胞，组织和器官的毒性。还提供了区分磷脂肪激活剂和自噬途径扰动剂的方法。

3. 发明授权

US09334281B2 Fluorochromes for organelle tracing and multi-color imaging 有权
标题翻译：荧光色素用于细胞器追踪和多色成像
公开(公告)号：US09334281B2
公开(公告)日：2016-05-10
申请号：US12231988
申请日：2008-09-08
申请人： Wayne Forrest Patton , Praveen Pande , Yuejun Xiang , Zaiguo Li , James J. Donegan , Elazar Rabbani
发明人： Wayne Forrest Patton , Praveen Pande , Yuejun Xiang , Zaiguo Li , James J. Donegan , Elazar Rabbani
IPC分类号： C07C211/61 , C07D487/06 , C07C225/34 , C07C225/36 , C07C229/18 , C07C335/20 , C07D213/74 , C07D295/135 , C07F9/53 , C07F9/6503 , C09B1/00 , C09B1/51 , C09B1/515 , C40B40/04 , G01N33/50
CPC分类号： C07D487/06 , C07C225/34 , C07C225/36 , C07C229/18 , C07C335/20 , C07C2603/24 , C07D213/74 , C07D295/135 , C07F9/5304 , C07F9/65038 , C09B1/005 , C09B1/51 , C09B1/512 , C09B1/5155 , C40B40/04 , G01N33/5005 , G01N33/5011
摘要： Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.
摘要翻译：提供了用于在感兴趣细胞中鉴定细胞器的化合物，方法和试剂盒，包括细胞核和除核以外的多种细胞器（非核细胞器）以及细胞区域或细胞结构域。这些化合物和方法可以与其它常规检测试剂一起使用，用于鉴定细胞器的位置或位置，甚至用于鉴别感兴趣的细胞中的细胞器。

4. 发明申请

US20100062429A1 Fluorochromes for organelle tracing and multi-color imaging 有权
标题翻译：荧光色素用于细胞器追踪和多色成像
公开(公告)号：US20100062429A1
公开(公告)日：2010-03-11
申请号：US12231988
申请日：2008-09-08
申请人： Wayne Forrest Patton , Praveen Pande , Yuejun Xiang , Zaiguo Li , James J. Donegan , Elazar Rabbani
发明人： Wayne Forrest Patton , Praveen Pande , Yuejun Xiang , Zaiguo Li , James J. Donegan , Elazar Rabbani
IPC分类号： C12Q1/68 , C07D241/04 , C07D231/54 , C07D241/02
CPC分类号： C07D487/06 , C07C225/34 , C07C225/36 , C07C229/18 , C07C335/20 , C07C2603/24 , C07D213/74 , C07D295/135 , C07F9/5304 , C07F9/65038 , C09B1/005 , C09B1/51 , C09B1/512 , C09B1/5155 , C40B40/04 , G01N33/5005 , G01N33/5011
摘要： Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.
摘要翻译：提供了用于在感兴趣细胞中鉴定细胞器的化合物，方法和试剂盒，包括细胞核和除核以外的多种细胞器（非核细胞器）以及细胞区域或细胞结构域。这些化合物和方法可以与其它常规检测试剂一起使用，用于鉴定细胞器的位置或位置，甚至用于鉴别感兴趣的细胞中的细胞器。

5. 发明授权

US09416153B2 Fluorescent dyes 有权
标题翻译：荧光染料
公开(公告)号：US09416153B2
公开(公告)日：2016-08-16
申请号：US13270456
申请日：2011-10-11
申请人： Zaiguo Li , Praveen Pande
发明人： Zaiguo Li , Praveen Pande
IPC分类号： C07D515/00 , C07D471/00 , C07D235/02 , C07D411/00 , C07D311/82 , C07D311/88 , C07H19/04 , C07H21/00 , C12Q1/70 , C09B11/24
CPC分类号： C07H21/00 , C07H19/04 , C09B11/02 , C09B11/06 , C09B11/24 , C12Q1/707
摘要： Provided are various compounds comprising the formula Also provided are fluorescent dyes comprising the above compound. Additionally, a fluorescence energy transfer system is provided that comprises the above-described fluorescent dye and a second dye, wherein the second dye is capable of energy transfer with the fluorescent dye. Further provided is a kit for labeling a target molecule, where the kit comprises the above-described fluorescent dye with additional reagents useful for labeling the target molecule. Additionally provided is a target molecule labeled with the above-described fluorescent dye. Methods of labeling a target molecule with the above-described fluorescent dye are also provided.
摘要翻译：提供包含该式的各种化合物还提供了包含上述化合物的荧光染料。此外，提供了包含上述荧光染料和第二染料的荧光能量转移系统，其中第二染料能够与荧光染料进行能量转移。进一步提供了用于标记靶分子的试剂盒，其中试剂盒包含上述荧光染料和另外用于标记靶分子的试剂。另外提供了用上述荧光染料标记的靶分子。还提供了用上述荧光染料标记靶分子的方法。

6. 发明授权

US08357801B2 Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits 有权
公开(公告)号：US08357801B2
公开(公告)日：2013-01-22
申请号：US12315629
申请日：2008-12-04
申请人： Praveen Pande , Zaiguo Li , Maciej Szczepanik , Wayne F. Patton
发明人： Praveen Pande , Zaiguo Li , Maciej Szczepanik , Wayne F. Patton
IPC分类号： C07F9/28 , C12Q1/00
CPC分类号： C09B23/164 , C09B23/0066 , C09B23/0075 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146 , C12Q1/68 , G01N33/583
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.

7. 发明授权

US08506655B1 Fluorescent dyes containing phosphorus or arsenic 有权
标题翻译：含磷或砷的荧光染料
公开(公告)号：US08506655B1
公开(公告)日：2013-08-13
申请号：US13565323
申请日：2012-08-02
申请人： Zaiguo Li , Praveen Pande
发明人： Zaiguo Li , Praveen Pande
IPC分类号： D06L3/04
CPC分类号： C09B69/103 , C09B11/24 , C09B11/28 , C09B57/02
摘要： The present invention provides a fluorescent dye that incorporates a pentavalent phosphorus or arsenic into its ring structure. Also provided is a fluorescence energy transfer system that comprises the above fluorescent dye and a second dye, where the second dye is capable of energy transfer with the fluorescent dye. Additionally provided is a kit for labeling a target molecule. In further embodiments, another kit for labeling a target molecule is provided. A target molecule labeled with the above-described fluorescent dye is also provided. In additional embodiments, methods of labeling a target molecule are provided.
摘要翻译：本发明提供一种将五价磷或砷掺入其环结构中的荧光染料。还提供了包含上述荧光染料和第二染料的荧光能量转移系统，其中第二染料能够与荧光染料进行能量转移。另外提供了用于标记靶分子的试剂盒。在另外的实施方案中，提供用于标记靶分子的另一试剂盒。还提供了用上述荧光染料标记的靶分子。在另外的实施方案中，提供了标记靶分子的方法。

8. 发明申请

US20090226954A1 Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits 有权
标题翻译：靶分子的标记，细胞器和其他应用的鉴定，新的组合物，方法和试剂盒
公开(公告)号：US20090226954A1
公开(公告)日：2009-09-10
申请号：US12315629
申请日：2008-12-04
申请人： Praveen Pande , Zaiguo Li , Maciej Szczepanik , Wayne F. Patton
发明人： Praveen Pande , Zaiguo Li , Maciej Szczepanik , Wayne F. Patton
IPC分类号： C12Q1/02 , C07F9/28 , C07D277/62 , C07D401/12
CPC分类号： C09B23/164 , C09B23/0066 , C09B23/0075 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146 , C12Q1/68 , G01N33/583
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.
摘要翻译：本发明提供可用于检测或定量所需靶分子（例如蛋白质，核酸和细胞器器）的染料，活性染料和标记试剂。提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。已经对本发明的新型染料进行了改进以提供有益的性质。

9. 发明授权

US08277775B2 Boron dipyrromethene difluoro (BODIPY) conjugates 有权
标题翻译：硼二吡咯亚甲基二氟（BODIPY）缀合物
公开(公告)号：US08277775B2
公开(公告)日：2012-10-02
申请号：US12673799
申请日：2008-08-15
申请人： Robert Bittman , Zaiguo Li
发明人： Robert Bittman , Zaiguo Li
IPC分类号： A61B5/055 , A61K31/41 , A61K31/69 , A61K51/00 , C07D249/00 , C07F5/04
CPC分类号： G01N33/533 , C07F5/022 , C07F9/6561
摘要： The present invention relates to FTY720 analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the alkyl side chain and methods of preparation. The compounds of the present invention can be used in fluorescence spectroscopy and fluorescence microscopy and in chromatography using fluorescence detection.
摘要翻译：本发明涉及在烷基侧链中带有二溴二溴（BODIPY）荧光团的FTY720类似物及其制备方法。本发明的化合物可用于荧光光谱和荧光显微镜和使用荧光检测的色谱中。

10. 发明申请

US20110082300A1 Boron Dipyrromethene Difluoro (Bodipy) Conjugates 有权
标题翻译：硼二吡咯亚甲基二氟（Bodipy）缀合物
公开(公告)号：US20110082300A1
公开(公告)日：2011-04-07
申请号：US12673799
申请日：2008-08-15
申请人： Robert Bittman , Zaiguo Li
发明人： Robert Bittman , Zaiguo Li
IPC分类号： C07F5/02
CPC分类号： G01N33/533 , C07F5/022 , C07F9/6561
摘要： The present invention relates to FTY720 analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the alkyl side chain and methods of preparation. The compounds of the present invention can be used in fluorescence spectroscopy and fluorescence microscopy and in chromatography using fluorescence detection.
摘要翻译：本发明涉及在烷基侧链中带有二溴二溴（BODIPY）荧光团的FTY720类似物及其制备方法。本发明的化合物可用于荧光光谱和荧光显微镜和使用荧光检测的色谱中。

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