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1. 发明授权

US09424356B2 Updating a search index using reported browser history data 有权
标题翻译：使用报告的浏览器历史数据更新搜索索引
公开(公告)号：US09424356B2
公开(公告)日：2016-08-23
申请号：US12964092
申请日：2010-12-09
申请人： Walter Sun , Junaid Ahmed , Yipeng Li , Peter Bailey , Nikhil Dandekar , Sasi Parthasarathy , Xin Chen , Xiao Zhang
发明人： Walter Sun , Junaid Ahmed , Yipeng Li , Peter Bailey , Nikhil Dandekar , Sasi Parthasarathy , Xin Chen , Xiao Zhang
IPC分类号： G06F17/30
CPC分类号： G06F17/30312 , G06F17/3053 , G06F17/30613 , G06F17/30864 , G06F17/30867 , G06F17/30876
摘要： Methods, systems, and computer-readable media are provided for updating a search index with new uniform resource locators (URLs) and spiking URLs with increased user interest. History data, provided from browser applications residing on users' computers that indicate URLs accessed by the users, is parsed to identify new/previously unknown URLs. The history data also indicates URLs in which there is increased interest based on a number of recent hits as compared to an average number of hits determined over time. Author postings of new URLs to social networking sites and a quality rating of the authors may also be used to identify and filter new URLs. Search indexes are updated with the new and spiking URL data. As such, lag time between posting of new URLs and spiking of URL interest and inclusion of this data in a search index is greatly decreased.
摘要翻译：提供了方法，系统和计算机可读介质，用于使用新的统一资源定位符（URL）更新搜索索引和增加用户兴趣的加标URL。由驻留在用户计算机上的用于指示用户访问的URL的浏览器应用程序提供的历史数据将被解析，以识别新的/以前未知的URL。与根据随时间确定的平均击球次数相比，历史数据还指示基于最近命中数的兴趣增加的URL。社交网站的新URL的作者发布和作者的品质评级也可用于识别和过滤新的URL。搜索索引将使用新的和加标的URL数据进行更新。因此，新的URL发布之间的滞后时间和URL兴趣的尖峰以及将这些数据包含在搜索索引中的时间大大降低。

2. 发明公开

US20240027403A1 Guided Wave Non-Destructive Testing Using Magnetostrictive Sensor with Moving Magnet and Partial Activation of Magnetostrictive Strip 审中-公开
公开(公告)号：US20240027403A1
公开(公告)日：2024-01-25
申请号：US18357142
申请日：2023-07-23
申请人： Sergey Vinogradov , Xin Chen , Jay Fisher
发明人： Sergey Vinogradov , Xin Chen , Jay Fisher
IPC分类号： G01N29/24 , G01N29/265
CPC分类号： G01N29/2412 , G01N29/265 , G01N2291/044 , G01N2291/0422
摘要： A “partial activation” method of magnetostrictive guided wave testing of a structure. A coil-wrapped magnetostrictive strip is acoustically coupled to the surface of the structure. A permanent magnet is placed over a portion of the strip, such that the permanent magnet covers all or most of the width of the strip but only a portion of its length. A pulsed alternating current source activates the magnetostrictive strip, thereby producing magnetostrictive vibrations in the magnetostrictive strip, and thereby resulting in guided waves in the structure. Response signals are received, then the permanent magnet is moved to a next position along the length of the magnetostrictive strip. As the magnet is moved along the strip, the strip is activated and response signals are received, thereby testing a desired portion of the structure under the strip. The response signals are analyzed to determine the presence of anomalies in the structure.

3. 发明授权

US11085076B2 Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis 有权
公开(公告)号：US11085076B2
公开(公告)日：2021-08-10
申请号：US15763364
申请日：2016-09-28
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/68 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q1/6869
摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

4. 发明授权

US10930031B2 Synchronization method and system for single event list type data in PET imaging 有权
公开(公告)号：US10930031B2
公开(公告)日：2021-02-23
申请号：US14408935
申请日：2012-08-14
申请人： Qingguo Xie , Yuanbao Chen , Jun Zhu , Xin Chen , Zhongyi Wu , Luyao Wang
发明人： Qingguo Xie , Yuanbao Chen , Jun Zhu , Xin Chen , Zhongyi Wu , Luyao Wang
IPC分类号： G06T11/00 , G01T1/29 , A61B6/03
摘要： A method for synchronizing list-mode data of single events in a PET imaging includes: acquiring list-mode data of single events of each independent detector module, calculating a probability density of time intervals between occurrences of single events in detector module and setting initial parameters, determining detection starting time difference of each detector module with iterative peak searching and graded time window, and performing synchronization correction and coincidence discrimination on the single event data in each detector module based on the detection starting time difference. A system for synchronizing list-mode data of single events in a PET imaging includes: a data acquisition and frequency difference compensation module, an initial parameter setting module, a coarse time scale coincidence module, a fine time scale coincidence module and a data synchronization correction and coincidence discrimination module.

5. 发明申请

US20190240198A1 FORMULATIONS AND METHODS FOR THE TREATMENT OF CANCERS 审中-公开
公开(公告)号：US20190240198A1
公开(公告)日：2019-08-08
申请号：US15888962
申请日：2018-02-05
申请人： Dean G. Tang , Xin Chen
发明人： Dean G. Tang , Xin Chen
IPC分类号： A61K31/4166 , A61P35/00
CPC分类号： A61K31/4166 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/551 , A61K2300/00 , A61P35/00
摘要： The present invention is directed to a formulation for treating cancer comprising an androgen receptor signaling inhibitor and a B-cell-lymphoma-2 inhibitor, which may further comprising a Bromodomain-and-Extra-Terminal protein inhibitor or a phosphoinositide 3-kinase inhibitor.

6. 发明授权

US10327739B2 Measuring tissue shear wave properties using one excitation pulse and excitation pulses having different widths and shapes 有权
公开(公告)号：US10327739B2
公开(公告)日：2019-06-25
申请号：US15090357
申请日：2016-04-04
申请人： Yi Zheng , Siping Chen , Tianfu Wang , Xin Chen , Haoming Lin
发明人： Yi Zheng , Siping Chen , Tianfu Wang , Xin Chen , Haoming Lin
IPC分类号： A61B8/08 , G01S7/52 , G01S7/62
摘要： Ultrasound radiation using a single tone burst pulse is applied to a selected location in a tissue region. The induced shear wave is detected in the region and its spectral distribution is calculated and analyzed. This detection may be repeated with other excitation pulses having different widths or different shapes at the same location. The spectral analysis of the detected shear wave is performed according to a nonlinear shear model for solving nonlinearity and viscoelasticity of the tissue at a single location. The detection location can be at one point at a time for imaging two-dimensional or three-dimensional tissue nonlinearities and shear wave properties including nonlinear magnitude variations, nonlinear phase variations, nonlinear coefficients, and viscoelasticity. The induced shear wave are detected at multiple locations along the shear propagation directions for calculating different shear group velocities and different shear phase velocities using different excitation pulses, and calculating nonlinearity and viscoelasticity.

7. 发明授权

US09725669B2 Synergistic mixtures of ionic liquids with other ionic liquids and/or with ashless thiophosphates for antiwear and/or friction reduction applications 有权
公开(公告)号：US09725669B2
公开(公告)日：2017-08-08
申请号：US13889037
申请日：2013-05-07
申请人： Pranesh Aswath , Xin Chen , Vibhu Sharma , Maria Amaya Igartua , Francesco Pagano , Wolfgang Binder , Parvin Zare , Nicole Doerr
发明人： Pranesh Aswath , Xin Chen , Vibhu Sharma , Maria Amaya Igartua , Francesco Pagano , Wolfgang Binder , Parvin Zare , Nicole Doerr
IPC分类号： C10M141/10 , C10M141/08
CPC分类号： C10M141/10 , C10M141/08 , C10M2215/04 , C10M2215/042 , C10M2215/221 , C10M2215/223 , C10M2215/224 , C10M2219/044 , C10M2219/082 , C10M2223/04 , C10M2223/047 , C10M2223/06 , C10N2220/04 , C10N2230/06 , C10N2230/08
摘要： Anti-wear and/or friction reducing formulations that include a mixture of at least one first ionic liquid and at least one ashless antiwear compound. The ashless antiwear compound can be a second ionic liquid or an ashless thiophosphate compound. The formulation desirably provides synergistic anti-wear and/or friction reducing properties. The first IL can be a monocationic ionic liquid or a dicationic ionic liquid. The second IL is a dicationic ionic liquid. The ashless thiophosphate is desirably a thiophosphate, such as a fluorothiophosphate (FTP), an alkylphosphorofluoridothiolate, or an alkylthioperoxydithiophosphate. Antiwear and/or friction reduction formulations comprising the above mixtures diluted up to 25% by weight in a base oil.

8. 发明授权

US09610413B2 Powder medicament mouthpiece and application 有权
公开(公告)号：US09610413B2
公开(公告)日：2017-04-04
申请号：US13994759
申请日：2011-12-15
申请人： Qingtang Chen , Xin Chen
发明人： Qingtang Chen , Xin Chen
IPC分类号： A61M15/00 , A61M15/06 , A61M11/00
CPC分类号： A61M15/00 , A61M11/003 , A61M15/0021 , A61M15/0028 , A61M15/0086 , A61M15/06 , A61M2202/064 , A61M2205/75
摘要： A powder medicament mouthpiece comprising at least one section of through suction tube (1) and a filter (2). One end of the suction tube is a medicament inlet, and the other end (16a) is a suction outlet. The filter (2) is arranged within the suction tube (1). The powder medicament mouthpiece can be connected to multiple models of dry powder inhalers to separate powder medicament from dry powder, and allows for significantly improved efficacy.

9. 发明申请

US20160255873A1 AUTOMATED FRUIT AND VEGETABLE CALYX OR STEM REMOVAL MACHINE 审中-公开
标题翻译：自动水果和蔬菜CALYX或STEM移除机
公开(公告)号：US20160255873A1
公开(公告)日：2016-09-08
申请号：US15152400
申请日：2016-05-11
申请人： Yang Tao , John Lin , Xin Chen , Gary E. Seibel
发明人： Yang Tao , John Lin , Xin Chen , Gary E. Seibel
IPC分类号： A23N15/02 , B26D7/06 , B26F3/00 , B26D5/00
CPC分类号： A23N15/02 , A23L19/03 , B26D5/00 , B26D5/007 , B26D5/34 , B26D7/0625 , B26F3/004
摘要： A system and methods are provided for removal of undesired portions of a fruit or vegetable, such as removal of calyxes from strawberries before they are flash frozen. An automated process for high-throughput fruit or vegetable calyx removal includes a loading system, an identification system, and a removal system. The loading system is configured to transport the fruit or vegetable through the automated process. The loading system may also orient the fruits or vegetables along an axis of the fruit and or align the fruit or vegetables in a desired pattern, orientation, and/or arrangement. The identification system is configured to locate the calyx and determines calyx position data and an optimal cutting path for individual fruit. The removal system uses data received from the identification system to separate the calyx from the fruit or vegetable.
摘要翻译：提供了用于去除水果或蔬菜的不期望的部分的系统和方法，例如在快速冷冻之前从草莓中除去花萼。用于高通量水果或蔬菜花萼去除的自动化过程包括加载系统，识别系统和去除系统。装载系统配置为通过自动化过程运输水果或蔬菜。装载系统还可以沿水果的轴线定向水果或蔬菜，或者以所需的图案，取向和/或布置方式对准水果或蔬菜。识别系统被配置为定位花萼并且确定花萼位置数据和用于单个果实的最佳切割路径。去除系统使用从识别系统接收的数据将花萼与水果或蔬菜分开。

10. 发明授权

US09339614B2 Filtering powder medicament inhaler and application 有权
标题翻译：过滤粉末药物吸入器及应用
公开(公告)号：US09339614B2
公开(公告)日：2016-05-17
申请号：US13994760
申请日：2011-12-15
申请人： Qingtang Chen , Xin Chen
发明人： Qingtang Chen , Xin Chen
IPC分类号： A61M11/00 , A61M15/00 , A61M15/08
CPC分类号： A61M15/0028 , A61M11/003 , A61M15/003 , A61M15/0035 , A61M15/0041 , A61M15/08 , A61M2202/064
摘要： A filtering powdered medicament inhaler comprising a base (1) and an upper base (2). The upper base (2) has arranged therein a separator (62), which is connected at the bottom to a pressure groove (63). The upper base (2) has arranged thereon a hollow tube exterior connector (10) matching a suction tube (131). The hollow tube (19a) and a cavity (9) on one side of the separator (62) are interconnected via conduit (18), or, the hollow tube (19a) is extended for about 8 centimeters to form a mouthpiece. The upper base (2) has arranged in the cavity (9) thereof a filter (121). The base (1) is provided with an external base cover (72) which covers a press-button (5a) so as to reduce air flow into the cavity (9). The medicament inhaling conduit of the inhaler is relatively sealed and allows for rapid entrainment of a sufficient dosage of powdered medicament.
摘要翻译：一种过滤粉末状药物吸入器，其包括基部（1）和上部基部（2）。上基座（2）在其中布置有分隔件（62），其在底部连接到压力槽（63）。上部基座（2）上布置有与抽吸管（131）相匹配的中空管外部连接器（10）。中空管（19a）和分离器（62）的一侧上的空腔（9）通过导管（18）互连，或者中空管（19a）延伸约8厘米以形成接口。上基座（2）在其空腔（9）中布置有过滤器（121）。基座（1）设置有覆盖按钮（5a）的外部基座盖（72），以减少进入空腔（9）的气流。吸入器的药物吸入管道相对密封，并允许快速夹带足够剂量的粉末状药物。

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