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1. 发明申请

US20070125375A1 Device and method for deagglomeration of powder for inhalation 审中-公开
标题翻译：用于吸入粉末解聚的装置和方法
公开(公告)号：US20070125375A1
公开(公告)日：2007-06-07
申请号：US11476899
申请日：2006-06-29
申请人： Warren Finlay , Zhaolin Wang
发明人： Warren Finlay , Zhaolin Wang
IPC分类号： A61M15/00 , B65D83/06
CPC分类号： A61M15/0086 , A61M11/003 , A61M15/0021 , A61M2202/064 , A61M2206/16
摘要： A device and method for deagglomerating powder agglomerates for inhalation. The device includes an inlet connected to a chamber and to a powder source for supplying the chamber with powder agglomerates and a flow of gas that define a swirling fluid flow inside the chamber. The device also includes an outlet connected to the chamber for inhalation such that the swirling fluid flow in the chamber can exit from the chamber as a longitudinal fluid flow that is directed along a longitudinal axis of the outlet, and a secondary fluid flow that is directed away from the longitudinal axis of the outlet. A mesh in the outlet prevents powder agglomerates above a predetermined size from traversing the mesh, and reduces the secondary fluid flow relative to the longitudinal fluid flow exiting from the chamber to thereby reduce powder deposition in a mouth and throat of a user.
摘要翻译：用于吸入的粉末团块解聚集的装置和方法。该装置包括连接到室的入口和用于向腔室供应粉末团聚体和在腔室内限定旋转流体流的气流的粉末源。该装置还包括连接到腔室以用于吸入的出口，使得腔室内的旋流流体可以沿着沿着出口的纵向轴线引导的纵向流体流动而从腔室排出，并且引导的次级流体流远离出口的纵向轴线。出口中的网格防止超过预定尺寸的粉末团聚物穿过网，并且相对于从室离开的纵向流体流减少二次流体流动，从而减少用户口腔和喉部中的粉末沉积。

2. 发明申请

US20060280691A1 Spray freeze dried liposomal ciprofloxacin powder aerosol drug delivery 审中-公开
标题翻译：喷雾冷冻干燥脂质体环丙沙星粉末气雾剂药物输送
公开(公告)号：US20060280691A1
公开(公告)日：2006-12-14
申请号：US11445347
申请日：2006-06-02
申请人： Zhaolin Wang , Helena Orszanska , Warren Finlay
发明人： Zhaolin Wang , Helena Orszanska , Warren Finlay
IPC分类号： A61K9/127 , A61K9/14 , A61L9/04
CPC分类号： A61K9/0075 , A61K9/127 , A61K9/1617
摘要： A powder for inhalatory aerosol delivery, the powder having: spray freeze dried liposome particles with a biologically active agent, such as an antibiotic, encapsulated within a phospholipid, and a method of producing a powder for inhalatory aerosol delivery, the method including the steps of: mixing a biologically active agent with a phospholipid to form a liquid liposome suspension; and spray freeze drying the liposome suspension to form particles of powder.
摘要翻译：一种用于吸入气雾剂输送的粉末，该粉末具有：具有包封在磷脂内的生物活性剂如抗生素的喷雾冷冻干燥脂质体颗粒，以及生产用于吸入性气雾剂递送的粉末的方法，所述方法包括以下步骤：：将生物活性剂与磷脂混合以形成液体脂质体悬浮液; 并喷雾冷冻干燥脂质体悬浮液以形成粉末颗粒。

3. 发明申请

US20060130355A1 Powder formation by atmospheric spray-freeze drying 有权
公开(公告)号：US20060130355A1
公开(公告)日：2006-06-22
申请号：US11318864
申请日：2005-12-28
申请人： Zhaolin Wang , Warren Finlay
发明人： Zhaolin Wang , Warren Finlay
IPC分类号： F26B5/06
CPC分类号： F26B5/06 , F26B13/30
摘要： A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.

4. 发明申请

US20050160615A1 Powder formation by atmospheric spray-freeze drying 有权
标题翻译：通过大气喷雾冷冻干燥形成粉末
公开(公告)号：US20050160615A1
公开(公告)日：2005-07-28
申请号：US10762300
申请日：2004-01-23
申请人： Zhaolin Wang , Warren Finlay
发明人： Zhaolin Wang , Warren Finlay
IPC分类号： F26B5/06 , F26B13/30
CPC分类号： F26B5/06 , F26B13/30
摘要： A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.
摘要翻译：公开了一种制造热敏药用粉末的方法。将原始药物溶解在悬浮液中，悬浮在悬浮液中，该悬浮液通过雾化喷嘴喷雾并在冷气相或液氮中在冷冻室或气套中同时雾化（用于冷却目的）。颗粒在大气压下在具有出口过滤器的下游流体流中冷冻干燥，从而除去截留在冷冻颗粒上或内部的水分。该系统适用于形成其他粉末。

5. 发明申请

US20070006876A1 Add-on spacer design concept for dry-powder inhalers 审中-公开
标题翻译：干粉吸入器附加垫片设计概念
公开(公告)号：US20070006876A1
公开(公告)日：2007-01-11
申请号：US10556048
申请日：2004-05-14
申请人： Warren Finlay , Edgar Matida , Carlos Lange
发明人： Warren Finlay , Edgar Matida , Carlos Lange
IPC分类号： A61M11/00
CPC分类号： A61M15/0086 , A61M2209/02
摘要： A spacer, for disposition between a user's mouth and a medicament inhaler outlet, has a hollow body defining an elongate internal chamber (10) with a diffuser portion (8) having a spacer inlet (9) adapted to engage the inhaler outlet in communication with the internal chamber, the diffuser portion extending axially outwardly from the spacer inlet; a buffer portion (6) extending axially from the diffuser portion; and a nozzle portion (7) having a spacer outlet (5) adapted to engage the user's mouth in communication with the internal chamber, the nozzle portion extending axially inwardly from the buffer portion.
摘要翻译：用于在使用者的嘴和药物吸入器出口之间的配置的间隔件具有限定细长的内部腔室（10）的中空体，该腔室具有扩散器部分（8），该扩散器部分具有适于与吸入器出口相接合的间隔物入口（9）所述内部腔室，所述扩散器部分从所述间隔件入口轴向向外延伸; 缓冲部分（6），其从所述扩散部分轴向延伸; 以及喷嘴部分（7），其具有适于与所述内部腔室连通的所述使用者嘴部的间隔件出口（5），所述喷嘴部分从所述缓冲部分轴向向内延伸。

6. 发明申请

US20050121045A1 Treatment of mainstream smoke constituents by use of oxygen storage and donor metal oxide oxidation catalyst 审中-公开
标题翻译：通过使用储氧和供体金属氧化物氧化催化剂处理主流烟雾成分
公开(公告)号：US20050121045A1
公开(公告)日：2005-06-09
申请号：US10941071
申请日：2004-09-15
申请人： Warren Finlay , Stanislav Snaidr , George Ayres , Steve Chapman , Peter Kaczmarek , E. Becker , Robert Hunsicker
发明人： Warren Finlay , Stanislav Snaidr , George Ayres , Steve Chapman , Peter Kaczmarek , E. Becker , Robert Hunsicker
IPC分类号： A24B15/28 , A24D1/02 , A24F1/20 , B01D53/86 , B01J23/63 , B01J29/06 , B01J29/08 , B01J29/12 , B01J37/00 , B01J37/02 , D21H21/14
CPC分类号： D21H21/14 , A24B15/28 , A24B15/282 , A24B15/286 , A24B15/287 , A24B15/288 , A24D1/02 , B01D53/8634 , B01D53/8668 , B01J23/63 , B01J29/06 , B01J29/088 , B01J29/126 , B01J37/0045 , B01J37/0221 , B01J2229/18 , B01J2229/20 , B01J2229/42
摘要： The use of a treatment composition for a cigarette to reduce at least one constituent of mainstream smoke from a burning cigarette, the treatment composition comprising, in combination, an oxygen storage and donor metal oxide oxidation catalyst and an essentially non-combustible finely divided porous particulate adjunct.
摘要翻译：使用用于香烟的处理组合物从燃烧的香烟中减少主流烟雾的至少一种成分，所述处理组合物组合物包含储氧和供体金属氧化物氧化催化剂和基本上不可燃的细碎多孔颗粒附件。

7. 发明申请

US20070031490A1 Effervescent powders for inhalation 有权
标题翻译：用于吸入的泡腾粉
公开(公告)号：US20070031490A1
公开(公告)日：2007-02-08
申请号：US11490331
申请日：2006-07-20
申请人： Raimar Loebenberg , Warren Finlay , Wilson Roa , Leticia Ely
发明人： Raimar Loebenberg , Warren Finlay , Wilson Roa , Leticia Ely
IPC分类号： A61K31/704 , A61K31/545 , A61K9/46
CPC分类号： A61K9/0073 , A61K9/0007 , A61K31/545 , A61K31/704 , Y10S977/773
摘要： Effervescent powders comprising inhalable particles are disclosed, as are methods for preparing these powders. The inhalable carrier particles comprise an inorganic or organic carbonate, and an acid, and exhibit effervescence when exposed to water or humid air. The particles have a mass median aerodynamic diameter suitable for nasal, bronchial, or pulmonary administration. The inhalable particles may be used as carriers for active agents. The inhalable particles may also be used to enhance permeability of mucosal and surface barriers on an inner surface of the nose, mouth, airway, and/or lungs of a patient, as well as to loosen, thin, cleanse, and remove mucus and extrinsic surface materials from an inner surface of the nose, mouth, airway, and/or lungs of a patient in need thereof.
摘要翻译：公开了包含可吸入颗粒的泡腾粉末，以及制备这些粉末的方法。可吸入的载体颗粒包含无机或有机碳酸盐和酸，并且当暴露于水或潮湿空气时表现出泡腾。颗粒具有适合于鼻，支气管或肺部给药的质量中值空气动力学直径。可吸入颗粒可用作活性剂的载体。可吸入颗粒也可用于增强患者鼻部，口腔，气道和/或肺的内表面上的粘膜和表面屏障的渗透性，以及松动，稀释，清洁和清除粘液和外在的来自患有需要的患者的鼻，口，气道和/或肺的内表面的表面材料。

8. 发明申请

US20050019270A1 Formulation of powder containing nanoparticles for aerosol delivery to the lungs 审中-公开
标题翻译：含有纳米颗粒的粉末制剂用于气雾剂输送至肺部
公开(公告)号：US20050019270A1
公开(公告)日：2005-01-27
申请号：US10624475
申请日：2003-07-23
申请人： Warren Finlay , Wilson Roa , Raimar Loebenberg
发明人： Warren Finlay , Wilson Roa , Raimar Loebenberg
IPC分类号： A61K9/00 , A61K9/16 , A61L9/04 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/1635
摘要： Respirable particles carrying active principles or diagnostics in nanoparticle form are created by mixing the nanoparticles with liquid carrier, then forming the resultant mixture into respirable particles. Spray-drying, freeze spray drying and drying followed by comminution may be used to create the respirable particles, which may be delivered to the lung via a dry powder inhaler. In one example, lactose was used as the excipient and spray-dried with two different types of nanoparticle: gelatin and poly butylcyanoacrylate nanoparticles. The incorporation of nanoparticles did not affect the respirable fraction of the carrier powders.
摘要翻译：通过将纳米颗粒与液体载体混合，然后将所得混合物形成可吸入颗粒来产生携带纳米颗粒形式的活性原理或诊断物的可吸入颗粒。喷雾干燥，冷冻喷雾干燥和干燥，然后粉碎可用于产生可吸入颗粒，其可通过干粉吸入器输送至肺。在一个实例中，使用乳糖作为赋形剂，并用两种不同类型的纳米颗粒：明胶和聚丁基氰基丙烯酸酯纳米颗粒喷雾干燥。纳米颗粒的掺入不影响载体粉末的可呼吸分数。

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