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1. 发明申请

US20070123589A1 Method for producing chiral or enantiomer-enriched beta-amino acids, aldehydes, ketones and gama-amino alcohols 审中-公开
标题翻译：制备手性或对映体富集的β-氨基酸，醛，酮和氨基醇的方法
公开(公告)号：US20070123589A1
公开(公告)日：2007-05-31
申请号：US10582671
申请日：2004-11-25
申请人： Walther Jary , Ben De Lange , Quirinus Broxterman , Peter Pochlauer , Marcellas Van Der Sluis , Patrick Uiterweerd , Heinz Falk , Gerhard Zuckerstatter
发明人： Walther Jary , Ben De Lange , Quirinus Broxterman , Peter Pochlauer , Marcellas Van Der Sluis , Patrick Uiterweerd , Heinz Falk , Gerhard Zuckerstatter
IPC分类号： A61K31/195 , A61K31/13 , C07C227/02
CPC分类号： C07C213/00 , C07C231/12 , Y02P20/55 , C07C215/28 , C07C233/18 , C07C233/31 , C07C233/47
摘要： The invention relates to an improved method for producing chiral or enantiomer-enriched beta amino acids, -aldehydes, -ketones and gamma-amino alcohols, during which an allyl amine of formula (I), in which: R1 represents an alkyl radical, a cycloalkyl radical, an alkyl radical, a heterocycle radical or a condensed or bridged ring system; R2, R3, R4 and R5, independent of one another, can represent H or an alkyl radical, a cyclo alkyl radical, an aryl radical, a heterocycle radical or a condensed or bridged ring system or radicals R1, R2, R3 and R4, together, form ring systems that can optionally contain one or more heteroatoms, whereby radicals R1, R2, R3, R4 and R5 can be substituted once or a number of times, and; R6 represents H or an N-protective group, is transformed; a) by ozonolysis in a solvent and; b) subsequent decomposition of the peroxide-containing solution by means of an oxidizing agent or reductive reprocessing, into the corresponding amino compound of formula (II), in which R1, R2, R3, R4 and R6 are defined as above, and; A, according to the reprocessing, represents a radical of formula COOH, —C(OH)R5 or —C(O)R5, whereby R5 is defined as above.
摘要翻译：本发明涉及制备手性或对映体富集的β氨基酸，醛，酮和γ-氨基醇的改进方法，其中式（I）的烯丙胺，其中：R1表示烷基，环烷基，烷基，杂环基或稠合或桥连环系; R 2，R 3，R 4和R 5彼此独立地可以表示H或烷基，环烷基，芳基，杂环基或稠合或桥接的环系或基团R 1，R 2，R 3和R 4，一起形成可任选地含有一个或多个杂原子的环系，其中基团R 1，R 2，R 3，R 4和R 5可以被取代一次或多次， R6表示H或N-保护基，被转化; a）通过溶剂中的臭氧分解; b）随后通过氧化剂或还原再加工将含过氧化物的溶液分解成相应的式（II）的氨基化合物，其中R 1，R 2，R 3，R 4和R 6如上定义; 根据后处理，A代表式COOH，-C（OH）R 5或-C（O）R 5的基团，其中R 5如上所定义。

2. 发明申请

US20070129553A1 Process for the preparation of glyceraldehyde acetonide 审中-公开
标题翻译：制备甘油醛缩酮的方法
公开(公告)号：US20070129553A1
公开(公告)日：2007-06-07
申请号：US10576447
申请日：2004-10-25
申请人： Peter Quaedflieg , Danniel Adrianus Franciscus Boxtel Van , Paulus Alsters , Peter Pojarliev , Walther Jary
发明人： Peter Quaedflieg , Danniel Adrianus Franciscus Boxtel Van , Paulus Alsters , Peter Pojarliev , Walther Jary
IPC分类号： C07D317/08 , C07D211/54
CPC分类号： C07D317/26
摘要： The invention relates to a process for the preparation of glyceraldehyde acetonide by oxidation of 2,2-dimethyl-1,3-dioxolane-4-methanol by an oxidizing agent, wherein the 2,2-dimethyl-1,3-dioxolane-4-methanol is oxidized by an organic N-chloro compound in the presence of an inert base and TEMPO or a TEMPO-derivative. In one embodiment of the invention enantiomerically enriched glyceraldehyde acetonide is prepared from the corresponding enantiomerically enriched 2,2-dimethyl-1,3-dioxolane-4-methanol. Preferably, the organic N-chloro compount is trichloroisocyanuric acid or dichlorodimethyl hydantoin. Preferably, the inert base is sodium acetate or sodium bicarbonate.
摘要翻译：本发明涉及通过氧化剂氧化2,2-二甲基-1,3-二氧戊环-4-甲醇制备甘油醛缩酮的方法，其中2,2-二甲基-1,3-二氧戊环-4 - 甲醇在惰性碱和TEMPO或TEMPO衍生物的存在下被有机N-氯化合物氧化。在本发明的一个实施方案中，对映异构体富集的甘油醛缩酮由相应的对映异构体富集的2,2-二甲基-1,3-二氧戊环-4-甲醇制备。优选地，有机N-氯化合物是三氯异氰脲酸或二氯二甲基乙内酰脲。优选地，惰性碱是乙酸钠或碳酸氢钠。

3. 发明申请

US20110098488A1 Process for Oxidizing Organic Substrates By Means of Singlet Oxygen Using a Modified Molybdate LDH Catalyst 审中-公开
标题翻译：使用改性钼酸盐LDH催化剂通过单线态氧氧化有机底物的方法
公开(公告)号：US20110098488A1
公开(公告)日：2011-04-28
申请号：US11918131
申请日：2006-03-18
申请人： Dirk De Vos , Pierre Jacobs , Joos Wahlen , Paul Alsters , Walther Jary
发明人： Dirk De Vos , Pierre Jacobs , Joos Wahlen , Paul Alsters , Walther Jary
IPC分类号： C07C409/04 , C07C409/18
CPC分类号： C07D493/08 , B01J31/1616 , B01J2231/70 , B01J2531/64 , C07B41/14 , C07C45/53 , C07C407/00 , C07C409/04 , C07C409/14 , C07C2601/14 , C07C2601/16 , Y02P20/588
摘要： Oxidation of organic substrates by means of singlet oxygen, in which organic substrates which react with 1O2 are admixed with 10-70% H2O2 in an organic solvent in the presence of a molybdate LDH catalyst modified by ethylene glycol, polyethylene glycol or polyol, and the catalytic decomposition of H2O2 to water and 1O2 is then followed by the oxidation to the corresponding oxidation products, and also modified molybdate LDH catalysts.
摘要翻译：在有机溶剂中，在乙二醇，聚乙二醇或多元醇改性的钼酸盐LDH催化剂的存在下，通过单线态氧氧化有机底物，其中与有机反应的有机底物与10-70％H 2 O 2在有机溶剂中混合，然后将H2O2催化分解成水和1OO，然后氧化成相应的氧化产物，还可以改性钼酸盐LDH催化剂。

4. 发明授权

US07371866B2 Preparation of aromatic and heteroaromatic carboxylic acids by catalytic ozonolysis 失效
标题翻译：通过催化臭氧分解制备芳香族和杂芳族羧酸
公开(公告)号：US07371866B2
公开(公告)日：2008-05-13
申请号：US10437994
申请日：2003-05-15
申请人： Walther Jary , Peter Poechlauer , Thorsten Ganglberger
发明人： Walther Jary , Peter Poechlauer , Thorsten Ganglberger
IPC分类号： C07D213/80 , C07D213/803 , C07D213/807 , C07C51/265
CPC分类号： C07D213/803 , C07C51/34 , C07D213/55 , C07C63/04 , C07C63/70
摘要： A process for catalytically oxidizing alkylaromatic compounds of the formula (I) Ar—CH2—R where Ar is an optionally substituted, aromatic or heteroaromatic 5-membered or 6-membered ring or a ring system having up to 20 carbon atoms where Ar may optionally be fused to a C1-C6-alkyl group in which up to 2 carbon atoms may be replaced by a heteroatom, and R is hydrogen, phenyl, benzyl or heteroaryl, where the phenyl, benzyl or heteroaryl radicals may also be joined to Ar by a bridge, or R together with Ar forms an optionally substituted ring system which may contain one or more optionally substituted heteroatoms, to the corresponding aromatic or heteroaromatic carboxylic acids in a solvent with ozone in the presence of a transition metal catalyst and optionally in the presence of an acid at a temperature between −70° C. and 110° C. to the corresponding carboxylic acid.
摘要翻译：用于催化氧化式（I）的烷基芳族化合物的方法<？in-line-formula description =“In-line Formulas”end =“lead”→Ar-CH 2 -R < 在线公式描述=“在线公式”end =“tail”？>其中Ar是任选取代的芳族或杂芳族5元或6元环或具有至多20个碳原子的环系，其中Ar 可以任选地与C 1 -C 6 - C 6 - 烷基稠合，其中最多2个碳原子可以被杂原子代替，并且R是氢，苯基，苄基或杂芳基，其中苯基，苄基或杂芳基也可以通过桥连接到Ar，或者R与Ar一起形成可以含有一个或多个任选取代的杂原子的任选取代的环系统到相应的芳族或杂芳族羧酸在含有过渡金属催化剂的臭氧的溶剂中，任选在酸存在下，在-70℃至110℃的温度下进行。到相应的羧酸。

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