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    • 2. 发明申请
    • Process for making amino acids
    • 制备氨基酸的方法
    • US20070166806A1
    • 2007-07-19
    • US11333937
    • 2006-01-18
    • Michael LloydEdward DaugsCynthia RandWei-Jun Peng
    • Michael LloydEdward DaugsCynthia RandWei-Jun Peng
    • C12P13/04C12P13/22C07C229/02
    • C07C227/32C07D317/30C12P13/04C12P41/006
    • A process for making an amino acid by the steps of: (a) contacting a compound of formula I with a hydroformylation catalyst and synthesis gas to produce a mixture of aldehyde compounds comprising the formulas IIa, IIb and IIc; (b) reacting the mixture of aldehyde compounds from step (a) to produce a mixture of derivative compounds; (c) contacting the mixture of derivative compounds from step (b) with an enantioselective hydrolase enzyme in the presence of water to produce an L-amino acid having the formula IV; (d) isolating the amino acid having the formula IV in substantially pure form, wherein in formulas I, IIa, IIb, IIc, IIIa, IIIb, IIIc and IV, R is H, alkyl or aryl and R1 and R2 are the same or different alkyl groups and wherein R1 and R2 may be fused
    • 通过以下步骤制备氨基酸的方法:(a)使式I化合物与加氢甲酰化催化剂和合成气接触以产生包含式IIa,IIb和IIc的醛化合物的混合物; (b)使来自步骤(a)的醛化合物的混合物反应以产生衍生化合物的混合物; (c)在水存在下将来自步骤(b)的衍生化合物的混合物与对映选择性水解酶接触以产生具有式IV的L-氨基酸; (d)以基本上纯的形式分离具有式IV的氨基酸,其中在式I,IIa,IIb,IIc,IIIa,IIIb,IIIc和IV中,R是H,烷基或芳基和R 1, SO 2和R 2是相同或不同的烷基,其中R 1和R 2可以是稠合的