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1. 发明授权

US06893634B1 Encapsulated cells producing cytochrome P450 有权
标题翻译：产生细胞色素P450的封闭细胞
公开(公告)号：US06893634B1
公开(公告)日：2005-05-17
申请号：US09160067
申请日：1998-09-24
申请人： Walter H. Günzburg , Peter Karle , Robert Saller , Brian Salmons , Matthias Löhr , Peter Müller
发明人： Walter H. Günzburg , Peter Karle , Robert Saller , Brian Salmons , Matthias Löhr , Peter Müller
IPC分类号： C12N15/09 , A61K9/48 , A61K9/50 , A61K31/00 , A61K31/664 , A61K31/717 , A61K35/12 , A61K38/44 , A61K48/00 , A61P35/00 , C12N5/10 , C12N7/00 , C12N9/02 , C12N15/86 , C12N15/867 , A01N63/00 , A01N43/04 , A61K49/00 , C12N5/00 , C12N15/63
CPC分类号： C12N15/86 , A61K48/00 , A61K2035/128 , C12N9/0079 , C12N2740/10043 , C12N2740/16043
摘要： The present invention relates to capsules encapsulating cytochrome P450 producing cells and cytochrome P450 producing retroviral packaging cells. Furthermore, the present invention relates to the treatment of cancer or any other relevant disease with said capsules and to the use of said capsules for the preparation of a pharmaceutical composition for said treatment.
摘要翻译：本发明涉及包囊细胞色素P450产生细胞和细胞色素P450产生逆转录病毒包装细胞的胶囊。此外，本发明涉及用所述胶囊治疗癌症或任何其它相关疾病，以及所述胶囊用于制备用于所述治疗的药物组合物的用途。

2. 发明授权

US06540995B1 Encapsulated cells producing cytochrome P450 有权
标题翻译：产生细胞色素P450的封闭细胞
公开(公告)号：US06540995B1
公开(公告)日：2003-04-01
申请号：US09442979
申请日：1999-11-18
申请人： Walter H. Günzburg , Peter Karle , Robert Saller , Brian Salmons , Matthias Löhr , Peter Müller
发明人： Walter H. Günzburg , Peter Karle , Robert Saller , Brian Salmons , Matthias Löhr , Peter Müller
IPC分类号： A01N6300
CPC分类号： C12N15/86 , A61K48/00 , A61K2035/128 , C12N9/0079 , C12N2740/10043
摘要： The present invention relates to capsules encapsulating cytochrome P450 producing cells and cytochrome P450 producing retroviral packaging cells. Furthermore, the present invention relates to the treatment of cancer or any other relevant disease with said capsules and to the use of said capsules for the preparation of a pharmaceutical composition for said treatment.
摘要翻译：本发明涉及包囊细胞色素P450产生细胞和细胞色素P450产生逆转录病毒包装细胞的胶囊。此外，本发明涉及用所述胶囊治疗癌症或任何其它相关疾病，以及所述胶囊用于制备用于所述治疗的药物组合物的用途。

3. 发明授权

US07052859B2 MUCIN 4 expression as a marker for pancreatic cancer 有权
标题翻译： MUCIN 4表达作为胰腺癌的标志物
公开(公告)号：US07052859B2
公开(公告)日：2006-05-30
申请号：US10279454
申请日：2002-10-24
申请人： Surinder K. Batra , Randall E Brand , Jöerg Ringel , Grit Faulmann , Matthias Löhr , Grish C. Varshney
发明人： Surinder K. Batra , Randall E Brand , Jöerg Ringel , Grit Faulmann , Matthias Löhr , Grish C. Varshney
IPC分类号： A01N1/02 , G01N33/53 , C12N15/85 , C07K16/00
CPC分类号： C07K16/303 , C07K16/3092 , C12Q1/6886 , C12Q2600/158 , G01N33/57438 , G01N2333/4725
摘要： Methods are provided for the diagnosis of pancreatic cancer.
摘要翻译：为诊断胰腺癌提供了方法。

4. 发明授权

US06576423B2 Specific mucin expression as a marker for pancreatic cancer 有权
标题翻译：特异性粘蛋白表达作为胰腺癌的标志物
公开(公告)号：US06576423B2
公开(公告)日：2003-06-10
申请号：US09733444
申请日：2000-12-08
申请人： Surinder K. Batra , Randall E. Brand , Jöerg Ringel , Grit Faulmann , Matthias Löhr , Grish C. Varshney
发明人： Surinder K. Batra , Randall E. Brand , Jöerg Ringel , Grit Faulmann , Matthias Löhr , Grish C. Varshney
IPC分类号： C12Q168
CPC分类号： C07K16/303 , C07K16/3092 , C12Q1/6886 , C12Q2600/158 , G01N33/57438 , G01N2333/4725
摘要： Methods are provided for the diagnosis of pancreatic cancer.
摘要翻译：为诊断胰腺癌提供了方法。

5. 发明申请

US20160215053A1 CXCL12 (CHEMOKINE (C-X-C MOTIF) LIGAND 12) AND IGFBP2 INHIBITORS FOR THE APPLICATION IN THE TREATMENT OF DIABETES MELLITUS ASSOCIATED PANCREATIC CANCER 审中-公开
标题翻译： CXCL12（CHEMOKINE（C-X-C MOTIF）LIGAND 12）和IGFBP2抑制剂在治疗糖尿病相关胰腺癌中的应用
公开(公告)号：US20160215053A1
公开(公告)日：2016-07-28
申请号：US14915590
申请日：2014-08-27
申请人： Gábor Firneisz , Ralf Jesenofsky , Matthias Löhr
发明人： Gábor Firneisz , Ralf Jesenofsky , Matthias Löhr
IPC分类号： C07K16/28 , A61K31/395 , A61K39/00 , A61K31/713
CPC分类号： C07K16/2866 , A61K31/395 , A61K31/713 , A61K39/0005 , A61K45/00 , A61K2039/53 , C07K14/4703 , C07K14/4743 , C07K14/522 , C07K16/2848 , C07K2317/21 , C07K2317/24
摘要： The subject of the invention is the application of CXCL12 (Chemokine (C-X-C motif) Ligand 12) and IGFBP2 inhibitors for the treatment of diabetes mellitus associated pancreatic cancer. The core of this invention is the discovery that the chronically increased glucose levels (chronic hyperglycemia) could may an important role in the development of the pancreatic cancer and that the development of the pancreatic cancer due to chronic hyperglycemia or an already developed pancreatic cancer may be prevented/inhibited/delayed by the inhibition of CXCL12 and IGFBP2. In addition the subject of the invention is the production of inhibitors for the application as a treatment of diabetes mellitus associated pancreatic cancer and pharmaceutical drugs containing the inhibitors.
摘要翻译：本发明的主题是CXCL12（趋化因子（C-X-C motif）配体12）和IGFBP2抑制剂在治疗糖尿病相关胰腺癌中的应用。本发明的核心是发现，长期增加的葡萄糖水平（慢性高血糖症）可能在胰腺癌的发展中起重要作用，并且由慢性高血糖或已经发展的胰腺癌引起的胰腺癌的发展可能是通过抑制CXCL12和IGFBP2预防/抑制/延迟。此外，本发明的主题是制备用于治疗糖尿病相关胰腺癌和含有抑制剂的药物的抑制剂。

6. 发明授权

US07083607B2 Injection device and method for injecting capsules 失效
标题翻译：注射装置和注射胶囊的方法
公开(公告)号：US07083607B2
公开(公告)日：2006-08-01
申请号：US10483711
申请日：2002-07-12
申请人： Matthias Löhr , Walter Günzburg
发明人： Matthias Löhr , Walter Günzburg
IPC分类号： A61M31/00
CPC分类号： A61M37/0069 , A61B17/3468
摘要： The invention relates to an injection device containing a hollow needle (1), a cutting needle that can be inserted into the hollow needle and that has a cutting tip projecting from the front end of the hollow needle, a catheter (9) that replaces said cutting needle and that can be inserted approximately up to its front end into the hollow needle (9), said catheter having a receiving chamber (30) for a substance in the form of a capsule on its distal end, in addition to a mandrin (29) that can be inserted into the catheter (9) and which can be placed in a position defining a receiving chamber (30) filled with capsules (22) on the distal end of said catheter, wherein the capsules (22) contained in the receiving chamber (30) of the inserted catheter (9) are released without exerting any pressure in the target area of the body (23) once the injection device has been arranged in a target area of a body (23) by relatively pulling back both the catheter (9) and the hollow needle (1) in relation to the mandrin (29) and by then withdrawing the mandrin (29). Preferably, the catheter (9) contains a removable sieve (28) on its frond end.
摘要翻译：本发明涉及一种包含中空针头（1）的注射装置，可插入中空针头并具有从中空针头前端伸出的切割尖端的切割针，替代所述中空针头的导管（9）切割针，并且可以将其大致直到其前端插入到中空针（9）中，所述导管具有用于其远端上的胶囊形式的物质的接收室（30），除了mandrin（ 29），其可以插入导管（9）中并且可以被放置在限定在所述导管的远端上填充有胶囊（22）的接收室（30）的位置，其中包含在所述导管一旦注射装置已经通过相对地拉回两者（23）而将注射装置布置在身体（23）的目标区域中，释放插入的导管（9）的接收室（30）而不施加在主体（23）的目标区域中的任何压力导管（9）和空心针（1）相对于mand（29），然后抽出mand（29）。优选地，导管（9）在其末端包含可移除的筛子（28）。

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