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1. 发明授权

US08481332B2 Method of detecting auto-antibodies from patients suffering from rheumatoid arthritis, a peptide and an assay kit 有权
标题翻译：从患有类风湿性关节炎的患者中检测自身抗体的方法，肽和测定试剂盒
公开(公告)号：US08481332B2
公开(公告)日：2013-07-09
申请号：US13012739
申请日：2011-01-24
申请人： Waltherus Jacobus Wilhelmus Van Venrooij , Jan Wouter Drijfhout , Martinus Adrianus Maria Van Boekel , Gerardus Jozef Maria Pruijn
发明人： Waltherus Jacobus Wilhelmus Van Venrooij , Jan Wouter Drijfhout , Martinus Adrianus Maria Van Boekel , Gerardus Jozef Maria Pruijn
IPC分类号： C07K7/08 , G01N33/564 , G01N33/543 , G01N33/68 , C07K7/52 , C07K7/64
CPC分类号： G01N33/564 , C07K7/08 , C07K7/52 , C07K7/64 , C07K14/4713 , G01N2410/00 , G01N2800/102 , Y10S435/973 , Y10S435/975 , Y10S530/806
摘要： A liposomal composition, preferably a vaccine, comprising liposomes formed of liposome forming compounds, containing coentrapped polysaccharide antigen and T-cell dependent protein carrier, such as tetanus toxoid or diphtheria toxin modified to render it non-toxic. The invention is of use in the production of vaccines against Haemophilus influenzae, Streptococcus pneumoniae or Neisseria meningitidis.
摘要翻译：脂质体组合物，优选疫苗，其包含由形成脂质体的化合物形成的脂质体，其含有包被的多糖抗原和T细胞依赖性蛋白质载体，例如经过修饰的破伤风类毒素或白喉毒素，使其无毒。本发明可用于生产针对流感嗜血杆菌，肺炎链球菌或脑膜炎奈瑟氏球菌的疫苗。

2. 发明申请

US20110195861A1 METHOD OF DETECTING AUTO-ANTIBODIES FROM PATIENTS SUFFERING FROM RHEUMATOID ARTHRITIS, A PEPTIDE AND AN ASSAY KIT 有权
标题翻译：检测患有炎症性疾病的患者的自身抗体的方法，肽和测定试剂盒
公开(公告)号：US20110195861A1
公开(公告)日：2011-08-11
申请号：US13012739
申请日：2011-01-24
申请人： Waltherus Jacobus Wilhelmus VAN VENROOIJ , Jan Wouter Drijfhout , Martinus Adrianus Maria Van Boekel , Gerardus Jozef Maria Pruijn
发明人： Waltherus Jacobus Wilhelmus VAN VENROOIJ , Jan Wouter Drijfhout , Martinus Adrianus Maria Van Boekel , Gerardus Jozef Maria Pruijn
IPC分类号： C40B30/04 , G01N33/566 , C07K7/08 , C07K7/64 , C07K19/00
CPC分类号： G01N33/564 , C07K7/08 , C07K7/52 , C07K7/64 , C07K14/4713 , G01N2410/00 , G01N2800/102 , Y10S435/973 , Y10S435/975 , Y10S530/806
摘要： A liposomal composition, preferably a vaccine, comprising liposomes formed of liposome forming compounds, containing coentrapped polysaccharide antigen and T-cell dependent protein carrier, such as tetanus toxoid or diphtheria toxin modified to render it non-toxic. The invention is of use in the production of vaccines against Haemophilus influenzae, Streptococcus pneumoniae or Neisseria meningitidis.
摘要翻译：脂质体组合物，优选疫苗，其包含由形成脂质体的化合物形成的脂质体，其含有包被的多糖抗原和T细胞依赖性蛋白质载体，例如经过修饰的破伤风类毒素或白喉毒素，使其无毒。本发明可用于生产针对流感嗜血杆菌，肺炎链球菌或脑膜炎奈瑟氏球菌的疫苗。

3. 发明授权

US07888133B2 Method of detecting auto-antibodies from patients suffering from rheumatoid arthritis, a peptide and an assay kit 有权
标题翻译：从患有类风湿性关节炎的患者中检测自身抗体的方法，肽和测定试剂盒
公开(公告)号：US07888133B2
公开(公告)日：2011-02-15
申请号：US10497667
申请日：2002-12-11
申请人： Waltherus Jacobus Wilhelmus Van Venrooij , Jan Wouter Drijfhout , Martinus Adrianus Maria Van Boekel , Gerardus Jozef Maria Pruijn
发明人： Waltherus Jacobus Wilhelmus Van Venrooij , Jan Wouter Drijfhout , Martinus Adrianus Maria Van Boekel , Gerardus Jozef Maria Pruijn
IPC分类号： C07K7/50 , C07K7/52 , C07K7/64 , G01N33/564 , G01N33/531 , G01N33/543
CPC分类号： G01N33/564 , C07K7/08 , C07K7/52 , C07K7/64 , C07K14/4713 , G01N2410/00 , G01N2800/102 , Y10S435/973 , Y10S435/975 , Y10S530/806
摘要： The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)filaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, and which peptide unit comprises the motif XG, and a peptide unit comprising the motif XnonG, wherein X is a citrulline or an analogue thereof, and nonG is an amino acid other than glycine.
摘要翻译：本发明涉及从患有类风湿性关节炎的患者中检测自身抗体的方法。为此，根据本发明，使用至少两个肽单元，其中至少一个肽单元包含不衍生自（亲）丝聚蛋白，纤维蛋白，纤维蛋白原，波形蛋白，细胞角蛋白1和细胞角蛋白9的部分，以及肽单元包含基序XG，和包含基序XnonG的肽单元，其中X是瓜氨酸或其类似物，而nonG是除甘氨酸以外的氨基酸。

4. 发明授权

US08404647B2 Peptidylarginine deiminase (PAD) inhibitors 失效
标题翻译：肽基精氨酸脱亚氨酶（PAD）抑制剂
公开(公告)号：US08404647B2
公开(公告)日：2013-03-26
申请号：US12965536
申请日：2010-12-10
申请人： Richard Hendrik Blaauw , Gerardus Jozef Maria Pruijn , Jozef Maria Hendrik Raats , Floris Petrus Johannes Theodorus Rutjes , Jan Wouter Drijfhout
发明人： Richard Hendrik Blaauw , Gerardus Jozef Maria Pruijn , Jozef Maria Hendrik Raats , Floris Petrus Johannes Theodorus Rutjes , Jan Wouter Drijfhout
IPC分类号： A61K38/10 , A61K38/16 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/47 , C07K14/4713
摘要： The invention relates to PAD inhibitors that are suitable to be used as a medicament against an autoimmune disease such as RA.
摘要翻译：本发明涉及适合用作抗自身免疫疾病如RA的药物的PAD抑制剂。

5. 发明申请

US20110142868A1 Peptidylarginine Deiminase (PAD) Inhibitors 失效
标题翻译：肽基精氨酸脱氨酶（PAD）抑制剂
公开(公告)号：US20110142868A1
公开(公告)日：2011-06-16
申请号：US12965536
申请日：2010-12-10
申请人： Richard Hendrik Blaauw , Gerardus Jozef Maria Pruijn , Jozef Maria Hendrik Raats , Floris Petrus Johannes Theodorus Rutjes , Jan Wouter Drijfhout
发明人： Richard Hendrik Blaauw , Gerardus Jozef Maria Pruijn , Jozef Maria Hendrik Raats , Floris Petrus Johannes Theodorus Rutjes , Jan Wouter Drijfhout
IPC分类号： A61K39/00 , C07K7/06 , C07K7/08 , A61K38/08 , A61K38/10 , A61P37/06 , A61P29/00
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/47 , C07K14/4713
摘要： The invention relates to PAD inhibitors that are suitable to be used as a medicament against an autoimmune disease such as RA.
摘要翻译：本发明涉及适合用作抗自身免疫疾病如RA的药物的PAD抑制剂。

6. 发明申请

US20100120683A1 Prame derived peptides and immunogenic compositions comprising these 有权
标题翻译：派生肽和包含这些的免疫原性组合物
公开(公告)号：US20100120683A1
公开(公告)日：2010-05-13
申请号：US12586625
申请日：2009-09-24
申请人： Jan Kessler , Marieke Griffioen , Cornelis Johannes Maria Melief , Jan Wouter Drijfhout
发明人： Jan Kessler , Marieke Griffioen , Cornelis Johannes Maria Melief , Jan Wouter Drijfhout
IPC分类号： A61K38/16 , C07K14/00 , A61P35/00 , A61P35/02
CPC分类号： C07K14/4748 , A61K39/00 , A61K39/0011 , A61K2039/57 , A61K2039/572
摘要： The invention relates to a peptide having a length of no more than 100 amino acids and comprising at least 19 contiguous amino acids from the amino acid sequence of the human PRAME protein, wherein the peptide comprises at least one HLA class II epitope and at least one HLA class I epitope from the amino acid sequence of the human PRAME protein and to its use as such or in a composition as a medicament for the treatment and/or prevention of cancer.
摘要翻译：本发明涉及长度不超过100个氨基酸并且包含来自人PRAME蛋白质的氨基酸序列的至少19个连续氨基酸的肽，其中所述肽包含至少一个HLA II类表位和至少一个来自人PRAME蛋白质的氨基酸序列的HLA I类表位，以及其本身的用途或组合物中用作治疗和/或预防癌症的药物。

7. 发明申请

US20080152780A1 Method For Detecting Gluten 有权
标题翻译：检测面筋的方法
公开(公告)号：US20080152780A1
公开(公告)日：2008-06-26
申请号：US11630818
申请日：2005-06-01
申请人： Jan Wouter Drijfhout , Frits Koning , Elisabeth Hermine Adriane Spaenij-Dekking
发明人： Jan Wouter Drijfhout , Frits Koning , Elisabeth Hermine Adriane Spaenij-Dekking
IPC分类号： A23L1/10 , G01N33/00 , G01N33/566 , A01H5/00
CPC分类号： G01N33/564
摘要： Provided is a mAb-based method for the detection of T cell stimulatory epitopes known to be involved in CD. The method has many advantages compared to the existing methods for the detection of gluten since it is the first method that can; (i) detect T cell stimulatory epitopes of gluten; (ii) detect the epitopes separately, (iii) detect T cell stimulatory epitopes present on gliadin and glutenin homologues present in other cereals also known to be involved in CD; and (iv) detect T cell stimulatory epitopes on both intact proteins and small protein fragments. The new method is a valuable tool in the screening of basic ingredients, semi manufactured ingredients and food products that are intended to be used in the gluten free diet of CD patients. Moreover the new method can also be used for the screening of cereals and different wheat varieties for the level of toxicity for CD patients. Thereby the method can help in the selection of cereals and wheat varieties with low toxicity which might form the basis for future breeding programs. In the future these cereals will be used for the production of safe food for CD patients.
摘要翻译：提供了用于检测已知参与CD的T细胞刺激表位的基于mAb的方法。该方法与现有的面筋检测方法相比具有许多优点，因为它是可以的第一种方法; （i）检测麸质的T细胞刺激表位; （ii）分别检测表位，（iii）检测存在于也已知参与CD的其他谷物中存在的麦醇溶蛋白和谷蛋白同源物上的T细胞刺激表位; 和（iv）检测完整蛋白质和小蛋白质片段上的T细胞刺激表位。新方法是筛选用于CD患者无麸质饮食的基本成分，半成品和食品的有价值的工具。此外，新方法还可用于筛选谷物和不同小麦品种的CD患者的毒性水平。因此，该方法可以帮助选择低毒的谷物和小麦品种，这可能成为未来育种计划的基础。将来这些谷物将用于生产CD患者的安全食品。

8. 发明授权

US09522962B2 Peptides, conjugates and method for increasing immunogenicity of a vaccine 有权
标题翻译：肽，缀合物和增加疫苗免疫原性的方法
公开(公告)号：US09522962B2
公开(公告)日：2016-12-20
申请号：US13635384
申请日：2011-03-15
申请人： Ferdinand Antonius Ossendorp , Cornelis Joseph Maria Melief , Jan Wouter Drijfhout
发明人： Ferdinand Antonius Ossendorp , Cornelis Joseph Maria Melief , Jan Wouter Drijfhout
IPC分类号： A61K39/00 , C07K17/02 , A61K39/385 , A61K39/40 , C07K14/33 , C07K16/12 , C07K7/08
CPC分类号： C07K17/02 , A61K39/00 , A61K39/385 , A61K39/40 , A61K2039/6037 , A61K2039/627 , C07K7/08 , C07K14/33 , C07K16/1282 , A61K2300/00
摘要： The present invention relates to conjugates comprising a peptide of at least 10 amino acid residues comprising the amino acid sequence GITELKKL (residues 383-390 of SEQ ID NO: 3) for induction of potent humoral and cellular immune responses when administered to subjects having antibodies against tetanus toxoid. In one embodiment the invention relates to a prophylactic and therapeutic vaccine and in a further embodiment the invention relates to the treatment or prevention of cancer or an infectious disease.
摘要翻译：本发明涉及包含至少10个氨基酸残基的肽的缀合物，其包含氨基酸序列GITELKKL（SEQ ID NO：3的残基383-390），用于在施用于具有抗体的抗体的受试者时诱导有效的体液和细胞免疫应答破伤风类毒素。在一个实施方案中，本发明涉及预防和治疗性疫苗，并且在进一步的实施方案中，本发明涉及癌症或感染性疾病的治疗或预防。

9. 发明授权

US07803756B2 Antimicrobial peptides derived from CAP18 失效
标题翻译：衍生自CAP18的抗微生物肽
公开(公告)号：US07803756B2
公开(公告)日：2010-09-28
申请号：US11658415
申请日：2005-07-26
申请人： Johannes Jakobus Grote , Jan Wouter Drijfhout , Pieter Sicco Hiemstra , Marcel Jan Vonk , Maartje Johanna Nell , Guido Vincent Bloemberg
发明人： Johannes Jakobus Grote , Jan Wouter Drijfhout , Pieter Sicco Hiemstra , Marcel Jan Vonk , Maartje Johanna Nell , Guido Vincent Bloemberg
IPC分类号： C07K14/00
CPC分类号： A61K38/17
摘要： The invention provides methods to exert antimicrobial effects in prophylactic or therapeutic treatment of bacterial or fungal infections employing polypeptides that have affinity to microbial and fungal toxins.
摘要翻译：本发明提供了使用对微生物和真菌毒素具有亲和力的多肽在预防或治疗性治疗细菌或真菌感染中发挥抗微生物作用的方法。

10. 发明申请

US20090220534A1 METHODS FOR IDENTIFYING T-CELL EPITOPES ASSOCIATED WITH IMPAIRED PEPTIDE PROCESSING AND APPLICATIONS OF THE IDENTIFIED EPITOPES 审中-公开
标题翻译：用于鉴定与缺陷肽加工相关的T细胞外膜的方法和鉴定的抗原决定簇的应用
公开(公告)号：US20090220534A1
公开(公告)日：2009-09-03
申请号：US12293054
申请日：2007-03-16
申请人： Thorbald van Hall , Andreas Oliver Weinzierl , Petrus Antonius van Veelen , Jan Wouter Drijfhout , Cornelis Johannes Maria Melief , Rienk Offringa
发明人： Thorbald van Hall , Andreas Oliver Weinzierl , Petrus Antonius van Veelen , Jan Wouter Drijfhout , Cornelis Johannes Maria Melief , Rienk Offringa
IPC分类号： A61K39/00 , C12N5/10 , C12N15/63 , C40B30/04 , C07K7/08 , C07H21/04
CPC分类号： G01N33/56977 , G01N33/505 , G01N2333/70539
摘要： The current invention provides methods for the identification of antigens and/or epitopes that are differentially displayed on TAP deficient or TAP impaired cells and are not detectably displayed on normal or TAP proficient cells. The identification and applications of these differentially presented antigens, which in this specification are referred to as TEIPP, T cell Epitopes associated with Impaired Peptide Processing, is a prime object of this invention. The invention also provides peptides comprising a TEIPP epitope obtained from the methods of the invention, which may be applied in medicaments and methods of treatment raising a T cell response against TAP deficient tumor cells or virally infected cells.
摘要翻译：本发明提供用于鉴定在TAP缺陷型或TAP受损细胞上差异显示并且不可检测地显示在正常或TAP精通细胞上的抗原和/或表位的方法。在本说明书中将这些差异表达的抗原的鉴定和应用称为TEIPP，与受损肽加工相关的T细胞表位，是本发明的主要目的。本发明还提供了包含可用于药物的本发明方法获得的TEIPP表位的肽，以及提高针对TAP缺陷型肿瘤细胞或病毒感染细胞的T细胞应答的治疗方法。

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